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PubMed:8428966 JSONTXT

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CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 112-119 Cell denotes T cells http://purl.obolibrary.org/obo/CL:0000084
T2 229-236 Cell denotes T cells http://purl.obolibrary.org/obo/CL:0000084
T3 275-281 Cell denotes T cell http://purl.obolibrary.org/obo/CL:0000084
T4 1417-1430 Cell denotes T lymphocytes http://purl.obolibrary.org/obo/CL:0000084

sentences

Id Subject Object Predicate Lexical cue
T1 0-136 Sentence denotes Characterization of the nuclear and cytoplasmic components of the lymphoid-specific nuclear factor of activated T cells (NF-AT) complex.
T2 137-418 Sentence denotes The lymphoid-specific transcription complex, NF-AT, is involved in early gene activation in T cells and is assembled from a pre-existing, T cell restricted cytoplasmic factor and an inducible ubiquitous nuclear component within 30 min after activation through the antigen receptor.
T3 419-518 Sentence denotes Recent studies have implicated the family of AP1 factors as components of the murine NF-AT complex.
T4 519-659 Sentence denotes Evidence is provided here that the nuclear component of human NF-AT contains the phorbol ester-inducible transcription factor AP1 (Jun/Fos).
T5 660-730 Sentence denotes We further characterize which AP1 family members can assume this role.
T6 731-835 Sentence denotes Antisera to Fos inhibits NF-AT DNA binding as does an oligonucleotide containing a binding site for AP1.
T7 836-1063 Sentence denotes Constitutive expression in vivo of Fos, and to a lesser extent Fra-1, eliminates the requirement for phorbol 12-myristate 13-acetate (PMA) stimulation, leaving NF-AT-directed transcription responsive to calcium ionophore alone.
T8 1064-1311 Sentence denotes Overexpression of cJun or JunD, but not JunB, also eliminates the requirement for PMA, indicating that many but not all Jun- and Fos-related proteins functionally activate NF-AT-dependent transcription in the presence of the cytoplasmic component.
T9 1312-1431 Sentence denotes NF-AT DNA binding can be reconstituted in vitro using semi-purified AP1 proteins mixed with cytosol from T lymphocytes.
T10 1432-1574 Sentence denotes Fos proteins are not needed for this reconstitution, and although JunB is not functional, it can participate in the NF-AT DNA binding complex.
T11 1575-1836 Sentence denotes Finally, we have partially purified the cytoplasmic component of NF-AT and show by elution and renaturation from SDS-polyacrylamide gel electrophoresis gels that it has a molecular mass between 94 and 116 kDa and may have multiple differentially modified forms.
T1 0-136 Sentence denotes Characterization of the nuclear and cytoplasmic components of the lymphoid-specific nuclear factor of activated T cells (NF-AT) complex.
T2 137-418 Sentence denotes The lymphoid-specific transcription complex, NF-AT, is involved in early gene activation in T cells and is assembled from a pre-existing, T cell restricted cytoplasmic factor and an inducible ubiquitous nuclear component within 30 min after activation through the antigen receptor.
T3 419-518 Sentence denotes Recent studies have implicated the family of AP1 factors as components of the murine NF-AT complex.
T4 519-659 Sentence denotes Evidence is provided here that the nuclear component of human NF-AT contains the phorbol ester-inducible transcription factor AP1 (Jun/Fos).
T5 660-730 Sentence denotes We further characterize which AP1 family members can assume this role.
T6 731-835 Sentence denotes Antisera to Fos inhibits NF-AT DNA binding as does an oligonucleotide containing a binding site for AP1.
T7 836-1063 Sentence denotes Constitutive expression in vivo of Fos, and to a lesser extent Fra-1, eliminates the requirement for phorbol 12-myristate 13-acetate (PMA) stimulation, leaving NF-AT-directed transcription responsive to calcium ionophore alone.
T8 1064-1311 Sentence denotes Overexpression of cJun or JunD, but not JunB, also eliminates the requirement for PMA, indicating that many but not all Jun- and Fos-related proteins functionally activate NF-AT-dependent transcription in the presence of the cytoplasmic component.
T9 1312-1431 Sentence denotes NF-AT DNA binding can be reconstituted in vitro using semi-purified AP1 proteins mixed with cytosol from T lymphocytes.
T10 1432-1574 Sentence denotes Fos proteins are not needed for this reconstitution, and although JunB is not functional, it can participate in the NF-AT DNA binding complex.
T11 1575-1836 Sentence denotes Finally, we have partially purified the cytoplasmic component of NF-AT and show by elution and renaturation from SDS-polyacrylamide gel electrophoresis gels that it has a molecular mass between 94 and 116 kDa and may have multiple differentially modified forms.

