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PubMed:8430069 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 4-31 protein denotes c-rel protooncogene product
T2 42-52 protein denotes NF-kappa B
T3 53-56 protein denotes p65
T4 165-185 DNA denotes long terminal repeat
T5 187-190 DNA denotes LTR
T6 251-271 DNA denotes 5' regulatory region
T7 297-333 protein denotes interleukin 2 receptor alpha subunit
T8 335-346 protein denotes IL-2R alpha
T9 365-390 DNA denotes kappa B enhancer elements
T10 489-514 DNA denotes kappa B enhancer elements
T11 601-604 protein denotes p50
T12 606-609 protein denotes p65
T13 634-653 DNA denotes c-rel protooncogene
T14 655-660 protein denotes c-Rel
T15 706-709 protein denotes p65
T16 714-717 protein denotes p50
T17 740-758 protein denotes NF-kappa B complex
T18 954-963 DNA denotes HIV-1 LTR
T19 971-991 DNA denotes IL-2R alpha promoter
T20 1041-1044 protein denotes p65
T21 1098-1103 protein denotes c-Rel
T22 1149-1176 protein denotes tumor necrosis factor alpha
T23 1211-1214 protein denotes p65
T24 1235-1238 protein denotes p65
T25 1317-1322 protein denotes c-Rel
T26 1411-1414 protein denotes p50
T27 1432-1437 protein denotes c-Rel
T28 1475-1482 protein denotes p50/p65
T29 1584-1589 protein denotes c-Rel
T30 1627-1636 DNA denotes HIV-1 LTR
T31 1641-1652 protein denotes IL-2R alpha
T32 1744-1747 protein denotes p65

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-160 Sentence denotes The c-rel protooncogene product represses NF-kappa B p65-mediated transcriptional activation of the long terminal repeat of type 1 human immunodeficiency virus.
S2 161-482 Sentence denotes The long terminal repeat (LTR) of the type 1 human immunodeficiency virus (HIV-1) and the 5' regulatory region of the gene encoding the interleukin 2 receptor alpha subunit (IL-2R alpha) share functional kappa B enhancer elements involved in the regulation of these inducible transcription units during T-cell activation.
S3 483-662 Sentence denotes These kappa B enhancer elements are recognized by a structurally related family of interactive proteins that includes p50, p65, and the product of the c-rel protooncogene (c-Rel).
S4 663-849 Sentence denotes Recent biochemical studies have shown that p65 and p50 form the prototypical NF-kappa B complex, which is rapidly translocated from the cytoplasm to the nucleus during T-cell activation.
S5 850-1045 Sentence denotes This intracellular signaling complex potently stimulates kappa B-directed transcription from either the HIV-1 LTR or the IL-2R alpha promoter via the strong transactivation domain present in p65.
S6 1046-1288 Sentence denotes We now demonstrate that nuclear expression of human c-Rel, which is induced by either phorbol ester or tumor necrosis factor alpha with delayed kinetics relative to p65, markedly represses p65-mediated activation of these transcription units.
S7 1289-1529 Sentence denotes These inhibitory effects of c-Rel correlate with its DNA-binding activity but not with its ability to heterodimerize with p50, suggesting that c-Rel inhibition involves competition with p50/p65 for occupancy of the kappa B enhancer element.
