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PubMed:8392437 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 26-42 protein denotes protein kinase C
T2 65-68 protein denotes CD3
T3 141-166 protein denotes AP-1 transcription factor
T4 228-244 protein denotes protein kinase C
T5 246-249 protein denotes PKC
T6 503-516 cell_type denotes T lymphocytes
T7 557-576 protein denotes CD3/T cell receptor
T8 578-581 protein denotes TcR
T9 592-599 cell_type denotes T cells
T10 744-756 protein denotes anti-CD3 mAb
T11 778-789 cell_type denotes lymphocytes
T12 974-987 protein denotes interleukin-2
T13 989-993 protein denotes IL-2
T14 1003-1014 protein denotes alpha chain
T15 1016-1020 protein denotes CD25
T16 1029-1042 protein denotes IL-2 receptor
T17 1044-1049 protein denotes IL-2R
T18 1115-1118 protein denotes CD3
T19 1119-1122 protein denotes TcR
T20 1169-1194 cell_line denotes PMA/Bt2cAMP-treated cells
T21 1280-1299 DNA denotes c-fos protooncogene
T22 1328-1332 protein denotes AP-1
T23 1380-1384 protein denotes CREB
T24 1388-1393 protein denotes NF-kB
T25 1716-1719 protein denotes TcR

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-167 Sentence denotes Costimulation of cAMP and protein kinase C pathways inhibits the CD3-dependent T cell activation and leads to a persistent expression of the AP-1 transcription factor.
S2 168-435 Sentence denotes The effects mediated by a combined stimulation of cAMP- and protein kinase C (PKC)-dependent pathways have been investigated in different cellular systems, and it has been shown that they may complement each other in activating cell proliferation and differentiation.
S3 436-591 Sentence denotes In this report, we show that upon the stimulation of both pathways T lymphocytes became refractory to activation via the CD3/T cell receptor (TcR) complex.
S4 592-880 Sentence denotes T cells preincubated with phorbol 12-myristate 13-acetate (PMA) and dibutyryl cAMP (Bt2cAMP) displayed a deficient proliferative ability in response to anti-CD3 mAb stimulation, whereas lymphocytes treated individually with either Bt2cAMP or PMA responded comparably to untreated samples.
S5 881-1051 Sentence denotes We detected an association between the reduced mitogenic response and low expression of both interleukin-2 (IL-2) and the alpha chain (CD25) of the IL-2 receptor (IL-2R).
S6 1052-1195 Sentence denotes Analysis of intracellular Ca2+ mobilization suggested that the CD3/TcR-dependent signal transduction was impaired in PMA/Bt2cAMP-treated cells.
S7 1196-1408 Sentence denotes Remarkably, we observed that these samples displayed a persistent expression of the c-fos protooncogene, associated to an increased AP-1 DNA-binding activity, whereas no variations of CREB or NF-kB were detected.
S8 1409-1568 Sentence denotes Neither Bt2cAMP nor PMA individually mediated these sustained effects, which therefore appear as a consequence of the interplay between both metabolic stimuli.
