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PubMed:8424101 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 0-20 protein denotes Transcription factor
T2 21-27 protein denotes GATA-1
T3 143-149 protein denotes GATA-1
T4 153-161 cell_type denotes red cell
T5 238-244 protein denotes GATA-1
T6 343-354 DNA denotes GATA-1 gene
T7 462-486 DNA denotes protein-coding sequences
T8 954-977 cell_line denotes GATA-1- erythroid cells
T9 1058-1064 protein denotes GATA-1
T10 1069-1081 protein denotes Epo receptor
T11 1097-1105 cell_type denotes red cell
T12 1232-1244 protein denotes Epo receptor
T13 1315-1326 DNA denotes GATA-1 gene
T14 1331-1348 cell_line denotes GATA-1- red cells
T15 1459-1471 DNA denotes globin genes
T16 1507-1513 protein denotes GATA-1
T17 1654-1684 cell_line denotes targeted erythroleukemia cells
T18 1756-1791 protein denotes GATA-binding protein family members
T19 1855-1872 protein denotes chimeric proteins
T20 2033-2039 protein denotes GATA-1
T21 2076-2082 protein denotes GATA-1
T22 2092-2106 DNA denotes red cell genes
T23 2112-2118 DNA denotes globin
T24 2126-2138 protein denotes Epo receptor
T25 2187-2208 protein denotes GATA-binding proteins
T26 2241-2247 protein denotes GATA-1
T27 2314-2320 protein denotes GATA-1
T28 2358-2364 protein denotes GATA-1
T29 2473-2489 DNA denotes globin promoters
T30 2593-2604 DNA denotes globin gene

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-54 Sentence denotes Transcription factor GATA-1 and erythroid development.
S2 55-193 Sentence denotes In summary, we derived an experimental system that allows us to dissect the function of GATA-1 in red cell development at a genetic level.
S3 194-297 Sentence denotes We have established the essential nature of GATA-1 during both primitive and definitive erythropoiesis.
S4 298-487 Sentence denotes By ablating the expression of the endogenous GATA-1 gene, we are in a position to introduce a variety of constructs that harbor subtle modifications in flanking or protein-coding sequences.
S5 488-661 Sentence denotes We can now study regulatory regions and functional domains of the protein in the context of a true erythroid environment, experiments that have not been possible heretofore.
S6 662-902 Sentence denotes Although the assay involves the dramatic loss of red cell production, it should be possible to define important regulatory domains that can then be assayed using less stringent systems, such as cell-free extracts for in vitro transcription.
S7 903-978 Sentence denotes The ideal situation would be analyses conducted in GATA-1- erythroid cells.
S8 979-1166 Sentence denotes However, these cells have been impossible to generate given the requirement of GATA-1 for Epo receptor expression and red cell viability (C. Simon and S. Orkin, unpublished observations).
S9 1167-1327 Sentence denotes It may be possible to produce such cells by first expressing the Epo receptor under the influence of a constitutive promoter and then targeting the GATA-1 gene.
S10 1328-1472 Sentence denotes If GATA-1- red cells were available, the analyses would involve the actual transcription of or chromatin structure surrounding the globin genes.
S11 1473-1589 Sentence denotes Structure-function studies of the GATA-1 protein could be greatly simplified and a larger number of mutants studied.
S12 1590-1702 Sentence denotes However, the ES cell system can be used as an alternative until targeted erythroleukemia cells become available.
S13 1703-1838 Sentence denotes Other applications involve the introduction of other GATA-binding protein family members to determine whether they rescue the mutation.
S14 1839-1958 Sentence denotes If they cannot, chimeric proteins can be tested to identify which amino acids distinguish the different family members.
S15 1959-2066 Sentence denotes We feel that these experiments are vital to understanding the function of GATA-1 during erythroid ontogeny.
S16 2067-2139 Sentence denotes How does GATA-1 regulate red cell genes like globin or the Epo receptor?
S17 2140-2310 Sentence denotes Once we identify the functional domains of the GATA-binding proteins, we hope to learn what proteins GATA-1 binds to in the basic transcription machinery or in chromatin.
S18 2311-2357 Sentence denotes Is GATA-1 necessary for globin gene switching?
S19 2358-2490 Sentence denotes GATA-1 may be modified differently during development so that the locus control region can interact with different globin promoters.
