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PubMed:8529108 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 0-10 protein denotes Hemoglobin
T2 77-98 protein denotes transcription factors
T3 100-106 protein denotes GATA-1
T4 111-114 protein denotes SP1
T5 187-197 protein denotes hemoglobin
T6 287-297 protein denotes hemoglobin
T7 299-302 protein denotes HbF
T8 464-475 DNA denotes globin gene
T9 534-550 cell_line denotes primary cultures
T10 583-604 cell_type denotes erythroid progenitors
T11 651-677 protein denotes transcriptional activators
T12 679-685 protein denotes GATA-1
T13 690-693 protein denotes SP1
T14 834-840 protein denotes GATA-1
T15 845-848 protein denotes SP1
T16 884-905 cell_type denotes erythroid progenitors
T17 1034-1040 protein denotes GATA-1
T18 1071-1074 protein denotes SP1
T19 1091-1111 cell_line denotes fetal liver cultures
T20 1212-1218 protein denotes GATA-1
T21 1223-1226 protein denotes SP1
T22 1404-1407 protein denotes HbF
T23 1523-1526 protein denotes HbF
T24 1605-1648 cell_type denotes human fetal and adult erythroid progenitors
T25 1671-1692 protein denotes transcription factors
T26 1860-1877 cell_type denotes fetal progenitors

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
8529108-4#56#62#gene2623 834-840 gene2623 denotes GATA-1
8529108-4#191#212#diseaseC0271980 969-990 diseaseC0271980 denotes beta zero-thalassemia
56#62#gene2623191#212#diseaseC0271980 8529108-4#56#62#gene2623 8529108-4#191#212#diseaseC0271980 associated_with GATA-1,beta zero-thalassemia

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-10 protein_molecule denotes Hemoglobin
T2 77-98 protein_family_or_group denotes transcription factors
T3 100-106 protein_molecule denotes GATA-1
T4 111-114 protein_molecule denotes SP1
T5 187-197 protein_molecule denotes hemoglobin
T6 281-286 other_name denotes fetal
T7 287-297 protein_molecule denotes hemoglobin
T8 299-302 protein_molecule denotes HbF
T9 361-372 other_name denotes thalassemia
T10 377-395 other_name denotes sickle cell anemia
T11 464-475 DNA_domain_or_region denotes globin gene
T12 534-550 cell_line denotes primary cultures
T13 583-604 cell_type denotes erythroid progenitors
T14 651-677 protein_family_or_group denotes transcriptional activators
T15 679-685 protein_molecule denotes GATA-1
T16 690-693 protein_molecule denotes SP1
T17 715-753 other_name denotes normal adult erythroid differentiation
T18 834-840 protein_molecule denotes GATA-1
T19 845-848 protein_molecule denotes SP1
T20 856-871 other_name denotes differentiation
T21 884-905 cell_type denotes erythroid progenitors
T22 919-929 tissue denotes cord blood
T23 939-951 body_part denotes fetal livers
T24 969-979 multi_cell denotes beta zero-
T25 979-990 other_name denotes thalassemia
T26 1034-1040 protein_molecule denotes GATA-1
T27 1071-1074 protein_molecule denotes SP1
T28 1091-1111 cell_line denotes fetal liver cultures
T29 1167-1196 tissue denotes normal adult peripheral blood
T30 1212-1218 protein_molecule denotes GATA-1
T31 1223-1226 protein_molecule denotes SP1
T32 1364-1374 multi_cell denotes beta zero-
T33 1374-1385 other_name denotes thalassemia
T34 1404-1407 protein_molecule denotes HbF
T35 1477-1489 multi_cell denotes 2 beta zero-
T36 1489-1500 other_name denotes thalassemia
T37 1523-1526 protein_molecule denotes HbF
T38 1528-1543 other_name denotes "adult" pattern
T39 1671-1692 protein_family_or_group denotes transcription factors
T40 1830-1843 other_name denotes anemic stress
T41 1860-1877 cell_type denotes fetal progenitors
T42 1891-1900 other_name denotes adulthood

