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PubMed:8428943 JSONTXT

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CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 38-44 Cell denotes T-cell http://purl.obolibrary.org/obo/CL:0000084
T2 109-115 Cell denotes T-cell http://purl.obolibrary.org/obo/CL:0000084
T3 685-691 Cell denotes T-cell http://purl.obolibrary.org/obo/CL:0000084

sentences

Id Subject Object Predicate Lexical cue
T1 0-82 Sentence denotes ras protein activity is essential for T-cell antigen receptor signal transduction.
T2 83-268 Sentence denotes In a Jurkat cell model of T-cell activation an interleukin-2 promoter/reporter gene construct was activated by antigen receptor agonism in combination with the lymphokine interleukin-1.
T3 269-440 Sentence denotes Antigen receptor signals could be mimicked by suboptimal activation of protein kinase C (PKC) with phorbol esters in combination with calcium mobilization by an ionophore.
T4 441-588 Sentence denotes In cotransfection experiments, oncogenic rats obviated the need for PKC stimulation but did not replace either the calcium signal or interleukin-1.
T5 589-719 Sentence denotes Activated ras expression also replaced the requirement for PKC stimulation in activation of the T-cell transcription factor NF-AT.
T6 720-872 Sentence denotes A dominant inhibitory ras mutant specifically blocked antigen receptor agonism, indicating that ras activity is required for antigen receptor signaling.
T7 873-1006 Sentence denotes In addition, an inhibitor of PKC blocked both activated ras and phorbol ester stimulation, suggesting a role for ras upstream of PKC.
T1 0-82 Sentence denotes ras protein activity is essential for T-cell antigen receptor signal transduction.
T2 83-268 Sentence denotes In a Jurkat cell model of T-cell activation an interleukin-2 promoter/reporter gene construct was activated by antigen receptor agonism in combination with the lymphokine interleukin-1.
T3 269-440 Sentence denotes Antigen receptor signals could be mimicked by suboptimal activation of protein kinase C (PKC) with phorbol esters in combination with calcium mobilization by an ionophore.
T4 441-588 Sentence denotes In cotransfection experiments, oncogenic rats obviated the need for PKC stimulation but did not replace either the calcium signal or interleukin-1.
T5 589-719 Sentence denotes Activated ras expression also replaced the requirement for PKC stimulation in activation of the T-cell transcription factor NF-AT.
T6 720-872 Sentence denotes A dominant inhibitory ras mutant specifically blocked antigen receptor agonism, indicating that ras activity is required for antigen receptor signaling.
T7 873-1006 Sentence denotes In addition, an inhibitor of PKC blocked both activated ras and phorbol ester stimulation, suggesting a role for ras upstream of PKC.

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 0-11 protein denotes ras protein
T2 38-61 protein denotes T-cell antigen receptor
T3 88-105 cell_line denotes Jurkat cell model
T4 130-176 DNA denotes interleukin-2 promoter/reporter gene construct
T5 194-210 protein denotes antigen receptor
T6 243-253 protein denotes lymphokine
T7 254-267 protein denotes interleukin-1
T8 340-356 protein denotes protein kinase C
T9 358-361 protein denotes PKC
T10 509-512 protein denotes PKC
T11 574-587 protein denotes interleukin-1
T12 599-602 protein denotes ras
T13 648-651 protein denotes PKC
T14 685-712 protein denotes T-cell transcription factor
T15 713-718 protein denotes NF-AT
T16 722-752 protein denotes dominant inhibitory ras mutant
T17 816-819 protein denotes ras
T18 845-861 protein denotes antigen receptor
T19 902-905 protein denotes PKC
T20 929-932 protein denotes ras
T21 986-989 protein denotes ras
T22 1002-1005 protein denotes PKC