S20 2491-2616 Sentence denotes We may find that one region of the protein is required for embryonic expression and another for adult globin gene expression.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 0-27 NP denotes Transcription factor GATA-1
C2 32-53 NP denotes erythroid development
C3 78-100 NP denotes an experimental system
C4 101-105 NP denotes that
C5 143-149 NP denotes GATA-1
C6 153-173 NP denotes red cell development
C7 238-244 NP denotes GATA-1
C9 343-349 NP denotes GATA-1
C8 328-354 NP denotes the endogenous GATA-1 gene
C10 390-413 NP denotes a variety of constructs
C11 414-418 NP denotes that
C12 610-621 NP denotes experiments
C13 622-626 NP denotes that
C14 764-792 NP denotes important regulatory domains
C15 793-797 NP denotes that
C16 954-977 NP denotes GATA-1- erythroid cells
C17 988-999 NP denotes these cells
C18 1058-1064 NP denotes GATA-1
C19 1197-1207 NP denotes such cells
C21 1315-1321 NP denotes GATA-1
C20 1311-1326 NP denotes the GATA-1 gene
C22 1331-1348 NP denotes GATA-1- red cells
C23 1455-1471 NP denotes the globin genes
C24 1507-1513 NP denotes GATA-1
C25 1750-1791 NP denotes other GATA-binding protein family members
C26 1813-1817 NP denotes they
C27 1842-1846 NP denotes they
C28 1929-1957 NP denotes the different family members
C29 2033-2039 NP denotes GATA-1
C30 2076-2082 NP denotes GATA-1
C31 2183-2208 NP denotes the GATA-binding proteins
C32 2241-2247 NP denotes GATA-1
C33 2314-2320 NP denotes GATA-1
C34 2335-2346 NP denotes globin gene
C35 2358-2364 NP denotes GATA-1
C36 2593-2604 NP denotes globin gene
R1 C4 C3 coref-ident that,an experimental system
R2 C5 C1 coref-ident GATA-1,Transcription factor GATA-1
R3 C6 C2 coref-other red cell development,erythroid development
R4 C7 C5 coref-ident GATA-1,GATA-1
R5 C9 C7 coref-ident GATA-1,GATA-1
R6 C11 C10 coref-relat that,a variety of constructs
R7 C13 C12 coref-relat that,experiments
R8 C15 C14 coref-relat that,important regulatory domains
R9 C17 C16 coref-ident these cells,GATA-1- erythroid cells
R10 C18 C9 coref-ident GATA-1,GATA-1
R11 C19 C17 coref-ident such cells,these cells
R12 C21 C18 coref-ident GATA-1,GATA-1
R13 C20 C8 coref-other the GATA-1 gene,the endogenous GATA-1 gene
R14 C22 C16 coref-other GATA-1- red cells,GATA-1- erythroid cells
R15 C24 C21 coref-ident GATA-1,GATA-1
R16 C26 C25 coref-pron they,other GATA-binding protein family members
R17 C27 C25 coref-pron they,other GATA-binding protein family members
R18 C28 C25 coref-other the different family members,other GATA-binding protein family members
R19 C29 C24 coref-ident GATA-1,GATA-1
R20 C30 C29 coref-ident GATA-1,GATA-1
R21 C31 C28 coref-other the GATA-binding proteins,the different family members
R22 C32 C30 coref-ident GATA-1,GATA-1
R23 C33 C32 coref-ident GATA-1,GATA-1
R24 C34 C23 coref-ident globin gene,the globin genes
R25 C35 C33 coref-ident GATA-1,GATA-1
R26 C36 C34 coref-ident globin gene,globin gene

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-20 protein_family_or_group denotes Transcription factor
T2 21-27 protein_molecule denotes GATA-1
T3 143-149 protein_molecule denotes GATA-1
T4 153-161 cell_type denotes red cell
T5 238-244 protein_molecule denotes GATA-1
T6 282-296 other_name denotes erythropoiesis
T7 343-349 protein_molecule denotes GATA-1
T8 462-486 DNA_domain_or_region denotes protein-coding sequences
T9 711-730 other_name denotes red cell production
T10 856-874 cell_component denotes cell-free extracts
T11 879-901 other_name denotes in vitro transcription
T12 954-960 protein_molecule denotes GATA-1
T13 1058-1064 protein_molecule denotes GATA-1
T14 1069-1081 protein_family_or_group denotes Epo receptor
T15 1097-1105 cell_type denotes red cell
T16 1232-1244 protein_molecule denotes Epo receptor
T17 1315-1321 protein_molecule denotes GATA-1
T18 1331-1337 protein_molecule denotes GATA-1
T19 1459-1471 DNA_family_or_group denotes globin genes
T20 1507-1513 protein_molecule denotes GATA-1
T21 1603-1617 other_name denotes ES cell system
T22 1654-1684 cell_line denotes targeted erythroleukemia cells
T23 1756-1791 protein_family_or_group denotes GATA-binding protein family members
T24 1855-1872 protein_family_or_group denotes chimeric proteins
T25 2033-2039 protein_molecule denotes GATA-1
T26 2047-2065 other_name denotes erythroid ontogeny
T27 2076-2082 protein_molecule denotes GATA-1
T28 2092-2106 DNA_family_or_group denotes red cell genes
T29 2112-2118 DNA_family_or_group denotes globin
T30 2126-2138 protein_molecule denotes Epo receptor
T31 2187-2208 protein_family_or_group denotes GATA-binding proteins
T32 2241-2247 protein_molecule denotes GATA-1
T33 2314-2320 protein_molecule denotes GATA-1
T34 2358-2364 protein_molecule denotes GATA-1
T35 2473-2489 DNA_domain_or_region denotes globin promoters
T36 2550-2570 other_name denotes embryonic expression
T37 2587-2592 other_name denotes adult
T38 2593-2604 DNA_family_or_group denotes globin gene