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PubMed:8558011 JSONTXT

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DisGeNET

Id Subject Object Predicate Lexical cue
T0 1698-1703 gene:3700 denotes gp120
T1 1772-1793 disease:C0001849 denotes AIDS dementia complex
R1 T0 T1 associated_with gp120,AIDS dementia complex

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 0-20 protein denotes HIV glycoprotein 120
T2 30-63 protein denotes intercellular adhesion molecule-1
T3 83-94 cell_type denotes glial cells
T4 111-123 protein denotes Janus kinase
T5 123-172 protein denotes /signal transducer and activator of transcription
T6 177-193 protein denotes protein kinase C
T7 256-267 cell_type denotes glial cells
T8 305-315 cell_type denotes astrocytes
T9 320-329 cell_type denotes microglia
T10 484-511 protein denotes major envelope glycoprotein
T11 520-536 protein denotes glycoprotein 120
T12 538-543 protein denotes gp120
T13 558-591 protein denotes intercellular adhesion molecule-1
T14 593-599 protein denotes ICAM-1
T15 615-626 cell_type denotes glial cells
T16 636-642 protein denotes ICAM-1
T17 725-743 cell_type denotes HIV-infected cells
T18 818-823 protein denotes gp120
T19 833-839 protein denotes ICAM-1
T20 859-881 cell_type denotes primary rat astrocytes
T21 883-907 cell_type denotes primary human astrocytes
T22 911-942 cell_line denotes human astroglioma cell line CRT
T23 948-969 cell_type denotes primary rat microglia
T24 1014-1019 protein denotes gp120
T25 1044-1050 protein denotes ICAM-1
T26 1088-1104 protein denotes protein kinase C
T27 1109-1124 protein denotes tyrosine kinase
T28 1148-1164 protein denotes protein kinase C
T29 1169-1184 protein denotes tyrosine kinase
T30 1194-1199 protein denotes gp120
T31 1209-1215 protein denotes ICAM-1
T32 1235-1245 cell_type denotes astrocytes
T33 1250-1259 cell_type denotes microglia
T34 1271-1276 protein denotes gp120
T35 1313-1361 protein denotes signal transducer and activator of transcription
T36 1363-1375 protein denotes STAT-1 alpha
T37 1392-1404 protein denotes Janus kinase
T38 1406-1410 protein denotes JAK2
T39 1415-1426 cell_type denotes glial cells
T40 1453-1458 protein denotes gp120
T41 1468-1474 protein denotes ICAM-1
T42 1545-1560 cell_type denotes monocytic cells
T43 1572-1605 cell_type denotes gp120-stimulated human astrocytes
T44 1612-1618 protein denotes ICAM-1
T45 1626-1634 protein denotes integrin
T46 1698-1703 protein denotes gp120
T47 1737-1748 cell_type denotes glial cells

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
8558011-7#44#49#gene3700 1698-1703 gene3700 denotes gp120
8558011-7#118#139#diseaseC0001849 1772-1793 diseaseC0001849 denotes AIDS dementia complex
44#49#gene3700118#139#diseaseC0001849 8558011-7#44#49#gene3700 8558011-7#118#139#diseaseC0001849 associated_with gp120,AIDS dementia complex

