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PubMed:8552097 JSONTXT

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DisGeNET

Id Subject Object Predicate Lexical cue
T0 228-233 gene:1869 denotes E2F-1
T1 295-309 disease:C0035335 denotes retinoblastoma
T2 339-345 gene:5111 denotes cyclin
T3 295-309 disease:C0035335 denotes retinoblastoma
R1 T0 T1 associated_with E2F-1,retinoblastoma
R2 T2 T3 associated_with cyclin,retinoblastoma

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 0-5 protein denotes E2F-1
T2 66-91 cell_type denotes transgenic megakaryocytes
T3 97-117 protein denotes transcription factor
T4 118-123 protein denotes E2F-1
T5 186-200 DNA denotes activate genes
T6 228-233 protein denotes E2F-1
T7 310-329 DNA denotes susceptibility gene
T8 339-363 protein denotes cyclin-dependent kinases
T9 508-513 protein denotes E2F-1
T10 560-574 cell_type denotes megakaryocytes
T11 583-592 cell_type denotes platelets
T12 625-630 protein denotes E2F-1
T13 645-659 cell_type denotes megakaryocytes
T14 769-783 cell_type denotes megakaryocytes
T15 930-973 protein denotes megakaryocyte growth and development factor
T16 977-990 protein denotes interleukin 6
T17 1051-1056 protein denotes E2F-1
T18 1072-1085 cell_type denotes megakaryocyte
T19 1222-1247 cell_type denotes transgenic megakaryocytes
T20 1274-1279 protein denotes E2F-1

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
8552097-2#111#117#gene5111 339-345 gene5111 denotes cyclin
8552097-2#67#81#diseaseC0035335 295-309 diseaseC0035335 denotes retinoblastoma
8552097-4#0#5#gene1869 625-630 gene1869 denotes E2F-1
8552097-4#98#114#diseaseC0040034 723-739 diseaseC0040034 denotes thrombocytopenia
111#117#gene511167#81#diseaseC0035335 8552097-2#111#117#gene5111 8552097-2#67#81#diseaseC0035335 associated_with cyclin,retinoblastoma
0#5#gene186998#114#diseaseC0040034 8552097-4#0#5#gene1869 8552097-4#98#114#diseaseC0040034 associated_with E2F-1,thrombocytopenia