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-115 Sentence denotes Hemoglobin switching in humans is accompanied by changes in the ratio of the transcription factors, GATA-1 and SP1.
S2 116-396 Sentence denotes BACKGROUND: Understanding the mechanism of developmental regulation of hemoglobin switching has scientific as well as clinical relevance because of the influence of fetal hemoglobin (HbF) production in adulthood on the clinical manifestation of thalassemia and sickle cell anemia.
S3 397-605 Sentence denotes We have previously found that the normal developmental patterns of globin gene expression are recapitulated in an experimental system of primary cultures that support differentiation of erythroid progenitors.
S4 606-754 Sentence denotes We further found that high activities of the transcriptional activators, GATA-1 and SP1, are associated with normal adult erythroid differentiation.
S5 755-1000 Sentence denotes MATERIALS AND METHODS: In the present work, we have studied, the activities of GATA-1 and SP1 during differentiation of cultured erythroid progenitors derived from cord blood and from fetal livers, as well as from beta zero-thalassemia patients.
S6 1001-1112 Sentence denotes RESULTS: The results showed high GATA-1 binding activity and very low SP1 activity in the fetal liver cultures.
S7 1113-1248 Sentence denotes This pattern was in contrast to cultures derived from normal adult peripheral blood, in which both GATA-1 and SP1 activities were high.
S8 1249-1332 Sentence denotes Cord blood cultures showed an additive combination of "adult" and "fetal" patterns.
S9 1333-1442 Sentence denotes The progenitors derived from a beta zero-thalassemia patient with high HbF production showed "fetal" pattern.
S10 1443-1557 Sentence denotes On the other hand, in cultures of 2 beta zero-thalassemia patients without high HbF, "adult" pattern was observed.
S11 1558-1789 Sentence denotes CONCLUSIONS: In the present work, we show that human fetal and adult erythroid progenitors are distinct in their transcription factors, and that the commitment to fetal or adult program occurs at a very early differentiation stage.
S12 1790-1901 Sentence denotes Our studies also demonstrate that under anemic stress, recruitment of fetal progenitors may occur in adulthood.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 0-20 NP denotes Hemoglobin switching
C2 73-98 NP denotes the transcription factors
C3 100-114 NP denotes GATA-1 and SP1
C4 187-207 NP denotes hemoglobin switching
C5 534-550 NP denotes primary cultures
C6 551-555 NP denotes that
C7 647-677 NP denotes the transcriptional activators
C8 679-693 NP denotes GATA-1 and SP1
C10 834-848 NP denotes GATA-1 and SP1
C9 816-848 NP denotes the activities of GATA-1 and SP1
C11 1113-1125 NP denotes This pattern
C12 1145-1196 NP denotes cultures derived from normal adult peripheral blood
C13 1201-1206 NP denotes which
C14 1207-1237 NP denotes both GATA-1 and SP1 activities
C15 1427-1441 NP denotes fetal" pattern
C16 1605-1648 NP denotes human fetal and adult erythroid progenitors
C17 1665-1670 NP denotes their
R1 C3 C2 coref-appos GATA-1 and SP1,the transcription factors
R2 C4 C1 coref-ident hemoglobin switching,Hemoglobin switching
R3 C6 C5 coref-relat that,primary cultures
R4 C7 C2 coref-ident the transcriptional activators,the transcription factors
R5 C8 C7 coref-appos GATA-1 and SP1,the transcriptional activators
R6 C10 C7 coref-ident GATA-1 and SP1,the transcriptional activators
R7 C13 C12 coref-relat which,cultures derived from normal adult peripheral blood
R8 C14 C9 coref-ident both GATA-1 and SP1 activities,the activities of GATA-1 and SP1
R9 C15 C11 coref-ident "fetal"" pattern",This pattern
R10 C17 C16 coref-pron their,human fetal and adult erythroid progenitors