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 66-98 protein denotes lymphoid-specific nuclear factor
T2 102-119 cell_type denotes activated T cells
T3 121-126 protein denotes NF-AT
T4 141-180 protein denotes lymphoid-specific transcription complex
T5 182-187 protein denotes NF-AT
T6 229-236 cell_type denotes T cells
T7 275-311 protein denotes T cell restricted cytoplasmic factor
T8 329-339 protein denotes ubiquitous
T9 340-357 protein denotes nuclear component
T10 401-417 protein denotes antigen receptor
T11 464-475 protein denotes AP1 factors
T12 497-517 protein denotes murine NF-AT complex
T13 575-586 protein denotes human NF-AT
T14 600-648 protein denotes phorbol ester-inducible transcription factor AP1
T15 650-657 protein denotes Jun/Fos
T16 690-708 protein denotes AP1 family members
T17 743-746 protein denotes Fos
T18 756-761 protein denotes NF-AT
T19 814-834 DNA denotes binding site for AP1
T20 871-874 protein denotes Fos
T21 899-904 protein denotes Fra-1
T22 996-1001 protein denotes NF-AT
T23 1082-1086 protein denotes cJun
T24 1090-1094 protein denotes JunD
T25 1104-1108 protein denotes JunB
T26 1184-1213 protein denotes Jun- and Fos-related proteins
T27 1236-1241 protein denotes NF-AT
T28 1312-1317 protein denotes NF-AT
T29 1366-1392 protein denotes semi-purified AP1 proteins
T30 1417-1430 cell_type denotes T lymphocytes
T31 1498-1502 protein denotes JunB
T32 1548-1573 protein denotes NF-AT DNA binding complex

