> top > docs > PubMed:8436816 > annotations

PubMed:8436816 JSONTXT

Annnotations TAB JSON ListView MergeView

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 61-101 protein denotes class II MHC X1 box DNA-binding proteins
T2 105-145 cell_line denotes wild-type and class II-deficient B cells
T3 151-163 DNA denotes X box region
T4 208-255 DNA denotes class II major histocompatibility complex genes
T5 259-272 cell_type denotes B lymphocytes
T6 291-337 protein denotes class II promoter-specific DNA binding factors
T7 368-380 DNA denotes X box region
T8 389-392 protein denotes RFX
T9 472-484 cell_line denotes B cell lines
T10 592-618 protein denotes X box DNA-binding proteins
T11 622-635 DNA denotes class II gene
T12 664-676 DNA denotes X box region
T13 698-715 cell_line denotes class II-positive
T14 720-744 cell_line denotes -negative lymphoid cells
T15 765-791 cell_line denotes wild-type B cell line Raji
T16 793-839 cell_line denotes two class II transcriptional mutant cell lines
T17 841-844 cell_line denotes SJO
T18 849-856 cell_line denotes RJ2.2.5
T19 862-868 cell_line denotes Jurkat
T20 872-901 cell_line denotes class II negative T cell line
T21 933-950 cell_line denotes wild-type B cells
T22 967-993 cell_line denotes class II mutant cell lines
T23 1008-1020 DNA denotes X box region
T24 1075-1088 DNA denotes reporter gene
T25 1207-1233 protein denotes X1 box DNA-binding protein
T26 1234-1237 protein denotes RFX
T27 1278-1295 cell_line denotes wild-type B cells
T28 1311-1318 cell_line denotes RJ2.2.5
T29 1337-1340 cell_line denotes SJO
T30 1345-1351 cell_line denotes Jurkat
T31 1422-1432 cell_line denotes cell lines
T32 1510-1530 protein denotes DNA binding proteins
T33 1574-1582 protein denotes protease
T34 1730-1749 protein denotes X1-specific factors
T35 1809-1812 protein denotes RFX
T36 1889-1901 cell_line denotes Jurkat cells
T37 1986-1989 protein denotes RFX
T38 2048-2051 cell_line denotes SJO
T39 2207-2221 cell_type denotes lymphoid cells
T40 2263-2266 protein denotes RFX

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-146 Sentence denotes Protease treatment of nuclear extracts distinguishes between class II MHC X1 box DNA-binding proteins in wild-type and class II-deficient B cells.
S2 147-273 Sentence denotes The X box region is critical for directing the expression of class II major histocompatibility complex genes in B lymphocytes.
S3 274-559 Sentence denotes Although several class II promoter-specific DNA binding factors have been described, only the X box region factor, RFX, shows a genetic correlation with class II expression, being deficient in some B cell lines derived from patients with class II-deficient congenital immunodeficiency.
S4 560-745 Sentence denotes To further evaluate the role of X box DNA-binding proteins in class II gene expression, the role of the X box region was examined in both class II-positive and -negative lymphoid cells.
S5 746-917 Sentence denotes In addition to the wild-type B cell line Raji, two class II transcriptional mutant cell lines, SJO and RJ2.2.5, and Jurkat, a class II negative T cell line, were examined.
S6 918-1178 Sentence denotes In contrast to wild-type B cells, neither of the class II mutant cell lines could use the X box region to direct the expression of a transiently transfected reporter gene, indicating that the X box-dependent transcriptional pathway is defective in these cells.
S7 1179-1352 Sentence denotes The binding activity of the X1 box DNA-binding protein RFX was examined and found to be present in wild-type B cells and the mutant RJ2.2.5 but was absent in SJO and Jurkat.
S8 1353-1433 Sentence denotes However, other X1 box-specific activities were detected in all these cell lines.
S9 1434-1750 Sentence denotes To determine whether these different X1 box activities represented distinct DNA binding proteins or multimeric forms of the same factor(s), protease treatment of the crude nuclear extracts followed by DNA-binding assays were carried out and demonstrated that B cell extracts contain at least two X1-specific factors.
S10 1751-1822 Sentence denotes One of these cleaved products (band 1 pk) correlates with RFX activity.
S11 1823-1999 Sentence denotes A similar comparison with protease-treated extracts prepared from Jurkat cells demonstrated the presence of the band 1pk activity despite an absence of the native RFX activity.
S12 2000-2114 Sentence denotes In contrast, protease treatment and analysis of SJO extracts showed no detectable levels of the band 1pk activity.
S13 2115-2314 Sentence denotes These results demonstrate that multiple X1 box-specific DNA-binding activities exist in all lymphoid cells, but the presence of an actively binding RFX species correlates with class II transcription.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 147-163 NP denotes The X box region
C2 364-387 NP denotes the X box region factor
C3 389-392 NP denotes RFX
C4 427-446 NP denotes class II expression
C5 622-646 NP denotes class II gene expression
C6 660-676 NP denotes the X box region
C7 761-791 NP denotes the wild-type B cell line Raji
C8 793-839 NP denotes two class II transcriptional mutant cell lines
C9 841-856 NP denotes SJO and RJ2.2.5
C10 862-868 NP denotes Jurkat
C11 870-901 NP denotes a class II negative T cell line
C12 933-950 NP denotes wild-type B cells
C13 1004-1020 NP denotes the X box region
C14 1166-1177 NP denotes these cells
C15 1203-1237 NP denotes the X1 box DNA-binding protein RFX
C17 1278-1295 NP denotes wild-type B cells
C16 1278-1351 NP denotes wild-type B cells and the mutant RJ2.2.5 but was absent in SJO and Jurkat
C18 1412-1432 NP denotes all these cell lines
C19 1809-1821 NP denotes RFX activity
C20 1931-1952 NP denotes the band 1pk activity
C21 1975-1998 NP denotes the native RFX activity
C22 2092-2113 NP denotes the band 1pk activity
R1 C3 C2 coref-appos RFX,the X box region factor
R2 C5 C4 coref-ident class II gene expression,class II expression
R3 C6 C1 coref-ident the X box region,The X box region
R4 C9 C8 coref-appos SJO and RJ2.2.5,two class II transcriptional mutant cell lines
R5 C11 C10 coref-appos a class II negative T cell line,Jurkat
R6 C12 C7 coref-ident wild-type B cells,the wild-type B cell line Raji
R7 C13 C6 coref-ident the X box region,the X box region
R8 C14 C8 coref-ident these cells,two class II transcriptional mutant cell lines
R9 C15 C3 coref-ident the X1 box DNA-binding protein RFX,RFX
R10 C16 C12 coref-ident wild-type B cells and the mutant RJ2.2.5 but was absent in SJO and Jurkat,wild-type B cells
R11 C18 C17 coref-ident all these cell lines,wild-type B cells
R12 C21 C19 coref-ident the native RFX activity,RFX activity
R13 C22 C20 coref-ident the band 1pk activity,the band 1pk activity

