PubMed:8399293
Annnotations
Anatomy-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 111-116 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/MAT_0000097 |
| T2 | 597-602 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/MAT_0000097 |
| T3 | 650-655 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/MAT_0000097 |
| T4 | 734-739 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/MAT_0000097 |
| T5 | 1382-1387 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/MAT_0000097 |
| T6 | 1467-1472 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/MAT_0000097 |
| T7 | 2147-2152 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/MAT_0000097 |
mondo_disease
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 1315-1319 | Disease | denotes | clam | http://purl.obolibrary.org/obo/MONDO_0011948 |
Glycan-GlyCosmos
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 1070-1073 | Glycan | denotes | GM1 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR |
GlyCosmos-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 1070-1073 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
GlyCosmos15-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 1315-1319 | Disease | denotes | clam | http://purl.obolibrary.org/obo/MONDO_0011948 |
GlyCosmos15-NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 14-26 | OrganismTaxon | denotes | Sendai virus | 11191 |
| T2 | 414-419 | OrganismTaxon | denotes | mouse | 10088|10090 |
GlyCosmos15-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 27-36 | Body_part | denotes | envelopes | http://purl.obolibrary.org/obo/GO_0031975 |
| T2 | 111-116 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
| T3 | 185-194 | Body_part | denotes | envelopes | http://purl.obolibrary.org/obo/GO_0031975 |
| T4 | 564-571 | Body_part | denotes | vesicle | http://purl.obolibrary.org/obo/GO_0031982 |
| T5 | 597-602 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
| T6 | 650-655 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
| T7 | 734-739 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
| T8 | 1008-1027 | Body_part | denotes | hepatic parenchymal | http://purl.obolibrary.org/obo/UBERON_0001280 |
| T9 | 1382-1387 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
| T10 | 1467-1472 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
| T11 | 2135-2143 | Body_part | denotes | membrane | http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158 |
| T14 | 2147-2152 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
GlyCosmos15-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 111-116 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/MAT_0000097 |
| T2 | 597-602 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/MAT_0000097 |
| T3 | 650-655 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/MAT_0000097 |
| T4 | 734-739 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/MAT_0000097 |
| T5 | 1382-1387 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/MAT_0000097 |
| T6 | 1467-1472 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/MAT_0000097 |
| T7 | 2147-2152 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/MAT_0000097 |
GlyCosmos15-Sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-123 | Sentence | denotes | Reconstituted Sendai virus envelopes as biological carriers: dual role of F protein in binding and fusion with liver cells. |
| T2 | 124-459 | Sentence | denotes | We have assessed the potential of reconstituted Sendai viral envelopes containing only the fusion protein (F-virosomes) as biological carriers for the delivery of drugs and macromolecules. [125I]lysozyme entrapped in F-virosome is used to study its distribution in various organs of Balb/c mouse in vivo as a function of dose and time. |
| T3 | 460-532 | Sentence | denotes | F-virosomes injected intravenously are rapidly cleared from circulation. |
| T4 | 533-710 | Sentence | denotes | A major percentage (55-60%) of vesicle contents is delivered to liver at 15 min after injection, showing thereby the liver to be the major site for the accumulation of vesicles. |
| T5 | 711-838 | Sentence | denotes | Uptake of virosomes by liver is found to reach a near saturation level at a dose of 0.5 mg F-protein associated with virosomes. |
| T6 | 839-1034 | Sentence | denotes | In competition studies, the inhibitory effect of asialofetuin on the uptake of F-virosomes suggests the involvement of asialoglycoprotein receptor in its recognition by hepatic parenchymal cells. |
| T7 | 1035-1131 | Sentence | denotes | Incorporation of asialoganglioside-GM1 in the F-virosomes enhanced the uptake by about 1.6-fold. |
| T8 | 1132-1335 | Sentence | denotes | The observed specific interaction of hepatic receptor with F-protein containing a terminal galactose moiety is further supported by degalactosylation of F-virosomes with hard-shelled clam exoglycosidase. |
| T9 | 1336-1425 | Sentence | denotes | The uptake of degalactosylated F-virosomes by liver is found to be significantly reduced. |
| T10 | 1426-1708 | Sentence | denotes | The subcellular radioactivity profile in liver cells exhibits a considerable decrease in cytosolic localisation of the degalactosylated F-virosomal contents with a concomitant increase in their accumulation in lysosomal/mitochondrial fraction as compared to the untreated virosomes. |
| T11 | 1709-1842 | Sentence | denotes | Trypsinized and heat-treated F-virosomes also reflect similar subcellular distribution profile as that of degalactosylated virosomes. |
| T12 | 1843-2004 | Sentence | denotes | Moreover, F-virosomes are able to interact and deliver [125I]lysozyme to the HepG2 cells in culture in the presence of a potent inhibitor of endocytotic process. |
| T13 | 2005-2193 | Sentence | denotes | These results indicate the involvement of specific binding of F-proteins with hepatic receptors followed by their fusion with the membrane of liver cells in the delivery of [125I]lysozyme. |
| T14 | 2194-2410 | Sentence | denotes | The findings reported here open up the possibility of using F-virosomes with defined specificity as fusogenic vehicles for efficient delivery of drugs and biologically active macromolecules both in vivo and in vitro. |
GlyCosmos15-Glycan
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 1070-1073 | Glycan | denotes | GM1 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR |
GlyCosmos15-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 1070-1073 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 14-26 | OrganismTaxon | denotes | Sendai virus | 11191 |
| T2 | 414-419 | OrganismTaxon | denotes | mouse | 10088|10090 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 27-36 | Body_part | denotes | envelopes | http://purl.obolibrary.org/obo/GO_0031975 |
| T2 | 111-116 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
| T3 | 185-194 | Body_part | denotes | envelopes | http://purl.obolibrary.org/obo/GO_0031975 |
| T4 | 564-571 | Body_part | denotes | vesicle | http://purl.obolibrary.org/obo/GO_0031982 |
| T5 | 597-602 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
| T6 | 650-655 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
| T7 | 734-739 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
| T8 | 1008-1027 | Body_part | denotes | hepatic parenchymal | http://purl.obolibrary.org/obo/UBERON_0001280 |
| T9 | 1382-1387 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
| T10 | 1467-1472 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
| T11 | 2135-2143 | Body_part | denotes | membrane | http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158 |
| T14 | 2147-2152 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/UBERON_0002107 |