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PubMed:8486665 JSONTXT

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GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 534-545 Glycan_Motif denotes chondroitin https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G43702JT

sentences

Id Subject Object Predicate Lexical cue
T1 0-64 Sentence denotes Deficient expression of decorin in infantile progeroid patients.
T2 65-215 Sentence denotes Fibroblasts from young patients exhibiting clinical features of progeroidal syndromes showed decreased biosynthesis of the small proteoglycan decorin.
T3 216-416 Sentence denotes Cells in culture were metabolically labeled, and proteoglycans secreted into the medium were analyzed electrophoretically after immunoprecipitation with antibodies raised against decorin and biglycan.
T4 417-566 Sentence denotes Fluorograms showed regularly a reduction to 15-30% of the normal amount of mature decorin and its core protein after chondroitin ABC lyase treatment.
T5 567-709 Sentence denotes The size of the glycosaminoglycan chains was increased, but there was no obvious anomaly in the secretion kinetics of the mature proteoglycan.
T6 710-839 Sentence denotes In addition, the patients' fibroblasts synthesized an increased amount of biglycan compared to control cells from healthy donors.
T7 840-1061 Sentence denotes Northern blot analysis clearly demonstrated a reduction by 85-94% in decorin mRNA, but biglycan mRNA was concomitantly increased, indicating that these alterations occur at the transcriptional level of protein expression.
T8 1062-1192 Sentence denotes Transcription of decorin in fibroblasts from one of the patients was stimulated up to 3-fold by treatment with interleukin-1 beta.
T9 1193-1310 Sentence denotes No response to interleukin-1 beta and transforming growth factor-beta was observed in the cells from another patient.
T10 1311-1454 Sentence denotes In situ hybridization of cultured cells with an antisense decorin probe showed that decorin levels were reduced throughout the cell population.
T11 1455-1637 Sentence denotes Surprisingly, subsequent examination of cells from one of the patients, now in mid-teenage, revealed a return to normal levels of decorin expression compared to age-matched controls.
T12 1638-1862 Sentence denotes These studies suggest that, as in Marfan's syndrome where the primary defect concerns the fibrillin gene, reduced decorin expression contributes to the formation of an abnormal matrix and the pathogenesis of these disorders.
T13 1863-2021 Sentence denotes They also indicate that this abnormality is likely to represent a secondary phenomenon which leads to a fault in the regulation of decorin gene transcription.
T1 0-64 Sentence denotes Deficient expression of decorin in infantile progeroid patients.
T2 65-215 Sentence denotes Fibroblasts from young patients exhibiting clinical features of progeroidal syndromes showed decreased biosynthesis of the small proteoglycan decorin.
T3 216-416 Sentence denotes Cells in culture were metabolically labeled, and proteoglycans secreted into the medium were analyzed electrophoretically after immunoprecipitation with antibodies raised against decorin and biglycan.
T4 417-566 Sentence denotes Fluorograms showed regularly a reduction to 15-30% of the normal amount of mature decorin and its core protein after chondroitin ABC lyase treatment.
T5 567-709 Sentence denotes The size of the glycosaminoglycan chains was increased, but there was no obvious anomaly in the secretion kinetics of the mature proteoglycan.
T6 710-839 Sentence denotes In addition, the patients' fibroblasts synthesized an increased amount of biglycan compared to control cells from healthy donors.
T7 840-1061 Sentence denotes Northern blot analysis clearly demonstrated a reduction by 85-94% in decorin mRNA, but biglycan mRNA was concomitantly increased, indicating that these alterations occur at the transcriptional level of protein expression.
T8 1062-1192 Sentence denotes Transcription of decorin in fibroblasts from one of the patients was stimulated up to 3-fold by treatment with interleukin-1 beta.
T9 1193-1310 Sentence denotes No response to interleukin-1 beta and transforming growth factor-beta was observed in the cells from another patient.
T10 1311-1454 Sentence denotes In situ hybridization of cultured cells with an antisense decorin probe showed that decorin levels were reduced throughout the cell population.
T11 1455-1637 Sentence denotes Surprisingly, subsequent examination of cells from one of the patients, now in mid-teenage, revealed a return to normal levels of decorin expression compared to age-matched controls.
T12 1638-1862 Sentence denotes These studies suggest that, as in Marfan's syndrome where the primary defect concerns the fibrillin gene, reduced decorin expression contributes to the formation of an abnormal matrix and the pathogenesis of these disorders.
T13 1863-2021 Sentence denotes They also indicate that this abnormality is likely to represent a secondary phenomenon which leads to a fault in the regulation of decorin gene transcription.

