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sentences

Id Subject Object Predicate Lexical cue
T1 0-52 Sentence denotes Oxidoreductive regulation of nuclear factor kappa B.
T2 53-109 Sentence denotes Involvement of a cellular reducing catalyst thioredoxin.
T3 110-401 Sentence denotes We have investigated an oxidoreductive regulatory pathway for the DNA binding activity of a pleiotropic cellular transcription factor, nuclear factor kappa B (NF kappa B), has been investigated by using NF kappa B prepared from the nucleus and the cytosol of the primary human T lymphocytes.
T4 402-616 Sentence denotes We show that a cellular reducing catalyst thioredoxin (Trx) plays a major role in activation of the DNA binding of NF kappa B in vitro and stimulation of transcription from the NF kappa B-dependent gene expression.
T5 617-824 Sentence denotes We demonstrate evidence suggesting that redox regulation of NF kappa B by Trx might be exerted at a step after dissociation of the inhibitory molecule I kappa B, a cytosolic-anchoring protein for NF kappa B.
T6 825-1082 Sentence denotes To examine the effect of Trx in intact cells, we performed transient assay with a chloramphenicol acetyltransferase-expressing plasmid under the control of human immunodeficiency virus (HIV) long terminal repeat and an effector plasmid expressing human Trx.
T7 1083-1263 Sentence denotes The promoter activity from HIV long terminal repeat was greatly augmented by co-transfecting the Trx-expressing plasmid, whose effect was dependent on the NF kappa B-binding sites.
T8 1264-1513 Sentence denotes These findings have suggested that cysteine residue(s) of NF kappa B might be involved in the DNA-recognition by NF kappa B and that the redox control mechanism mediated by Trx might have a regulatory role in the NF kappa B-mediated gene expression.
T9 1514-1657 Sentence denotes These results may also provide a clue to understanding of the molecular process of AIDS pathogenesis and its possible biochemical intervention.
T1 0-52 Sentence denotes Oxidoreductive regulation of nuclear factor kappa B.
T2 53-109 Sentence denotes Involvement of a cellular reducing catalyst thioredoxin.
T3 110-401 Sentence denotes We have investigated an oxidoreductive regulatory pathway for the DNA binding activity of a pleiotropic cellular transcription factor, nuclear factor kappa B (NF kappa B), has been investigated by using NF kappa B prepared from the nucleus and the cytosol of the primary human T lymphocytes.
T4 402-616 Sentence denotes We show that a cellular reducing catalyst thioredoxin (Trx) plays a major role in activation of the DNA binding of NF kappa B in vitro and stimulation of transcription from the NF kappa B-dependent gene expression.
T5 617-824 Sentence denotes We demonstrate evidence suggesting that redox regulation of NF kappa B by Trx might be exerted at a step after dissociation of the inhibitory molecule I kappa B, a cytosolic-anchoring protein for NF kappa B.
T6 825-1082 Sentence denotes To examine the effect of Trx in intact cells, we performed transient assay with a chloramphenicol acetyltransferase-expressing plasmid under the control of human immunodeficiency virus (HIV) long terminal repeat and an effector plasmid expressing human Trx.
T7 1083-1263 Sentence denotes The promoter activity from HIV long terminal repeat was greatly augmented by co-transfecting the Trx-expressing plasmid, whose effect was dependent on the NF kappa B-binding sites.
T8 1264-1513 Sentence denotes These findings have suggested that cysteine residue(s) of NF kappa B might be involved in the DNA-recognition by NF kappa B and that the redox control mechanism mediated by Trx might have a regulatory role in the NF kappa B-mediated gene expression.
T9 1514-1657 Sentence denotes These results may also provide a clue to understanding of the molecular process of AIDS pathogenesis and its possible biochemical intervention.

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 29-51 protein denotes nuclear factor kappa B
T2 97-108 protein denotes thioredoxin
T3 202-243 protein denotes pleiotropic cellular transcription factor
T4 245-267 protein denotes nuclear factor kappa B
T5 269-279 protein denotes NF kappa B
T6 313-323 protein denotes NF kappa B
T7 373-400 cell_type denotes primary human T lymphocytes
T8 444-455 protein denotes thioredoxin
T9 457-460 protein denotes Trx
T10 517-527 protein denotes NF kappa B
T11 579-589 protein denotes NF kappa B
T12 677-687 protein denotes NF kappa B
T13 691-694 protein denotes Trx
T14 768-777 protein denotes I kappa B
T15 781-808 protein denotes cytosolic-anchoring protein
T16 813-823 protein denotes NF kappa B
T17 850-853 protein denotes Trx
T18 907-959 DNA denotes chloramphenicol acetyltransferase-expressing plasmid
T19 981-1036 DNA denotes human immunodeficiency virus (HIV) long terminal repeat
T20 1044-1060 DNA denotes effector plasmid
T21 1072-1081 protein denotes human Trx
T22 1110-1134 DNA denotes HIV long terminal repeat
T23 1180-1202 DNA denotes Trx-expressing plasmid
T24 1238-1248 protein denotes NF kappa B
T25 1322-1332 protein denotes NF kappa B
T26 1377-1387 protein denotes NF kappa B
T27 1437-1440 protein denotes Trx
T28 1477-1487 protein denotes NF kappa B

