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PubMed:8506326 JSONTXT

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DisGeNET

Id Subject Object Predicate Lexical cue
T0 250-260 gene:3558 denotes lymphokine
T1 171-203 disease:C0085110 denotes severe combined immunodeficiency
R1 T0 T1 associated_with lymphokine,severe combined immunodeficiency

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 30-40 protein denotes lymphokine
T2 141-154 cell_type denotes T lymphocytes
T3 250-266 DNA denotes lymphokine genes
T4 280-283 DNA denotes IL2
T5 285-288 DNA denotes IL3
T6 290-293 DNA denotes IL4
T7 299-302 DNA denotes IL5
T8 317-329 protein denotes interleukins
T9 346-350 protein denotes IL-2
T10 352-354 protein denotes -3
T11 356-358 protein denotes -4
T12 364-366 protein denotes -5
T13 418-431 cell_type denotes T lymphocytes
T14 443-462 protein denotes trans-acting factor
T15 486-502 DNA denotes lymphokine genes
T16 531-546 protein denotes nuclear factors
T17 566-579 cell_type denotes T lymphocytes
T18 621-638 DNA denotes regulatory region
T19 642-645 DNA denotes IL2
T20 647-667 protein denotes Nuclear factor NF-kB
T21 669-689 protein denotes activation protein 1
T22 691-695 protein denotes AP-1
T23 698-703 protein denotes OCT-1
T24 709-717 protein denotes NF-IL-2B
T25 780-815 protein denotes nuclear factor of activated T cells
T26 817-822 protein denotes NF-AT
T27 855-867 DNA denotes IL2 enhancer
T28 878-905 DNA denotes NF-AT-like response element
T29 921-933 DNA denotes IL4 enhancer
T30 982-987 protein denotes NF-AT
T31 1077-1090 cell_type denotes T lymphocytes
T32 1145-1179 protein denotes chloramphenicol acetyl transferase
T33 1181-1184 protein denotes CAT
T34 1218-1239 DNA denotes IL2 regulatory region
T35 1270-1288 DNA denotes enhancer sequences
T36 1321-1342 DNA denotes IL2 regulatory region
T37 1367-1385 DNA denotes NF-AT-binding site
T38 1455-1463 DNA denotes CAT gene
T39 1505-1541 DNA denotes OCT-1 proximal (OCT-1p)-binding site
T40 1643-1648 protein denotes NF-AT
T41 1675-1685 protein denotes lymphokine

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
8506326-1#146#156#gene3558 250-260 gene3558 denotes lymphokine
8506326-1#195#198#gene3567 299-302 gene3567 denotes IL5
8506326-1#67#99#diseaseC0085110 171-203 diseaseC0085110 denotes severe combined immunodeficiency
146#156#gene355867#99#diseaseC0085110 8506326-1#146#156#gene3558 8506326-1#67#99#diseaseC0085110 associated_with lymphokine,severe combined immunodeficiency
195#198#gene356767#99#diseaseC0085110 8506326-1#195#198#gene3567 8506326-1#67#99#diseaseC0085110 associated_with IL5,severe combined immunodeficiency

