Id |
Subject |
Object |
Predicate |
Lexical cue |
TextSentencer_T1 |
0-134 |
Sentence |
denotes |
Structure of the saponin adjuvant QS-21 and its base-catalyzed isomerization product by 1H and natural abundance 13C NMR spectroscopy. |
TextSentencer_T2 |
135-282 |
Sentence |
denotes |
The saponin QS-21, derived from the bark of the Quillaja saponaria Molina tree, has shown great potential as an adjuvant with a number of vaccines. |
TextSentencer_T3 |
283-561 |
Sentence |
denotes |
Kinetic studies carried out to establish the stability of vaccine formulations show that commercially supplied QS-21 (primarily QS-21A) is converted slowly at pH 5.5, and rapidly at higher pH, to an equilibrium mixture of two regioisomers, QS-21A and QS-21B, in a ratio of 20:1. |
TextSentencer_T4 |
562-691 |
Sentence |
denotes |
NMR studies show that QS-21A and QS-21B differ only in the point of attachment of the fatty acyl moiety to the fucose sugar ring. |
TextSentencer_T5 |
692-872 |
Sentence |
denotes |
The major isomer, QS-21A, has the fatty acyl portion attached at the 4-hydroxyl group whereas the minor isomer, QS-21B, has the fatty acyl portion attached at the 3-hydroxyl group. |
TextSentencer_T6 |
873-1004 |
Sentence |
denotes |
The isomerization most likely involves ionization of the 3-hydroxy group and intramolecular acyl transfer from the 4-hydroxy group. |
TextSentencer_T7 |
1005-1118 |
Sentence |
denotes |
The relative stereochemistry of the triterpene and the sugar anomeric centers is also established by NMR methods. |
T1 |
0-134 |
Sentence |
denotes |
Structure of the saponin adjuvant QS-21 and its base-catalyzed isomerization product by 1H and natural abundance 13C NMR spectroscopy. |
T2 |
135-282 |
Sentence |
denotes |
The saponin QS-21, derived from the bark of the Quillaja saponaria Molina tree, has shown great potential as an adjuvant with a number of vaccines. |
T3 |
283-561 |
Sentence |
denotes |
Kinetic studies carried out to establish the stability of vaccine formulations show that commercially supplied QS-21 (primarily QS-21A) is converted slowly at pH 5.5, and rapidly at higher pH, to an equilibrium mixture of two regioisomers, QS-21A and QS-21B, in a ratio of 20:1. |
T4 |
562-691 |
Sentence |
denotes |
NMR studies show that QS-21A and QS-21B differ only in the point of attachment of the fatty acyl moiety to the fucose sugar ring. |
T5 |
692-872 |
Sentence |
denotes |
The major isomer, QS-21A, has the fatty acyl portion attached at the 4-hydroxyl group whereas the minor isomer, QS-21B, has the fatty acyl portion attached at the 3-hydroxyl group. |
T6 |
873-1004 |
Sentence |
denotes |
The isomerization most likely involves ionization of the 3-hydroxy group and intramolecular acyl transfer from the 4-hydroxy group. |
T7 |
1005-1118 |
Sentence |
denotes |
The relative stereochemistry of the triterpene and the sugar anomeric centers is also established by NMR methods. |