> top > docs > PubMed:8621667 > annotations

PubMed:8621667 JSONTXT

Annnotations TAB JSON ListView MergeView

sentences

Id Subject Object Predicate Lexical cue
T1 0-137 Sentence denotes The natural mutation Y248C of human angiotensinogen leads to abnormal glycosylation and altered immunological recognition of the protein.
T2 138-237 Sentence denotes Common molecular variants of the angiotensinogen gene have been associated with human hypertension.
T3 238-337 Sentence denotes The rare Tyr to Cys change at residue 248 of mature angiotensinogen was identified in one pedigree.
T4 338-487 Sentence denotes Heterozygous individuals (Y248C) had a 40% decrease in plasma angiotensinogen concentration and a 35% reduction of the angiotensin I production rate.
T5 488-603 Sentence denotes Recombinant wild-type (Tyr-248) and mutant (Cys-248) proteins were stably expressed in Chinese hamster ovary cells.
T6 604-796 Sentence denotes Angiotensinogen monoclonal antibodies revealed marked differences in the epitope recognition of the mutant protein and allowed the demonstration of its presence in plasma of Y248C individuals.
T7 797-900 Sentence denotes Similar kinetic constants of angiotensin I production with human renin were observed for both proteins.
T8 901-1061 Sentence denotes Western blot analysis showed similar heterogeneities; however, a 3-kDa increase in molecular mass for the Cys-248 protein was observed after immunopurification.
T9 1062-1267 Sentence denotes Metabolic labeling of the intracellular Cys-248 protein showed a 61-kDa band in addition to the 55.5- and 58-kDa bands observed for the Tyr-248 protein, with all bands being sensitive to endoglycosidase H.
T10 1268-1368 Sentence denotes In addition, pulse-chase studies revealed a slower intracellular processing for the Cys-248 protein.
T11 1369-1600 Sentence denotes In conclusion, the Cys-248 mutation alters the structure, glycosylation, and secretion of angiotensinogen in Chinese hamster ovary cells and is accompanied by a decrease in plasma angiotensinogen concentration in Y248C individuals.
T1 0-137 Sentence denotes The natural mutation Y248C of human angiotensinogen leads to abnormal glycosylation and altered immunological recognition of the protein.
T2 138-237 Sentence denotes Common molecular variants of the angiotensinogen gene have been associated with human hypertension.
T3 238-337 Sentence denotes The rare Tyr to Cys change at residue 248 of mature angiotensinogen was identified in one pedigree.
T4 338-487 Sentence denotes Heterozygous individuals (Y248C) had a 40% decrease in plasma angiotensinogen concentration and a 35% reduction of the angiotensin I production rate.
T5 488-603 Sentence denotes Recombinant wild-type (Tyr-248) and mutant (Cys-248) proteins were stably expressed in Chinese hamster ovary cells.
T6 604-796 Sentence denotes Angiotensinogen monoclonal antibodies revealed marked differences in the epitope recognition of the mutant protein and allowed the demonstration of its presence in plasma of Y248C individuals.
T7 797-900 Sentence denotes Similar kinetic constants of angiotensin I production with human renin were observed for both proteins.
T8 901-1061 Sentence denotes Western blot analysis showed similar heterogeneities; however, a 3-kDa increase in molecular mass for the Cys-248 protein was observed after immunopurification.
T9 1062-1267 Sentence denotes Metabolic labeling of the intracellular Cys-248 protein showed a 61-kDa band in addition to the 55.5- and 58-kDa bands observed for the Tyr-248 protein, with all bands being sensitive to endoglycosidase H.
T10 1268-1368 Sentence denotes In addition, pulse-chase studies revealed a slower intracellular processing for the Cys-248 protein.
T11 1369-1600 Sentence denotes In conclusion, the Cys-248 mutation alters the structure, glycosylation, and secretion of angiotensinogen in Chinese hamster ovary cells and is accompanied by a decrease in plasma angiotensinogen concentration in Y248C individuals.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 171-186 gene:183 denotes angiotensinogen
T1 224-236 disease:C0020538 denotes hypertension
R1 T0 T1 associated_with angiotensinogen,hypertension

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
8621667-1#33#48#gene183 171-186 gene183 denotes angiotensinogen
8621667-1#86#98#diseaseC0020538 224-236 diseaseC0020538 denotes hypertension
33#48#gene18386#98#diseaseC0020538 8621667-1#33#48#gene183 8621667-1#86#98#diseaseC0020538 associated_with angiotensinogen,hypertension

PubCasesHPO

Id Subject Object Predicate Lexical cue
TI1 61-83 HP:0012345 denotes abnormal glycosylation
AB1 224-236 HP:0000822 denotes hypertension

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 224-236 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 61-83 Phenotype denotes abnormal glycosylation HP:0012345
T2 224-236 Phenotype denotes hypertension HP:0000822

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 30-35 OrganismTaxon denotes human 9606
T2 218-223 OrganismTaxon denotes human 9606
T3 575-590 OrganismTaxon denotes Chinese hamster 10029
T4 856-861 OrganismTaxon denotes human 9606
T5 1478-1493 OrganismTaxon denotes Chinese hamster 10029

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 393-399 Body_part denotes plasma http://purl.obolibrary.org/obo/UBERON_0001969
T2 591-596 Body_part denotes ovary http://purl.obolibrary.org/obo/UBERON_0000992
T3 768-774 Body_part denotes plasma http://purl.obolibrary.org/obo/UBERON_0001969
T4 1088-1101 Body_part denotes intracellular http://purl.obolibrary.org/obo/GO_0005622
T5 1319-1332 Body_part denotes intracellular http://purl.obolibrary.org/obo/GO_0005622
T6 1494-1499 Body_part denotes ovary http://purl.obolibrary.org/obo/UBERON_0000992
T7 1542-1548 Body_part denotes plasma http://purl.obolibrary.org/obo/UBERON_0001969

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 1134-1138 Cell denotes band http://purl.obolibrary.org/obo/CL:0000560