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PubMed:8617766 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
T1 0-103 Sentence denotes Ubiquitinylation of transcription factors c-Jun and c-Fos using reconstituted ubiquitinylating enzymes.
T2 104-264 Sentence denotes Recombinant c-Jun and c-Fos were ubiquitinylated by the ubiquitin carrier enzymes E214K, E220K, or E232K in the presence of the ubiquitin-activating enzyme, E1.
T3 265-383 Sentence denotes Addition of ubiquitin protein ligase E3 substantially enhanced the E214K-mediated ubiquitinylation of c-Jun and c-Fos.
T4 384-625 Sentence denotes Truncated c-Jun and c-Fos mutant proteins including wbJun and wbFos were also ubiquitinylated under the same conditions, suggesting the sites of ubiquitinylation are located within the dimerization and DNA binding domains of c-Jun and c-Fos.
T5 626-731 Sentence denotes The E3-dependent ubiquitinylation of c-Jun was inhibited upon the heterodimerization of c-Jun with c-Fos.
T6 732-864 Sentence denotes Further addition of E220K significantly enhanced ubiquitinylation of c-Jun in the heterodimer suggesting a regulatory role of E220K.
T7 865-1020 Sentence denotes Polyubiquitinylated c-Jun, wbFos, and wbJun, but not E220K-ubiquitinylated c-Jun, were readily degraded by the ATP-dependent 26 S multicatalytic proteases.
T8 1021-1335 Sentence denotes These results suggest that the temporal control of c-Jun and c-Fos may be regulated through the ubiquitinylation pathways, and the ubiquitinylation of c-Jun and c-Fos may in turn be regulated in response to the heterodimerization between them and the cooperation between E220K and E3 mediated polyubiquitinylation.
T1 0-103 Sentence denotes Ubiquitinylation of transcription factors c-Jun and c-Fos using reconstituted ubiquitinylating enzymes.
T2 104-264 Sentence denotes Recombinant c-Jun and c-Fos were ubiquitinylated by the ubiquitin carrier enzymes E214K, E220K, or E232K in the presence of the ubiquitin-activating enzyme, E1.
T3 265-383 Sentence denotes Addition of ubiquitin protein ligase E3 substantially enhanced the E214K-mediated ubiquitinylation of c-Jun and c-Fos.
T4 384-625 Sentence denotes Truncated c-Jun and c-Fos mutant proteins including wbJun and wbFos were also ubiquitinylated under the same conditions, suggesting the sites of ubiquitinylation are located within the dimerization and DNA binding domains of c-Jun and c-Fos.
T5 626-731 Sentence denotes The E3-dependent ubiquitinylation of c-Jun was inhibited upon the heterodimerization of c-Jun with c-Fos.
T6 732-864 Sentence denotes Further addition of E220K significantly enhanced ubiquitinylation of c-Jun in the heterodimer suggesting a regulatory role of E220K.
T7 865-1020 Sentence denotes Polyubiquitinylated c-Jun, wbFos, and wbJun, but not E220K-ubiquitinylated c-Jun, were readily degraded by the ATP-dependent 26 S multicatalytic proteases.
T8 1021-1335 Sentence denotes These results suggest that the temporal control of c-Jun and c-Fos may be regulated through the ubiquitinylation pathways, and the ubiquitinylation of c-Jun and c-Fos may in turn be regulated in response to the heterodimerization between them and the cooperation between E220K and E3 mediated polyubiquitinylation.