S8 1530-1748 Sentence denotes Together, these findings suggest that one function of c-Rel is as a physiologic repressor of the HIV-1 LTR and IL-2R alpha promoters, serving to efficiently counter the strong transcriptional activating effects of p65.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 0-31 NP denotes The c-rel protooncogene product
C2 96-159 NP denotes the long terminal repeat of type 1 human immunodeficiency virus
C4 161-242 NP denotes The long terminal repeat (LTR) of the type 1 human immunodeficiency virus (HIV-1)
C6 293-347 NP denotes the interleukin 2 receptor alpha subunit (IL-2R alpha)
C5 247-347 NP denotes the 5' regulatory region of the gene encoding the interleukin 2 receptor alpha subunit (IL-2R alpha)
C3 161-347 NP denotes The long terminal repeat (LTR) of the type 1 human immunodeficiency virus (HIV-1) and the 5' regulatory region of the gene encoding the interleukin 2 receptor alpha subunit (IL-2R alpha)
C8 421-456 NP denotes these inducible transcription units
C9 464-481 NP denotes T-cell activation
C7 354-481 NP denotes functional kappa B enhancer elements involved in the regulation of these inducible transcription units during T-cell activation
C10 483-514 NP denotes These kappa B enhancer elements
C11 533-586 NP denotes a structurally related family of interactive proteins
C12 587-591 NP denotes that
C13 601-604 NP denotes p50
C14 606-609 NP denotes p65
C16 630-661 NP denotes the c-rel protooncogene (c-Rel)
C15 615-661 NP denotes the product of the c-rel protooncogene (c-Rel)
C17 706-709 NP denotes p65
C18 714-717 NP denotes p50
C19 723-758 NP denotes the prototypical NF-kappa B complex
C20 760-765 NP denotes which
C21 831-848 NP denotes T-cell activation
C22 850-886 NP denotes This intracellular signaling complex
C23 950-963 NP denotes the HIV-1 LTR
C25 971-982 NP denotes IL-2R alpha
C24 967-991 NP denotes the IL-2R alpha promoter
C26 1041-1044 NP denotes p65
C28 1092-1103 NP denotes human c-Rel
C27 1070-1103 NP denotes nuclear expression of human c-Rel
C29 1105-1110 NP denotes which
C30 1211-1214 NP denotes p65
C31 1262-1287 NP denotes these transcription units
C32 1317-1322 NP denotes c-Rel
C33 1338-1341 NP denotes its
C34 1376-1379 NP denotes its
C35 1411-1414 NP denotes p50
C36 1432-1437 NP denotes c-Rel
C37 1475-1478 NP denotes p50
C38 1479-1482 NP denotes p65
C39 1500-1528 NP denotes the kappa B enhancer element
C40 1584-1589 NP denotes c-Rel
C41 1627-1636 NP denotes HIV-1 LTR
C43 1641-1652 NP denotes IL-2R alpha
C42 1641-1662 NP denotes IL-2R alpha promoters
C44 1744-1747 NP denotes p65
R1 C4 C2 coref-ident The long terminal repeat (LTR) of the type 1 human immunodeficiency virus (HIV-1),the long terminal repeat of type 1 human immunodeficiency virus
R2 C8 C3 coref-other these inducible transcription units,The long terminal repeat (LTR) of the type 1 human immunodeficiency virus (HIV-1) and the 5' regulatory region of the gene encoding the interleukin 2 receptor alpha subunit (IL-2R alpha)
R3 C10 C7 coref-ident These kappa B enhancer elements,functional kappa B enhancer elements involved in the regulation of these inducible transcription units during T-cell activation
R4 C12 C11 coref-relat that,a structurally related family of interactive proteins
R5 C15 C1 coref-ident the product of the c-rel protooncogene (c-Rel),The c-rel protooncogene product
R6 C17 C14 coref-ident p65,p65
R7 C18 C13 coref-ident p50,p50
R8 C20 C19 coref-relat which,the prototypical NF-kappa B complex
R9 C21 C9 coref-ident T-cell activation,T-cell activation
