PubMed:8541299
Annnotations
GlyCosmos15-Species
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| 32 | 230-234 | Species | denotes | mice | 10090 |
| 33 | 239-243 | Species | denotes | rats | 10116 |
| 46 | 674-678 | Species | denotes | mice | 10090 |
| 47 | 786-789 | Species | denotes | rat | 10116 |
| 48 | 942-947 | Species | denotes | Human | 9606 |
| 54 | 1033-1039 | Species | denotes | bovine | 9913 |
| 55 | 1052-1055 | Species | denotes | rat | 10116 |
| 59 | 1189-1194 | Species | denotes | human | 9606 |
| 63 | 1385-1390 | Species | denotes | human | 9606 |
Anatomy-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 24-29 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/MAT_0000083|http://purl.obolibrary.org/obo/MAT_0000315 |
| T3 | 99-104 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/MAT_0000083|http://purl.obolibrary.org/obo/MAT_0000315 |
| T5 | 270-275 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/MAT_0000097 |
| T6 | 469-474 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/MAT_0000083|http://purl.obolibrary.org/obo/MAT_0000315 |
| T8 | 536-541 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/MAT_0000097 |
| T9 | 609-614 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/MAT_0000083|http://purl.obolibrary.org/obo/MAT_0000315 |
| T11 | 703-708 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/MAT_0000097 |
| T12 | 790-795 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/MAT_0000097 |
| T13 | 1477-1482 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/MAT_0000097 |
GlyCosmos15-Glycan
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 361-364 | Glycan | denotes | GM1 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR |
| T2 | 1014-1017 | Glycan | denotes | GM1 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR |
| T3 | 1103-1106 | Glycan | denotes | GM1 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR |
Glycan-GlyCosmos
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 361-364 | Glycan | denotes | GM1 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR |
| T2 | 1014-1017 | Glycan | denotes | GM1 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR |
| T3 | 1103-1106 | Glycan | denotes | GM1 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR |
GlyCosmos-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 361-364 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
| T2 | 1014-1017 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
| T3 | 1103-1106 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
GlyCosmos15-NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 230-234 | OrganismTaxon | denotes | mice | 10088 |
| T2 | 239-243 | OrganismTaxon | denotes | rats | 10114|10116 |
| T4 | 674-678 | OrganismTaxon | denotes | mice | 10088 |
| T5 | 786-789 | OrganismTaxon | denotes | rat | 10114|10116 |
| T7 | 942-947 | OrganismTaxon | denotes | Human | 9606 |
| T8 | 1033-1039 | OrganismTaxon | denotes | bovine | 9913 |
| T9 | 1052-1055 | OrganismTaxon | denotes | rat | 10114|10116 |
| T11 | 1189-1194 | OrganismTaxon | denotes | human | 9606 |
| T12 | 1385-1390 | OrganismTaxon | denotes | human | 9606 |
GlyCosmos15-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 24-29 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/UBERON_0000178 |
| T2 | 99-104 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/UBERON_0000178 |
| T3 | 160-186 | Body_part | denotes | reticuloendothelial system | http://purl.obolibrary.org/obo/UBERON_0000363 |
| T4 | 188-191 | Body_part | denotes | RES | http://purl.obolibrary.org/obo/UBERON_0000363 |
| T5 | 270-275 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
| T6 | 469-474 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/UBERON_0000178 |
| T7 | 536-541 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
| T8 | 555-560 | Body_part | denotes | organ | http://purl.obolibrary.org/obo/UBERON_0000062|http://purl.obolibrary.org/obo/UBERON_0003103 |
| T10 | 609-614 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/UBERON_0000178 |
| T11 | 703-708 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
| T12 | 790-795 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
| T13 | 1274-1279 | Body_part | denotes | venom | http://purl.obolibrary.org/obo/UBERON_0007113 |
| T14 | 1477-1482 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
GlyCosmos15-Sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-82 | Sentence | denotes | Liposome clearance from blood: different animal species have different mechanisms. |
| T2 | 83-245 | Sentence | denotes | The kinetics of blood clearance and the mechanisms of liposome uptake by the reticuloendothelial system (RES) were compared in two animal species (mice and rats). |
| T3 | 246-526 | Sentence | denotes | By employing an in situ liver perfusion technique with selected liposome compositions (PC/Chol, PC/Cho/PS, PC/Chol/GM1 and PC/Chol/PEG5000-PE), we demonstrated that liposomes with same lipid composition exhibited different blood circulation half-lives in different animal species. |
