| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-150 |
Sentence |
denotes |
The three human syntrophin genes are expressed in diverse tissues, have distinct chromosomal locations, and each bind to dystrophin and its relatives. |
| T2 |
151-279 |
Sentence |
denotes |
The syntrophins are a biochemically heterogeneous group of 58-kDa intracellular membrane-associated dystrophin-binding proteins. |
| T3 |
280-405 |
Sentence |
denotes |
We have cloned and characterized human acidic (alpha 1-) syntrophin and a second isoform of human basic (beta 2-) syntrophin. |
| T4 |
406-597 |
Sentence |
denotes |
Comparison of the deduced amino acid structure of the three human isoforms of syntrophin (together with the previously reported human beta 1-syntrophin) demonstrates their overall similarity. |
| T5 |
598-960 |
Sentence |
denotes |
The deduced amino acid sequences of human alpha 1- and beta 2-syntrophin are nearly identical to their homologues in mouse, suggesting a strong functional conservation among the individual isoforms, Much like beta 1-syntrophin, human beta 2-syntrophin has multiple transcript classes and is expressed widely, although in a distinct pattern of relative abundance. |
| T6 |
961-1075 |
Sentence |
denotes |
In contrast, human alpha 1-syntrophin is most abundant in heart and skeletal muscle, and less so in other tissues. |
| T7 |
1076-1278 |
Sentence |
denotes |
Somatic cell hybrids and fluorescent in situ hybridization were both used to determine their chromosomal locations: beta 2-syntrophin to chromosome 16q22-23 and alpha 1-syntrophin to chromosome 20q11.2. |
| T8 |
1279-1573 |
Sentence |
denotes |
Finally, we used in vitro translated proteins in an immunoprecipitation assay to show that, like beta 1-syntrophin, both beta 2- and alpha 1-syntrophin interact with peptides encoding the syntrophin-binding region of dystrophin, utrophin/dystrophin related protein, and the Torpedo 87K protein. |
| T1 |
0-150 |
Sentence |
denotes |
The three human syntrophin genes are expressed in diverse tissues, have distinct chromosomal locations, and each bind to dystrophin and its relatives. |
| T2 |
151-279 |
Sentence |
denotes |
The syntrophins are a biochemically heterogeneous group of 58-kDa intracellular membrane-associated dystrophin-binding proteins. |
| T3 |
280-405 |
Sentence |
denotes |
We have cloned and characterized human acidic (alpha 1-) syntrophin and a second isoform of human basic (beta 2-) syntrophin. |
| T4 |
406-597 |
Sentence |
denotes |
Comparison of the deduced amino acid structure of the three human isoforms of syntrophin (together with the previously reported human beta 1-syntrophin) demonstrates their overall similarity. |
| T5 |
598-960 |
Sentence |
denotes |
The deduced amino acid sequences of human alpha 1- and beta 2-syntrophin are nearly identical to their homologues in mouse, suggesting a strong functional conservation among the individual isoforms, Much like beta 1-syntrophin, human beta 2-syntrophin has multiple transcript classes and is expressed widely, although in a distinct pattern of relative abundance. |
| T6 |
961-1075 |
Sentence |
denotes |
In contrast, human alpha 1-syntrophin is most abundant in heart and skeletal muscle, and less so in other tissues. |
| T7 |
1076-1278 |
Sentence |
denotes |
Somatic cell hybrids and fluorescent in situ hybridization were both used to determine their chromosomal locations: beta 2-syntrophin to chromosome 16q22-23 and alpha 1-syntrophin to chromosome 20q11.2. |
| T8 |
1279-1573 |
Sentence |
denotes |
Finally, we used in vitro translated proteins in an immunoprecipitation assay to show that, like beta 1-syntrophin, both beta 2- and alpha 1-syntrophin interact with peptides encoding the syntrophin-binding region of dystrophin, utrophin/dystrophin related protein, and the Torpedo 87K protein. |
