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PubMed:8548755 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-96 Sentence denotes CDKN2/p16 or RB alterations occur in the majority of glioblastomas and are inversely correlated.
TextSentencer_T2 97-232 Sentence denotes p16 is involved in a cell cycle regulatory cascade that includes cyclin-dependent kinase 4 (cdk4), cyclin D1, and pRb (retinoblastoma).
TextSentencer_T3 233-361 Sentence denotes Alterations of each of these components have been described in primary human glioblastoma multiforme (GBM) or in GBM cell lines.
TextSentencer_T4 362-655 Sentence denotes Because perturbation of any component in this pathway may have similar oncogenic effects, we studied the relationship between abnormalities of CDKN2/p16 and RB, the two commonly involved tumor suppressor genes, in 55 astrocytic gliomas (42 GBMs, 8 anaplastic astrocytomas, and 5 astrocytomas).
TextSentencer_T5 656-799 Sentence denotes By using comparative multiplex PCR, homozygous deletions of the CDKN2/p16 gene were detected in 24 GBMs (57%) and in 2 anaplastic astrocytomas.
TextSentencer_T6 800-960 Sentence denotes Two additional GBMs and one anaplastic astrocytoma had allelic loss of chromosome 9p, as assessed by microsatellite polymorphisms flanking the CDKN2/p16 region.
TextSentencer_T7 961-1181 Sentence denotes Single-strand conformation polymorphism and DNA sequencing analysis of all three coding exons of CDKN2/p16 revealed a frameshift mutation (four-bp deletion) in one of the three GBMs that had lost the remaining 9p allele.
TextSentencer_T8 1182-1331 Sentence denotes Allelic loss of chromosome 13q at the RB gene, RB gene mutations, or loss of pRb expression was noted in 14 GBMs (33%) and 2 anaplastic astrocytomas.
TextSentencer_T9 1332-1510 Sentence denotes Thirty-six of 42 GBMs (86%) had alterations of either CDKN2/p16 (n = 22), RB (n = 10), or both (n = 4); these two genetic changes, however, were relatively exclusive (P = 0.003).
TextSentencer_T10 1511-1628 Sentence denotes Furthermore, of the six GBMs without either CDKN2/p16 or RB gene abnormalities, one case had CDK4 gene amplification.
TextSentencer_T11 1629-1745 Sentence denotes These data indicate that the vast majority of GBMs probably have inactivation of the p16-cdk4/cyclin D1-pRb pathway.
TextSentencer_T12 1746-1904 Sentence denotes The findings also provide corroborative evidence that CDKN2/p16 and RB are the critical glioma tumor suppressor genes on chromosomes 9p and 13q, respectively.
T1 0-96 Sentence denotes CDKN2/p16 or RB alterations occur in the majority of glioblastomas and are inversely correlated.
T2 97-232 Sentence denotes p16 is involved in a cell cycle regulatory cascade that includes cyclin-dependent kinase 4 (cdk4), cyclin D1, and pRb (retinoblastoma).
T3 233-361 Sentence denotes Alterations of each of these components have been described in primary human glioblastoma multiforme (GBM) or in GBM cell lines.
T4 362-655 Sentence denotes Because perturbation of any component in this pathway may have similar oncogenic effects, we studied the relationship between abnormalities of CDKN2/p16 and RB, the two commonly involved tumor suppressor genes, in 55 astrocytic gliomas (42 GBMs, 8 anaplastic astrocytomas, and 5 astrocytomas).
T5 656-799 Sentence denotes By using comparative multiplex PCR, homozygous deletions of the CDKN2/p16 gene were detected in 24 GBMs (57%) and in 2 anaplastic astrocytomas.
T6 800-960 Sentence denotes Two additional GBMs and one anaplastic astrocytoma had allelic loss of chromosome 9p, as assessed by microsatellite polymorphisms flanking the CDKN2/p16 region.
T7 961-1181 Sentence denotes Single-strand conformation polymorphism and DNA sequencing analysis of all three coding exons of CDKN2/p16 revealed a frameshift mutation (four-bp deletion) in one of the three GBMs that had lost the remaining 9p allele.
T8 1182-1331 Sentence denotes Allelic loss of chromosome 13q at the RB gene, RB gene mutations, or loss of pRb expression was noted in 14 GBMs (33%) and 2 anaplastic astrocytomas.
T9 1332-1510 Sentence denotes Thirty-six of 42 GBMs (86%) had alterations of either CDKN2/p16 (n = 22), RB (n = 10), or both (n = 4); these two genetic changes, however, were relatively exclusive (P = 0.003).
T10 1511-1628 Sentence denotes Furthermore, of the six GBMs without either CDKN2/p16 or RB gene abnormalities, one case had CDK4 gene amplification.
T11 1629-1745 Sentence denotes These data indicate that the vast majority of GBMs probably have inactivation of the p16-cdk4/cyclin D1-pRb pathway.
T12 1746-1904 Sentence denotes The findings also provide corroborative evidence that CDKN2/p16 and RB are the critical glioma tumor suppressor genes on chromosomes 9p and 13q, respectively.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 1800-1805 gene:1017 denotes CDKN2
T1 1834-1840 disease:C0017638 denotes glioma
T2 1800-1805 gene:1029 denotes CDKN2
T3 1834-1840 disease:C0017638 denotes glioma
R1 T0 T1 associated_with CDKN2,glioma
R2 T2 T3 associated_with CDKN2,glioma

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
8548755-1#99#108#gene595 196-205 gene595 denotes cyclin D1
8548755-1#119#133#diseaseC0035335 216-230 diseaseC0035335 denotes retinoblastoma
99#108#gene595119#133#diseaseC0035335 8548755-1#99#108#gene595 8548755-1#119#133#diseaseC0035335 associated_with cyclin D1,retinoblastoma

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T221 0-5 gene:1017 denotes CDKN2
T222 53-66 disease:C0017636 denotes glioblastomas
T223 720-725 gene:1017 denotes CDKN2
T224 775-798 disease:C0334579 denotes anaplastic astrocytomas
T1521 505-510 gene:1017 denotes CDKN2
T1522 579-597 disease:C0004114 denotes astrocytic gliomas
R1 T221 T222 associated_with CDKN2,glioblastomas
R2 T221 T222 associated_with CDKN2,glioblastomas
R3 T223 T224 associated_with CDKN2,anaplastic astrocytomas
R4 T223 T224 associated_with CDKN2,anaplastic astrocytomas
R1 T1521 T1522 associated_with CDKN2,astrocytic gliomas
R2 T1521 T1522 associated_with CDKN2,astrocytic gliomas