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-92 Sentence denotes E2F-1 blocks terminal differentiation and causes proliferation in transgenic megakaryocytes.
S2 93-227 Sentence denotes The transcription factor E2F-1 plays a central role in the cell cycle through its ability to activate genes involved in cell division.
S3 228-472 Sentence denotes E2F-1 activity is regulated by a number of proteins, including the retinoblastoma susceptibility gene product, cyclin-dependent kinases, and their inhibitors, proteins that have been implicated in the control of certain developmental processes.
S4 473-624 Sentence denotes To investigate a potential role of E2F-1 in differentiation, we assayed the ability of megakaryocytes to form platelets in an in vivo transgenic model.
S5 625-740 Sentence denotes E2F-1 expression in megakaryocytes blocked differentiation during maturation, resulting in severe thrombocytopenia.
S6 741-911 Sentence denotes Ultrastructural analysis of megakaryocytes revealed abnormal development characterized by hyperdemarcation of cytoplasmic membranes and reduced numbers of alpha granules.
S7 912-1036 Sentence denotes Administration of megakaryocyte growth and development factor or interleukin 6 could not overcome the differentiation block.
S8 1037-1170 Sentence denotes Additionally, E2F-1 caused massive megakaryocyte accumulation in both normal and ectopic sites, first evident in E15 embryonic liver.
S9 1171-1248 Sentence denotes Furthermore, significant apoptosis was observed in transgenic megakaryocytes.
S10 1249-1371 Sentence denotes These data indicate that E2F-1 can prevent terminal differentiation, probably through its cell cycle-stimulatory activity.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 0-5 NP denotes E2F-1
C2 13-37 NP denotes terminal differentiation
C3 66-91 NP denotes transgenic megakaryocytes
C4 93-123 NP denotes The transcription factor E2F-1
C5 171-174 NP denotes its
C6 259-279 NP denotes a number of proteins
C8 339-363 NP denotes cyclin-dependent kinases
C9 369-374 NP denotes their
C10 387-395 NP denotes proteins
C11 396-400 NP denotes that
C7 291-471 NP denotes the retinoblastoma susceptibility gene product, cyclin-dependent kinases, and their inhibitors, proteins that have been implicated in the control of certain developmental processes
C12 508-513 NP denotes E2F-1
C13 1051-1056 NP denotes E2F-1
C14 1222-1247 NP denotes transgenic megakaryocytes
C15 1274-1279 NP denotes E2F-1
C16 1292-1316 NP denotes terminal differentiation
C17 1335-1338 NP denotes its
R1 C4 C1 coref-ident The transcription factor E2F-1,E2F-1
R2 C5 C4 coref-pron its,The transcription factor E2F-1
R3 C9 C8 coref-pron their,cyclin-dependent kinases
R4 C11 C10 coref-relat that,proteins
R5 C7 C6 coref-part-whole "the retinoblastoma susceptibility gene product, cyclin-dependent kinases, and their inhibitors, proteins that have been implicated in the control of certain developmental processes",a number of proteins
R6 C12 C4 coref-ident E2F-1,The transcription factor E2F-1
R7 C13 C12 coref-ident E2F-1,E2F-1
R8 C14 C3 coref-ident transgenic megakaryocytes,transgenic megakaryocytes
R9 C15 C13 coref-ident E2F-1,E2F-1
R10 C16 C2 coref-ident terminal differentiation,terminal differentiation
R11 C17 C15 coref-pron its,E2F-1

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-5 protein_molecule denotes E2F-1
T2 66-91 cell_type denotes transgenic megakaryocytes
T3 97-117 protein_family_or_group denotes transcription factor
T4 118-123 protein_molecule denotes E2F-1
T5 152-162 other_name denotes cell cycle
T6 186-200 DNA_family_or_group denotes activate genes
T7 213-226 other_name denotes cell division
T8 228-233 protein_molecule denotes E2F-1
T9 295-309 other_name denotes retinoblastoma
T10 310-329 DNA_domain_or_region denotes susceptibility gene
T11 339-363 protein_family_or_group denotes cyclin-dependent kinases
T12 369-385 other_name denotes their inhibitors
T13 440-471 other_name denotes certain developmental processes
T14 508-513 protein_molecule denotes E2F-1
T15 517-532 other_name denotes differentiation
T16 560-574 cell_type denotes megakaryocytes
T17 583-592 cell_type denotes platelets
T18 599-623 other_name denotes in vivo transgenic model
T19 625-630 protein_molecule denotes E2F-1
T20 645-659 cell_type denotes megakaryocytes
T21 716-722 other_name denotes severe
T22 723-739 other_name denotes thrombocytopenia
T23 769-783 cell_type denotes megakaryocytes
T24 831-847 other_name denotes hyperdemarcation
T25 851-872 cell_component denotes cytoplasmic membranes
T26 896-910 cell_component denotes alpha granules
T27 930-943 cell_type denotes megakaryocyte
T28 977-990 protein_molecule denotes interleukin 6
T29 1014-1035 other_name denotes differentiation block
T30 1051-1056 protein_molecule denotes E2F-1
T31 1064-1071 other_name denotes massive
T32 1072-1085 cell_type denotes megakaryocyte
T33 1150-1169 body_part denotes E15 embryonic liver
T34 1196-1205 other_name denotes apoptosis
T35 1222-1232 cell_type denotes transgenic
T36 1233-1247 cell_type denotes megakaryocytes
T37 1274-1279 protein_molecule denotes E2F-1
T38 1301-1316 other_name denotes differentiation
T39 1339-1349 other_name denotes cell cycle