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PubMed:8522361 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 77-82 DNA denotes c-fos
T2 86-104 cell_line denotes B and T cell lines
T3 122-127 DNA denotes c-fos
T4 140-162 protein denotes surface immunoglobulin
T5 167-191 protein denotes T cell antigen receptors
T6 211-230 DNA denotes protooncogene c-fos
T7 289-297 protein denotes kinase C
T8 318-326 protein denotes Kinase C
T9 371-392 protein denotes serum response factor
T10 394-397 protein denotes SRF
T11 424-446 DNA denotes serum response element
T12 448-451 DNA denotes SRE
T13 516-520 protein denotes CREB
T14 522-561 protein denotes cAMP regulatory element binding protein
T15 593-609 protein denotes protein kinase A
T16 613-640 protein denotes calmodulin-regulated kinase
T17 693-717 cell_line denotes Burkitt's lymphoma cells
T18 719-724 cell_line denotes Ramos
T19 729-734 cell_line denotes Daudi
T20 749-772 cell_line denotes T lymphocytic cell line
T21 774-780 cell_line denotes Jurkat
T22 876-881 DNA denotes c-fos
T23 902-910 protein denotes kinase C
T24 1048-1053 DNA denotes c-fos
T25 1130-1135 DNA denotes c-fos
T26 1216-1221 DNA denotes c-fos
T27 1304-1309 cell_line denotes Ramos
T28 1311-1318 cell_type denotes B cells
T29 1324-1330 cell_line denotes Jurkat
T30 1332-1339 cell_type denotes T cells
T31 1362-1367 DNA denotes c-fos
T32 1421-1427 cell_line denotes Jurkat
T33 1453-1458 cell_line denotes Ramos
T34 1472-1476 protein denotes AP-1
T35 1564-1574 RNA denotes c-fos mRNA
T36 1644-1648 protein denotes AP-1
T37 1672-1679 cell_type denotes B cells
T38 1687-1694 protein denotes anti-Ig
T39 1721-1729 protein denotes kinase C
T40 1794-1804 RNA denotes c-fos mRNA
T41 1862-1870 protein denotes kinase C
T42 1918-1923 DNA denotes c-fos
T43 1975-1980 DNA denotes c-fos
T44 2042-2049 protein denotes anti-Ig
T45 2063-2068 DNA denotes c-fos
T46 2153-2160 protein denotes anti-Ig
T47 2174-2179 DNA denotes c-fos
T48 2271-2276 DNA denotes c-fos
T49 2311-2316 DNA denotes c-fos
T50 2333-2363 protein denotes B and T cell antigen receptors

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 16-44 other_name denotes signal transduction pathways
T2 77-82 DNA_domain_or_region denotes c-fos
T3 122-127 DNA_domain_or_region denotes c-fos
T4 140-162 protein_family_or_group denotes surface immunoglobulin
T5 167-191 protein_family_or_group denotes T cell antigen receptors
T6 211-224 DNA_family_or_group denotes protooncogene
T7 225-230 DNA_domain_or_region denotes c-fos
T8 259-278 other_name denotes regulatory pathways
T9 289-297 protein_molecule denotes kinase C
T10 299-303 nucleotide denotes cAMP
T11 309-316 atom denotes calcium
T12 318-326 protein_family_or_group denotes Kinase C
T13 352-367 other_name denotes phosphorylation
T14 371-392 protein_molecule denotes serum response factor
T15 394-397 protein_molecule denotes SRF
T16 424-446 DNA_domain_or_region denotes serum response element
T17 448-451 DNA_domain_or_region denotes SRE
T18 454-458 nucleotide denotes cAMP
T19 463-470 atom denotes calcium
T20 497-512 other_name denotes phosphorylation
T21 516-520 protein_molecule denotes CREB
T22 522-526 nucleotide denotes cAMP
T23 593-609 protein_molecule denotes protein kinase A
T24 613-640 protein_family_or_group denotes calmodulin-regulated kinase
T25 693-717 cell_line denotes Burkitt's lymphoma cells
T26 719-724 cell_line denotes Ramos
T27 729-734 cell_line denotes Daudi
T28 749-772 cell_line denotes T lymphocytic cell line
T29 774-780 cell_line denotes Jurkat
T30 876-881 DNA_domain_or_region denotes c-fos
T31 902-910 protein_molecule denotes kinase C
T32 923-926 other_organic_compound denotes PMA
T33 961-965 nucleotide denotes cAMP
T34 967-985 other_organic_compound denotes forskolin plus MIX
T35 990-997 atom denotes calcium
T36 1011-1020 other_name denotes ionophore
T37 1048-1053 DNA_domain_or_region denotes c-fos
T38 1078-1082 nucleotide denotes cAMP
T39 1102-1109 atom denotes calcium
T40 1130-1135 DNA_domain_or_region denotes c-fos
