PubMed:8481397
Annnotations
Anatomy-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 64-72 | Body_part | denotes | proximal | http://purl.obolibrary.org/obo/MAT_0000491 |
| T2 | 256-264 | Body_part | denotes | proximal | http://purl.obolibrary.org/obo/MAT_0000491 |
mondo_disease
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 58-63 | Disease | denotes | tumor | http://purl.obolibrary.org/obo/MONDO_0005070 |
| T2 | 250-255 | Disease | denotes | tumor | http://purl.obolibrary.org/obo/MONDO_0005070 |
| T3 | 904-909 | Disease | denotes | tumor | http://purl.obolibrary.org/obo/MONDO_0005070 |
| T4 | 1196-1201 | Disease | denotes | tumor | http://purl.obolibrary.org/obo/MONDO_0005070 |
| T5 | 1422-1427 | Disease | denotes | tumor | http://purl.obolibrary.org/obo/MONDO_0005070 |
HP-phenotype
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 58-63 | Phenotype | denotes | tumor | HP:0002664 |
| T2 | 250-255 | Phenotype | denotes | tumor | HP:0002664 |
| T3 | 904-909 | Phenotype | denotes | tumor | HP:0002664 |
| T4 | 1196-1201 | Phenotype | denotes | tumor | HP:0002664 |
| T5 | 1422-1427 | Phenotype | denotes | tumor | HP:0002664 |
Glycan-GlyCosmos
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 27-43 | Glycan | denotes | lactosylceramide | https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW |
| T2 | 1576-1592 | Glycan | denotes | lactosylceramide | https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW |
GlyCosmos-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 27-43 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | lactosylceramide | http://www.glycoepitope.jp/epitopes/EP0078 |
| T2 | 1576-1592 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | lactosylceramide | http://www.glycoepitope.jp/epitopes/EP0078 |
GlyCosmos15-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 58-63 | Phenotype | denotes | tumor | HP:0002664 |
| T2 | 250-255 | Phenotype | denotes | tumor | HP:0002664 |
| T3 | 904-909 | Phenotype | denotes | tumor | HP:0002664 |
| T4 | 1196-1201 | Phenotype | denotes | tumor | HP:0002664 |
| T5 | 1422-1427 | Phenotype | denotes | tumor | HP:0002664 |
GlyCosmos15-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 58-63 | Disease | denotes | tumor | http://purl.obolibrary.org/obo/MONDO_0005070 |
| T2 | 250-255 | Disease | denotes | tumor | http://purl.obolibrary.org/obo/MONDO_0005070 |
| T3 | 904-909 | Disease | denotes | tumor | http://purl.obolibrary.org/obo/MONDO_0005070 |
| T4 | 1196-1201 | Disease | denotes | tumor | http://purl.obolibrary.org/obo/MONDO_0005070 |
| T5 | 1422-1427 | Disease | denotes | tumor | http://purl.obolibrary.org/obo/MONDO_0005070 |
GlyCosmos15-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 64-72 | Body_part | denotes | proximal | http://purl.obolibrary.org/obo/MAT_0000491 |
| T2 | 256-264 | Body_part | denotes | proximal | http://purl.obolibrary.org/obo/MAT_0000491 |
GlyCosmos15-Sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-87 | Sentence | denotes | Regulation of synthesis of lactosylceramide in normal and tumor proximal tubular cells. |
| T2 | 88-284 | Sentence | denotes | We have measured the binding and degradation of low-density lipoprotein (LDL) and LDL-mediated effects on cholesteryl ester (CE) synthesis in cultured normal and tumor proximal tubular (PT) cells. |
| T3 | 285-545 | Sentence | denotes | The effects of LDL on the regulation of glycosphingolipid metabolism in cells was pursued employing radioactive precursors, e.g., [3H]serine, and [3H]glucose and by measuring the activity of UDP-galactose: glucosylceramide: B1-4 galactosyltransferase (GalT-2). |
| T4 | 546-716 | Sentence | denotes | In normal PT cells, there was a saturable and displaceable binding and degradation of 125I-LDL and a LDL mediated 14-fold stimulation of cholesteryl ester (CE) synthesis. |
| T5 | 717-900 | Sentence | denotes | This was accompanied by a suppression (70-80%) of incorporation of [3H]glucose and [3H]serine into GlcCer, LacCer, GbOse3Cer and GbOse4Cer and suppression (70-80%) of GalT-2 activity. |
| T6 | 901-1027 | Sentence | denotes | In tumor PT cells, displaceable binding and degradation of 125I-LDL was not observed and LDL failed to stimulate CE synthesis. |
| T7 | 1028-1146 | Sentence | denotes | In such cells, LDL exerted a concentration-dependent stimulation of [3H]glucose and [3H]serine incorporation into GSL. |
| T8 | 1147-1253 | Sentence | denotes | Maximum stimulation (250%) of GalT-2 activity in tumor PT cells occurred with 25 micrograms LDL/ml medium. |
| T9 | 1254-1359 | Sentence | denotes | We conclude that LDL taken up via receptor mediated pathway decreases GaIT-2 activity in normal PT cells. |
| T10 | 1360-1603 | Sentence | denotes | In contrast, LDL not taken up via the LDL receptor pathway in tumor PT cells failed to suppress the incorporation of [3H]glucose and [3H]serine into glycosphingolipids and GalT-2 activity leading to a stimulation of lactosylceramide synthesis. |
GlyCosmos15-Glycan
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 27-43 | Glycan | denotes | lactosylceramide | https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW |
| T2 | 1576-1592 | Glycan | denotes | lactosylceramide | https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW |
GlyCosmos15-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 27-43 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | lactosylceramide | http://www.glycoepitope.jp/epitopes/EP0078 |
| T2 | 1576-1592 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | lactosylceramide | http://www.glycoepitope.jp/epitopes/EP0078 |