| T4 | 527-670 | Sentence | denotes | Although liver is the major organ responsible for the clearance of liposomes from blood in both animal species, the specific mechanisms differ. |
| T5 | 671-749 | Sentence | denotes | In mice, liposome uptake by the liver did not involve specific serum opsonins. |
| T6 | 750-837 | Sentence | denotes | In contrast, liposome uptake by the rat liver was strongly dependent on serum opsonins. |
| T7 | 838-941 | Sentence | denotes | Further, the activity of serum opsonins for a given liposome composition differed among animal species. |
| T8 | 942-1356 | Sentence | denotes | Human serum exhibited higher opsonin activities for PC/Chol and PC/Chol/GM1 liposomes than bovine sera, while rat serum displayed a high opsonizing activity for GM1 liposomes and none for liposomes composed of PC and Chol. The opsonin activity of human serum could be removed or decreased by treatment with EGTA/Mg2+, EDTA or cobra venom factor, suggesting that the activity is likely due to complement components. |
| T9 | 1357-1483 | Sentence | denotes | It is likely that C3 of the human complement system plays an important role in mediating the uptake of liposomes by the liver. |
GlyCosmos15-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 361-364 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
| T2 | 1014-1017 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
| T3 | 1103-1106 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
GlyCosmos15-FMA
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 24-29 | Body_part | denotes | blood | FMA:9670 |
| T2 | 99-104 | Body_part | denotes | blood | FMA:9670 |
| T3 | 160-186 | Body_part | denotes | reticuloendothelial system | FMA:84189 |
| T4 | 188-191 | Body_part | denotes | RES | FMA:84189 |
| T5 | 270-275 | Body_part | denotes | liver | FMA:7197 |
| T6 | 469-474 | Body_part | denotes | blood | FMA:9670 |
| T7 | 536-541 | Body_part | denotes | liver | FMA:7197 |
| T8 | 555-560 | Body_part | denotes | organ | FMA:67498 |
| T9 | 609-614 | Body_part | denotes | blood | FMA:9670 |
| T10 | 703-708 | Body_part | denotes | liver | FMA:7197 |
| T11 | 734-739 | Body_part | denotes | serum | FMA:63083 |
| T12 | 790-795 | Body_part | denotes | liver | FMA:7197 |
| T13 | 822-827 | Body_part | denotes | serum | FMA:63083 |
| T14 | 863-868 | Body_part | denotes | serum | FMA:63083 |
| T15 | 948-953 | Body_part | denotes | serum | FMA:63083 |
| T16 | 1056-1061 | Body_part | denotes | serum | FMA:63083 |
| T17 | 1195-1200 | Body_part | denotes | serum | FMA:63083 |
| T18 | 1477-1482 | Body_part | denotes | liver | FMA:7197 |
GlyCosmos15-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 24-29 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/MAT_0000315 |
| T2 | 99-104 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/MAT_0000315 |
| T3 | 270-275 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/MAT_0000097 |
| T4 | 469-474 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/MAT_0000315 |
| T5 | 536-541 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/MAT_0000097 |
| T6 | 609-614 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/MAT_0000315 |
| T7 | 703-708 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/MAT_0000097 |
| T8 | 790-795 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/MAT_0000097 |
| T9 | 1477-1482 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/MAT_0000097 |
NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 230-234 | OrganismTaxon | denotes | mice | 10088 |
| T2 | 239-243 | OrganismTaxon | denotes | rats | 10114|10116 |
| T4 | 674-678 | OrganismTaxon | denotes | mice | 10088 |
| T5 | 786-789 | OrganismTaxon | denotes | rat | 10114|10116 |
| T7 | 942-947 | OrganismTaxon | denotes | Human | 9606 |
| T8 | 1033-1039 | OrganismTaxon | denotes | bovine | 9913 |
| T9 | 1052-1055 | OrganismTaxon | denotes | rat | 10114|10116 |
| T11 | 1189-1194 | OrganismTaxon | denotes | human | 9606 |
| T12 | 1385-1390 | OrganismTaxon | denotes | human | 9606 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 24-29 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/UBERON_0000178 |
| T2 | 99-104 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/UBERON_0000178 |
| T3 | 160-186 | Body_part | denotes | reticuloendothelial system | http://purl.obolibrary.org/obo/UBERON_0000363 |
| T4 | 188-191 | Body_part | denotes | RES | http://purl.obolibrary.org/obo/UBERON_0000363 |
| T5 | 270-275 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
| T6 | 469-474 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/UBERON_0000178 |
| T7 | 536-541 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
| T8 | 555-560 | Body_part | denotes | organ | http://purl.obolibrary.org/obo/UBERON_0000062|http://purl.obolibrary.org/obo/UBERON_0003103 |
| T10 | 609-614 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/UBERON_0000178 |
| T11 | 703-708 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
| T12 | 790-795 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
| T13 | 1274-1279 | Body_part | denotes | venom | http://purl.obolibrary.org/obo/UBERON_0007113 |
| T14 | 1477-1482 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/UBERON_0002107 |