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-136 Sentence denotes Characterization of the nuclear and cytoplasmic components of the lymphoid-specific nuclear factor of activated T cells (NF-AT) complex.
S2 137-418 Sentence denotes The lymphoid-specific transcription complex, NF-AT, is involved in early gene activation in T cells and is assembled from a pre-existing, T cell restricted cytoplasmic factor and an inducible ubiquitous nuclear component within 30 min after activation through the antigen receptor.
S3 419-518 Sentence denotes Recent studies have implicated the family of AP1 factors as components of the murine NF-AT complex.
S4 519-659 Sentence denotes Evidence is provided here that the nuclear component of human NF-AT contains the phorbol ester-inducible transcription factor AP1 (Jun/Fos).
S5 660-730 Sentence denotes We further characterize which AP1 family members can assume this role.
S6 731-835 Sentence denotes Antisera to Fos inhibits NF-AT DNA binding as does an oligonucleotide containing a binding site for AP1.
S7 836-1063 Sentence denotes Constitutive expression in vivo of Fos, and to a lesser extent Fra-1, eliminates the requirement for phorbol 12-myristate 13-acetate (PMA) stimulation, leaving NF-AT-directed transcription responsive to calcium ionophore alone.
S8 1064-1311 Sentence denotes Overexpression of cJun or JunD, but not JunB, also eliminates the requirement for PMA, indicating that many but not all Jun- and Fos-related proteins functionally activate NF-AT-dependent transcription in the presence of the cytoplasmic component.
S9 1312-1431 Sentence denotes NF-AT DNA binding can be reconstituted in vitro using semi-purified AP1 proteins mixed with cytosol from T lymphocytes.
S10 1432-1574 Sentence denotes Fos proteins are not needed for this reconstitution, and although JunB is not functional, it can participate in the NF-AT DNA binding complex.
S11 1575-1836 Sentence denotes Finally, we have partially purified the cytoplasmic component of NF-AT and show by elution and renaturation from SDS-polyacrylamide gel electrophoresis gels that it has a molecular mass between 94 and 116 kDa and may have multiple differentially modified forms.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C2 62-135 NP denotes the lymphoid-specific nuclear factor of activated T cells (NF-AT) complex
C1 20-135 NP denotes the nuclear and cytoplasmic components of the lymphoid-specific nuclear factor of activated T cells (NF-AT) complex
C3 137-180 NP denotes The lymphoid-specific transcription complex
C4 182-187 NP denotes NF-AT
C5 229-236 NP denotes T cells
C8 275-281 NP denotes T cell
C7 259-311 NP denotes a pre-existing, T cell restricted cytoplasmic factor
C9 316-357 NP denotes an inducible ubiquitous nuclear component
C6 259-357 NP denotes a pre-existing, T cell restricted cytoplasmic factor and an inducible ubiquitous nuclear component
C10 450-475 NP denotes the family of AP1 factors
C11 493-517 NP denotes the murine NF-AT complex
C13 575-586 NP denotes human NF-AT
C12 550-586 NP denotes the nuclear component of human NF-AT
C14 596-658 NP denotes the phorbol ester-inducible transcription factor AP1 (Jun/Fos)
C15 690-700 NP denotes AP1 family
C16 743-746 NP denotes Fos
C18 756-761 NP denotes NF-AT
C17 756-773 NP denotes NF-AT DNA binding
C19 831-834 NP denotes AP1
C20 871-874 NP denotes Fos
C21 937-974 NP denotes phorbol 12-myristate 13-acetate (PMA)
C22 996-1024 NP denotes NF-AT-directed transcription
C23 1104-1108 NP denotes JunB
C24 1146-1149 NP denotes PMA
C25 1236-1265 NP denotes NF-AT-dependent transcription
C26 1285-1310 NP denotes the cytoplasmic component
C28 1312-1317 NP denotes NF-AT
C27 1312-1329 NP denotes NF-AT DNA binding
C29 1380-1383 NP denotes AP1
C30 1432-1435 NP denotes Fos
C31 1498-1502 NP denotes JunB
C32 1522-1524 NP denotes it
C34 1548-1553 NP denotes NF-AT
C33 1548-1565 NP denotes NF-AT DNA binding
C36 1640-1645 NP denotes NF-AT
C35 1611-1645 NP denotes the cytoplasmic component of NF-AT
C37 1737-1739 NP denotes it
R1 C3 C2 coref-ident The lymphoid-specific transcription complex,the lymphoid-specific nuclear factor of activated T cells (NF-AT) complex
R2 C4 C3 coref-appos NF-AT,The lymphoid-specific transcription complex
R3 C8 C5 coref-ident T cell,T cells
R4 C6 C1 coref-other "a pre-existing, T cell restricted cytoplasmic factor and an inducible ubiquitous nuclear component",the nuclear and cytoplasmic components of the lymphoid-specific nuclear factor of activated T cells (NF-AT) complex
R5 C11 C3 coref-other the murine NF-AT complex,The lymphoid-specific transcription complex
R6 C13 C3 coref-other human NF-AT,The lymphoid-specific transcription complex
R7 C12 C9 coref-other the nuclear component of human NF-AT,an inducible ubiquitous nuclear component
R8 C15 C10 coref-ident AP1 family,the family of AP1 factors
R9 C18 C13 coref-ident NF-AT,human NF-AT
R10 C19 C14 coref-other AP1,the phorbol ester-inducible transcription factor AP1 (Jun/Fos)
R11 C20 C16 coref-ident Fos,Fos
R12 C24 C21 coref-ident PMA,phorbol 12-myristate 13-acetate (PMA)
R13 C25 C22 coref-other NF-AT-dependent transcription,NF-AT-directed transcription
R14 C26 C7 coref-ident the cytoplasmic component,"a pre-existing, T cell restricted cytoplasmic factor"
R15 C28 C18 coref-ident NF-AT,NF-AT
R16 C27 C17 coref-ident NF-AT DNA binding,NF-AT DNA binding
R17 C29 C19 coref-ident AP1,AP1
R18 C30 C20 coref-ident Fos,Fos
R19 C31 C23 coref-ident JunB,JunB
R20 C32 C31 coref-pron it,JunB
R21 C34 C28 coref-ident NF-AT,NF-AT
R22 C33 C27 coref-ident NF-AT DNA binding,NF-AT DNA binding
R23 C36 C34 coref-ident NF-AT,NF-AT
R24 C35 C26 coref-ident the cytoplasmic component of NF-AT,the cytoplasmic component
R25 C37 C35 coref-pron it,the cytoplasmic component of NF-AT

