> top > docs > PubMed:8505309 > annotations

PubMed:8505309 JSONTXT

Annnotations TAB JSON ListView MergeView

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 116-125 Cell denotes monocytic http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054
T3 257-266 Cell denotes monocytic http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054
T5 675-684 Cell denotes monocytic http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054
T7 1324-1333 Cell denotes monocytic http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054

sentences

Id Subject Object Predicate Lexical cue
T1 0-138 Sentence denotes Lipopolysaccharide induces phosphorylation of MAD3 and activation of c-Rel and related NF-kappa B proteins in human monocytic THP-1 cells.
T2 139-332 Sentence denotes Many effects of lipopolysaccharide (LPS) on gene expression, including that of human immunodeficiency virus (HIV), in monocytic cells are mediated by activation of kappa B DNA-binding proteins.
T3 333-528 Sentence denotes However, the specific members of the NF-kappa B/Rel transcription factor family involved in the LPS response, and the mechanisms through which LPS-generated signals are transduced remain unclear.
T4 529-697 Sentence denotes Here we show that LPS induces nuclear expression of c-Rel/p50 heterodimers as well as p50/p65 (NF-kappa B) kappa B DNA-binding complexes in human monocytic THP-1 cells.
T5 698-872 Sentence denotes Nuclear localization of these proteins occurred concomitantly with a rapid decrease in their cytosolic levels and was independent of phorbol ester-sensitive protein kinase C.
T6 873-994 Sentence denotes Within 24 h following LPS stimulation there was a striking increase in the levels of c-Rel, p105, and p50 in the cytosol.
T7 995-1127 Sentence denotes The increased levels of these proteins correlated with increases in the amounts of their mRNAs during LPS activation of THP-1 cells.
T8 1128-1293 Sentence denotes LPS activation of THP-1 cells resulted in phosphorylation of MAD3 (an I kappa B-like protein), a rapid increase in MAD3 mRNA, and an increase in MAD3 protein by 2 h.
T9 1294-1444 Sentence denotes Thus, LPS activation of human monocytic cells results in nuclear expression of c-Rel/p50 and p50/p65 (NF-kappa B) and induces phosphorylation of MAD3.
T1 0-138 Sentence denotes Lipopolysaccharide induces phosphorylation of MAD3 and activation of c-Rel and related NF-kappa B proteins in human monocytic THP-1 cells.
T2 139-332 Sentence denotes Many effects of lipopolysaccharide (LPS) on gene expression, including that of human immunodeficiency virus (HIV), in monocytic cells are mediated by activation of kappa B DNA-binding proteins.
T3 333-528 Sentence denotes However, the specific members of the NF-kappa B/Rel transcription factor family involved in the LPS response, and the mechanisms through which LPS-generated signals are transduced remain unclear.
T4 529-697 Sentence denotes Here we show that LPS induces nuclear expression of c-Rel/p50 heterodimers as well as p50/p65 (NF-kappa B) kappa B DNA-binding complexes in human monocytic THP-1 cells.
T5 698-872 Sentence denotes Nuclear localization of these proteins occurred concomitantly with a rapid decrease in their cytosolic levels and was independent of phorbol ester-sensitive protein kinase C.
T6 873-994 Sentence denotes Within 24 h following LPS stimulation there was a striking increase in the levels of c-Rel, p105, and p50 in the cytosol.
T7 995-1127 Sentence denotes The increased levels of these proteins correlated with increases in the amounts of their mRNAs during LPS activation of THP-1 cells.
T8 1128-1293 Sentence denotes LPS activation of THP-1 cells resulted in phosphorylation of MAD3 (an I kappa B-like protein), a rapid increase in MAD3 mRNA, and an increase in MAD3 protein by 2 h.
T9 1294-1444 Sentence denotes Thus, LPS activation of human monocytic cells results in nuclear expression of c-Rel/p50 and p50/p65 (NF-kappa B) and induces phosphorylation of MAD3.