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-95 Sentence denotes HIV glycoprotein 120 enhances intercellular adhesion molecule-1 gene expression in glial cells.
S2 96-213 Sentence denotes Involvement of Janus kinase/signal transducer and activator of transcription and protein kinase C signaling pathways.
S3 214-433 Sentence denotes It is well established that the two major glial cells in the central nervous system (CNS), astrocytes and microglia, are key participants in mediating the neurologic dysfunction associated with HIV infection of the CNS.
S4 434-791 Sentence denotes In this study, we investigated the ability of the major envelope glycoprotein of HIV, glycoprotein 120 (gp120), to regulate intercellular adhesion molecule-1 (ICAM-1) expression in glial cells, because ICAM-1 is important in mediating immune responsiveness in the CNS, facilitating entry of HIV-infected cells into the CNS, and promoting syncytia formation.
S5 792-970 Sentence denotes Our results indicate that gp120 enhances ICAM-1 gene expression in primary rat astrocytes, primary human astrocytes, a human astroglioma cell line CRT, and primary rat microglia.
S6 971-1260 Sentence denotes The signal transduction events involved in gp120-mediated enhancement of ICAM-1 appear to involve activation of both protein kinase C and tyrosine kinase, because inhibitors of protein kinase C and tyrosine kinase abrogate gp120-mediated ICAM-1 expression in both astrocytes and microglia.
S7 1261-1427 Sentence denotes Moreover, gp120 induces tyrosine phosphorylation of signal transducer and activator of transcription (STAT-1 alpha) as well as the Janus kinase (JAK2) in glial cells.
S8 1428-1653 Sentence denotes We also demonstrate that gp120-mediated ICAM-1 expression has functional significance, as it enhances the ability of monocytic cells to bind to gp120-stimulated human astrocytes in an ICAM-1/beta 2 integrin-dependent fashion.
S9 1654-1794 Sentence denotes These results provide new insights into how gp120 can influence the involvement of glial cells in the pathogenesis of AIDS dementia complex.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C2 83-94 NP denotes glial cells
C1 30-94 NP denotes intercellular adhesion molecule-1 gene expression in glial cells
C4 271-303 NP denotes the central nervous system (CNS)
C3 242-303 NP denotes the two major glial cells in the central nervous system (CNS)
C5 305-329 NP denotes astrocytes and microglia
C6 425-432 NP denotes the CNS
C7 480-518 NP denotes the major envelope glycoprotein of HIV
C8 520-544 NP denotes glycoprotein 120 (gp120)
C10 615-626 NP denotes glial cells
C9 558-626 NP denotes intercellular adhesion molecule-1 (ICAM-1) expression in glial cells
C11 694-701 NP denotes the CNS
C12 749-756 NP denotes the CNS
C13 818-823 NP denotes gp120
C14 833-855 NP denotes ICAM-1 gene expression
C15 1014-1020 NP denotes gp120-
C16 1088-1104 NP denotes protein kinase C
C17 1109-1124 NP denotes tyrosine kinase
C18 1148-1164 NP denotes protein kinase C
C19 1169-1184 NP denotes tyrosine kinase
C21 1194-1200 NP denotes gp120-
C20 1194-1226 NP denotes gp120-mediated ICAM-1 expression
C22 1271-1276 NP denotes gp120
C23 1415-1426 NP denotes glial cells
C25 1453-1459 NP denotes gp120-
C24 1453-1485 NP denotes gp120-mediated ICAM-1 expression
C26 1518-1520 NP denotes it
C27 1572-1578 NP denotes gp120-
C28 1698-1703 NP denotes gp120
C29 1737-1748 NP denotes glial cells
R1 C5 C3 coref-ident astrocytes and microglia,the two major glial cells in the central nervous system (CNS)
R2 C6 C4 coref-ident the CNS,the central nervous system (CNS)
R3 C8 C7 coref-appos glycoprotein 120 (gp120),the major envelope glycoprotein of HIV
R4 C10 C2 coref-ident glial cells,glial cells
R5 C9 C1 coref-ident intercellular adhesion molecule-1 (ICAM-1) expression in glial cells,intercellular adhesion molecule-1 gene expression in glial cells
R6 C11 C6 coref-ident the CNS,the CNS
R7 C12 C11 coref-ident the CNS,the CNS
R8 C13 C8 coref-ident gp120,glycoprotein 120 (gp120)
R9 C14 C9 coref-ident ICAM-1 gene expression,intercellular adhesion molecule-1 (ICAM-1) expression in glial cells
R10 C15 C13 coref-ident gp120-,gp120
R11 C18 C16 coref-ident protein kinase C,protein kinase C
R12 C19 C17 coref-ident tyrosine kinase,tyrosine kinase
R13 C20 C15 coref-ident gp120-mediated ICAM-1 expression,gp120-
R14 C22 C20 coref-ident gp120,gp120-mediated ICAM-1 expression
R15 C23 C10 coref-ident glial cells,glial cells
R16 C25 C21 coref-ident gp120-,gp120-
R17 C24 C22 coref-ident gp120-mediated ICAM-1 expression,gp120
R18 C26 C25 coref-ident it,gp120-
R19 C27 C24 coref-ident gp120-,gp120-mediated ICAM-1 expression
R20 C28 C27 coref-ident gp120,gp120-
R21 C29 C23 coref-ident glial cells,glial cells