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-103 Sentence denotes Molecular basis of a multiple lymphokine deficiency in a patient with severe combined immunodeficiency.
S2 104-368 Sentence denotes We have previously reported that the T lymphocytes of a child with severe combined immunodeficiency are defective in the transcription of several lymphokine genes that include IL2, IL3, IL4, and IL5, which encode interleukins 2, 3, 4, and 5 (IL-2, -3, -4, and -5).
S3 369-646 Sentence denotes To determine whether the defect in the patient's T lymphocytes involved a trans-acting factor common to the affected lymphokine genes, we examined the ability of nuclear factors from the patient's T lymphocytes to bind response elements present in the regulatory region of IL2.
S4 647-747 Sentence denotes Nuclear factor NF-kB, activation protein 1 (AP-1), OCT-1, and NF-IL-2B binding activity were normal.
S5 748-947 Sentence denotes In contrast, the binding of the nuclear factor of activated T cells (NF-AT) to its response element in the IL2 enhancer and to an NF-AT-like response element present in the IL4 enhancer was abnormal.
S6 948-1289 Sentence denotes To ascertain whether the abnormal NF-AT binding activity was related to an impaired function, we transfected patient and control T lymphocytes with constructs containing the reporter gene encoding chloramphenicol acetyl transferase (CAT) under the control of the entire IL2 regulatory region or of multimers of individual enhancer sequences.
S7 1290-1441 Sentence denotes CAT expression directed by the IL2 regulatory region or by a multimer of the NF-AT-binding site was markedly lower in the patient relative to controls.
S8 1442-1581 Sentence denotes In contrast, CAT gene expression directed by a multimer of the OCT-1 proximal (OCT-1p)-binding site was equivalent in patient and controls.
S9 1582-1713 Sentence denotes These results indicate that an abnormality of/or influencing NF-AT may underlie the multiple lymphokine deficiency in this patient.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C2 55-102 NP denotes a patient with severe combined immunodeficiency
C1 19-102 NP denotes a multiple lymphokine deficiency in a patient with severe combined immunodeficiency
C4 158-203 NP denotes a child with severe combined immunodeficiency
C3 137-203 NP denotes the T lymphocytes of a child with severe combined immunodeficiency
C6 242-266 NP denotes several lymphokine genes
C7 267-271 NP denotes that
C9 280-283 NP denotes IL2
C8 280-302 NP denotes IL2, IL3, IL4, and IL5
C5 221-302 NP denotes the transcription of several lymphokine genes that include IL2, IL3, IL4, and IL5
C10 304-309 NP denotes which
C12 317-331 NP denotes interleukins 2
C11 317-367 NP denotes interleukins 2, 3, 4, and 5 (IL-2, -3, -4, and -5)
C14 404-417 NP denotes the patient's
C13 404-431 NP denotes the patient's T lymphocytes
C15 473-502 NP denotes the affected lymphokine genes
C17 552-565 NP denotes the patient's
C16 552-579 NP denotes the patient's T lymphocytes
C18 642-645 NP denotes IL2
C19 776-823 NP denotes the nuclear factor of activated T cells (NF-AT)
C20 827-830 NP denotes its
C21 1057-1064 NP denotes patient
C22 1207-1239 NP denotes the entire IL2 regulatory region
C23 1317-1342 NP denotes the IL2 regulatory region
C24 1408-1419 NP denotes the patient
C25 1560-1567 NP denotes patient
C27 1700-1712 NP denotes this patient
C26 1662-1712 NP denotes the multiple lymphokine deficiency in this patient
R1 C4 C2 coref-ident a child with severe combined immunodeficiency,a patient with severe combined immunodeficiency
R2 C7 C6 coref-relat that,several lymphokine genes
R3 C10 C5 coref-relat which,"the transcription of several lymphokine genes that include IL2, IL3, IL4, and IL5"
R4 C12 C9 coref-ident interleukins 2,IL2
R5 C11 C8 coref-ident "interleukins 2, 3, 4, and 5 (IL-2, -3, -4, and -5)","IL2, IL3, IL4, and IL5"
R6 C14 C3 coref-ident the patient's,the T lymphocytes of a child with severe combined immunodeficiency
R7 C13 C4 coref-ident the patient's T lymphocytes,a child with severe combined immunodeficiency
R8 C15 C6 coref-ident the affected lymphokine genes,several lymphokine genes
R9 C17 C13 coref-ident the patient's,the patient's T lymphocytes
R10 C16 C14 coref-ident the patient's T lymphocytes,the patient's
R11 C18 C11 coref-ident IL2,"interleukins 2, 3, 4, and 5 (IL-2, -3, -4, and -5)"
R12 C20 C19 coref-pron its,the nuclear factor of activated T cells (NF-AT)
R13 C21 C17 coref-ident patient,the patient's
R14 C23 C22 coref-ident the IL2 regulatory region,the entire IL2 regulatory region
R15 C24 C17 coref-ident the patient,the patient's
R16 C25 C24 coref-ident patient,the patient
R17 C27 C25 coref-ident this patient,patient
R18 C26 C1 coref-ident the multiple lymphokine deficiency in this patient,a multiple lymphokine deficiency in a patient with severe combined immunodeficiency

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 30-40 protein_family_or_group denotes lymphokine
T2 70-102 other_name denotes severe combined immunodeficiency
T3 141-154 cell_type denotes T lymphocytes
T4 171-203 other_name denotes severe combined immunodeficiency
T5 250-260 protein_family_or_group denotes lymphokine
T6 261-266 DNA_family_or_group denotes genes
T7 280-283 DNA_domain_or_region denotes IL2
T8 285-288 DNA_domain_or_region denotes IL3
T9 290-293 DNA_domain_or_region denotes IL4
T10 299-302 DNA_domain_or_region denotes IL5
T11 317-329 protein_family_or_group denotes interleukins
T12 346-350 protein_molecule denotes IL-2
T13 352-354 protein_molecule denotes -3
T14 356-358 protein_molecule denotes -4
T15 364-366 protein_molecule denotes -5
T16 418-431 cell_type denotes T lymphocytes
T17 443-462 protein_family_or_group denotes trans-acting factor
T18 486-496 protein_family_or_group denotes lymphokine
T19 497-502 DNA_family_or_group denotes genes
T20 531-546 protein_family_or_group denotes nuclear factors
T21 566-579 cell_type denotes T lymphocytes
T22 621-638 DNA_domain_or_region denotes regulatory region
T23 642-645 DNA_domain_or_region denotes IL2
T24 647-667 protein_molecule denotes Nuclear factor NF-kB
T25 669-689 protein_molecule denotes activation protein 1
T26 691-695 protein_molecule denotes AP-1
T27 698-703 protein_molecule denotes OCT-1
T28 709-717 protein_molecule denotes NF-IL-2B
T29 718-734 other_name denotes binding activity
T30 780-797 protein_molecule denotes nuclear factor of
T31 798-807 cell_type denotes activated
T32 808-815 cell_type denotes T cells
T33 817-822 protein_molecule denotes NF-AT
T34 855-858 DNA_domain_or_region denotes IL2
T35 878-883 protein_molecule denotes NF-AT
T36 921-933 DNA_domain_or_region denotes IL4 enhancer
T37 973-981 other_name denotes abnormal
T38 982-987 protein_molecule denotes NF-AT
T39 1077-1090 cell_type denotes T lymphocytes
T40 1145-1179 protein_molecule denotes chloramphenicol acetyl transferase
T41 1181-1184 protein_molecule denotes CAT
T42 1218-1221 DNA_domain_or_region denotes IL2
T43 1270-1288 DNA_domain_or_region denotes enhancer sequences
T44 1321-1324 DNA_domain_or_region denotes IL2
T45 1367-1372 protein_molecule denotes NF-AT
T46 1412-1419 multi_cell denotes patient
T47 1455-1463 DNA_family_or_group denotes CAT gene
T48 1505-1541 DNA_domain_or_region denotes OCT-1 proximal (OCT-1p)-binding site
T49 1643-1648 protein_molecule denotes NF-AT
T50 1675-1685 protein_family_or_group denotes lymphokine
T51 1705-1712 multi_cell denotes patient