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sentences

Id Subject Object Predicate Lexical cue
T1 0-109 Sentence denotes Identification of a physical interaction between calcineurin and nuclear factor of activated T cells (NFATp).
T2 110-283 Sentence denotes In T lymphocytes, the calcium/calmodulin-dependent serine/threonine phosphatase, calcineurin, plays a pivotal role in transducing membrane-associated signals to the nucleus.
T3 284-538 Sentence denotes One of the putative targets of calcineurin is the pre-existing, cytosolic component of the nuclear factor of activated T cells (NFATp; also referred to as NFAT1), which is one of several transcription factors required for the expression of interleukin 2.
T4 539-693 Sentence denotes Inhibition of calcineurin by the immunosuppressive drugs cyclosporin A and FK506 prevents dephosphorylation of NFATp and its translocation to the nucleus.
T5 694-782 Sentence denotes However, a physical interaction between calcineurin and NFATp has not been demonstrated.
T6 783-875 Sentence denotes Here we demonstrate the binding of NFATp from lysates of T cells to immobilized calcineurin.
T7 876-1008 Sentence denotes Stimulation of T cells with calcium ionophore induced a shift in the molecular weight of NFATp that is due to its dephosphorylation.
T8 1009-1119 Sentence denotes This dephosphorylation was inhibited by treatment of T cells with cyclosporin A or FK506 prior to stimulation.
T9 1120-1213 Sentence denotes Of note, both the phosphorylated and the dephosphorylated form of NFATp bound to calcineurin.
T10 1214-1368 Sentence denotes Furthermore, the binding of both forms of NFATp to calcineurin was inhibited by pretreatment of calcineurin with a complex of FK506 and its ligand FKBP12.
T11 1369-1564 Sentence denotes Taken together these data strongly suggest a direct interaction of calcineurin with NFATp and that this interaction does not depend upon the phosphorylation sites of NFATp affected by activation.
T1 0-109 Sentence denotes Identification of a physical interaction between calcineurin and nuclear factor of activated T cells (NFATp).
T2 110-283 Sentence denotes In T lymphocytes, the calcium/calmodulin-dependent serine/threonine phosphatase, calcineurin, plays a pivotal role in transducing membrane-associated signals to the nucleus.
T3 284-538 Sentence denotes One of the putative targets of calcineurin is the pre-existing, cytosolic component of the nuclear factor of activated T cells (NFATp; also referred to as NFAT1), which is one of several transcription factors required for the expression of interleukin 2.
T4 539-693 Sentence denotes Inhibition of calcineurin by the immunosuppressive drugs cyclosporin A and FK506 prevents dephosphorylation of NFATp and its translocation to the nucleus.
T5 694-782 Sentence denotes However, a physical interaction between calcineurin and NFATp has not been demonstrated.
T6 783-875 Sentence denotes Here we demonstrate the binding of NFATp from lysates of T cells to immobilized calcineurin.
T7 876-1008 Sentence denotes Stimulation of T cells with calcium ionophore induced a shift in the molecular weight of NFATp that is due to its dephosphorylation.
T8 1009-1119 Sentence denotes This dephosphorylation was inhibited by treatment of T cells with cyclosporin A or FK506 prior to stimulation.
T9 1120-1213 Sentence denotes Of note, both the phosphorylated and the dephosphorylated form of NFATp bound to calcineurin.
T10 1214-1368 Sentence denotes Furthermore, the binding of both forms of NFATp to calcineurin was inhibited by pretreatment of calcineurin with a complex of FK506 and its ligand FKBP12.
T11 1369-1564 Sentence denotes Taken together these data strongly suggest a direct interaction of calcineurin with NFATp and that this interaction does not depend upon the phosphorylation sites of NFATp affected by activation.