T41 1147-1159 other_organic_compound denotes Okadaic acid
T42 1216-1221 DNA_domain_or_region denotes c-fos
T43 1270-1274 nucleotide denotes cAMP
T44 1304-1309 cell_line denotes Ramos
T45 1311-1318 cell_type denotes B cells
T46 1324-1330 cell_line denotes Jurkat
T47 1332-1339 cell_type denotes T cells
T48 1362-1367 DNA_domain_or_region denotes c-fos
T49 1376-1380 nucleotide denotes cAMP
T50 1386-1393 atom denotes calcium
T51 1421-1427 cell_line denotes Jurkat
T52 1453-1458 cell_line denotes Ramos
T53 1472-1476 protein_molecule denotes AP-1
T54 1492-1517 other_name denotes gel mobility shift assays
T55 1564-1569 DNA_domain_or_region denotes c-fos
T56 1644-1648 protein_molecule denotes AP-1
T57 1672-1679 cell_type denotes B cells
T58 1687-1694 protein_family_or_group denotes anti-Ig
T59 1721-1729 protein_molecule denotes kinase C
T60 1770-1777 atom denotes calcium
T61 1794-1799 DNA_domain_or_region denotes c-fos
T62 1862-1870 protein_molecule denotes kinase C
T63 1886-1893 atom denotes calcium
T64 1918-1923 DNA_domain_or_region denotes c-fos
T65 1975-1980 DNA_domain_or_region denotes c-fos
T66 2042-2049 protein_family_or_group denotes anti-Ig
T67 2063-2068 DNA_domain_or_region denotes c-fos
T68 2099-2103 nucleotide denotes cAMP
T69 2153-2160 protein_family_or_group denotes anti-Ig
T70 2174-2179 DNA_domain_or_region denotes c-fos
T71 2271-2276 DNA_domain_or_region denotes c-fos
T72 2311-2316 DNA_domain_or_region denotes c-fos

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-192 Sentence denotes Synergy between signal transduction pathways is obligatory for expression of c-fos in B and T cell lines: implication for c-fos control via surface immunoglobulin and T cell antigen receptors.
S2 193-317 Sentence denotes Expression of the protooncogene c-fos is controlled by three main regulatory pathways involving kinase C, cAMP, and calcium.
S3 318-641 Sentence denotes Kinase C mediates its effects via phosphorylation of serum response factor (SRF) which interacts with the serum response element (SRE); cAMP and calcium mediate their effects via phosphorylation of CREB (cAMP regulatory element binding protein) presumably by activation of a protein kinase A or calmodulin-regulated kinase.
S4 642-782 Sentence denotes We have examined the function of these elements in Burkitt's lymphoma cells (Ramos and Daudi) as well as a T lymphocytic cell line (Jurkat).
S5 783-892 Sentence denotes We have found that stimulation of any one of these pathways alone has little or no effect on c-fos induction.
S6 893-1064 Sentence denotes However, kinase C activation (PMA stimulation) combined with either cAMP (forskolin plus MIX) or calcium stimulation (ionophore) leads to greatly enhanced c-fos induction.
S7 1065-1146 Sentence denotes By contrast, cAMP in the presence of calcium shows no synergy in c-fos induction.
S8 1147-1275 Sentence denotes Okadaic acid augments PMA- as well as calcium-mediated activation of c-fos, and has little or no effect when combined with cAMP.
S9 1276-1459 Sentence denotes The main difference between Ramos (B cells) and Jurkat (T cells) in the regulation of c-fos is that cAMP plus calcium is strongly synergistic in Jurkat and is without effect in Ramos.
S10 1460-1658 Sentence denotes Analysis of AP-1 activity using gel mobility shift assays confirms that the requirements for synergy in c-fos mRNA induction are paralleled by requirements for synergy in induction of AP-1 activity.
S11 1659-1815 Sentence denotes Signaling in B cells due to anti-Ig stimulation involves both kinase C activation and release of intracellular calcium, and results in c-fos mRNA induction.
S12 1816-1986 Sentence denotes Our results indicate that synergy between the kinase C activation and calcium is needed for efficient c-fos induction since neither of these two alone induces c-fos well.
S13 1987-2180 Sentence denotes That synergy of signaling pathways is relevant for the anti-Ig induction of c-fos is supported by the fact that cAMP-inducing agents and okadaic acid further enhance anti-Ig induction of c-fos.
