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PubMed:8555467 JSONTXT

Annnotations TAB JSON ListView MergeView

DisGeNET

Id Subject Object Predicate Lexical cue
T0 148-180 gene:57209 denotes Kruppel-type zinc finger protein
T1 316-325 disease:C0024299 denotes lymphomas
T2 110-115 gene:604 denotes BCL-6
T3 316-325 disease:C0024299 denotes lymphomas
T4 148-180 gene:5178 denotes Kruppel-type zinc finger protein
T5 222-238 disease:C0079731 denotes B-cell lymphomas
T6 148-180 gene:5178 denotes Kruppel-type zinc finger protein
T7 316-325 disease:C0024299 denotes lymphomas
T8 148-180 gene:57209 denotes Kruppel-type zinc finger protein
T9 222-238 disease:C0079731 denotes B-cell lymphomas
T10 355-360 gene:604 denotes BCL-6
T11 520-535 disease:C0598766 denotes lymphomagenesis
R1 T0 T1 associated_with Kruppel-type zinc finger protein,lymphomas
R2 T2 T3 associated_with BCL-6,lymphomas
R3 T4 T5 associated_with Kruppel-type zinc finger protein,B-cell lymphomas
R4 T6 T7 associated_with Kruppel-type zinc finger protein,lymphomas
R5 T8 T9 associated_with Kruppel-type zinc finger protein,B-cell lymphomas
R6 T10 T11 associated_with BCL-6,lymphomagenesis

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 38-51 protein denotes BCL-6 protein
T2 110-120 RNA denotes BCL-6 gene
T3 132-180 protein denotes nuclear-located Kruppel-type zinc finger protein
T4 222-238 cell_type denotes B-cell lymphomas
T5 280-303 cell_type denotes germinal center B cells
T6 355-360 protein denotes BCL-6
T7 417-440 cell_type denotes germinal center B cells
T8 591-604 protein denotes BCL-6 protein
T9 767-792 cell_type denotes malignant cell population
T10 804-813 cell_type denotes L&H cells
T11 967-988 protein denotes monoclonal antibodies
T12 989-994 protein denotes PG-B6
T13 999-1005 protein denotes PG-B6p
T14 1049-1075 protein denotes formalin-resistant epitope
T15 1083-1103 protein denotes aminoterminal region
T16 1111-1129 protein denotes BCL-6 gene product
T17 1179-1192 protein denotes BCL-6 protein
T18 1209-1226 cell_type denotes tumor (L&H) cells
T19 1263-1268 protein denotes BCL-6
T20 1313-1345 cell_line denotes Hodgkin and Reed-Sternberg cells
T21 1405-1431 cell_type denotes reactive CD3+/CD4+ T cells
T22 1463-1472 cell_type denotes L&H cells
T23 1501-1506 protein denotes BCL-6
T24 1520-1531 protein denotes CD40 ligand
T25 1533-1538 protein denotes CD40L
T26 1659-1676 cell_type denotes CD3+/CD4+ T cells
T27 1689-1694 protein denotes BCL-6
T28 1696-1701 protein denotes CD40L
T29 1852-1857 protein denotes BCL-6

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
8555467-0#38#43#gene604 38-43 gene604 denotes BCL-6
8555467-0#87#104#diseaseC0019829 87-104 diseaseC0019829 denotes Hodgkin's disease
8555467-1#4#9#gene604 110-115 gene604 denotes BCL-6
8555467-1#116#132#diseaseC0079731 222-238 diseaseC0079731 denotes B-cell lymphomas
8555467-1#210#219#diseaseC0024299 316-325 diseaseC0024299 denotes lymphomas
8555467-2#28#33#gene604 355-360 gene604 denotes BCL-6
8555467-2#193#208#diseaseC0598766 520-535 diseaseC0598766 denotes lymphomagenesis
38#43#gene60487#104#diseaseC0019829 8555467-0#38#43#gene604 8555467-0#87#104#diseaseC0019829 associated_with BCL-6,Hodgkin's disease
4#9#gene604116#132#diseaseC0079731 8555467-1#4#9#gene604 8555467-1#116#132#diseaseC0079731 associated_with BCL-6,B-cell lymphomas
4#9#gene604210#219#diseaseC0024299 8555467-1#4#9#gene604 8555467-1#210#219#diseaseC0024299 associated_with BCL-6,lymphomas
28#33#gene604193#208#diseaseC0598766 8555467-2#28#33#gene604 8555467-2#193#208#diseaseC0598766 associated_with BCL-6,lymphomagenesis