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-52 Sentence denotes Oxidoreductive regulation of nuclear factor kappa B.
S2 53-109 Sentence denotes Involvement of a cellular reducing catalyst thioredoxin.
S3 110-401 Sentence denotes We have investigated an oxidoreductive regulatory pathway for the DNA binding activity of a pleiotropic cellular transcription factor, nuclear factor kappa B (NF kappa B), has been investigated by using NF kappa B prepared from the nucleus and the cytosol of the primary human T lymphocytes.
S4 402-616 Sentence denotes We show that a cellular reducing catalyst thioredoxin (Trx) plays a major role in activation of the DNA binding of NF kappa B in vitro and stimulation of transcription from the NF kappa B-dependent gene expression.
S5 617-824 Sentence denotes We demonstrate evidence suggesting that redox regulation of NF kappa B by Trx might be exerted at a step after dissociation of the inhibitory molecule I kappa B, a cytosolic-anchoring protein for NF kappa B.
S6 825-1082 Sentence denotes To examine the effect of Trx in intact cells, we performed transient assay with a chloramphenicol acetyltransferase-expressing plasmid under the control of human immunodeficiency virus (HIV) long terminal repeat and an effector plasmid expressing human Trx.
S7 1083-1263 Sentence denotes The promoter activity from HIV long terminal repeat was greatly augmented by co-transfecting the Trx-expressing plasmid, whose effect was dependent on the NF kappa B-binding sites.
S8 1264-1513 Sentence denotes These findings have suggested that cysteine residue(s) of NF kappa B might be involved in the DNA-recognition by NF kappa B and that the redox control mechanism mediated by Trx might have a regulatory role in the NF kappa B-mediated gene expression.
S9 1514-1657 Sentence denotes These results may also provide a clue to understanding of the molecular process of AIDS pathogenesis and its possible biochemical intervention.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 29-51 NP denotes nuclear factor kappa B
C2 200-243 NP denotes a pleiotropic cellular transcription factor
C3 245-280 NP denotes nuclear factor kappa B (NF kappa B)
C4 313-323 NP denotes NF kappa B
C5 444-461 NP denotes thioredoxin (Trx)
C6 517-527 NP denotes NF kappa B
C7 575-615 NP denotes the NF kappa B-dependent gene expression
C8 677-687 NP denotes NF kappa B
C9 691-694 NP denotes Trx
C10 744-777 NP denotes the inhibitory molecule I kappa B
C12 813-823 NP denotes NF kappa B
C11 779-823 NP denotes a cytosolic-anchoring protein for NF kappa B
C13 850-853 NP denotes Trx
C14 981-1036 NP denotes human immunodeficiency virus (HIV) long terminal repeat
C16 1072-1081 NP denotes human Trx
C15 1041-1081 NP denotes an effector plasmid expressing human Trx
C17 1110-1134 NP denotes HIV long terminal repeat
C19 1180-1184 NP denotes Trx-
C18 1176-1202 NP denotes the Trx-expressing plasmid
C20 1204-1209 NP denotes whose
C21 1238-1249 NP denotes NF kappa B-
C22 1322-1332 NP denotes NF kappa B
C23 1377-1387 NP denotes NF kappa B
C24 1437-1440 NP denotes Trx
C25 1473-1512 NP denotes the NF kappa B-mediated gene expression
C26 1572-1614 NP denotes the molecular process of AIDS pathogenesis
C27 1619-1622 NP denotes its
R1 C1 C3 coref-ident nuclear factor kappa B,nuclear factor kappa B (NF kappa B)
R2 C3 C2 coref-appos nuclear factor kappa B (NF kappa B),a pleiotropic cellular transcription factor
R3 C4 C3 coref-ident NF kappa B,nuclear factor kappa B (NF kappa B)
R4 C6 C4 coref-ident NF kappa B,NF kappa B
R5 C8 C6 coref-ident NF kappa B,NF kappa B
R6 C9 C5 coref-ident Trx,thioredoxin (Trx)
R7 C12 C6 coref-ident NF kappa B,NF kappa B
R8 C11 C10 coref-appos a cytosolic-anchoring protein for NF kappa B,the inhibitory molecule I kappa B
R9 C13 C9 coref-ident Trx,Trx
R10 C16 C13 coref-ident human Trx,Trx
R11 C17 C14 coref-ident HIV long terminal repeat,human immunodeficiency virus (HIV) long terminal repeat
R12 C19 C16 coref-ident Trx-,human Trx
R13 C18 C15 coref-ident the Trx-expressing plasmid,an effector plasmid expressing human Trx
R14 C20 C18 coref-relat whose,the Trx-expressing plasmid
R15 C21 C12 coref-ident NF kappa B-,NF kappa B
R16 C22 C21 coref-ident NF kappa B,NF kappa B-
R17 C23 C22 coref-ident NF kappa B,NF kappa B
R18 C24 C16 coref-ident Trx,human Trx
R19 C25 C7 coref-other the NF kappa B-mediated gene expression,the NF kappa B-dependent gene expression
R20 C27 C26 coref-pron its,the molecular process of AIDS pathogenesis