S14 2181-2364 Sentence denotes These results suggest that cell-specific patterns of synergy are an essential feature for c-fos induction and may be relevant for c-fos control through B and T cell antigen receptors.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 0-44 NP denotes Synergy between signal transduction pathways
C3 77-82 NP denotes c-fos
C2 63-82 NP denotes expression of c-fos
C4 122-135 NP denotes c-fos control
C5 140-191 NP denotes surface immunoglobulin and T cell antigen receptors
C7 207-230 NP denotes the protooncogene c-fos
C6 193-230 NP denotes Expression of the protooncogene c-fos
C9 289-297 NP denotes kinase C
C10 299-316 NP denotes cAMP, and calcium
C8 248-316 NP denotes three main regulatory pathways involving kinase C, cAMP, and calcium
C11 318-326 NP denotes Kinase C
C12 336-339 NP denotes its
C13 371-398 NP denotes serum response factor (SRF)
C14 399-404 NP denotes which
C15 454-470 NP denotes cAMP and calcium
C16 479-484 NP denotes their
C17 693-735 NP denotes Burkitt's lymphoma cells (Ramos and Daudi)
C18 747-781 NP denotes a T lymphocytic cell line (Jurkat)
C19 828-842 NP denotes these pathways
C20 876-891 NP denotes c-fos induction
C21 902-939 NP denotes kinase C activation (PMA stimulation)
C22 1078-1082 NP denotes cAMP
C23 1102-1109 NP denotes calcium
C24 1130-1145 NP denotes c-fos induction
C25 1147-1159 NP denotes Okadaic acid
C26 1216-1221 NP denotes c-fos
C27 1270-1274 NP denotes cAMP
C28 1304-1319 NP denotes Ramos (B cells)
C29 1324-1340 NP denotes Jurkat (T cells)
C30 1362-1367 NP denotes c-fos
C31 1376-1380 NP denotes cAMP
C32 1386-1393 NP denotes calcium
C33 1421-1427 NP denotes Jurkat
C34 1453-1458 NP denotes Ramos
C35 1564-1584 NP denotes c-fos mRNA induction
C36 1672-1679 NP denotes B cells
C37 1721-1740 NP denotes kinase C activation
C38 1794-1814 NP denotes c-fos mRNA induction
C40 1858-1881 NP denotes the kinase C activation
C41 1886-1893 NP denotes calcium
C39 1842-1893 NP denotes synergy between the kinase C activation and calcium
C42 1908-1933 NP denotes efficient c-fos induction
C43 1975-1980 NP denotes c-fos
C44 1992-2021 NP denotes synergy of signaling pathways
C46 2063-2068 NP denotes c-fos
C45 2038-2068 NP denotes the anti-Ig induction of c-fos
C47 2085-2093 NP denotes the fact
C48 2094-2098 NP denotes that
C49 2124-2136 NP denotes okadaic acid
C51 2174-2179 NP denotes c-fos
C50 2153-2179 NP denotes anti-Ig induction of c-fos
C52 2271-2286 NP denotes c-fos induction
C53 2311-2324 NP denotes c-fos control
C54 2333-2363 NP denotes B and T cell antigen receptors
R1 C7 C3 coref-ident the protooncogene c-fos,c-fos
R2 C6 C2 coref-ident Expression of the protooncogene c-fos,expression of c-fos
R3 C11 C9 coref-ident Kinase C,kinase C
R4 C12 C11 coref-pron its,Kinase C
R5 C14 C13 coref-relat which,serum response factor (SRF)
R6 C15 C10 coref-ident cAMP and calcium,"cAMP, and calcium"
R7 C16 C15 coref-pron their,cAMP and calcium
R8 C19 C8 coref-ident these pathways,"three main regulatory pathways involving kinase C, cAMP, and calcium"
R9 C24 C20 coref-ident c-fos induction,c-fos induction
R10 C26 C7 coref-ident c-fos,the protooncogene c-fos
R11 C27 C22 coref-ident cAMP,cAMP
R12 C28 C17 coref-ident Ramos (B cells),Burkitt's lymphoma cells (Ramos and Daudi)
R13 C29 C18 coref-ident Jurkat (T cells),a T lymphocytic cell line (Jurkat)
R14 C30 C2 coref-ident c-fos,expression of c-fos
R15 C31 C27 coref-ident cAMP,cAMP
R16 C32 C23 coref-ident calcium,calcium
R17 C33 C29 coref-ident Jurkat,Jurkat (T cells)
R18 C34 C28 coref-ident Ramos,Ramos (B cells)
R19 C36 C28 coref-ident B cells,Ramos (B cells)
R20 C37 C21 coref-ident kinase C activation,kinase C activation (PMA stimulation)
R21 C38 C35 coref-ident c-fos mRNA induction,c-fos mRNA induction
R22 C40 C37 coref-ident the kinase C activation,kinase C activation
R23 C41 C32 coref-ident calcium,calcium
R24 C43 C30 coref-ident c-fos,c-fos
R25 C44 C1 coref-ident synergy of signaling pathways,Synergy between signal transduction pathways
R26 C46 C43 coref-ident c-fos,c-fos
R27 C48 C47 coref-relat that,the fact
R28 C49 C25 coref-ident okadaic acid,Okadaic acid
R29 C51 C46 coref-ident c-fos,c-fos
R30 C50 C45 coref-ident anti-Ig induction of c-fos,the anti-Ig induction of c-fos
R31 C52 C42 coref-ident c-fos induction,efficient c-fos induction
R32 C53 C4 coref-ident c-fos control,c-fos control
R33 C54 C5 coref-ident B and T cell antigen receptors,surface immunoglobulin and T cell antigen receptors