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 46-50 protein denotes MAD3
T2 69-74 protein denotes c-Rel
T3 87-97 protein denotes NF-kappa B
T4 110-137 cell_line denotes human monocytic THP-1 cells
T5 257-272 cell_type denotes monocytic cells
T6 370-412 protein denotes NF-kappa B/Rel transcription factor family
T7 581-603 protein denotes c-Rel/p50 heterodimers
T8 615-622 protein denotes p50/p65
T9 624-634 protein denotes NF-kappa B
T10 669-696 cell_line denotes human monocytic THP-1 cells
T11 831-871 protein denotes phorbol ester-sensitive protein kinase C
T12 958-963 protein denotes c-Rel
T13 965-969 protein denotes p105
T14 975-978 protein denotes p50
T15 1084-1089 RNA denotes mRNAs
T16 1115-1126 cell_line denotes THP-1 cells
T17 1146-1157 cell_line denotes THP-1 cells
T18 1189-1193 protein denotes MAD3
T19 1198-1207 protein denotes I kappa B
T20 1243-1252 RNA denotes MAD3 mRNA
T21 1273-1277 protein denotes MAD3
T22 1324-1339 cell_type denotes monocytic cells
T23 1373-1382 protein denotes c-Rel/p50
T24 1387-1394 protein denotes p50/p65
T25 1396-1406 protein denotes NF-kappa B
T26 1439-1443 protein denotes MAD3

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-138 Sentence denotes Lipopolysaccharide induces phosphorylation of MAD3 and activation of c-Rel and related NF-kappa B proteins in human monocytic THP-1 cells.
S2 139-332 Sentence denotes Many effects of lipopolysaccharide (LPS) on gene expression, including that of human immunodeficiency virus (HIV), in monocytic cells are mediated by activation of kappa B DNA-binding proteins.
S3 333-528 Sentence denotes However, the specific members of the NF-kappa B/Rel transcription factor family involved in the LPS response, and the mechanisms through which LPS-generated signals are transduced remain unclear.
S4 529-697 Sentence denotes Here we show that LPS induces nuclear expression of c-Rel/p50 heterodimers as well as p50/p65 (NF-kappa B) kappa B DNA-binding complexes in human monocytic THP-1 cells.
S5 698-872 Sentence denotes Nuclear localization of these proteins occurred concomitantly with a rapid decrease in their cytosolic levels and was independent of phorbol ester-sensitive protein kinase C.
S6 873-994 Sentence denotes Within 24 h following LPS stimulation there was a striking increase in the levels of c-Rel, p105, and p50 in the cytosol.
S7 995-1127 Sentence denotes The increased levels of these proteins correlated with increases in the amounts of their mRNAs during LPS activation of THP-1 cells.
S8 1128-1293 Sentence denotes LPS activation of THP-1 cells resulted in phosphorylation of MAD3 (an I kappa B-like protein), a rapid increase in MAD3 mRNA, and an increase in MAD3 protein by 2 h.
S9 1294-1444 Sentence denotes Thus, LPS activation of human monocytic cells results in nuclear expression of c-Rel/p50 and p50/p65 (NF-kappa B) and induces phosphorylation of MAD3.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 0-18 NP denotes Lipopolysaccharide
C3 46-50 NP denotes MAD3
C2 27-50 NP denotes phosphorylation of MAD3
C4 110-137 NP denotes human monocytic THP-1 cells
C5 155-179 NP denotes lipopolysaccharide (LPS)
C6 447-461 NP denotes the mechanisms
C7 470-475 NP denotes which
C8 547-550 NP denotes LPS
C11 669-696 NP denotes human monocytic THP-1 cells
C10 581-696 NP denotes c-Rel/p50 heterodimers as well as p50/p65 (NF-kappa B) kappa B DNA-binding complexes in human monocytic THP-1 cells
C9 559-696 NP denotes nuclear expression of c-Rel/p50 heterodimers as well as p50/p65 (NF-kappa B) kappa B DNA-binding complexes in human monocytic THP-1 cells
C12 722-736 NP denotes these proteins
C13 785-790 NP denotes their
C15 958-993 NP denotes c-Rel, p105, and p50 in the cytosol
C14 921-993 NP denotes a striking increase in the levels of c-Rel, p105, and p50 in the cytosol
C17 1019-1033 NP denotes these proteins
C16 995-1033 NP denotes The increased levels of these proteins
C18 1078-1083 NP denotes their
C20 1115-1126 NP denotes THP-1 cells
C19 1097-1126 NP denotes LPS activation of THP-1 cells
C21 1128-1157 NP denotes LPS activation of THP-1 cells
C23 1189-1193 NP denotes MAD3
C22 1170-1221 NP denotes phosphorylation of MAD3 (an I kappa B-like protein)
C24 1273-1285 NP denotes MAD3 protein
C25 1300-1339 NP denotes LPS activation of human monocytic cells
C26 1351-1407 NP denotes nuclear expression of c-Rel/p50 and p50/p65 (NF-kappa B)
C28 1439-1443 NP denotes MAD3
C27 1420-1443 NP denotes phosphorylation of MAD3
R1 C5 C1 coref-ident lipopolysaccharide (LPS),Lipopolysaccharide
R2 C7 C6 coref-relat which,the mechanisms
R3 C8 C5 coref-ident LPS,lipopolysaccharide (LPS)
R4 C11 C4 coref-ident human monocytic THP-1 cells,human monocytic THP-1 cells
R5 C12 C10 coref-ident these proteins,c-Rel/p50 heterodimers as well as p50/p65 (NF-kappa B) kappa B DNA-binding complexes in human monocytic THP-1 cells
R6 C13 C12 coref-pron their,these proteins
R7 C17 C15 coref-ident these proteins,"c-Rel, p105, and p50 in the cytosol"
R8 C16 C14 coref-ident The increased levels of these proteins,"a striking increase in the levels of c-Rel, p105, and p50 in the cytosol"
R9 C18 C17 coref-pron their,these proteins
R10 C20 C11 coref-ident THP-1 cells,human monocytic THP-1 cells
R11 C21 C19 coref-ident LPS activation of THP-1 cells,LPS activation of THP-1 cells
R12 C23 C3 coref-ident MAD3,MAD3
R13 C22 C2 coref-ident phosphorylation of MAD3 (an I kappa B-like protein),phosphorylation of MAD3
R14 C24 C23 coref-ident MAD3 protein,MAD3
R15 C25 C21 coref-ident LPS activation of human monocytic cells,LPS activation of THP-1 cells
R16 C26 C9 coref-ident nuclear expression of c-Rel/p50 and p50/p65 (NF-kappa B),nuclear expression of c-Rel/p50 heterodimers as well as p50/p65 (NF-kappa B) kappa B DNA-binding complexes in human monocytic THP-1 cells
R17 C28 C23 coref-ident MAD3,MAD3
R18 C27 C22 coref-ident phosphorylation of MAD3,phosphorylation of MAD3 (an I kappa B-like protein)