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 49-60 protein denotes calcineurin
T2 65-100 protein denotes nuclear factor of activated T cells
T3 102-107 protein denotes NFATp
T4 113-126 cell_type denotes T lymphocytes
T5 132-189 protein denotes calcium/calmodulin-dependent serine/threonine phosphatase
T6 191-202 protein denotes calcineurin
T7 315-326 protein denotes calcineurin
T8 348-367 protein denotes cytosolic component
T9 375-410 protein denotes nuclear factor of activated T cells
T10 412-417 protein denotes NFATp
T11 439-444 protein denotes NFAT1
T12 471-492 protein denotes transcription factors
T13 524-537 protein denotes interleukin 2
T14 553-564 protein denotes calcineurin
T15 650-655 protein denotes NFATp
T16 734-745 protein denotes calcineurin
T17 750-755 protein denotes NFATp
T18 818-823 protein denotes NFATp
T19 840-847 cell_type denotes T cells
T20 863-874 protein denotes calcineurin
T21 891-898 cell_type denotes T cells
T22 965-970 protein denotes NFATp
T23 1062-1069 cell_type denotes T cells
T24 1186-1191 protein denotes NFATp
T25 1201-1212 protein denotes calcineurin
T26 1256-1261 protein denotes NFATp
T27 1265-1276 protein denotes calcineurin
T28 1310-1321 protein denotes calcineurin
T29 1436-1447 protein denotes calcineurin
T30 1453-1458 protein denotes NFATp
T31 1510-1531 DNA denotes phosphorylation sites
T32 1535-1540 protein denotes NFATp

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-109 Sentence denotes Identification of a physical interaction between calcineurin and nuclear factor of activated T cells (NFATp).
S2 110-283 Sentence denotes In T lymphocytes, the calcium/calmodulin-dependent serine/threonine phosphatase, calcineurin, plays a pivotal role in transducing membrane-associated signals to the nucleus.
S3 284-538 Sentence denotes One of the putative targets of calcineurin is the pre-existing, cytosolic component of the nuclear factor of activated T cells (NFATp; also referred to as NFAT1), which is one of several transcription factors required for the expression of interleukin 2.
S4 539-693 Sentence denotes Inhibition of calcineurin by the immunosuppressive drugs cyclosporin A and FK506 prevents dephosphorylation of NFATp and its translocation to the nucleus.
S5 694-782 Sentence denotes However, a physical interaction between calcineurin and NFATp has not been demonstrated.
S6 783-875 Sentence denotes Here we demonstrate the binding of NFATp from lysates of T cells to immobilized calcineurin.
S7 876-1008 Sentence denotes Stimulation of T cells with calcium ionophore induced a shift in the molecular weight of NFATp that is due to its dephosphorylation.
S8 1009-1119 Sentence denotes This dephosphorylation was inhibited by treatment of T cells with cyclosporin A or FK506 prior to stimulation.
S9 1120-1213 Sentence denotes Of note, both the phosphorylated and the dephosphorylated form of NFATp bound to calcineurin.
S10 1214-1368 Sentence denotes Furthermore, the binding of both forms of NFATp to calcineurin was inhibited by pretreatment of calcineurin with a complex of FK506 and its ligand FKBP12.
