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PubMed:8395188 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 0-30 protein denotes Tumor necrosis factor receptor
T2 69-89 cell_type denotes HIV-1-infected cells
T3 195-228 protein denotes tumor necrosis factor (TNF)-alpha
T4 312-325 cell_type denotes promyelocytic
T5 330-348 cell_type denotes promonocytic cells
T6 407-420 protein denotes TNF receptors
T7 431-434 protein denotes TNF
T8 490-509 protein denotes monoclonal antibody
T9 653-674 protein denotes reverse transcriptase
T10 826-844 protein denotes 75 kd TNF receptor
T11 846-850 protein denotes TR75
T12 872-890 protein denotes 55 kD TNF receptor
T13 892-896 protein denotes TR55
T14 948-983 cell_line denotes uninfected parental HL-60 subclones
T15 996-1000 protein denotes TR75
T16 1035-1044 protein denotes TNF-alpha
T17 1065-1069 protein denotes TR75
T18 1116-1125 protein denotes TNF-alpha
T19 1196-1200 protein denotes TR75
T20 1276-1295 cell_line denotes HL-60 promyelocytes
T21 1306-1310 protein denotes TR55
T22 1343-1352 protein denotes TNF-alpha
T23 1469-1473 protein denotes TR55
T24 1493-1512 protein denotes exogenous TNF-alpha
T25 1576-1580 protein denotes TR75
T26 1594-1604 protein denotes NF-kappa B
T27 1680-1711 protein denotes antagonistic anti-TR55 antibody
T28 1722-1740 protein denotes Anti-TR55 antibody
T29 1758-1803 cell_line denotes chronically infected U1 promonocytic cultures
T30 1987-2000 protein denotes TNF receptors
T31 2065-2081 protein denotes immunoregulatory

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-90 Sentence denotes Tumor necrosis factor receptor expression and signal transduction in HIV-1-infected cells.
S2 91-294 Sentence denotes OBJECTIVE: To examine the inter-relationship between HIV-1 infection and the cell surface receptors for tumor necrosis factor (TNF)-alpha, an immunoregulatory cytokine that can enhance HIV-1 replication.
S3 295-421 Sentence denotes DESIGN: Infected promyelocytic and promonocytic cells were examined because they normally express both types of TNF receptors.
S4 422-601 Sentence denotes METHODS: TNF receptor surface expression was determined by specific monoclonal antibody recognition and flow cytometry, and signal transduction was detected by gel shift analysis.
S5 602-681 Sentence denotes HIV-1 activation and expression was quantitated by reverse transcriptase assay.
S6 682-935 Sentence denotes RESULTS: In the OM-10.1 promyelocytic model of chronic infection, TNF-alpha-induced HIV-1 expression also resulted in a substantial increase in 75 kd TNF receptor (TR75) expression although 55 kD TNF receptor (TR55) levels were not dramatically altered.
S7 936-1055 Sentence denotes A series of uninfected parental HL-60 subclones all reduced TR75 surface expression in response to TNF-alpha treatment.
S8 1056-1180 Sentence denotes Enhanced TR75 expression on OM-10.1 cells followed the same TNF-alpha-dose dependency as that observed for HIV-1 production.
S9 1181-1296 Sentence denotes An increase in TR75 expression was also evident during the peak of an acute HIV-1 infection of HL-60 promyelocytes.
S10 1297-1442 Sentence denotes Although TR55 expression was unaltered during TNF-alpha-induced HIV activation, this receptor was still involved in the viral activation process.
S11 1443-1634 Sentence denotes Antibody cross-linking of TR55, in the absence of exogenous TNF-alpha, induced maximal HIV-1 expression, an up-modulation of surface TR75, and nuclear NF-kappa B activity in OM-10.1 cultures.
S12 1635-1721 Sentence denotes Surprisingly, this was the case even when an antagonistic anti-TR55 antibody was used.
S13 1722-1875 Sentence denotes Anti-TR55 antibody cross-linking in chronically infected U1 promonocytic cultures could only partially substitute for TNF-alpha-induced HIV-1 expression.
