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sentences

Id Subject Object Predicate Lexical cue
T1 0-83 Sentence denotes Characterization of the structure and function of a novel MAP kinase kinase (MKK6).
T2 84-224 Sentence denotes Mitogen-activated protein (MAP) kinases require dual phosphorylation on threonine and tyrosine residues in order to gain enzymatic activity.
T3 225-322 Sentence denotes This activation is carried out by a family of enzymes known as MAP kinase kinases (MKKs or MEKs).
T4 323-533 Sentence denotes It appears that there are at least four subgroups in this family; MEK1/MEK2 subgroup that activates ERK1/ERK2, MEK5 that activates ERK5/BMK1, MKK3 that activates p38, and MKK4 that activates p38 and Jun kinase.
T5 534-596 Sentence denotes Here we describe the characteristics of a new MKK termed MKK6.
T6 597-754 Sentence denotes The clones we isolated encode two splice isoforms of human MKK6 comprised of 278 and 334 amino acids, respectively, and one murine MKK6 with 237 amino acids.
T7 755-854 Sentence denotes Sequence information derived from cDNA cloning indicated that MKK6 is most closely related to MKK3.
T8 855-974 Sentence denotes The functional data revealed from co-transfection assays suggests that MKK6, like MKK3, selectively phosphorylates p38.
T9 975-1126 Sentence denotes Unlike the previously described MKKs (or MEKs), MKK6 exists in a variety of alternatively spliced isoforms with distinct patterns of tissue expression.
T10 1127-1221 Sentence denotes This suggests novel mechanisms regulating activation and/or function of various forms of MKK6.
T1 0-83 Sentence denotes Characterization of the structure and function of a novel MAP kinase kinase (MKK6).
T2 84-224 Sentence denotes Mitogen-activated protein (MAP) kinases require dual phosphorylation on threonine and tyrosine residues in order to gain enzymatic activity.
T3 225-322 Sentence denotes This activation is carried out by a family of enzymes known as MAP kinase kinases (MKKs or MEKs).
T4 323-533 Sentence denotes It appears that there are at least four subgroups in this family; MEK1/MEK2 subgroup that activates ERK1/ERK2, MEK5 that activates ERK5/BMK1, MKK3 that activates p38, and MKK4 that activates p38 and Jun kinase.
T5 534-596 Sentence denotes Here we describe the characteristics of a new MKK termed MKK6.
T6 597-754 Sentence denotes The clones we isolated encode two splice isoforms of human MKK6 comprised of 278 and 334 amino acids, respectively, and one murine MKK6 with 237 amino acids.
T7 755-854 Sentence denotes Sequence information derived from cDNA cloning indicated that MKK6 is most closely related to MKK3.
T8 855-974 Sentence denotes The functional data revealed from co-transfection assays suggests that MKK6, like MKK3, selectively phosphorylates p38.
T9 975-1126 Sentence denotes Unlike the previously described MKKs (or MEKs), MKK6 exists in a variety of alternatively spliced isoforms with distinct patterns of tissue expression.
T10 1127-1221 Sentence denotes This suggests novel mechanisms regulating activation and/or function of various forms of MKK6.

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 308-312 Disease denotes MKKs http://purl.obolibrary.org/obo/MONDO_0009367
T2 1007-1011 Disease denotes MKKs http://purl.obolibrary.org/obo/MONDO_0009367

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 650-655 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 1108-1114 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479