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PubMed:8581890 JSONTXT

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GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 673-679 Glycan_Motif denotes fucose https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G82576YO

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 673-679 https://glytoucan.org/Structures/Glycans/G82576YO denotes fucose

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 183-201 OrganismTaxon denotes Quillaja saponaria NCBItxid:32244
T2 202-208 OrganismTaxon denotes Molina NCBItxid:356573

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-134 Sentence denotes Structure of the saponin adjuvant QS-21 and its base-catalyzed isomerization product by 1H and natural abundance 13C NMR spectroscopy.
TextSentencer_T2 135-282 Sentence denotes The saponin QS-21, derived from the bark of the Quillaja saponaria Molina tree, has shown great potential as an adjuvant with a number of vaccines.
TextSentencer_T3 283-561 Sentence denotes Kinetic studies carried out to establish the stability of vaccine formulations show that commercially supplied QS-21 (primarily QS-21A) is converted slowly at pH 5.5, and rapidly at higher pH, to an equilibrium mixture of two regioisomers, QS-21A and QS-21B, in a ratio of 20:1.
TextSentencer_T4 562-691 Sentence denotes NMR studies show that QS-21A and QS-21B differ only in the point of attachment of the fatty acyl moiety to the fucose sugar ring.
TextSentencer_T5 692-872 Sentence denotes The major isomer, QS-21A, has the fatty acyl portion attached at the 4-hydroxyl group whereas the minor isomer, QS-21B, has the fatty acyl portion attached at the 3-hydroxyl group.
TextSentencer_T6 873-1004 Sentence denotes The isomerization most likely involves ionization of the 3-hydroxy group and intramolecular acyl transfer from the 4-hydroxy group.
TextSentencer_T7 1005-1118 Sentence denotes The relative stereochemistry of the triterpene and the sugar anomeric centers is also established by NMR methods.
T1 0-134 Sentence denotes Structure of the saponin adjuvant QS-21 and its base-catalyzed isomerization product by 1H and natural abundance 13C NMR spectroscopy.
T2 135-282 Sentence denotes The saponin QS-21, derived from the bark of the Quillaja saponaria Molina tree, has shown great potential as an adjuvant with a number of vaccines.
T3 283-561 Sentence denotes Kinetic studies carried out to establish the stability of vaccine formulations show that commercially supplied QS-21 (primarily QS-21A) is converted slowly at pH 5.5, and rapidly at higher pH, to an equilibrium mixture of two regioisomers, QS-21A and QS-21B, in a ratio of 20:1.
T4 562-691 Sentence denotes NMR studies show that QS-21A and QS-21B differ only in the point of attachment of the fatty acyl moiety to the fucose sugar ring.
T5 692-872 Sentence denotes The major isomer, QS-21A, has the fatty acyl portion attached at the 4-hydroxyl group whereas the minor isomer, QS-21B, has the fatty acyl portion attached at the 3-hydroxyl group.
T6 873-1004 Sentence denotes The isomerization most likely involves ionization of the 3-hydroxy group and intramolecular acyl transfer from the 4-hydroxy group.
T7 1005-1118 Sentence denotes The relative stereochemistry of the triterpene and the sugar anomeric centers is also established by NMR methods.