S9 1569-1744 Sentence denotes Altogether, the data provide the evidence that both pathways complement each other in regulating gene expression and, conversely, downregulate the TcR transduction mechanisms.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C3 17-21 NP denotes cAMP
C4 26-51 NP denotes protein kinase C pathways
C2 17-51 NP denotes cAMP and protein kinase C pathways
C1 0-51 NP denotes Costimulation of cAMP and protein kinase C pathways
C7 218-223 NP denotes cAMP-
C8 228-269 NP denotes protein kinase C (PKC)-dependent pathways
C6 218-269 NP denotes cAMP- and protein kinase C (PKC)-dependent pathways
C5 192-269 NP denotes a combined stimulation of cAMP- and protein kinase C (PKC)-dependent pathways
C9 351-355 NP denotes they
C10 489-502 NP denotes both pathways
C11 553-590 NP denotes the CD3/T cell receptor (TcR) complex
C12 618-655 NP denotes phorbol 12-myristate 13-acetate (PMA)
C13 660-684 NP denotes dibutyryl cAMP (Bt2cAMP)
C14 823-830 NP denotes Bt2cAMP
C15 834-837 NP denotes PMA
C16 1115-1123 NP denotes CD3/TcR-
C17 1417-1424 NP denotes Bt2cAMP
C18 1429-1432 NP denotes PMA
C19 1455-1478 NP denotes these sustained effects
C20 1480-1485 NP denotes which
C21 1598-1610 NP denotes the evidence
C22 1611-1615 NP denotes that
C23 1616-1629 NP denotes both pathways
R1 C7 C2 coref-ident cAMP-,cAMP and protein kinase C pathways
R2 C8 C4 coref-ident protein kinase C (PKC)-dependent pathways,protein kinase C pathways
R3 C6 C3 coref-ident cAMP- and protein kinase C (PKC)-dependent pathways,cAMP
R4 C5 C1 coref-ident a combined stimulation of cAMP- and protein kinase C (PKC)-dependent pathways,Costimulation of cAMP and protein kinase C pathways
R5 C9 C7 coref-pron they,cAMP-
R6 C10 C7 coref-ident both pathways,cAMP-
R7 C14 C13 coref-ident Bt2cAMP,dibutyryl cAMP (Bt2cAMP)
R8 C15 C12 coref-ident PMA,phorbol 12-myristate 13-acetate (PMA)
R9 C16 C11 coref-ident CD3/TcR-,the CD3/T cell receptor (TcR) complex
R10 C17 C14 coref-ident Bt2cAMP,Bt2cAMP
R11 C18 C15 coref-ident PMA,PMA
R12 C20 C19 coref-relat which,these sustained effects
R13 C22 C21 coref-relat that,the evidence
R14 C23 C10 coref-ident both pathways,both pathways

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 17-21 nucleotide denotes cAMP
T2 26-42 protein_molecule denotes protein kinase C
T3 65-68 protein_molecule denotes CD3
T4 141-145 protein_molecule denotes AP-1
T5 218-222 nucleotide denotes cAMP
T6 228-244 protein_molecule denotes protein kinase C
T7 246-249 protein_molecule denotes PKC
T8 503-516 cell_type denotes T lymphocytes
T9 557-576 protein_molecule denotes CD3/T cell receptor
T10 578-581 protein_molecule denotes TcR
T11 592-599 cell_type denotes T cells
T12 618-649 other_organic_compound denotes phorbol 12-myristate 13-acetate
T13 651-654 other_organic_compound denotes PMA
T14 660-674 nucleotide denotes dibutyryl cAMP
T15 676-683 nucleotide denotes Bt2cAMP
T16 744-756 protein_family_or_group denotes anti-CD3 mAb
T17 778-789 cell_type denotes lymphocytes
T18 823-830 nucleotide denotes Bt2cAMP
T19 834-837 other_organic_compound denotes PMA
T20 974-987 protein_molecule denotes interleukin-2
T21 989-993 protein_molecule denotes IL-2
T22 1003-1014 protein_subunit denotes alpha chain
T23 1016-1020 protein_subunit denotes CD25
T24 1029-1042 protein_molecule denotes IL-2 receptor
T25 1044-1049 protein_molecule denotes IL-2R
T26 1078-1082 atom denotes Ca2+
T27 1115-1118 protein_molecule denotes CD3
T28 1119-1122 protein_family_or_group denotes TcR
T29 1169-1194 cell_line denotes PMA/Bt2cAMP-treated cells
T30 1280-1299 DNA_domain_or_region denotes c-fos protooncogene
T31 1328-1332 protein_molecule denotes AP-1
T32 1380-1384 protein_molecule denotes CREB
T33 1388-1393 protein_molecule denotes NF-kB
T34 1417-1424 nucleotide denotes Bt2cAMP
T35 1429-1432 other_organic_compound denotes PMA
T36 1550-1567 other_name denotes metabolic stimuli
T37 1666-1681 other_name denotes gene expression
T38 1716-1719 protein_molecule denotes TcR