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 534-545 https://glytoucan.org/Structures/Glycans/G43702JT denotes chondroitin

Glycosmos6-GlycoEpitope

Id Subject Object Predicate Lexical cue
T1 534-545 http://www.glycoepitope.jp/epitopes/EP0081 denotes chondroitin

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
8486665-11#114#121#gene1634 1752-1759 gene1634 denotes decorin
8486665-11#34#51#diseaseC0024796 1672-1689 diseaseC0024796 denotes Marfan's syndrome
114#121#gene163434#51#diseaseC0024796 8486665-11#114#121#gene1634 8486665-11#34#51#diseaseC0024796 associated_with decorin,Marfan's syndrome

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 129-150 Disease denotes progeroidal syndromes http://purl.obolibrary.org/obo/MONDO_0015333
T2 1672-1689 Disease denotes Marfan's syndrome http://purl.obolibrary.org/obo/MONDO_0007947

Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 534-545 Glycan denotes chondroitin https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT

GlyCosmos15-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 129-150 Disease denotes progeroidal syndromes http://purl.obolibrary.org/obo/MONDO_0015333
T2 1672-1689 Disease denotes Marfan's syndrome http://purl.obolibrary.org/obo/MONDO_0007947

GlyCosmos15-NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 1302-1309 OrganismTaxon denotes patient 9606

GlyCosmos15-CL

Id Subject Object Predicate Lexical cue cl_id
T1 65-76 Cell denotes Fibroblasts http://purl.obolibrary.org/obo/CL:0000057
T2 737-748 Cell denotes fibroblasts http://purl.obolibrary.org/obo/CL:0000057
T3 1090-1101 Cell denotes fibroblasts http://purl.obolibrary.org/obo/CL:0000057
T4 1336-1350 Cell denotes cultured cells http://purl.obolibrary.org/obo/CL:0000010

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 65-76 Body_part denotes Fibroblasts http://purl.obolibrary.org/obo/CL_0000057
T2 737-748 Body_part denotes fibroblasts http://purl.obolibrary.org/obo/CL_0000057
T3 1090-1101 Body_part denotes fibroblasts http://purl.obolibrary.org/obo/CL_0000057

sentences

Id Subject Object Predicate Lexical cue
T1 0-64 Sentence denotes Deficient expression of decorin in infantile progeroid patients.
T2 65-215 Sentence denotes Fibroblasts from young patients exhibiting clinical features of progeroidal syndromes showed decreased biosynthesis of the small proteoglycan decorin.
T3 216-416 Sentence denotes Cells in culture were metabolically labeled, and proteoglycans secreted into the medium were analyzed electrophoretically after immunoprecipitation with antibodies raised against decorin and biglycan.
T4 417-566 Sentence denotes Fluorograms showed regularly a reduction to 15-30% of the normal amount of mature decorin and its core protein after chondroitin ABC lyase treatment.
T5 567-709 Sentence denotes The size of the glycosaminoglycan chains was increased, but there was no obvious anomaly in the secretion kinetics of the mature proteoglycan.
T6 710-839 Sentence denotes In addition, the patients' fibroblasts synthesized an increased amount of biglycan compared to control cells from healthy donors.
T7 840-1061 Sentence denotes Northern blot analysis clearly demonstrated a reduction by 85-94% in decorin mRNA, but biglycan mRNA was concomitantly increased, indicating that these alterations occur at the transcriptional level of protein expression.
T8 1062-1192 Sentence denotes Transcription of decorin in fibroblasts from one of the patients was stimulated up to 3-fold by treatment with interleukin-1 beta.
T9 1193-1310 Sentence denotes No response to interleukin-1 beta and transforming growth factor-beta was observed in the cells from another patient.
T10 1311-1454 Sentence denotes In situ hybridization of cultured cells with an antisense decorin probe showed that decorin levels were reduced throughout the cell population.
T11 1455-1637 Sentence denotes Surprisingly, subsequent examination of cells from one of the patients, now in mid-teenage, revealed a return to normal levels of decorin expression compared to age-matched controls.
T12 1638-1862 Sentence denotes These studies suggest that, as in Marfan's syndrome where the primary defect concerns the fibrillin gene, reduced decorin expression contributes to the formation of an abnormal matrix and the pathogenesis of these disorders.
T13 1863-2021 Sentence denotes They also indicate that this abnormality is likely to represent a secondary phenomenon which leads to a fault in the regulation of decorin gene transcription.
T1 0-64 Sentence denotes Deficient expression of decorin in infantile progeroid patients.
T2 65-215 Sentence denotes Fibroblasts from young patients exhibiting clinical features of progeroidal syndromes showed decreased biosynthesis of the small proteoglycan decorin.
T3 216-416 Sentence denotes Cells in culture were metabolically labeled, and proteoglycans secreted into the medium were analyzed electrophoretically after immunoprecipitation with antibodies raised against decorin and biglycan.
T4 417-566 Sentence denotes Fluorograms showed regularly a reduction to 15-30% of the normal amount of mature decorin and its core protein after chondroitin ABC lyase treatment.
T5 567-709 Sentence denotes The size of the glycosaminoglycan chains was increased, but there was no obvious anomaly in the secretion kinetics of the mature proteoglycan.
T6 710-839 Sentence denotes In addition, the patients' fibroblasts synthesized an increased amount of biglycan compared to control cells from healthy donors.
T7 840-1061 Sentence denotes Northern blot analysis clearly demonstrated a reduction by 85-94% in decorin mRNA, but biglycan mRNA was concomitantly increased, indicating that these alterations occur at the transcriptional level of protein expression.
T8 1062-1192 Sentence denotes Transcription of decorin in fibroblasts from one of the patients was stimulated up to 3-fold by treatment with interleukin-1 beta.
T9 1193-1310 Sentence denotes No response to interleukin-1 beta and transforming growth factor-beta was observed in the cells from another patient.
T10 1311-1454 Sentence denotes In situ hybridization of cultured cells with an antisense decorin probe showed that decorin levels were reduced throughout the cell population.
T11 1455-1637 Sentence denotes Surprisingly, subsequent examination of cells from one of the patients, now in mid-teenage, revealed a return to normal levels of decorin expression compared to age-matched controls.
T12 1638-1862 Sentence denotes These studies suggest that, as in Marfan's syndrome where the primary defect concerns the fibrillin gene, reduced decorin expression contributes to the formation of an abnormal matrix and the pathogenesis of these disorders.
T13 1863-2021 Sentence denotes They also indicate that this abnormality is likely to represent a secondary phenomenon which leads to a fault in the regulation of decorin gene transcription.

