PubMed:8504161
Annnotations
Anatomy-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 392-397 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/MAT_0000097 |
| T2 | 402-408 | Body_part | denotes | spleen | http://purl.obolibrary.org/obo/MAT_0000085 |
| T3 | 800-805 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/MAT_0000097 |
| T4 | 941-946 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/MAT_0000097 |
Glycan-GlyCosmos
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 16-19 | Glycan | denotes | GM1 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR |
| T2 | 124-127 | Glycan | denotes | GM1 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR |
| T3 | 510-513 | Glycan | denotes | GM1 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR |
| T4 | 557-560 | Glycan | denotes | GM1 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR |
| T5 | 660-663 | Glycan | denotes | GM1 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR |
GlyCosmos15-CL
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 368-378 | Cell | denotes | phagocytic | http://purl.obolibrary.org/obo/CL:0000234 |
| T2 | 947-957 | Cell | denotes | phagocytes | http://purl.obolibrary.org/obo/CL:0000234 |
GlyCosmos15-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 77-80 | Body_part | denotes | RES | http://purl.obolibrary.org/obo/UBERON_0000363 |
| T2 | 317-343 | Body_part | denotes | reticuloendothelial system | http://purl.obolibrary.org/obo/UBERON_0000363 |
| T3 | 345-348 | Body_part | denotes | RES | http://purl.obolibrary.org/obo/UBERON_0000363 |
| T4 | 392-397 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
| T5 | 402-408 | Body_part | denotes | spleen | http://purl.obolibrary.org/obo/UBERON_0002106 |
| T6 | 469-476 | Body_part | denotes | vesicle | http://purl.obolibrary.org/obo/GO_0031982 |
| T7 | 605-608 | Body_part | denotes | RES | http://purl.obolibrary.org/obo/UBERON_0000363 |
| T8 | 800-805 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
| T9 | 901-904 | Body_part | denotes | RES | http://purl.obolibrary.org/obo/UBERON_0000363 |
| T10 | 941-946 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
| T11 | 947-957 | Body_part | denotes | phagocytes | http://purl.obolibrary.org/obo/CL_0000234 |
GlyCosmos15-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 392-397 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/MAT_0000097 |
| T2 | 402-408 | Body_part | denotes | spleen | http://purl.obolibrary.org/obo/MAT_0000085 |
| T3 | 800-805 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/MAT_0000097 |
| T4 | 941-946 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/MAT_0000097 |
GlyCosmos15-Sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-90 | Sentence | denotes | The presence of GM1 in liposomes with entrapped doxorubicin does not prevent RES blockade. |
| T2 | 91-254 | Sentence | denotes | The incorporation of ganglioside GM1 or phosphatidylethanolamine-polyethyleneglycol conjugates into liposomes can result in extended circulation lifetimes in vivo. |
| T3 | 255-409 | Sentence | denotes | This has been attributed to an ability to avoid uptake by the reticuloendothelial system (RES), specifically the phagocytic cells of the liver and spleen. |
| T4 | 410-609 | Sentence | denotes | Here we examine whether a representative large unilamellar vesicle (LUV) formulation which contains GM1 (distearoylphosphatidylcholine/cholesterol/GM1, 45:45:10 mol/mol), actually does avoid the RES. |
| T5 | 610-806 | Sentence | denotes | It is shown that a pre-dose of LUVs which contain GM1 and entrapped doxorubicin blocks the accumulation of subsequently injected empty distearoylphosphatidylcholine/cholesterol liposomes in liver. |
| T6 | 807-958 | Sentence | denotes | It is therefore concluded that liposomes exhibiting extended circulation lifetimes can induce RES blockade and do not avoid uptake by liver phagocytes. |
GlyCosmos15-Glycan
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 16-19 | Glycan | denotes | GM1 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR |
| T2 | 124-127 | Glycan | denotes | GM1 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR |
| T3 | 510-513 | Glycan | denotes | GM1 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR |
| T4 | 557-560 | Glycan | denotes | GM1 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR |
| T5 | 660-663 | Glycan | denotes | GM1 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR |
GlyCosmos15-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 16-19 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
| T2 | 124-127 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
| T3 | 510-513 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
| T4 | 557-560 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
| T5 | 660-663 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
GlyCosmos-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 16-19 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
| T2 | 124-127 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
| T3 | 510-513 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
| T4 | 557-560 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
| T5 | 660-663 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 77-80 | Body_part | denotes | RES | http://purl.obolibrary.org/obo/UBERON_0000363 |
| T2 | 317-343 | Body_part | denotes | reticuloendothelial system | http://purl.obolibrary.org/obo/UBERON_0000363 |
| T3 | 345-348 | Body_part | denotes | RES | http://purl.obolibrary.org/obo/UBERON_0000363 |
| T4 | 392-397 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
| T5 | 402-408 | Body_part | denotes | spleen | http://purl.obolibrary.org/obo/UBERON_0002106 |
| T6 | 469-476 | Body_part | denotes | vesicle | http://purl.obolibrary.org/obo/GO_0031982 |
| T7 | 605-608 | Body_part | denotes | RES | http://purl.obolibrary.org/obo/UBERON_0000363 |
| T8 | 800-805 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
| T9 | 901-904 | Body_part | denotes | RES | http://purl.obolibrary.org/obo/UBERON_0000363 |
| T10 | 941-946 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
| T11 | 947-957 | Body_part | denotes | phagocytes | http://purl.obolibrary.org/obo/CL_0000234 |
CL-cell
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 368-378 | Cell | denotes | phagocytic | http://purl.obolibrary.org/obo/CL:0000234 |
| T2 | 947-957 | Cell | denotes | phagocytes | http://purl.obolibrary.org/obo/CL:0000234 |