R10 C22 C19 coref-ident This intracellular signaling complex,the prototypical NF-kappa B complex
R11 C23 C4 coref-ident the HIV-1 LTR,The long terminal repeat (LTR) of the type 1 human immunodeficiency virus (HIV-1)
R12 C25 C6 coref-ident IL-2R alpha,the interleukin 2 receptor alpha subunit (IL-2R alpha)
R13 C24 C5 coref-other the IL-2R alpha promoter,the 5' regulatory region of the gene encoding the interleukin 2 receptor alpha subunit (IL-2R alpha)
R14 C26 C17 coref-ident p65,p65
R15 C28 C16 coref-other human c-Rel,the c-rel protooncogene (c-Rel)
R16 C29 C27 coref-relat which,nuclear expression of human c-Rel
R17 C30 C26 coref-ident p65,p65
R18 C31 C8 coref-ident these transcription units,these inducible transcription units
R19 C32 C28 coref-other c-Rel,human c-Rel
R20 C33 C32 coref-pron its,c-Rel
R21 C34 C32 coref-pron its,c-Rel
R22 C35 C18 coref-ident p50,p50
R23 C36 C32 coref-ident c-Rel,c-Rel
R24 C37 C35 coref-ident p50,p50
R25 C38 C30 coref-ident p65,p65
R26 C39 C10 coref-other the kappa B enhancer element,These kappa B enhancer elements
R27 C40 C36 coref-ident c-Rel,c-Rel
R28 C41 C23 coref-ident HIV-1 LTR,the HIV-1 LTR
R29 C43 C25 coref-ident IL-2R alpha,IL-2R alpha
R30 C42 C24 coref-ident IL-2R alpha promoters,the IL-2R alpha promoter
R31 C44 C38 coref-ident p65,p65

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 4-23 DNA_domain_or_region denotes c-rel protooncogene
T2 42-52 protein_molecule denotes NF-kappa B
T3 53-56 protein_subunit denotes p65
T4 66-92 other_name denotes transcriptional activation
T5 131-159 virus denotes human immunodeficiency virus
T6 165-185 DNA_domain_or_region denotes long terminal repeat
T7 187-190 DNA_domain_or_region denotes LTR
T8 199-205 virus denotes type 1
T9 206-234 virus denotes human immunodeficiency virus
T10 236-241 virus denotes HIV-1
T11 251-271 DNA_domain_or_region denotes 5' regulatory region
T12 297-333 protein_subunit denotes interleukin 2 receptor alpha subunit
T13 335-346 protein_subunit denotes IL-2R alpha
T14 365-390 DNA_domain_or_region denotes kappa B enhancer elements
T15 464-481 other_name denotes T-cell activation
T16 489-514 DNA_domain_or_region denotes kappa B enhancer elements
T17 601-604 protein_molecule denotes p50
T18 606-609 protein_molecule denotes p65
T19 634-653 DNA_domain_or_region denotes c-rel protooncogene
T20 655-660 protein_molecule denotes c-Rel
T21 706-709 protein_molecule denotes p65
T22 714-717 protein_molecule denotes p50
T23 740-750 protein_molecule denotes NF-kappa B
T24 799-808 cell_component denotes cytoplasm
T25 816-823 cell_component denotes nucleus
T26 831-848 other_name denotes T-cell activation
T27 907-937 other_name denotes kappa B-directed transcription
T28 954-963 DNA_domain_or_region denotes HIV-1 LTR
T29 971-982 protein_molecule denotes IL-2R alpha
T30 1041-1044 protein_molecule denotes p65
T31 1098-1103 protein_molecule denotes c-Rel
T32 1132-1145 other_organic_compound denotes phorbol ester
T33 1149-1176 protein_molecule denotes tumor necrosis factor alpha
T34 1211-1214 protein_subunit denotes p65
T35 1235-1238 protein_molecule denotes p65
T36 1317-1322 protein_molecule denotes c-Rel
T37 1342-1362 other_name denotes DNA-binding activity
T38 1411-1414 protein_molecule denotes p50
T39 1432-1437 protein_molecule denotes c-Rel
T40 1475-1478 protein_molecule denotes p50
T41 1478-1482 protein_molecule denotes /p65
T42 1584-1589 protein_molecule denotes c-Rel
T43 1627-1636 DNA_domain_or_region denotes HIV-1 LTR
T44 1641-1652 protein_molecule denotes IL-2R alpha
T45 1744-1747 protein_molecule denotes p65