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-105 Sentence denotes Distinctive expression pattern of the BCL-6 protein in nodular lymphocyte predominance Hodgkin's disease.
S2 106-326 Sentence denotes The BCL-6 gene encoding a nuclear-located Kruppel-type zinc finger protein is rearranged in about 30% diffuse large B-cell lymphomas and is expressed predominantly in normal germinal center B cells and related lymphomas.
S3 327-536 Sentence denotes These findings suggest that BCL-6 may play a role in regulating differentiation of normal germinal center B cells and that its deregulated expression caused by rearrangements may contribute to lymphomagenesis.
S4 537-858 Sentence denotes This prompted us to investigate the expression of the BCL-6 protein in Hodgkin's disease (HD), focusing on the nodular lymphocyte predominance subtype (NLPHD), which differs from classical HD by virtue of the B-cell nature of the malignant cell population (so-called L&H cells) and its relationship with germinal centers.
S5 859-1144 Sentence denotes Forty-one HD samples (19 NLPHD, 12 nodular sclerosis, and 10 mixed cellularity) were immunostained with the monoclonal antibodies PG-B6 and PG-B6p that react with a fixative-sensitive and a formalin-resistant epitope on the aminoterminal region of the BCL-6 gene product, respectively.
S6 1145-1249 Sentence denotes Strong nuclear positivity for the BCL-6 protein was detected in tumor (L&H) cells in all cases of NLPHD.
S7 1250-1381 Sentence denotes In contrast, BCL-6 was expressed only in a small percentage of Hodgkin and Reed-Sternberg cells in about 30% of classical HD cases.
S8 1382-1551 Sentence denotes Notably, the nuclei of reactive CD3+/CD4+ T cells nearby to and rosetting around L&H cells in NLPHD were also strongly BCL-6+, but lacked CD40 ligand (CD40L) expression.
S9 1552-1713 Sentence denotes This staining pattern clearly differed from that of classical HD, whose cellular background was made up of CD3+/CD4+ T cells showing the BCL-6-/CD40L+ phenotype.
S10 1714-1877 Sentence denotes These results further support the concept that NLPHD is an histogenetically distinct, B-cell-derived subtype of HD and suggest a role for BCL-6 in its development.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 34-104 NP denotes the BCL-6 protein in nodular lymphocyte predominance Hodgkin's disease
C2 273-303 NP denotes normal germinal center B cells
C3 355-360 NP denotes BCL-6
C4 410-440 NP denotes normal germinal center B cells
C5 450-453 NP denotes its
C7 608-630 NP denotes Hodgkin's disease (HD)
C6 587-630 NP denotes the BCL-6 protein in Hodgkin's disease (HD)
C8 644-695 NP denotes the nodular lymphocyte predominance subtype (NLPHD)
C9 697-702 NP denotes which
C10 716-728 NP denotes classical HD
C11 763-814 NP denotes the malignant cell population (so-called L&H cells)
C12 819-822 NP denotes its
C13 963-1005 NP denotes the monoclonal antibodies PG-B6 and PG-B6p
C14 1006-1010 NP denotes that
C15 1175-1192 NP denotes the BCL-6 protein
C16 1243-1248 NP denotes NLPHD
C17 1263-1268 NP denotes BCL-6
C18 1463-1472 NP denotes L&H cells
C19 1476-1481 NP denotes NLPHD
C20 1552-1573 NP denotes This staining pattern
C21 1596-1600 NP denotes that
C22 1604-1616 NP denotes classical HD
C23 1618-1623 NP denotes whose
C24 1744-1755 NP denotes the concept
C25 1756-1760 NP denotes that
C26 1761-1766 NP denotes NLPHD
C27 1826-1828 NP denotes HD
C28 1852-1857 NP denotes BCL-6
C29 1861-1864 NP denotes its
R1 C4 C2 coref-ident normal germinal center B cells,normal germinal center B cells
R2 C5 C3 coref-pron its,BCL-6
R3 C6 C1 coref-other the BCL-6 protein in Hodgkin's disease (HD),the BCL-6 protein in nodular lymphocyte predominance Hodgkin's disease
R4 C9 C8 coref-relat which,the nodular lymphocyte predominance subtype (NLPHD)
R5 C12 C8 coref-pron its,the nodular lymphocyte predominance subtype (NLPHD)
R6 C14 C13 coref-ident that,the monoclonal antibodies PG-B6 and PG-B6p
R7 C15 C6 coref-ident the BCL-6 protein,the BCL-6 protein in Hodgkin's disease (HD)
R8 C16 C8 coref-ident NLPHD,the nodular lymphocyte predominance subtype (NLPHD)
R9 C17 C3 coref-ident BCL-6,BCL-6
R10 C18 C11 coref-ident L&H cells,the malignant cell population (so-called L&H cells)
R11 C19 C16 coref-ident NLPHD,NLPHD
R12 C21 C20 coref-pron that,This staining pattern
R13 C22 C10 coref-ident classical HD,classical HD
R14 C23 C22 coref-relat whose,classical HD
R15 C25 C24 coref-relat that,the concept
R16 C26 C19 coref-ident NLPHD,NLPHD
R17 C27 C7 coref-ident HD,Hodgkin's disease (HD)
R18 C28 C17 coref-ident BCL-6,BCL-6
R19 C29 C26 coref-ident its,NLPHD