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 61-101 protein_family_or_group denotes class II MHC X1 box DNA-binding proteins
T2 151-163 DNA_domain_or_region denotes X box region
T3 208-255 DNA_family_or_group denotes class II major histocompatibility complex genes
T4 259-272 cell_type denotes B lymphocytes
T5 291-337 protein_family_or_group denotes class II promoter-specific DNA binding factors
T6 368-380 DNA_domain_or_region denotes X box region
T7 389-392 protein_molecule denotes RFX
T8 427-446 other_name denotes class II expression
T9 472-484 cell_line denotes B cell lines
T10 512-558 other_name denotes class II-deficient congenital immunodeficiency
T11 592-618 protein_family_or_group denotes X box DNA-binding proteins
T12 622-635 DNA_family_or_group denotes class II gene
T13 664-676 DNA_domain_or_region denotes X box region
T14 698-715 cell_line denotes class II-positive
T15 720-744 cell_line denotes -negative lymphoid cells
T16 765-791 cell_line denotes wild-type B cell line Raji
T17 793-839 cell_line denotes two class II transcriptional mutant cell lines
T18 841-844 cell_line denotes SJO
T19 849-856 cell_line denotes RJ2.2.5
T20 862-868 cell_line denotes Jurkat
T21 872-901 cell_line denotes class II negative T cell line
T22 933-950 cell_line denotes wild-type B cells
T23 967-993 cell_line denotes class II mutant cell lines
T24 1008-1020 DNA_domain_or_region denotes X box region
T25 1075-1088 DNA_family_or_group denotes reporter gene
T26 1110-1149 other_name denotes X box-dependent transcriptional pathway
T27 1207-1233 protein_molecule denotes X1 box DNA-binding protein
T28 1234-1237 protein_molecule denotes RFX
T29 1278-1295 cell_line denotes wild-type B cells
T30 1311-1318 cell_line denotes RJ2.2.5
T31 1337-1340 cell_line denotes SJO
T32 1345-1351 cell_line denotes Jurkat
T33 1368-1394 other_name denotes X1 box-specific activities
T34 1422-1432 cell_line denotes cell lines
T35 1471-1488 other_name denotes X1 box activities
T36 1510-1530 protein_family_or_group denotes DNA binding proteins
T37 1574-1582 protein_family_or_group denotes protease
T38 1635-1653 other_name denotes DNA-binding assays
T39 1693-1708 cell_component denotes B cell extracts
T40 1730-1749 protein_family_or_group denotes X1-specific factors
T41 1809-1812 protein_molecule denotes RFX
T42 1889-1895 cell_line denotes Jurkat
T43 1935-1952 other_name denotes band 1pk activity
T44 1979-1985 other_name denotes native
T45 1986-1989 protein_molecule denotes RFX
T46 2048-2051 cell_line denotes SJO
T47 2096-2113 other_name denotes band 1pk activity
T48 2155-2193 other_name denotes X1 box-specific DNA-binding activities
T49 2207-2221 cell_type denotes lymphoid cells
T50 2263-2266 protein_molecule denotes RFX
T51 2291-2313 other_name denotes class II transcription