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 20-41 protein denotes transcription factors
T2 42-47 protein denotes c-Jun
T3 52-57 protein denotes c-Fos
T4 64-102 protein denotes reconstituted ubiquitinylating enzymes
T5 116-121 protein denotes c-Jun
T6 126-131 protein denotes c-Fos
T7 160-185 protein denotes ubiquitin carrier enzymes
T8 186-191 protein denotes E214K
T9 193-198 protein denotes E220K
T10 203-208 protein denotes E232K
T11 232-259 protein denotes ubiquitin-activating enzyme
T12 261-263 protein denotes E1
T13 277-304 protein denotes ubiquitin protein ligase E3
T14 332-337 protein denotes E214K
T15 367-372 protein denotes c-Jun
T16 377-382 protein denotes c-Fos
T17 384-425 protein denotes Truncated c-Jun and c-Fos mutant proteins
T18 436-441 protein denotes wbJun
T19 446-451 protein denotes wbFos
T20 569-605 protein denotes dimerization and DNA binding domains
T21 609-614 protein denotes c-Jun
T22 619-624 protein denotes c-Fos
T23 663-668 protein denotes c-Jun
T24 714-719 protein denotes c-Jun
T25 725-730 protein denotes c-Fos
T26 752-757 protein denotes E220K
T27 801-806 protein denotes c-Jun
T28 858-863 protein denotes E220K
T29 885-890 protein denotes c-Jun
T30 892-897 protein denotes wbFos
T31 903-908 protein denotes wbJun
T32 918-945 protein denotes E220K-ubiquitinylated c-Jun
T33 976-1019 protein denotes ATP-dependent 26 S multicatalytic proteases
T34 1072-1077 protein denotes c-Jun
T35 1082-1087 protein denotes c-Fos
T36 1172-1177 protein denotes c-Jun
T37 1182-1187 protein denotes c-Fos
T38 1292-1297 protein denotes E220K

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-103 Sentence denotes Ubiquitinylation of transcription factors c-Jun and c-Fos using reconstituted ubiquitinylating enzymes.
S2 104-264 Sentence denotes Recombinant c-Jun and c-Fos were ubiquitinylated by the ubiquitin carrier enzymes E214K, E220K, or E232K in the presence of the ubiquitin-activating enzyme, E1.
S3 265-383 Sentence denotes Addition of ubiquitin protein ligase E3 substantially enhanced the E214K-mediated ubiquitinylation of c-Jun and c-Fos.
S4 384-625 Sentence denotes Truncated c-Jun and c-Fos mutant proteins including wbJun and wbFos were also ubiquitinylated under the same conditions, suggesting the sites of ubiquitinylation are located within the dimerization and DNA binding domains of c-Jun and c-Fos.
S5 626-731 Sentence denotes The E3-dependent ubiquitinylation of c-Jun was inhibited upon the heterodimerization of c-Jun with c-Fos.
S6 732-864 Sentence denotes Further addition of E220K significantly enhanced ubiquitinylation of c-Jun in the heterodimer suggesting a regulatory role of E220K.
S7 865-1020 Sentence denotes Polyubiquitinylated c-Jun, wbFos, and wbJun, but not E220K-ubiquitinylated c-Jun, were readily degraded by the ATP-dependent 26 S multicatalytic proteases.
S8 1021-1335 Sentence denotes These results suggest that the temporal control of c-Jun and c-Fos may be regulated through the ubiquitinylation pathways, and the ubiquitinylation of c-Jun and c-Fos may in turn be regulated in response to the heterodimerization between them and the cooperation between E220K and E3 mediated polyubiquitinylation.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C2 42-47 NP denotes c-Jun
C3 52-57 NP denotes c-Fos
C1 0-57 NP denotes Ubiquitinylation of transcription factors c-Jun and c-Fos
C4 186-191 NP denotes E214K
C5 193-198 NP denotes E220K
C6 228-259 NP denotes the ubiquitin-activating enzyme
C7 261-263 NP denotes E1
C8 277-304 NP denotes ubiquitin protein ligase E3
C9 328-346 NP denotes the E214K-mediated
C10 367-372 NP denotes c-Jun
C11 377-382 NP denotes c-Fos
C12 609-614 NP denotes c-Jun
C13 619-624 NP denotes c-Fos
C14 630-633 NP denotes E3-
