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PubMed:8622883 JSONTXT

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DisGeNET

Id Subject Object Predicate Lexical cue
T0 1346-1349 gene:1029 denotes p16
T1 1298-1306 disease:C0023418 denotes leukemia
R1 T0 T1 associated_with p16,leukemia

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 12-15 protein denotes p16
T2 23-53 protein denotes E2F-dependent thymidine kinase
T3 97-123 DNA denotes MTS1 tumor suppressor gene
T4 127-142 DNA denotes chromosome 9p21
T5 158-161 protein denotes p16
T6 180-211 protein denotes cyclin-dependent-kinase-4 and 6
T7 271-293 protein denotes retinoblastoma protein
T8 297-329 protein denotes cyclin-dependent kinases 4 and 6
T9 364-384 protein denotes transcription factor
T10 385-388 protein denotes E2F
T11 436-459 DNA denotes S phase regulated genes
T12 469-485 protein denotes thymidine kinase
T13 506-509 protein denotes p16
T14 591-612 DNA denotes tumor suppressor gene
T15 628-631 protein denotes E2F
T16 688-704 protein denotes thymidine kinase
T17 708-762 cell_line denotes phytohemagglutinin-stimulated normal human lymphocytes
T18 774-832 cell_line denotes p16-negative human acute lymphoblastic leukemia cell lines
T19 834-840 cell_line denotes MOLT-4
T20 845-848 cell_line denotes CEM
T21 862-880 cell_type denotes normal lymphocytes
T22 882-902 cell_line denotes MOLT-4 and CEM cells
T23 949-965 protein denotes thymidine kinase
T24 1012-1018 protein denotes enzyme
T25 1031-1052 RNA denotes thymidine kinase mRNA
T26 1089-1092 protein denotes p16
T27 1187-1207 cell_line denotes MOLT-4 and CEM cells
T28 1249-1271 protein denotes retinoblastoma protein
T29 1298-1317 cell_line denotes leukemia cell lines
T30 1346-1349 protein denotes p16
T31 1389-1405 protein denotes thymidine kinase
T32 1468-1490 protein denotes retinoblastoma protein
T33 1512-1515 protein denotes E2F
T34 1542-1567 DNA denotes thymidine kinase promoter
T35 1597-1600 protein denotes p16
T36 1651-1657 protein denotes enzyme
T37 1676-1679 protein denotes E2F
T38 1705-1727 protein denotes retinoblastoma protein

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
8622883-1#114#139#gene1019 180-205 gene1019 denotes cyclin-dependent-kinase-4
8622883-1#150#163#diseaseC0596263 216-229 diseaseC0596263 denotes tumorigenesis
8622883-7#73#76#gene1029 1346-1349 gene1029 denotes p16
8622883-7#25#33#diseaseC0023418 1298-1306 diseaseC0023418 denotes leukemia
114#139#gene1019150#163#diseaseC0596263 8622883-1#114#139#gene1019 8622883-1#150#163#diseaseC0596263 associated_with cyclin-dependent-kinase-4,tumorigenesis
73#76#gene102925#33#diseaseC0023418 8622883-7#73#76#gene1029 8622883-7#25#33#diseaseC0023418 associated_with p16,leukemia

