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PubMed:8473495 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 39-70 DNA denotes human interleukin 2 (IL-2) gene
T2 116-145 protein denotes nuclear transcription factors
T3 146-150 protein denotes AP-1
T4 155-160 protein denotes NF-AT
T5 162-171 DNA denotes IL-2 gene
T6 209-225 protein denotes nuclear proteins
T7 296-305 DNA denotes IL-2 gene
T8 356-372 protein denotes nuclear proteins
T9 427-454 cell_type denotes primary human T lymphocytes
T10 579-583 protein denotes AP-1
T11 588-593 protein denotes NF-AT
T12 606-611 protein denotes NF-kB
T13 616-625 protein denotes OCT-1/OAF
T14 663-681 DNA denotes IL-2 gene promoter
T15 820-833 DNA denotes IL-2 promoter
T16 883-895 cell_line denotes Jurkat cells
T17 918-926 DNA denotes plasmids
T18 956-969 DNA denotes IL-2 promoter
T19 977-1006 DNA denotes AP-1, NF-AT, and NF-kB motifs
T20 1026-1039 DNA denotes IL-2 promoter
T21 1048-1052 DNA denotes AP-1
T22 1066-1071 DNA denotes NF-AT
T23 1076-1090 DNA denotes NF-kB plasmids
T24 1123-1136 DNA denotes IL-2 promoter
T25 1145-1150 DNA denotes NF-AT
T26 1164-1168 DNA denotes AP-1
T27 1173-1187 DNA denotes NF-kB plasmids
T28 1219-1238 cell_type denotes human T lymphocytes
T29 1266-1275 DNA denotes IL-2 gene
T30 1316-1337 protein denotes transcription factors
T31 1338-1342 protein denotes AP-1
T32 1347-1352 protein denotes NF-AT
T33 1430-1451 protein denotes transcription factors
T34 1453-1457 protein denotes AP-1

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-161 Sentence denotes Negative transcriptional regulation of human interleukin 2 (IL-2) gene by glucocorticoids through interference with nuclear transcription factors AP-1 and NF-AT.
S2 162-226 Sentence denotes IL-2 gene transcription is affected by several nuclear proteins.
S3 227-404 Sentence denotes We asked whether dexamethasone (Dex) and cyclosporin A (CsA) inhibit IL-2 gene transcription by interfering with the activity of nuclear proteins that bind to the IL-2 promoter.
S4 405-514 Sentence denotes Nuclear extracts from primary human T lymphocytes were analyzed by electrophoretic DNA mobility shift assays.
S5 515-682 Sentence denotes Both Dex and CsA inhibited the binding of transcription factors AP-1 and NF-AT, but not of NF-kB and OCT-1/OAF, to their corresponding sites on the IL-2 gene promoter.
S6 683-882 Sentence denotes To correlate changes in nuclear factor binding in vitro with transcriptional activity in vivo and define the structural requirements for IL-2 promoter repression, we used transient DNA transfections.
S7 883-1007 Sentence denotes Jurkat cells were transfected with plasmids containing either the intact IL-2 promoter or its AP-1, NF-AT, and NF-kB motifs.
S8 1008-1091 Sentence denotes Dex inhibited the IL-2 promoter and the AP-1, but not the NF-AT and NF-kB plasmids.
S9 1092-1188 Sentence denotes In contrast, CsA inhibited the IL-2 promoter and the NF-AT, but not the AP-1 and NF-kB plasmids.
S10 1189-1353 Sentence denotes These results suggest that in human T lymphocytes both Dex and CsA inhibited IL-2 gene transcription through interference with transcription factors AP-1 and NF-AT.