C15 663-668 NP denotes c-Jun
C16 714-719 NP denotes c-Jun
C17 725-730 NP denotes c-Fos
C18 752-757 NP denotes E220K
C19 801-806 NP denotes c-Jun
C20 858-863 NP denotes E220K
C21 918-924 NP denotes E220K-
C22 1072-1077 NP denotes c-Jun
C23 1082-1087 NP denotes c-Fos
C26 1172-1177 NP denotes c-Jun
C27 1182-1187 NP denotes c-Fos
C25 1172-1187 NP denotes c-Jun and c-Fos
C24 1148-1187 NP denotes the ubiquitinylation of c-Jun and c-Fos
C28 1259-1263 NP denotes them
C29 1292-1297 NP denotes E220K
C30 1302-1304 NP denotes E3
R1 C7 C6 coref-appos E1,the ubiquitin-activating enzyme
R2 C9 C4 coref-ident the E214K-mediated,E214K
R3 C10 C2 coref-ident c-Jun,c-Jun
R4 C11 C3 coref-ident c-Fos,c-Fos
R5 C12 C10 coref-ident c-Jun,c-Jun
R6 C13 C11 coref-ident c-Fos,c-Fos
R7 C14 C8 coref-ident E3-,ubiquitin protein ligase E3
R8 C15 C12 coref-ident c-Jun,c-Jun
R9 C16 C15 coref-ident c-Jun,c-Jun
R10 C17 C13 coref-ident c-Fos,c-Fos
R11 C18 C5 coref-ident E220K,E220K
R12 C19 C16 coref-ident c-Jun,c-Jun
R13 C20 C18 coref-ident E220K,E220K
R14 C21 C20 coref-ident E220K-,E220K
R15 C22 C19 coref-ident c-Jun,c-Jun
R16 C23 C17 coref-ident c-Fos,c-Fos
R17 C27 C23 coref-ident c-Fos,c-Fos
R18 C25 C22 coref-ident c-Jun and c-Fos,c-Jun
R19 C24 C1 coref-ident the ubiquitinylation of c-Jun and c-Fos,Ubiquitinylation of transcription factors c-Jun and c-Fos
R20 C28 C26 coref-pron them,c-Jun
R21 C29 C21 coref-ident E220K,E220K-
R22 C30 C14 coref-ident E3,E3-

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-16 other_name denotes Ubiquitinylation
T2 20-41 protein_family_or_group denotes transcription factors
T3 42-47 protein_molecule denotes c-Jun
T4 52-57 protein_molecule denotes c-Fos
T5 64-102 protein_family_or_group denotes reconstituted ubiquitinylating enzymes
T6 116-121 protein_molecule denotes c-Jun
T7 126-131 protein_molecule denotes c-Fos
T8 160-185 protein_family_or_group denotes ubiquitin carrier enzymes
T9 186-191 protein_molecule denotes E214K
T10 193-198 protein_molecule denotes E220K
T11 203-208 protein_molecule denotes E232K
T12 232-259 protein_family_or_group denotes ubiquitin-activating enzyme
T13 261-263 protein_molecule denotes E1
T14 277-304 protein_molecule denotes ubiquitin protein ligase E3
T15 332-337 protein_molecule denotes E214K
T16 367-372 protein_molecule denotes c-Jun
T17 377-382 protein_molecule denotes c-Fos
T18 436-441 protein_molecule denotes wbJun
T19 446-451 protein_molecule denotes wbFos
T20 529-545 other_name denotes ubiquitinylation
T21 609-614 protein_molecule denotes c-Jun
T22 619-624 protein_molecule denotes c-Fos
T23 630-642 other_name denotes E3-dependent
T24 643-659 other_name denotes ubiquitinylation
T25 663-668 protein_molecule denotes c-Jun
T26 692-710 other_name denotes heterodimerization
T27 714-719 protein_molecule denotes c-Jun
T28 725-730 protein_molecule denotes c-Fos
T29 752-757 protein_molecule denotes E220K
T30 781-797 other_name denotes ubiquitinylation
T31 801-806 protein_molecule denotes c-Jun
T32 858-863 protein_molecule denotes E220K
T33 885-890 protein_molecule denotes c-Jun
T34 892-897 protein_molecule denotes wbFos
T35 903-908 protein_molecule denotes wbJun
T36 918-923 protein_molecule denotes E220K
T37 940-945 protein_molecule denotes c-Jun
T38 976-1019 protein_family_or_group denotes ATP-dependent 26 S multicatalytic proteases
T39 1072-1077 protein_molecule denotes c-Jun
T40 1082-1087 protein_molecule denotes c-Fos
T41 1117-1133 other_name denotes ubiquitinylation
T42 1152-1168 other_name denotes ubiquitinylation
T43 1172-1177 protein_molecule denotes c-Jun
T44 1182-1187 protein_molecule denotes c-Fos
T45 1232-1250 other_name denotes heterodimerization
T46 1292-1297 protein_molecule denotes E220K
T47 1302-1334 other_name denotes E3 mediated polyubiquitinylation