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sentences

Id Subject Object Predicate Lexical cue
T1 0-102 Sentence denotes Identification of vascular endothelial growth factor determinants for binding KDR and FLT-1 receptors.
T2 103-179 Sentence denotes Generation of receptor-selective VEGF variants by site-directed mutagenesis.
T3 180-295 Sentence denotes Vascular endothelial growth factor (VEGF) expression in various cell types is induced by hypoxia and other stimuli.
T4 296-521 Sentence denotes VEGF mediates endothelial cell proliferation, angiogenesis, vascular growth, and vascular permeability via the endothelial cell receptors, kinase insert domain-containing receptor (KDR)/fetal liver kinase 1 (Flk-1) and FLT-1.
T5 522-644 Sentence denotes Alanine-scanning mutagenesis was used to identify a positively charged surface in VEGF that mediates binding to KDR/Flk-1.
T6 645-840 Sentence denotes Arg82, Lys84 and His86, located in a hairpin loop, were found to be critical for binding KDR/Flk-1, while negatively charged residues, Asp63, Glu64, and Glu67, were associated with FLT-1 binding.
T7 841-990 Sentence denotes A VEGF model based on PDGFb indicated these positively and negatively charged regions are distal in the monomer but are spatially close in the dimer.
T8 991-1124 Sentence denotes Mutations within the KDR site had minimal effect on FLT-1 binding, and mutants deficient in FLT-1 binding did not affect KDR binding.
T9 1125-1263 Sentence denotes Endothelial cell mitogenesis was abolished in mutants lacking KDR affinity; however, FLT-1 deficient mutants induced normal proliferation.
T10 1264-1422 Sentence denotes These results suggest dual sets of determinants in the VEGF dimer that cross-link cell surface receptors, triggering endothelial cell growth and angiogenesis.
T11 1423-1544 Sentence denotes Furthermore, this mutational analysis implicates KDR, but not FLT-1, in VEGF induction of endothelial cell proliferation.
T1 0-102 Sentence denotes Identification of vascular endothelial growth factor determinants for binding KDR and FLT-1 receptors.
T2 103-179 Sentence denotes Generation of receptor-selective VEGF variants by site-directed mutagenesis.
T3 180-295 Sentence denotes Vascular endothelial growth factor (VEGF) expression in various cell types is induced by hypoxia and other stimuli.
T4 296-521 Sentence denotes VEGF mediates endothelial cell proliferation, angiogenesis, vascular growth, and vascular permeability via the endothelial cell receptors, kinase insert domain-containing receptor (KDR)/fetal liver kinase 1 (Flk-1) and FLT-1.
T5 522-644 Sentence denotes Alanine-scanning mutagenesis was used to identify a positively charged surface in VEGF that mediates binding to KDR/Flk-1.
T6 645-840 Sentence denotes Arg82, Lys84 and His86, located in a hairpin loop, were found to be critical for binding KDR/Flk-1, while negatively charged residues, Asp63, Glu64, and Glu67, were associated with FLT-1 binding.
T7 841-990 Sentence denotes A VEGF model based on PDGFb indicated these positively and negatively charged regions are distal in the monomer but are spatially close in the dimer.
T8 991-1124 Sentence denotes Mutations within the KDR site had minimal effect on FLT-1 binding, and mutants deficient in FLT-1 binding did not affect KDR binding.
T9 1125-1263 Sentence denotes Endothelial cell mitogenesis was abolished in mutants lacking KDR affinity; however, FLT-1 deficient mutants induced normal proliferation.
T10 1264-1422 Sentence denotes These results suggest dual sets of determinants in the VEGF dimer that cross-link cell surface receptors, triggering endothelial cell growth and angiogenesis.
T11 1423-1544 Sentence denotes Furthermore, this mutational analysis implicates KDR, but not FLT-1, in VEGF induction of endothelial cell proliferation.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 488-493 http://purl.obolibrary.org/obo/MAT_0000097 denotes liver

AIMed

Id Subject Object Predicate Lexical cue
T1 78-81 protein denotes KDR
T2 86-91 protein denotes FLT-1
T3 136-140 protein denotes VEGF
T4 180-214 protein denotes Vascular endothelial growth factor
T5 216-220 protein denotes VEGF
T6 296-300 protein denotes VEGF
T7 435-475 protein denotes kinase insert domain-containing receptor
T8 477-480 protein denotes KDR
T9 482-502 protein denotes fetal liver kinase 1
T10 504-509 protein denotes Flk-1
T11 515-520 protein denotes FLT-1
T12 604-608 protein denotes VEGF
T13 634-637 protein denotes KDR
T14 638-643 protein denotes Flk-1
T15 734-737 protein denotes KDR
T16 738-743 protein denotes Flk-1
T17 826-831 protein denotes FLT-1
T18 843-847 protein denotes VEGF
T19 863-868 protein denotes PDGFb
T20 1012-1015 protein denotes KDR
T21 1043-1048 protein denotes FLT-1
T22 1083-1088 protein denotes FLT-1
T23 1112-1115 protein denotes KDR
T24 1187-1190 protein denotes KDR
T25 1210-1215 protein denotes FLT-1
T26 1319-1323 protein denotes VEGF
T27 1472-1475 protein denotes KDR
T28 1485-1490 protein denotes FLT-1
T29 1495-1499 protein denotes VEGF

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 488-493 Body_part denotes liver http://purl.obolibrary.org/obo/MAT_0000097

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 269-276 Phenotype denotes hypoxia HP:0012418

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 310-326 Body_part denotes endothelial cell http://purl.obolibrary.org/obo/CL_0000115
T2 407-423 Body_part denotes endothelial cell http://purl.obolibrary.org/obo/CL_0000115
T3 488-493 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T4 1125-1141 Body_part denotes Endothelial cell http://purl.obolibrary.org/obo/CL_0000115
T5 1381-1397 Body_part denotes endothelial cell http://purl.obolibrary.org/obo/CL_0000115
T6 1513-1529 Body_part denotes endothelial cell http://purl.obolibrary.org/obo/CL_0000115

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 310-326 Cell denotes endothelial cell http://purl.obolibrary.org/obo/CL:0000115
T2 407-423 Cell denotes endothelial cell http://purl.obolibrary.org/obo/CL:0000115
T3 1125-1141 Cell denotes Endothelial cell http://purl.obolibrary.org/obo/CL:0000115
T4 1381-1397 Cell denotes endothelial cell http://purl.obolibrary.org/obo/CL:0000115
T5 1513-1529 Cell denotes endothelial cell http://purl.obolibrary.org/obo/CL:0000115