S14 1876-2102 Sentence denotes CONCLUSIONS: Our results demonstrated that HIV-1 infection can selectively influence the surface expression of TNF receptors, potentially influencing its own expression and altering normal immunoregulatory signal transduction.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 144-159 NP denotes HIV-1 infection
C2 195-228 NP denotes tumor necrosis factor (TNF)-alpha
C4 230-258 NP denotes an immunoregulatory cytokine
C5 259-263 NP denotes that
C3 230-293 NP denotes an immunoregulatory cytokine that can enhance HIV-1 replication
C6 303-348 NP denotes Infected promyelocytic and promonocytic cells
C7 371-375 NP denotes they
C8 407-420 NP denotes TNF receptors
C9 431-462 NP denotes TNF receptor surface expression
C11 748-758 NP denotes TNF-alpha-
C10 748-782 NP denotes TNF-alpha-induced HIV-1 expression
C12 826-862 NP denotes 75 kd TNF receptor (TR75) expression
C13 1116-1126 NP denotes TNF-alpha-
C14 1196-1211 NP denotes TR75 expression
C15 1306-1321 NP denotes TR55 expression
C16 1343-1353 NP denotes TNF-alpha-
C17 1377-1390 NP denotes this receptor
C18 1503-1512 NP denotes TNF-alpha
C19 1522-1546 NP denotes maximal HIV-1 expression
C20 1548-1580 NP denotes an up-modulation of surface TR75
C22 1840-1850 NP denotes TNF-alpha-
C21 1840-1874 NP denotes TNF-alpha-induced HIV-1 expression
C23 1919-1934 NP denotes HIV-1 infection
C25 1987-2000 NP denotes TNF receptors
C24 1961-2000 NP denotes the surface expression of TNF receptors
C26 2026-2029 NP denotes its
R1 C4 C2 coref-appos an immunoregulatory cytokine,tumor necrosis factor (TNF)-alpha
R2 C5 C3 coref-relat that,an immunoregulatory cytokine that can enhance HIV-1 replication
R3 C7 C6 coref-pron they,Infected promyelocytic and promonocytic cells
R4 C11 C2 coref-ident TNF-alpha-,tumor necrosis factor (TNF)-alpha
R5 C13 C11 coref-ident TNF-alpha-,TNF-alpha-
R6 C14 C12 coref-other TR75 expression,75 kd TNF receptor (TR75) expression
R7 C15 C14 coref-ident TR55 expression,TR75 expression
R8 C16 C13 coref-ident TNF-alpha-,TNF-alpha-
R9 C17 C15 coref-ident this receptor,TR55 expression
R10 C18 C16 coref-ident TNF-alpha,TNF-alpha-
R11 C20 C19 coref-appos an up-modulation of surface TR75,maximal HIV-1 expression
R12 C22 C18 coref-ident TNF-alpha-,TNF-alpha
R13 C21 C10 coref-ident TNF-alpha-induced HIV-1 expression,TNF-alpha-induced HIV-1 expression
R14 C23 C1 coref-ident HIV-1 infection,HIV-1 infection
R15 C25 C8 coref-ident TNF receptors,TNF receptors
R16 C24 C9 coref-ident the surface expression of TNF receptors,TNF receptor surface expression
R17 C26 C23 coref-pron its,HIV-1 infection

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-21 protein_molecule denotes Tumor necrosis factor
T2 69-74 virus denotes HIV-1
T3 144-149 virus denotes HIV-1
T4 195-228 protein_molecule denotes tumor necrosis factor (TNF)-alpha
T5 276-281 virus denotes HIV-1
T6 312-325 cell_type denotes promyelocytic
T7 330-348 cell_type denotes promonocytic cells
T8 407-420 protein_family_or_group denotes TNF receptors
T9 431-434 protein_family_or_group denotes TNF
T10 490-509 protein_family_or_group denotes monoclonal antibody
T11 526-540 other_name denotes flow cytometry
T12 546-565 other_name denotes signal transduction
T13 582-600 other_name denotes gel shift analysis
T14 602-607 virus denotes HIV-1
T15 623-633 other_name denotes expression
T16 653-674 protein_molecule denotes reverse transcriptase
T17 748-765 other_name denotes TNF-alpha-induced
T18 766-771 virus denotes HIV-1
T19 826-844 protein_molecule denotes 75 kd TNF receptor
T20 846-850 protein_molecule denotes TR75
T21 872-890 protein_molecule denotes 55 kD TNF receptor
T22 892-896 protein_molecule denotes TR55
T23 948-983 cell_line denotes uninfected parental HL-60 subclones
T24 996-1000 protein_molecule denotes TR75
T25 1035-1044 protein_molecule denotes TNF-alpha
T26 1065-1069 protein_molecule denotes TR75
T27 1116-1125 protein_molecule denotes TNF-alpha
T28 1163-1168 virus denotes HIV-1
T29 1196-1200 protein_molecule denotes TR75
T30 1251-1256 other_name denotes acute
T31 1257-1262 virus denotes HIV-1
T32 1276-1295 cell_line denotes HL-60 promyelocytes
T33 1306-1310 protein_molecule denotes TR55
T34 1343-1352 protein_molecule denotes TNF-alpha
T35 1417-1441 other_name denotes viral activation process
T36 1469-1473 protein_molecule denotes TR55
T37 1493-1512 protein_molecule denotes exogenous TNF-alpha
T38 1530-1535 virus denotes HIV-1
T39 1576-1580 protein_molecule denotes TR75
T40 1594-1604 protein_molecule denotes NF-kappa B
T41 1680-1711 protein_molecule denotes antagonistic anti-TR55 antibody
T42 1722-1740 protein_molecule denotes Anti-TR55 antibody
T43 1758-1803 cell_line denotes chronically infected U1 promonocytic cultures
T44 1858-1863 virus denotes HIV-1
T45 1919-1924 virus denotes HIV-1
T46 1965-1983 other_name denotes surface expression
T47 1987-2000 protein_family_or_group denotes TNF receptors
T48 2058-2064 other_name denotes normal
T49 2065-2081 protein_family_or_group denotes immunoregulatory