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-18 lipid denotes Lipopolysaccharide
T2 46-50 protein_molecule denotes MAD3
T3 69-74 protein_molecule denotes c-Rel
T4 87-97 protein_molecule denotes NF-kappa B
T5 110-137 cell_line denotes human monocytic THP-1 cells
T6 155-173 lipid denotes lipopolysaccharide
T7 175-178 lipid denotes LPS
T8 183-198 other_name denotes gene expression
T9 218-246 virus denotes human immunodeficiency virus
T10 248-251 virus denotes HIV
T11 257-272 cell_type denotes monocytic cells
T12 370-380 protein_molecule denotes NF-kappa B
T13 385-405 protein_family_or_group denotes transcription factor
T14 429-432 lipid denotes LPS
T15 476-479 lipid denotes LPS
T16 547-550 lipid denotes LPS
T17 559-577 other_name denotes nuclear expression
T18 581-603 protein_complex denotes c-Rel/p50 heterodimers
T19 615-622 protein_complex denotes p50/p65
T20 624-634 protein_molecule denotes NF-kappa B
T21 669-696 cell_line denotes human monocytic THP-1 cells
T22 698-718 other_name denotes Nuclear localization
T23 791-807 other_name denotes cytosolic levels
T24 831-871 protein_molecule denotes phorbol ester-sensitive protein kinase C
T25 895-898 lipid denotes LPS
T26 958-963 protein_molecule denotes c-Rel
T27 965-969 protein_molecule denotes p105
T28 975-978 protein_subunit denotes p50
T29 986-993 cell_component denotes cytosol
T30 1084-1089 RNA_family_or_group denotes mRNAs
T31 1097-1100 lipid denotes LPS
T32 1115-1126 cell_line denotes THP-1 cells
T33 1128-1131 lipid denotes LPS
T34 1146-1157 cell_line denotes THP-1 cells
T35 1189-1193 protein_molecule denotes MAD3
T36 1198-1207 protein_molecule denotes I kappa B
T37 1243-1247 protein_molecule denotes MAD3
T38 1273-1277 protein_molecule denotes MAD3
T39 1300-1303 lipid denotes LPS
T40 1324-1339 cell_type denotes monocytic cells
T41 1373-1378 protein_molecule denotes c-Rel
T42 1387-1394 protein_complex denotes p50/p65
T43 1396-1406 protein_molecule denotes NF-kappa B
T44 1439-1443 protein_molecule denotes MAD3

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 224-240 Phenotype denotes immunodeficiency HP:0002721

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 224-240 Disease denotes immunodeficiency http://purl.obolibrary.org/obo/MONDO_0021094

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 110-115 OrganismTaxon denotes human 9606
T2 218-223 OrganismTaxon denotes human 9606
T3 669-674 OrganismTaxon denotes human 9606
T4 1318-1323 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 986-993 Body_part denotes cytosol http://purl.obolibrary.org/obo/GO_0005829