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-25 other_name denotes Oxidoreductive regulation
T2 29-51 protein_molecule denotes nuclear factor kappa B
T3 97-108 protein_molecule denotes thioredoxin
T4 134-167 other_name denotes oxidoreductive regulatory pathway
T5 176-196 other_name denotes DNA binding activity
T6 202-243 protein_family_or_group denotes pleiotropic cellular transcription factor
T7 245-267 protein_molecule denotes nuclear factor kappa B
T8 269-279 protein_molecule denotes NF kappa B
T9 313-323 protein_molecule denotes NF kappa B
T10 342-349 cell_component denotes nucleus
T11 358-365 cell_component denotes cytosol
T12 373-400 cell_type denotes primary human T lymphocytes
T13 444-455 protein_molecule denotes thioredoxin
T14 457-460 protein_molecule denotes Trx
T15 517-527 protein_molecule denotes NF kappa B
T16 579-589 protein_molecule denotes NF kappa B
T17 677-687 protein_molecule denotes NF kappa B
T18 691-694 protein_molecule denotes Trx
T19 768-777 protein_molecule denotes I kappa B
T20 781-808 protein_family_or_group denotes cytosolic-anchoring protein
T21 813-823 protein_molecule denotes NF kappa B
T22 850-853 protein_molecule denotes Trx
T23 884-899 other_name denotes transient assay
T24 907-922 other_organic_compound denotes chloramphenicol
T25 981-1036 DNA_domain_or_region denotes human immunodeficiency virus (HIV) long terminal repeat
T26 1044-1060 DNA_molecule denotes effector plasmid
T27 1072-1081 protein_molecule denotes human Trx
T28 1087-1104 other_name denotes promoter activity
T29 1110-1134 DNA_domain_or_region denotes HIV long terminal repeat
T30 1180-1202 DNA_molecule denotes Trx-expressing plasmid
T31 1238-1248 protein_molecule denotes NF kappa B
T32 1299-1315 amino_acid_monomer denotes cysteine residue
T33 1322-1332 protein_molecule denotes NF kappa B
T34 1377-1387 protein_molecule denotes NF kappa B
T35 1437-1440 protein_molecule denotes Trx
T36 1477-1487 protein_family_or_group denotes NF kappa B
T37 1597-1601 other_name denotes AIDS
T38 1632-1656 other_name denotes biochemical intervention

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 987-1003 Phenotype denotes immunodeficiency HP:0002721

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 987-1003 Disease denotes immunodeficiency http://purl.obolibrary.org/obo/MONDO_0021094
T2 1597-1601 Disease denotes AIDS http://purl.obolibrary.org/obo/MONDO_0012268

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 381-386 OrganismTaxon denotes human 9606
T2 981-986 OrganismTaxon denotes human 9606
T3 1072-1077 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 342-349 Body_part denotes nucleus http://purl.obolibrary.org/obo/GO_0005634|http://purl.obolibrary.org/obo/UBERON_0000125
T3 358-365 Body_part denotes cytosol http://purl.obolibrary.org/obo/GO_0005829
T4 387-400 Body_part denotes T lymphocytes http://purl.obolibrary.org/obo/CL_0000084

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 387-400 Cell denotes T lymphocytes http://purl.obolibrary.org/obo/CL:0000084