S11 1354-1487 Sentence denotes We propose that, while maximum inhibition may involve interaction with both transcription factors, AP-1 is the primary target of Dex.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 39-70 NP denotes human interleukin 2 (IL-2) gene
C4 146-150 NP denotes AP-1
C5 155-160 NP denotes NF-AT
C3 116-160 NP denotes nuclear transcription factors AP-1 and NF-AT
C2 98-160 NP denotes interference with nuclear transcription factors AP-1 and NF-AT
C6 162-185 NP denotes IL-2 gene transcription
C7 244-263 NP denotes dexamethasone (Dex)
C8 268-287 NP denotes cyclosporin A (CsA)
C9 296-319 NP denotes IL-2 gene transcription
C10 386-403 NP denotes the IL-2 promoter
C11 427-454 NP denotes primary human T lymphocytes
C12 488-491 NP denotes DNA
C13 520-523 NP denotes Dex
C14 528-531 NP denotes CsA
C16 579-583 NP denotes AP-1
C17 588-593 NP denotes NF-AT
C15 557-593 NP denotes transcription factors AP-1 and NF-AT
C18 606-611 NP denotes NF-kB
C19 659-681 NP denotes the IL-2 gene promoter
C20 864-867 NP denotes DNA
C22 945-969 NP denotes the intact IL-2 promoter
C23 973-976 NP denotes its
C24 977-981 NP denotes AP-1
C25 983-988 NP denotes NF-AT
C26 994-999 NP denotes NF-kB
C21 918-1006 NP denotes plasmids containing either the intact IL-2 promoter or its AP-1, NF-AT, and NF-kB motifs
C27 1008-1011 NP denotes Dex
C28 1022-1039 NP denotes the IL-2 promoter
C29 1044-1052 NP denotes the AP-1
C31 1066-1071 NP denotes NF-AT
C33 1076-1081 NP denotes NF-kB
C32 1076-1090 NP denotes NF-kB plasmids
C30 1062-1090 NP denotes the NF-AT and NF-kB plasmids
C34 1105-1108 NP denotes CsA
C35 1119-1136 NP denotes the IL-2 promoter
C36 1145-1150 NP denotes NF-AT
C38 1160-1168 NP denotes the AP-1
C40 1173-1178 NP denotes NF-kB
C39 1173-1187 NP denotes NF-kB plasmids
C37 1160-1187 NP denotes the AP-1 and NF-kB plasmids
C41 1219-1238 NP denotes human T lymphocytes
C42 1244-1247 NP denotes Dex
C43 1252-1255 NP denotes CsA
C44 1266-1289 NP denotes IL-2 gene transcription
C47 1338-1342 NP denotes AP-1
C48 1347-1352 NP denotes NF-AT
C46 1316-1352 NP denotes transcription factors AP-1 and NF-AT
C45 1298-1352 NP denotes interference with transcription factors AP-1 and NF-AT
C49 1425-1451 NP denotes both transcription factors
C50 1453-1457 NP denotes AP-1
C52 1483-1486 NP denotes Dex
C51 1461-1486 NP denotes the primary target of Dex
R1 C9 C6 coref-ident IL-2 gene transcription,IL-2 gene transcription
R2 C13 C7 coref-ident Dex,dexamethasone (Dex)
R3 C14 C8 coref-ident CsA,cyclosporin A (CsA)
R4 C16 C4 coref-ident AP-1,AP-1
R5 C17 C5 coref-ident NF-AT,NF-AT
R6 C15 C3 coref-ident transcription factors AP-1 and NF-AT,nuclear transcription factors AP-1 and NF-AT
R7 C19 C10 coref-ident the IL-2 gene promoter,the IL-2 promoter
R8 C20 C12 coref-ident DNA,DNA
R9 C22 C19 coref-other the intact IL-2 promoter,the IL-2 gene promoter
R10 C23 C22 coref-pron its,the intact IL-2 promoter
R11 C24 C16 coref-ident AP-1,AP-1
R12 C25 C17 coref-ident NF-AT,NF-AT
R13 C26 C18 coref-ident NF-kB,NF-kB
R14 C27 C13 coref-ident Dex,Dex
R15 C28 C22 coref-ident the IL-2 promoter,the intact IL-2 promoter
R16 C29 C24 coref-ident the AP-1,AP-1
R17 C31 C25 coref-ident NF-AT,NF-AT
R18 C33 C18 coref-ident NF-kB,NF-kB
R19 C30 C21 coref-part-whole the NF-AT and NF-kB plasmids,"plasmids containing either the intact IL-2 promoter or its AP-1, NF-AT, and NF-kB motifs"
R20 C34 C14 coref-ident CsA,CsA
