PubMed:8599092 JSONTXT

{"project":"AIMed","denotations":[{"id":"T1","span":{"begin":0,"end":4},"obj":"protein"},{"id":"T2","span":{"begin":35,"end":57},"obj":"protein"},{"id":"T3","span":{"begin":100,"end":113},"obj":"protein"},{"id":"T4","span":{"begin":115,"end":119},"obj":"protein"},{"id":"T5","span":{"begin":158,"end":164},"obj":"protein"},{"id":"T6","span":{"begin":190,"end":196},"obj":"protein"},{"id":"T7","span":{"begin":289,"end":311},"obj":"protein"},{"id":"T8","span":{"begin":313,"end":323},"obj":"protein"},{"id":"T9","span":{"begin":354,"end":358},"obj":"protein"},{"id":"T10","span":{"begin":360,"end":391},"obj":"protein"},{"id":"T11","span":{"begin":523,"end":529},"obj":"protein"},{"id":"T12","span":{"begin":560,"end":564},"obj":"protein"},{"id":"T13","span":{"begin":566,"end":570},"obj":"protein"},{"id":"T14","span":{"begin":599,"end":605},"obj":"protein"},{"id":"T15","span":{"begin":673,"end":677},"obj":"protein"},{"id":"T16","span":{"begin":775,"end":785},"obj":"protein"}],"text":"IRAK: a kinase associated with the interleukin-1 receptor.\nThe pleiotropic biological activities of interleukin-1 (IL-1) are mediated by its type I receptor (IL-1RI). When the ligand binds, IL-1RI initiates a signaling cascade that results in the activation of the transcription regulator nuclear factor kappa B (NF-kappa B). A protein kinase designated IRAK (IL-1 receptor-associated kinase) was purified, and its complementary DNA was molecularly cloned. When human embryonic kidney cells (cell line 293) over-expressing IL-1RI or HeLa cells were exposed to IL-1, IRAK rapidly associated with the IL-1RI complex and was phosphorylated. The primary amino acid sequence of IRAK shares similarity with that of Pelle, a protein kinase that is essential for the activation of a NF-kappa B homolog in Drosophila."}