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-65 Sentence denotes The role of p16 in the E2F-dependent thymidine kinase regulation.
S2 66-247 Sentence denotes The role of alterations of the MTS1 tumor suppressor gene on chromosome 9p21, which encodes p16, the inhibitor of cyclin-dependent-kinase-4 and 6, in tumorigenesis is not yet clear.
S3 248-486 Sentence denotes Phosphorylation of the retinoblastoma protein by cyclin-dependent kinases 4 and 6 prevents its interaction with the transcription factor E2F, which subsequently promotes the expression of S phase regulated genes, such as thymidine kinase.
S4 487-653 Sentence denotes Although a role of p16 in this regulation has been presumed, there is no proof so far that loss of this tumor suppressor gene really affects E2F-mediated regulations.
S5 654-849 Sentence denotes We investigated the regulation of thymidine kinase in phytohemagglutinin-stimulated normal human lymphocytes and in the p16-negative human acute lymphoblastic leukemia cell lines, MOLT-4 and CEM.
S6 850-1064 Sentence denotes Compared to normal lymphocytes, MOLT-4 and CEM cells exhibited an altered cell cycle regulation of thymidine kinase, a much higher intracellular activity of this enzyme, and higher thymidine kinase mRNA expression.
S7 1065-1272 Sentence denotes Transient expression of p16 in normal human lymphocytes caused arrest in G1, but was without effect on the cell growth of MOLT-4 and CEM cells, although all of them express functional retinoblastoma protein.
S8 1273-1568 Sentence denotes Nevertheless, in the two leukemia cell lines transient overexpression of p16 reestablished the normal regulation of thymidine kinase, paralleled by an increase of the underphosphorylated form of retinoblastoma protein and decrease of free E2F bound to its motif in the thymidine kinase promoter.
S9 1569-1728 Sentence denotes We demonstrate that loss of p16 causes upregulation of this DNA precursor pathway enzyme via activation of E2F by a mechanism involving retinoblastoma protein.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 12-15 NP denotes p16
C2 23-27 NP denotes E2F-
C3 93-123 NP denotes the MTS1 tumor suppressor gene
C4 127-142 NP denotes chromosome 9p21
C5 144-149 NP denotes which
C6 158-161 NP denotes p16
C7 163-211 NP denotes the inhibitor of cyclin-dependent-kinase-4 and 6
C8 267-293 NP denotes the retinoblastoma protein
C9 339-342 NP denotes its
C10 360-388 NP denotes the transcription factor E2F
C11 390-395 NP denotes which
C12 469-485 NP denotes thymidine kinase
C13 506-509 NP denotes p16
C14 560-565 NP denotes proof
C15 573-577 NP denotes that
C17 586-612 NP denotes this tumor suppressor gene
C16 578-612 NP denotes loss of this tumor suppressor gene
C18 628-632 NP denotes E2F-
C19 688-704 NP denotes thymidine kinase
C21 774-778 NP denotes p16-
C20 770-832 NP denotes the p16-negative human acute lymphoblastic leukemia cell lines
C22 834-848 NP denotes MOLT-4 and CEM
C23 862-880 NP denotes normal lymphocytes
C24 882-902 NP denotes MOLT-4 and CEM cells
C25 949-965 NP denotes thymidine kinase
C26 1007-1018 NP denotes this enzyme
C27 1089-1092 NP denotes p16
C28 1096-1120 NP denotes normal human lymphocytes
C29 1187-1207 NP denotes MOLT-4 and CEM cells
C31 1225-1229 NP denotes them
C30 1218-1229 NP denotes all of them
C32 1346-1349 NP denotes p16
C33 1389-1405 NP denotes thymidine kinase
C34 1468-1490 NP denotes retinoblastoma protein
C35 1525-1528 NP denotes its
C37 1597-1600 NP denotes p16
C36 1589-1600 NP denotes loss of p16
C38 1624-1657 NP denotes this DNA precursor pathway enzyme
C39 1676-1679 NP denotes E2F
C40 1705-1727 NP denotes retinoblastoma protein
R1 C5 C4 coref-relat which,chromosome 9p21
R2 C6 C1 coref-ident p16,p16
R3 C7 C6 coref-appos the inhibitor of cyclin-dependent-kinase-4 and 6,p16
R4 C9 C8 coref-pron its,the retinoblastoma protein
R5 C10 C2 coref-ident the transcription factor E2F,E2F-
R6 C11 C10 coref-relat which,the transcription factor E2F
R7 C13 C6 coref-ident p16,p16
R8 C15 C14 coref-relat that,proof
R9 C17 C3 coref-ident this tumor suppressor gene,the MTS1 tumor suppressor gene
R10 C18 C10 coref-ident E2F-,the transcription factor E2F
R11 C19 C12 coref-ident thymidine kinase,thymidine kinase
R12 C21 C13 coref-ident p16-,p16
R13 C22 C20 coref-appos MOLT-4 and CEM,the p16-negative human acute lymphoblastic leukemia cell lines
R14 C24 C22 coref-ident MOLT-4 and CEM cells,MOLT-4 and CEM
R15 C25 C19 coref-ident thymidine kinase,thymidine kinase
R16 C26 C25 coref-ident this enzyme,thymidine kinase
R17 C27 C21 coref-ident p16,p16-
R18 C28 C23 coref-ident normal human lymphocytes,normal lymphocytes
R19 C31 C29 coref-pron them,MOLT-4 and CEM cells
R20 C30 C29 coref-ident all of them,MOLT-4 and CEM cells
R21 C32 C27 coref-ident p16,p16
R22 C33 C25 coref-ident thymidine kinase,thymidine kinase
R23 C35 C34 coref-pron its,retinoblastoma protein
R24 C37 C32 coref-ident p16,p16
R25 C36 C16 coref-ident loss of p16,loss of this tumor suppressor gene
R26 C38 C26 coref-ident this DNA precursor pathway enzyme,this enzyme
R27 C39 C18 coref-ident E2F,E2F-
R28 C40 C34 coref-ident retinoblastoma protein,retinoblastoma protein

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 12-15 protein_molecule denotes p16
T2 23-53 protein_molecule denotes E2F-dependent thymidine kinase
T3 97-101 DNA_domain_or_region denotes MTS1
T4 127-142 DNA_molecule denotes chromosome 9p21
T5 158-161 protein_molecule denotes p16
T6 216-229 other_name denotes tumorigenesis
T7 271-293 protein_family_or_group denotes retinoblastoma protein
T8 364-384 protein_family_or_group denotes transcription factor
T9 385-388 protein_molecule denotes E2F
T10 436-443 other_name denotes S phase
T11 469-485 protein_family_or_group denotes thymidine kinase
T12 506-509 protein_molecule denotes p16
T13 591-612 DNA_domain_or_region denotes tumor suppressor gene
T14 628-631 protein_molecule denotes E2F
T15 688-704 protein_family_or_group denotes thymidine kinase
T16 708-726 protein_molecule denotes phytohemagglutinin
T17 774-777 protein_molecule denotes p16
T18 834-840 cell_line denotes MOLT-4
T19 845-848 cell_line denotes CEM
T20 862-880 cell_type denotes normal lymphocytes
T21 924-945 other_name denotes cell cycle regulation
T22 949-965 protein_family_or_group denotes thymidine kinase
T23 1012-1018 protein_family_or_group denotes enzyme
T24 1031-1047 protein_family_or_group denotes thymidine kinase
T25 1089-1092 protein_molecule denotes p16
T26 1249-1271 protein_family_or_group denotes retinoblastoma protein
T27 1298-1317 cell_line denotes leukemia cell lines
T28 1346-1349 protein_molecule denotes p16
T29 1389-1405 protein_family_or_group denotes thymidine kinase
T30 1468-1490 protein_family_or_group denotes retinoblastoma protein
T31 1512-1515 protein_molecule denotes E2F
T32 1542-1558 protein_family_or_group denotes thymidine kinase
T33 1597-1600 protein_molecule denotes p16
T34 1629-1650 other_name denotes DNA precursor pathway
T35 1651-1657 protein_family_or_group denotes enzyme
T36 1676-1679 protein_molecule denotes E2F
T37 1705-1727 protein_family_or_group denotes retinoblastoma protein