PubMed:8565075 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/8565075","sourcedb":"PubMed","sourceid":"8565075","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/8565075","text":"TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways.\nTumor necrosis factor (TNF) can induce apoptosis and activate NF-kappa B through signaling cascades emanating from TNF receptor 1 (TNFR1). TRADD is a TNFR1-associated signal transducer that is involved in activating both pathways. Here we show that TRADD directly interacts with TRAF2 and FADD, signal transducers that activate NF-kappa B and induce apoptosis, respectively. A TRAF2 mutant lacking its N-terminal RING finger domain is a dominant-negative inhibitor of TNF-mediated NF-kappa B activation, but does not affect TNF-induced apoptosis. Conversely, a FADD mutant lacking its N-terminal 79 amino acids is a dominant-negative inhibitor of TNF-induced apoptosis, but does not inhibit NF-kappa B activation. Thus, these two TNFR1-TRADD signaling cascades appear to bifurcate at TRADD.","tracks":[{"project":"AIMed","denotations":[{"id":"T1","span":{"begin":0,"end":5},"obj":"protein"},{"id":"T2","span":{"begin":6,"end":11},"obj":"protein"},{"id":"T3","span":{"begin":16,"end":21},"obj":"protein"},{"id":"T4","span":{"begin":22,"end":26},"obj":"protein"},{"id":"T5","span":{"begin":60,"end":74},"obj":"protein"},{"id":"T6","span":{"begin":167,"end":177},"obj":"protein"},{"id":"T7","span":{"begin":220,"end":234},"obj":"protein"},{"id":"T8","span":{"begin":236,"end":241},"obj":"protein"},{"id":"T9","span":{"begin":244,"end":249},"obj":"protein"},{"id":"T10","span":{"begin":255,"end":260},"obj":"protein"},{"id":"T11","span":{"begin":354,"end":359},"obj":"protein"},{"id":"T12","span":{"begin":384,"end":389},"obj":"protein"},{"id":"T13","span":{"begin":394,"end":398},"obj":"protein"},{"id":"T14","span":{"begin":433,"end":443},"obj":"protein"},{"id":"T15","span":{"begin":482,"end":487},"obj":"protein"},{"id":"T16","span":{"begin":586,"end":596},"obj":"protein"},{"id":"T17","span":{"begin":666,"end":670},"obj":"protein"},{"id":"T18","span":{"begin":796,"end":806},"obj":"protein"},{"id":"T19","span":{"begin":835,"end":840},"obj":"protein"},{"id":"T20","span":{"begin":841,"end":846},"obj":"protein"},{"id":"T21","span":{"begin":889,"end":894},"obj":"protein"}],"attributes":[{"subj":"T1","pred":"source","obj":"AIMed"},{"subj":"T2","pred":"source","obj":"AIMed"},{"subj":"T3","pred":"source","obj":"AIMed"},{"subj":"T4","pred":"source","obj":"AIMed"},{"subj":"T5","pred":"source","obj":"AIMed"},{"subj":"T6","pred":"source","obj":"AIMed"},{"subj":"T7","pred":"source","obj":"AIMed"},{"subj":"T8","pred":"source","obj":"AIMed"},{"subj":"T9","pred":"source","obj":"AIMed"},{"subj":"T10","pred":"source","obj":"AIMed"},{"subj":"T11","pred":"source","obj":"AIMed"},{"subj":"T12","pred":"source","obj":"AIMed"},{"subj":"T13","pred":"source","obj":"AIMed"},{"subj":"T14","pred":"source","obj":"AIMed"},{"subj":"T15","pred":"source","obj":"AIMed"},{"subj":"T16","pred":"source","obj":"AIMed"},{"subj":"T17","pred":"source","obj":"AIMed"},{"subj":"T18","pred":"source","obj":"AIMed"},{"subj":"T19","pred":"source","obj":"AIMed"},{"subj":"T20","pred":"source","obj":"AIMed"},{"subj":"T21","pred":"source","obj":"AIMed"}]},{"project":"HP-phenotype","denotations":[{"id":"T1","span":{"begin":105,"end":110},"obj":"Phenotype"}],"attributes":[{"id":"A1","pred":"hp_id","subj":"T1","obj":"HP:0002664"},{"subj":"T1","pred":"source","obj":"HP-phenotype"}],"namespaces":[{"prefix":"HP","uri":"http://purl.obolibrary.org/obo/HP_"}]},{"project":"mondo_disease","denotations":[{"id":"T1","span":{"begin":105,"end":110},"obj":"Disease"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/MONDO_0005070"},{"subj":"T1","pred":"source","obj":"mondo_disease"}]},{"project":"Anatomy-UBERON","denotations":[{"id":"T1","span":{"begin":518,"end":529},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"uberon_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/UBERON_0003624"},{"subj":"T1","pred":"source","obj":"Anatomy-UBERON"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"AIMed","color":"#ec93cf","default":true},{"id":"HP-phenotype","color":"#93e9ec"},{"id":"mondo_disease","color":"#ecd493"},{"id":"Anatomy-UBERON","color":"#ba93ec"}]}]}}