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-64 Sentence denotes Deficient expression of decorin in infantile progeroid patients.
T2 65-215 Sentence denotes Fibroblasts from young patients exhibiting clinical features of progeroidal syndromes showed decreased biosynthesis of the small proteoglycan decorin.
T3 216-416 Sentence denotes Cells in culture were metabolically labeled, and proteoglycans secreted into the medium were analyzed electrophoretically after immunoprecipitation with antibodies raised against decorin and biglycan.
T4 417-566 Sentence denotes Fluorograms showed regularly a reduction to 15-30% of the normal amount of mature decorin and its core protein after chondroitin ABC lyase treatment.
T5 567-709 Sentence denotes The size of the glycosaminoglycan chains was increased, but there was no obvious anomaly in the secretion kinetics of the mature proteoglycan.
T6 710-839 Sentence denotes In addition, the patients' fibroblasts synthesized an increased amount of biglycan compared to control cells from healthy donors.
T7 840-1061 Sentence denotes Northern blot analysis clearly demonstrated a reduction by 85-94% in decorin mRNA, but biglycan mRNA was concomitantly increased, indicating that these alterations occur at the transcriptional level of protein expression.
T8 1062-1192 Sentence denotes Transcription of decorin in fibroblasts from one of the patients was stimulated up to 3-fold by treatment with interleukin-1 beta.
T9 1193-1310 Sentence denotes No response to interleukin-1 beta and transforming growth factor-beta was observed in the cells from another patient.
T10 1311-1454 Sentence denotes In situ hybridization of cultured cells with an antisense decorin probe showed that decorin levels were reduced throughout the cell population.
T11 1455-1637 Sentence denotes Surprisingly, subsequent examination of cells from one of the patients, now in mid-teenage, revealed a return to normal levels of decorin expression compared to age-matched controls.
T12 1638-1862 Sentence denotes These studies suggest that, as in Marfan's syndrome where the primary defect concerns the fibrillin gene, reduced decorin expression contributes to the formation of an abnormal matrix and the pathogenesis of these disorders.
T13 1863-2021 Sentence denotes They also indicate that this abnormality is likely to represent a secondary phenomenon which leads to a fault in the regulation of decorin gene transcription.

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 534-545 Glycan denotes chondroitin https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT

GlyCosmos15-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 534-545 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes chondroitin http://www.glycoepitope.jp/epitopes/EP0081

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 1302-1309 OrganismTaxon denotes patient 9606

GlyCosmos-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 534-545 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes chondroitin http://www.glycoepitope.jp/epitopes/EP0081

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 65-76 Body_part denotes Fibroblasts http://purl.obolibrary.org/obo/CL_0000057
T2 737-748 Body_part denotes fibroblasts http://purl.obolibrary.org/obo/CL_0000057
T3 1090-1101 Body_part denotes fibroblasts http://purl.obolibrary.org/obo/CL_0000057

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 65-76 Cell denotes Fibroblasts http://purl.obolibrary.org/obo/CL:0000057
T2 737-748 Cell denotes fibroblasts http://purl.obolibrary.org/obo/CL:0000057
T3 1090-1101 Cell denotes fibroblasts http://purl.obolibrary.org/obo/CL:0000057
T4 1336-1350 Cell denotes cultured cells http://purl.obolibrary.org/obo/CL:0000010