R21 C35 C28 coref-ident the IL-2 promoter,the IL-2 promoter
R22 C36 C31 coref-ident NF-AT,NF-AT
R23 C38 C29 coref-ident the AP-1,the AP-1
R24 C40 C33 coref-ident NF-kB,NF-kB
R25 C39 C32 coref-ident NF-kB plasmids,NF-kB plasmids
R26 C37 C30 coref-ident the AP-1 and NF-kB plasmids,the NF-AT and NF-kB plasmids
R27 C41 C11 coref-other human T lymphocytes,primary human T lymphocytes
R28 C42 C27 coref-ident Dex,Dex
R29 C43 C34 coref-ident CsA,CsA
R30 C44 C9 coref-ident IL-2 gene transcription,IL-2 gene transcription
R31 C47 C29 coref-ident AP-1,the AP-1
R32 C48 C36 coref-ident NF-AT,NF-AT
R33 C46 C15 coref-ident transcription factors AP-1 and NF-AT,transcription factors AP-1 and NF-AT
R34 C45 C2 coref-ident interference with transcription factors AP-1 and NF-AT,interference with nuclear transcription factors AP-1 and NF-AT
R35 C49 C46 coref-ident both transcription factors,transcription factors AP-1 and NF-AT
R36 C50 C47 coref-ident AP-1,AP-1
R37 C52 C42 coref-ident Dex,Dex
R38 C51 C50 coref-ident the primary target of Dex,AP-1

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-35 other_name denotes Negative transcriptional regulation
T2 39-58 protein_molecule denotes human interleukin 2
T3 60-64 protein_molecule denotes IL-2
T4 74-89 lipid denotes glucocorticoids
T5 116-145 protein_family_or_group denotes nuclear transcription factors
T6 146-150 protein_molecule denotes AP-1
T7 155-160 protein_molecule denotes NF-AT
T8 162-171 DNA_domain_or_region denotes IL-2 gene
T9 209-225 protein_family_or_group denotes nuclear proteins
T10 244-257 lipid denotes dexamethasone
T11 259-262 lipid denotes Dex
T12 268-281 other_organic_compound denotes cyclosporin A
T13 283-286 other_organic_compound denotes CsA
T14 296-305 DNA_domain_or_region denotes IL-2 gene
T15 356-372 protein_family_or_group denotes nuclear proteins
T16 427-454 cell_type denotes primary human T lymphocytes
T17 472-513 other_name denotes electrophoretic DNA mobility shift assays
T18 520-523 lipid denotes Dex
T19 528-531 other_organic_compound denotes CsA
T20 579-583 protein_molecule denotes AP-1
T21 588-593 protein_molecule denotes NF-AT
T22 606-611 protein_family_or_group denotes NF-kB
T23 616-625 protein_molecule denotes OCT-1/OAF
T24 663-681 DNA_domain_or_region denotes IL-2 gene promoter
T25 820-833 DNA_domain_or_region denotes IL-2 promoter
T26 883-895 cell_line denotes Jurkat cells
T27 918-926 DNA_molecule denotes plasmids
T28 956-969 DNA_domain_or_region denotes IL-2 promoter
T29 1026-1039 DNA_domain_or_region denotes IL-2 promoter
T30 1048-1052 DNA_molecule denotes AP-1
T31 1066-1071 DNA_molecule denotes NF-AT
T32 1076-1090 DNA_molecule denotes NF-kB plasmids
T33 1105-1108 other_organic_compound denotes CsA
T34 1123-1136 DNA_domain_or_region denotes IL-2 promoter
T35 1145-1150 DNA_molecule denotes NF-AT
T36 1164-1168 DNA_molecule denotes AP-1
T37 1173-1187 DNA_molecule denotes NF-kB plasmids
T38 1219-1238 cell_type denotes human T lymphocytes
T39 1244-1247 lipid denotes Dex
T40 1252-1255 other_organic_compound denotes CsA
T41 1266-1275 DNA_domain_or_region denotes IL-2 gene
T42 1316-1337 protein_family_or_group denotes transcription factors
T43 1338-1342 protein_molecule denotes AP-1
T44 1347-1352 protein_molecule denotes NF-AT
T45 1430-1451 protein_family_or_group denotes transcription factors
T46 1453-1457 protein_molecule denotes AP-1
T47 1483-1486 lipid denotes Dex