S11 1369-1564 Sentence denotes Taken together these data strongly suggest a direct interaction of calcineurin with NFATp and that this interaction does not depend upon the phosphorylation sites of NFATp affected by activation.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C2 49-60 NP denotes calcineurin
C3 65-108 NP denotes nuclear factor of activated T cells (NFATp)
C1 18-108 NP denotes a physical interaction between calcineurin and nuclear factor of activated T cells (NFATp)
C4 128-189 NP denotes the calcium/calmodulin-dependent serine/threonine phosphatase
C5 191-202 NP denotes calcineurin
C6 271-282 NP denotes the nucleus
C7 315-326 NP denotes calcineurin
C8 371-445 NP denotes the nuclear factor of activated T cells (NFATp; also referred to as NFAT1)
C9 447-452 NP denotes which
C10 553-564 NP denotes calcineurin
C11 568-628 NP denotes the immunosuppressive drugs cyclosporin A and FK506 prevents
C13 650-655 NP denotes NFATp
C12 629-655 NP denotes dephosphorylation of NFATp
C14 660-663 NP denotes its
C15 681-692 NP denotes the nucleus
C17 734-745 NP denotes calcineurin
C18 750-755 NP denotes NFATp
C16 703-755 NP denotes a physical interaction between calcineurin and NFATp
C19 818-823 NP denotes NFATp
C20 840-847 NP denotes T cells
C21 891-898 NP denotes T cells
C23 965-970 NP denotes NFATp
C22 930-970 NP denotes a shift in the molecular weight of NFATp
C24 971-975 NP denotes that
C26 986-989 NP denotes its
C25 986-1007 NP denotes its dephosphorylation
C27 1009-1031 NP denotes This dephosphorylation
C28 1062-1069 NP denotes T cells
C29 1075-1097 NP denotes cyclosporin A or FK506
C31 1186-1191 NP denotes NFATp
C30 1129-1191 NP denotes both the phosphorylated and the dephosphorylated form of NFATp
C32 1201-1212 NP denotes calcineurin
C34 1256-1261 NP denotes NFATp
C33 1242-1261 NP denotes both forms of NFATp
C35 1265-1276 NP denotes calcineurin
C36 1310-1321 NP denotes calcineurin
C37 1327-1345 NP denotes a complex of FK506
C38 1350-1353 NP denotes its
C40 1436-1447 NP denotes calcineurin
C41 1453-1458 NP denotes NFATp
C39 1412-1458 NP denotes a direct interaction of calcineurin with NFATp
C42 1468-1484 NP denotes this interaction
R1 C4 C2 coref-ident the calcium/calmodulin-dependent serine/threonine phosphatase,calcineurin
R2 C5 C4 coref-appos calcineurin,the calcium/calmodulin-dependent serine/threonine phosphatase
R3 C7 C5 coref-ident calcineurin,calcineurin
R4 C8 C3 coref-ident the nuclear factor of activated T cells (NFATp; also referred to as NFAT1),nuclear factor of activated T cells (NFATp)
R5 C9 C8 coref-relat which,the nuclear factor of activated T cells (NFATp; also referred to as NFAT1)
R6 C10 C7 coref-ident calcineurin,calcineurin
R7 C13 C8 coref-ident NFATp,the nuclear factor of activated T cells (NFATp; also referred to as NFAT1)
R8 C14 C13 coref-pron its,NFATp
R9 C15 C6 coref-ident the nucleus,the nucleus
R10 C17 C10 coref-ident calcineurin,calcineurin
R11 C18 C13 coref-ident NFATp,NFATp
R12 C16 C1 coref-ident a physical interaction between calcineurin and NFATp,a physical interaction between calcineurin and nuclear factor of activated T cells (NFATp)
R13 C19 C18 coref-ident NFATp,NFATp
R14 C21 C20 coref-ident T cells,T cells
R15 C23 C19 coref-ident NFATp,NFATp
R16 C24 C22 coref-relat that,a shift in the molecular weight of NFATp
R17 C26 C12 coref-ident its,dephosphorylation of NFATp
R18 C25 C23 coref-pron its dephosphorylation,NFATp
R19 C27 C26 coref-ident This dephosphorylation,its
R20 C28 C21 coref-ident T cells,T cells
R21 C29 C11 coref-ident cyclosporin A or FK506,the immunosuppressive drugs cyclosporin A and FK506 prevents
R22 C31 C23 coref-ident NFATp,NFATp
R23 C32 C17 coref-ident calcineurin,calcineurin
R24 C34 C31 coref-ident NFATp,NFATp