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 38-43 protein_molecule denotes BCL-6
T2 55-104 other_name denotes nodular lymphocyte predominance Hodgkin's disease
T3 110-115 protein_molecule denotes BCL-6
T4 132-180 protein_family_or_group denotes nuclear-located Kruppel-type zinc finger protein
T5 222-238 cell_type denotes B-cell lymphomas
T6 280-303 cell_type denotes germinal center B cells
T7 316-325 tissue denotes lymphomas
T8 355-360 protein_molecule denotes BCL-6
T9 417-440 cell_type denotes germinal center B cells
T10 520-535 other_name denotes lymphomagenesis
T11 591-596 protein_molecule denotes BCL-6
T12 608-625 other_name denotes Hodgkin's disease
T13 627-629 other_name denotes HD
T14 648-687 other_name denotes nodular lymphocyte predominance subtype
T15 689-694 other_name denotes NLPHD
T16 716-725 other_name denotes classical
T17 726-728 other_name denotes HD
T18 746-759 other_name denotes B-cell nature
T19 767-792 cell_type denotes malignant cell population
T20 804-805 cell_type denotes L
T21 805-806 cell_type denotes &
T22 806-813 cell_type denotes H cells
T23 869-871 other_name denotes HD
T24 884-889 other_name denotes NLPHD
T25 894-911 other_name denotes nodular sclerosis
T26 967-988 protein_family_or_group denotes monoclonal antibodies
T27 989-994 protein_molecule denotes PG-B6
T28 999-1005 protein_molecule denotes PG-B6p
T29 1049-1075 protein_domain_or_region denotes formalin-resistant epitope
T30 1083-1103 protein_domain_or_region denotes aminoterminal region
T31 1111-1116 protein_molecule denotes BCL-6
T32 1179-1184 protein_molecule denotes BCL-6
T33 1209-1217 cell_type denotes tumor (L
T34 1217-1218 cell_type denotes &
T35 1218-1226 cell_type denotes H) cells
T36 1243-1248 other_name denotes NLPHD
T37 1263-1268 protein_molecule denotes BCL-6
T38 1313-1345 cell_line denotes Hodgkin and Reed-Sternberg cells
T39 1372-1374 other_name denotes HD
T40 1405-1431 cell_type denotes reactive CD3+/CD4+ T cells
T41 1463-1464 cell_type denotes L
T42 1464-1465 cell_type denotes &
T43 1465-1472 cell_type denotes H cells
T44 1476-1481 other_name denotes NLPHD
T45 1501-1506 protein_molecule denotes BCL-6
T46 1520-1531 protein_molecule denotes CD40 ligand
T47 1533-1538 protein_molecule denotes CD40L
T48 1614-1616 other_name denotes HD
T49 1659-1676 cell_type denotes CD3+/CD4+ T cells
T50 1689-1694 protein_molecule denotes BCL-6
T51 1696-1701 protein_molecule denotes CD40L
T52 1761-1766 other_name denotes NLPHD
T53 1800-1822 other_name denotes B-cell-derived subtype
T54 1826-1828 other_name denotes HD
T55 1852-1857 protein_molecule denotes BCL-6