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 66-98 protein_family_or_group denotes lymphoid-specific nuclear factor
T2 102-119 cell_type denotes activated T cells
T3 121-126 protein_complex denotes NF-AT
T4 141-180 protein_complex denotes lymphoid-specific transcription complex
T5 182-187 protein_complex denotes NF-AT
T6 229-236 cell_type denotes T cells
T7 275-311 protein_family_or_group denotes T cell restricted cytoplasmic factor
T8 329-339 protein_family_or_group denotes ubiquitous
T9 340-357 protein_molecule denotes nuclear component
T10 401-417 protein_family_or_group denotes antigen receptor
T11 464-475 protein_family_or_group denotes AP1 factors
T12 497-517 protein_complex denotes murine NF-AT complex
T13 554-571 other_name denotes nuclear component
T14 575-586 protein_complex denotes human NF-AT
T15 600-648 protein_molecule denotes phorbol ester-inducible transcription factor AP1
T16 650-657 protein_molecule denotes Jun/Fos
T17 690-708 protein_family_or_group denotes AP1 family members
T18 731-739 other_name denotes Antisera
T19 743-746 protein_molecule denotes Fos
T20 756-761 protein_molecule denotes NF-AT
T21 785-800 polynucleotide denotes oligonucleotide
T22 814-830 DNA_domain_or_region denotes binding site for
T23 831-834 protein_family_or_group denotes AP1
T24 871-874 protein_molecule denotes Fos
T25 899-904 protein_molecule denotes Fra-1
T26 937-968 other_organic_compound denotes phorbol 12-myristate 13-acetate
T27 970-973 other_organic_compound denotes PMA
T28 996-1001 protein_molecule denotes NF-AT
T29 1039-1056 other_organic_compound denotes calcium ionophore
T30 1082-1086 protein_molecule denotes cJun
T31 1090-1094 protein_molecule denotes JunD
T32 1104-1108 protein_molecule denotes JunB
T33 1146-1149 other_organic_compound denotes PMA
T34 1184-1213 protein_family_or_group denotes Jun- and Fos-related proteins
T35 1236-1241 protein_molecule denotes NF-AT
T36 1312-1317 protein_molecule denotes NF-AT
T37 1366-1392 protein_domain_or_region denotes semi-purified AP1 proteins
T38 1404-1411 other_name denotes cytosol
T39 1417-1430 cell_type denotes T lymphocytes
T40 1498-1502 protein_molecule denotes JunB
T41 1548-1573 protein_complex denotes NF-AT DNA binding complex
T42 1688-1731 other_name denotes SDS-polyacrylamide gel electrophoresis gels
T43 1746-1760 other_name denotes molecular mass

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 970-973 Disease denotes PMA http://purl.obolibrary.org/obo/MONDO_0016692|http://purl.obolibrary.org/obo/MONDO_0018687
T3 1146-1149 Disease denotes PMA http://purl.obolibrary.org/obo/MONDO_0016692|http://purl.obolibrary.org/obo/MONDO_0018687

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 575-580 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 36-47 Body_part denotes cytoplasmic http://purl.obolibrary.org/obo/GO_0005737
T2 275-281 Body_part denotes T cell http://purl.obolibrary.org/obo/CL_0000084
T3 293-304 Body_part denotes cytoplasmic http://purl.obolibrary.org/obo/GO_0005737
T4 1289-1300 Body_part denotes cytoplasmic http://purl.obolibrary.org/obo/GO_0005737
T5 1404-1411 Body_part denotes cytosol http://purl.obolibrary.org/obo/GO_0005829
T6 1417-1430 Body_part denotes T lymphocytes http://purl.obolibrary.org/obo/CL_0000084
T7 1615-1626 Body_part denotes cytoplasmic http://purl.obolibrary.org/obo/GO_0005737