R25 C33 C30 coref-ident both forms of NFATp,both the phosphorylated and the dephosphorylated form of NFATp
R26 C35 C32 coref-ident calcineurin,calcineurin
R27 C36 C32 coref-ident calcineurin,calcineurin
R28 C38 C37 coref-pron its,a complex of FK506
R29 C40 C36 coref-ident calcineurin,calcineurin
R30 C41 C34 coref-ident NFATp,NFATp
R31 C42 C39 coref-ident this interaction,a direct interaction of calcineurin with NFATp

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 49-60 protein_molecule denotes calcineurin
T2 65-100 protein_molecule denotes nuclear factor of activated T cells
T3 102-107 protein_molecule denotes NFATp
T4 113-126 cell_type denotes T lymphocytes
T5 132-189 protein_family_or_group denotes calcium/calmodulin-dependent serine/threonine phosphatase
T6 191-202 protein_molecule denotes calcineurin
T7 228-267 other_name denotes transducing membrane-associated signals
T8 275-282 cell_component denotes nucleus
T9 315-326 protein_molecule denotes calcineurin
T10 348-367 protein_domain_or_region denotes cytosolic component
T11 375-410 protein_molecule denotes nuclear factor of activated T cells
T12 412-417 protein_molecule denotes NFATp
T13 439-444 protein_molecule denotes NFAT1
T14 471-492 protein_family_or_group denotes transcription factors
T15 524-537 protein_molecule denotes interleukin 2
T16 553-564 protein_molecule denotes calcineurin
T17 572-595 other_organic_compound denotes immunosuppressive drugs
T18 596-609 other_organic_compound denotes cyclosporin A
T19 614-619 other_organic_compound denotes FK506
T20 650-655 protein_molecule denotes NFATp
T21 685-692 cell_component denotes nucleus
T22 734-745 protein_molecule denotes calcineurin
T23 750-755 protein_molecule denotes NFATp
T24 818-823 protein_molecule denotes NFATp
T25 840-847 cell_type denotes T cells
T26 863-874 protein_molecule denotes calcineurin
T27 891-898 cell_type denotes T cells
T28 904-921 other_organic_compound denotes calcium ionophore
T29 965-970 protein_molecule denotes NFATp
T30 990-1007 other_name denotes dephosphorylation
T31 1014-1031 other_name denotes dephosphorylation
T32 1062-1069 cell_type denotes T cells
T33 1075-1088 other_organic_compound denotes cyclosporin A
T34 1092-1097 other_organic_compound denotes FK506
T35 1186-1191 protein_molecule denotes NFATp
T36 1201-1212 protein_molecule denotes calcineurin
T37 1256-1261 protein_molecule denotes NFATp
T38 1265-1276 protein_molecule denotes calcineurin
T39 1310-1321 protein_molecule denotes calcineurin
T40 1340-1345 other_organic_compound denotes FK506
T41 1361-1367 other_organic_compound denotes FKBP12
T42 1436-1447 protein_molecule denotes calcineurin
T43 1453-1458 protein_molecule denotes NFATp
T44 1510-1531 DNA_domain_or_region denotes phosphorylation sites
T45 1535-1540 protein_molecule denotes NFATp

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 113-126 Body_part denotes T lymphocytes http://purl.obolibrary.org/obo/CL_0000084
T2 240-248 Body_part denotes membrane http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158
T5 275-282 Body_part denotes nucleus http://purl.obolibrary.org/obo/GO_0005634|http://purl.obolibrary.org/obo/UBERON_0000125
T7 685-692 Body_part denotes nucleus http://purl.obolibrary.org/obo/GO_0005634|http://purl.obolibrary.org/obo/UBERON_0000125

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 93-100 Cell denotes T cells http://purl.obolibrary.org/obo/CL:0000084
T2 113-126 Cell denotes T lymphocytes http://purl.obolibrary.org/obo/CL:0000084
T3 403-410 Cell denotes T cells http://purl.obolibrary.org/obo/CL:0000084
T4 840-847 Cell denotes T cells http://purl.obolibrary.org/obo/CL:0000084
T5 891-898 Cell denotes T cells http://purl.obolibrary.org/obo/CL:0000084
T6 1062-1069 Cell denotes T cells http://purl.obolibrary.org/obo/CL:0000084