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PubMed:8496329 JSONTXT

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DisGeNET

Id Subject Object Predicate Lexical cue
T0 25-45 gene:7253 denotes thyrotropin receptor
T1 54-80 disease:C0178468 denotes autoimmune thyroid disease
R1 T0 T1 associated_with thyrotropin receptor,autoimmune thyroid disease

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 25-50 DNA denotes thyrotropin receptor gene
T2 155-204 protein denotes major histocompatibility complex classes I and II
T3 214-251 DNA denotes human TSH receptor (TSH-R) cDNA probe
T4 269-274 protein denotes TSH-R
T5 452-457 protein denotes TSH-R
T6 546-564 protein denotes thyroid peroxidase
T7 588-601 protein denotes thyroglobulin
T8 633-655 DNA denotes nuclear oncogene c-fos
T9 688-693 protein denotes c-myc
T10 704-709 protein denotes TSH-R
T11 792-838 protein denotes major histocompatibility complex class I or II
T12 840-851 protein denotes MHC I or II
T13 902-907 protein denotes MHC I
T14 931-937 protein denotes MHC II
T15 1007-1018 cell_type denotes lymphocytes
T16 1020-1033 cell_type denotes thyroid cells
T17 1064-1082 protein denotes MHC II transcripts
T18 1084-1100 protein denotes gamma-Interferon
T19 1248-1257 cell_type denotes thyrocyte
T20 1330-1335 protein denotes TSH-R
T21 1337-1355 protein denotes thyroid peroxidase
T22 1357-1370 protein denotes thyroglobulin
T23 1410-1422 protein denotes MHC I and II

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
8496329-0#25#45#gene7253 25-45 gene7253 denotes thyrotropin receptor
8496329-0#54#80#diseaseC0178468 54-80 diseaseC0178468 denotes autoimmune thyroid disease
8496329-1#63#68#gene7253 269-274 gene7253 denotes TSH-R
8496329-1#146#161#diseaseC0018213 352-367 diseaseC0018213 denotes Graves' disease
25#45#gene725354#80#diseaseC0178468 8496329-0#25#45#gene7253 8496329-0#54#80#diseaseC0178468 associated_with thyrotropin receptor,autoimmune thyroid disease
63#68#gene7253146#161#diseaseC0018213 8496329-1#63#68#gene7253 8496329-1#146#161#diseaseC0018213 associated_with TSH-R,Graves' disease

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-205 Sentence denotes Expression levels of the thyrotropin receptor gene in autoimmune thyroid disease: coregulation with parameters of thyroid function and inverse relation to major histocompatibility complex classes I and II.
S2 206-451 Sentence denotes Using a human TSH receptor (TSH-R) cDNA probe, we investigated TSH-R transcript levels in 13 human thyroid fragments by Northern blot analysis; 7 Graves' disease, 2 Hashimoto's disease, 3 endemic goiter, and 1 healthy thyroid gland were studied.
S3 452-694 Sentence denotes TSH-R expression levels were variable, but displayed a close correlation to the expression of thyroid peroxidase (r = 0.703; P < 0.05), thyroglobulin (r = 0.817; P < 0.01), and the nuclear oncogene c-fos (r = 0.935; P < 0.001), but not c-myc.
S4 695-961 Sentence denotes Overall, TSH-R transcript levels were low or absent in those thyroids in which expression of the major histocompatibility complex class I or II (MHC I or II) was high, thus establishing an inverse relation (MHC I, r = -0.791; P < 0.01; MHC II, r = -0.784; P < 0.01).
S5 962-1083 Sentence denotes In situ hybridization showed that apart from lymphocytes, thyroid cells themselves were the source of MHC II transcripts.
S6 1084-1156 Sentence denotes gamma-Interferon expression was only detectable in 1 Hashimoto's goiter.
S7 1157-1424 Sentence denotes Our findings suggest that next to lymphocyte infiltration, active regulatory events in the thyrocyte are responsible for the inverse relation between functional parameters (TSH-R, thyroid peroxidase, thyroglobulin, and c-fos) and immunological markers (MHC I and II).

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 155-204 NP denotes major histocompatibility complex classes I and II
C3 296-322 NP denotes 13 human thyroid fragments
C2 269-322 NP denotes TSH-R transcript levels in 13 human thyroid fragments
C4 704-727 NP denotes TSH-R transcript levels
C5 750-764 NP denotes those thyroids
C6 768-773 NP denotes which
C7 788-852 NP denotes the major histocompatibility complex class I or II (MHC I or II)
C8 1020-1033 NP denotes thyroid cells
C9 1034-1044 NP denotes themselves
C10 1387-1423 NP denotes immunological markers (MHC I and II)
R1 C4 C2 coref-ident TSH-R transcript levels,TSH-R transcript levels in 13 human thyroid fragments
R2 C5 C2 coref-ident those thyroids,TSH-R transcript levels in 13 human thyroid fragments
R3 C6 C5 coref-relat which,those thyroids
R4 C7 C1 coref-ident the major histocompatibility complex class I or II (MHC I or II),major histocompatibility complex classes I and II
R5 C9 C8 coref-pron themselves,thyroid cells
R6 C10 C1 coref-ident immunological markers (MHC I and II),major histocompatibility complex classes I and II

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 25-50 DNA_domain_or_region denotes thyrotropin receptor gene
T2 214-232 protein_molecule denotes human TSH receptor
T3 234-239 protein_molecule denotes TSH-R
T4 269-274 protein_molecule denotes TSH-R
T5 299-322 tissue denotes human thyroid fragments
T6 326-348 other_name denotes Northern blot analysis
T7 352-367 other_name denotes Graves' disease
T8 371-390 other_name denotes Hashimoto's disease
T9 394-408 other_name denotes endemic goiter
T10 416-437 body_part denotes healthy thyroid gland
T11 452-457 protein_molecule denotes TSH-R
T12 546-564 protein_family_or_group denotes thyroid peroxidase
T13 588-601 protein_molecule denotes thyroglobulin
T14 633-655 DNA_molecule denotes nuclear oncogene c-fos
T15 688-693 protein_family_or_group denotes c-myc
T16 704-709 protein_molecule denotes TSH-R
T17 756-764 body_part denotes thyroids
T18 902-907 protein_family_or_group denotes MHC I
T19 931-937 protein_family_or_group denotes MHC II
T20 962-983 other_name denotes In situ hybridization
T21 1007-1018 cell_type denotes lymphocytes
T22 1020-1033 cell_type denotes thyroid cells
T23 1064-1070 protein_family_or_group denotes MHC II
T24 1084-1100 protein_molecule denotes gamma-Interferon
T25 1137-1155 other_name denotes Hashimoto's goiter
T26 1191-1214 other_name denotes lymphocyte infiltration
T27 1248-1257 cell_type denotes thyrocyte
T28 1330-1335 protein_molecule denotes TSH-R
T29 1337-1355 protein_family_or_group denotes thyroid peroxidase
T30 1357-1370 protein_molecule denotes thyroglobulin
T31 1387-1408 other_name denotes immunological markers