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-20 protein_molecule denotes HIV glycoprotein 120
T2 30-63 protein_molecule denotes intercellular adhesion molecule-1
T3 83-94 cell_type denotes glial cells
T4 111-123 protein_family_or_group denotes Janus kinase
T5 123-172 protein_family_or_group denotes /signal transducer and activator of transcription
T6 177-193 protein_molecule denotes protein kinase C
T7 256-267 cell_type denotes glial cells
T8 275-297 body_part denotes central nervous system
T9 299-302 body_part denotes CNS
T10 305-315 cell_type denotes astrocytes
T11 320-329 cell_type denotes microglia
T12 369-391 other_name denotes neurologic dysfunction
T13 408-411 virus denotes HIV
T14 429-432 body_part denotes CNS
T15 484-511 protein_family_or_group denotes major envelope glycoprotein
T16 515-518 virus denotes HIV
T17 520-536 protein_molecule denotes glycoprotein 120
T18 538-543 protein_molecule denotes gp120
T19 558-591 protein_molecule denotes intercellular adhesion molecule-1
T20 593-599 protein_molecule denotes ICAM-1
T21 615-626 cell_type denotes glial cells
T22 636-642 protein_molecule denotes ICAM-1
T23 669-690 other_name denotes immune responsiveness
T24 698-701 body_part denotes CNS
T25 725-728 virus denotes HIV
T26 753-756 body_part denotes CNS
T27 818-823 protein_molecule denotes gp120
T28 833-839 protein_molecule denotes ICAM-1
T29 859-870 cell_type denotes primary rat
T30 871-881 cell_type denotes astrocytes
T31 883-896 cell_type denotes primary human
T32 897-907 cell_type denotes astrocytes
T33 911-942 cell_line denotes human astroglioma cell line CRT
T34 948-959 cell_type denotes primary rat
T35 960-969 cell_type denotes microglia
T36 1014-1019 protein_molecule denotes gp120
T37 1044-1050 protein_molecule denotes ICAM-1
T38 1088-1104 protein_molecule denotes protein kinase C
T39 1109-1117 amino_acid_monomer denotes tyrosine
T40 1148-1164 protein_molecule denotes protein kinase C
T41 1169-1177 amino_acid_monomer denotes tyrosine
T42 1194-1199 protein_molecule denotes gp120
T43 1209-1215 protein_molecule denotes ICAM-1
T44 1235-1245 cell_type denotes astrocytes
T45 1250-1259 cell_type denotes microglia
T46 1271-1276 protein_molecule denotes gp120
T47 1285-1293 amino_acid_monomer denotes tyrosine
T48 1313-1361 protein_family_or_group denotes signal transducer and activator of transcription
T49 1363-1375 protein_molecule denotes STAT-1 alpha
T50 1392-1404 protein_family_or_group denotes Janus kinase
T51 1406-1410 protein_molecule denotes JAK2
T52 1415-1426 cell_type denotes glial cells
T53 1453-1458 protein_molecule denotes gp120
T54 1468-1474 protein_molecule denotes ICAM-1
T55 1545-1560 cell_type denotes monocytic cells
T56 1572-1577 protein_molecule denotes gp120
T57 1595-1605 cell_type denotes astrocytes
T58 1612-1618 protein_molecule denotes ICAM-1
T59 1626-1634 protein_family_or_group denotes integrin
T60 1698-1703 protein_molecule denotes gp120
T61 1737-1748 cell_type denotes glial cells
T62 1772-1793 other_name denotes AIDS dementia complex