PubMed:8599116 JSONTXT

{"project":"AIMed","denotations":[{"id":"T1","span":{"begin":43,"end":49},"obj":"protein"},{"id":"T2","span":{"begin":146,"end":155},"obj":"protein"},{"id":"T3","span":{"begin":350,"end":353},"obj":"protein"},{"id":"T4","span":{"begin":359,"end":373},"obj":"protein"},{"id":"T5","span":{"begin":375,"end":386},"obj":"protein"},{"id":"T6","span":{"begin":388,"end":391},"obj":"protein"},{"id":"T7","span":{"begin":414,"end":440},"obj":"protein"},{"id":"T8","span":{"begin":442,"end":448},"obj":"protein"},{"id":"T9","span":{"begin":521,"end":537},"obj":"protein"},{"id":"T10","span":{"begin":539,"end":542},"obj":"protein"},{"id":"T11","span":{"begin":551,"end":557},"obj":"protein"},{"id":"T12","span":{"begin":597,"end":600},"obj":"protein"},{"id":"T13","span":{"begin":604,"end":607},"obj":"protein"},{"id":"T14","span":{"begin":642,"end":645},"obj":"protein"},{"id":"T15","span":{"begin":650,"end":656},"obj":"protein"},{"id":"T16","span":{"begin":688,"end":694},"obj":"protein"}],"text":"Coordination of three signaling enzymes by AKAP79, a mammalian scaffold protein.\nMultivalent binding proteins, such as the yeast scaffold protein Sterile-5, coordinate the location of kinases by serving as platforms for the assembly of signaling units. Similarly, in mammalian cells the cyclic adenosine 3',5'-monophosphate-dependent protein kinase (PKA) and phosphatase 2B [calcineurin (CaN)] are complexed by an A kinase anchoring protein, AKAP79. Deletion analysis and binding studies demonstrate that a third enzyme, protein kinase C (PKC), binds AKAP79 at a site distinct from those bound by PKA or CaN. The subcellular distributions of PKC and AKAP79 were similar in neurons. Thus, AKAP79 appears to function as a scaffold protein for three multifunctional enzymes."}