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-82 Sentence denotes ras protein activity is essential for T-cell antigen receptor signal transduction.
S2 83-268 Sentence denotes In a Jurkat cell model of T-cell activation an interleukin-2 promoter/reporter gene construct was activated by antigen receptor agonism in combination with the lymphokine interleukin-1.
S3 269-440 Sentence denotes Antigen receptor signals could be mimicked by suboptimal activation of protein kinase C (PKC) with phorbol esters in combination with calcium mobilization by an ionophore.
S4 441-588 Sentence denotes In cotransfection experiments, oncogenic rats obviated the need for PKC stimulation but did not replace either the calcium signal or interleukin-1.
S5 589-719 Sentence denotes Activated ras expression also replaced the requirement for PKC stimulation in activation of the T-cell transcription factor NF-AT.
S6 720-872 Sentence denotes A dominant inhibitory ras mutant specifically blocked antigen receptor agonism, indicating that ras activity is required for antigen receptor signaling.
S7 873-1006 Sentence denotes In addition, an inhibitor of PKC blocked both activated ras and phorbol ester stimulation, suggesting a role for ras upstream of PKC.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C2 0-11 NP denotes ras protein
C1 0-20 NP denotes ras protein activity
C3 194-218 NP denotes antigen receptor agonism
C4 239-267 NP denotes the lymphokine interleukin-1
C5 340-362 NP denotes protein kinase C (PKC)
C6 368-382 NP denotes phorbol esters
C8 509-512 NP denotes PKC
C7 509-524 NP denotes PKC stimulation
C9 574-587 NP denotes interleukin-1
C10 599-602 NP denotes ras
C12 648-651 NP denotes PKC
C11 648-663 NP denotes PKC stimulation
C13 742-745 NP denotes ras
C14 774-798 NP denotes antigen receptor agonism
C16 816-819 NP denotes ras
C15 816-828 NP denotes ras activity
C17 902-905 NP denotes PKC
C18 919-932 NP denotes activated ras
C19 937-950 NP denotes phorbol ester
C20 986-989 NP denotes ras
C21 1002-1005 NP denotes PKC
R1 C8 C5 coref-ident PKC,protein kinase C (PKC)
R2 C9 C4 coref-ident interleukin-1,the lymphokine interleukin-1
R3 C10 C2 coref-ident ras,ras protein
R4 C12 C8 coref-ident PKC,PKC
R5 C11 C7 coref-ident PKC stimulation,PKC stimulation
R6 C13 C10 coref-ident ras,ras
R7 C14 C3 coref-ident antigen receptor agonism,antigen receptor agonism
R8 C16 C13 coref-ident ras,ras
R9 C15 C3 coref-other ras activity,antigen receptor agonism
R10 C17 C12 coref-ident PKC,PKC
R11 C18 C16 coref-other activated ras,ras
R12 C19 C6 coref-ident phorbol ester,phorbol esters
R13 C20 C16 coref-ident ras,ras
R14 C21 C17 coref-ident PKC,PKC

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-11 protein_molecule denotes ras protein
T2 38-61 protein_family_or_group denotes T-cell antigen receptor
T3 88-105 cell_line denotes Jurkat cell model
T4 109-126 other_name denotes T-cell activation
T5 130-143 protein_molecule denotes interleukin-2
T6 194-210 protein_family_or_group denotes antigen receptor
T7 243-253 protein_family_or_group denotes lymphokine
T8 254-267 protein_molecule denotes interleukin-1
T9 315-336 other_name denotes suboptimal activation
T10 340-356 protein_molecule denotes protein kinase C
T11 358-361 protein_molecule denotes PKC
T12 368-382 other_organic_compound denotes phorbol esters
T13 403-410 atom denotes calcium
T14 430-439 other_organic_compound denotes ionophore
T15 472-486 other_artificial_source denotes oncogenic rats
T16 509-512 protein_molecule denotes PKC
T17 556-563 atom denotes calcium
T18 574-587 protein_molecule denotes interleukin-1
T19 599-602 protein_molecule denotes ras
T20 648-651 protein_molecule denotes PKC
T21 685-712 protein_molecule denotes T-cell transcription factor
T22 713-718 protein_molecule denotes NF-AT
T23 722-752 protein_molecule denotes dominant inhibitory ras mutant
T24 816-819 protein_molecule denotes ras
T25 845-861 protein_family_or_group denotes antigen receptor
T26 902-905 protein_molecule denotes PKC
T27 929-932 protein_molecule denotes ras
T28 937-950 other_organic_compound denotes phorbol ester
T29 986-989 protein_molecule denotes ras
T30 1002-1005 protein_molecule denotes PKC

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 482-486 OrganismTaxon denotes rats 10114|10116

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 38-44 Body_part denotes T-cell http://purl.obolibrary.org/obo/CL_0000084
T2 109-115 Body_part denotes T-cell http://purl.obolibrary.org/obo/CL_0000084
T3 685-691 Body_part denotes T-cell http://purl.obolibrary.org/obo/CL_0000084