> top > docs > PubMed:8392092 > annotations

PubMed:8392092 JSONTXT

Annnotations TAB JSON ListView MergeView

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-142 Sentence denotes Minimally modified low density lipoprotein-induced inflammatory responses in endothelial cells are mediated by cyclic adenosine monophosphate.
T2 143-439 Sentence denotes We have previously shown that minimally oxidized LDL (MM-LDL) activated endothelial cells to increase their interaction with monocytes but not neutrophils, inducing monocyte but not neutrophil binding and synthesis of monocyte chemotactic protein-1 and monocyte colony-stimulating factor (M-CSF).
T3 440-555 Sentence denotes In the present studies we have examined the signaling pathways by which this monocyte-specific response is induced.
T4 556-693 Sentence denotes Both induction of monocyte binding and mRNA levels for M-CSF by MM-LDL were not inhibited in protein kinase C-depleted endothelial cells.
T5 694-799 Sentence denotes A number of our studies indicate that cAMP is the second messenger for the effects of MM-LDL cited above.
T6 800-896 Sentence denotes Incubation of endothelial cells with MM-LDL caused a 173% increase in intracellular cAMP levels.
T7 897-1040 Sentence denotes Agents which increased cAMP levels, including cholera toxin, pertussis toxin, dibutyryl cAMP, and isoproterenol mimicked the actions of MM-LDL.
T8 1041-1207 Sentence denotes Agents which elevated cAMP were also shown to activate NF kappa B, suggesting a role for this transcription factor in activation of monocyte-endothelial interactions.
T9 1208-1397 Sentence denotes Although endothelial leukocyte adhesion molecule (ELAM) mRNA synthesis can be regulated by NF kappa B, ELAM was not expressed and ELAM mRNA was only slightly elevated in response to MM-LDL.
T10 1398-1521 Sentence denotes We present evidence that induction of neutrophil binding by LPS is actually suppressed by agents that elevated cAMP levels.
T1 0-142 Sentence denotes Minimally modified low density lipoprotein-induced inflammatory responses in endothelial cells are mediated by cyclic adenosine monophosphate.
T2 143-439 Sentence denotes We have previously shown that minimally oxidized LDL (MM-LDL) activated endothelial cells to increase their interaction with monocytes but not neutrophils, inducing monocyte but not neutrophil binding and synthesis of monocyte chemotactic protein-1 and monocyte colony-stimulating factor (M-CSF).
T3 440-555 Sentence denotes In the present studies we have examined the signaling pathways by which this monocyte-specific response is induced.
T4 556-693 Sentence denotes Both induction of monocyte binding and mRNA levels for M-CSF by MM-LDL were not inhibited in protein kinase C-depleted endothelial cells.
T5 694-799 Sentence denotes A number of our studies indicate that cAMP is the second messenger for the effects of MM-LDL cited above.
T6 800-896 Sentence denotes Incubation of endothelial cells with MM-LDL caused a 173% increase in intracellular cAMP levels.
T7 897-1040 Sentence denotes Agents which increased cAMP levels, including cholera toxin, pertussis toxin, dibutyryl cAMP, and isoproterenol mimicked the actions of MM-LDL.
T8 1041-1207 Sentence denotes Agents which elevated cAMP were also shown to activate NF kappa B, suggesting a role for this transcription factor in activation of monocyte-endothelial interactions.
T9 1208-1397 Sentence denotes Although endothelial leukocyte adhesion molecule (ELAM) mRNA synthesis can be regulated by NF kappa B, ELAM was not expressed and ELAM mRNA was only slightly elevated in response to MM-LDL.
T10 1398-1521 Sentence denotes We present evidence that induction of neutrophil binding by LPS is actually suppressed by agents that elevated cAMP levels.

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 31-42 protein denotes lipoprotein
T2 77-94 cell_type denotes endothelial cells
T3 173-232 cell_line denotes minimally oxidized LDL (MM-LDL) activated endothelial cells
T4 268-277 cell_type denotes monocytes
T5 286-297 cell_type denotes neutrophils
T6 361-391 protein denotes monocyte chemotactic protein-1
T7 396-430 protein denotes monocyte colony-stimulating factor
T8 432-437 protein denotes M-CSF
T9 611-616 protein denotes M-CSF
T10 620-626 protein denotes MM-LDL
T11 675-692 cell_type denotes endothelial cells
T12 780-786 protein denotes MM-LDL
T13 814-831 cell_type denotes endothelial cells
T14 837-843 protein denotes MM-LDL
T15 1033-1039 protein denotes MM-LDL
T16 1096-1106 protein denotes NF kappa B
T17 1217-1268 RNA denotes endothelial leukocyte adhesion molecule (ELAM) mRNA
T18 1299-1309 protein denotes NF kappa B
T19 1311-1315 protein denotes ELAM
T20 1338-1347 RNA denotes ELAM mRNA
T21 1390-1396 protein denotes MM-LDL
T22 1436-1446 cell_type denotes neutrophil

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-142 Sentence denotes Minimally modified low density lipoprotein-induced inflammatory responses in endothelial cells are mediated by cyclic adenosine monophosphate.
S2 143-439 Sentence denotes We have previously shown that minimally oxidized LDL (MM-LDL) activated endothelial cells to increase their interaction with monocytes but not neutrophils, inducing monocyte but not neutrophil binding and synthesis of monocyte chemotactic protein-1 and monocyte colony-stimulating factor (M-CSF).
S3 440-555 Sentence denotes In the present studies we have examined the signaling pathways by which this monocyte-specific response is induced.
S4 556-693 Sentence denotes Both induction of monocyte binding and mRNA levels for M-CSF by MM-LDL were not inhibited in protein kinase C-depleted endothelial cells.
S5 694-799 Sentence denotes A number of our studies indicate that cAMP is the second messenger for the effects of MM-LDL cited above.
S6 800-896 Sentence denotes Incubation of endothelial cells with MM-LDL caused a 173% increase in intracellular cAMP levels.
S7 897-1040 Sentence denotes Agents which increased cAMP levels, including cholera toxin, pertussis toxin, dibutyryl cAMP, and isoproterenol mimicked the actions of MM-LDL.
S8 1041-1207 Sentence denotes Agents which elevated cAMP were also shown to activate NF kappa B, suggesting a role for this transcription factor in activation of monocyte-endothelial interactions.
S9 1208-1397 Sentence denotes Although endothelial leukocyte adhesion molecule (ELAM) mRNA synthesis can be regulated by NF kappa B, ELAM was not expressed and ELAM mRNA was only slightly elevated in response to MM-LDL.
S10 1398-1521 Sentence denotes We present evidence that induction of neutrophil binding by LPS is actually suppressed by agents that elevated cAMP levels.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 173-232 NP denotes minimally oxidized LDL (MM-LDL) activated endothelial cells
C2 245-250 NP denotes their
C3 480-502 NP denotes the signaling pathways
C4 506-511 NP denotes which
C5 620-626 NP denotes MM-LDL
C6 732-736 NP denotes cAMP
C7 740-798 NP denotes the second messenger for the effects of MM-LDL cited above
C8 837-843 NP denotes MM-LDL
C9 897-903 NP denotes Agents
C10 904-909 NP denotes which
C11 920-924 NP denotes cAMP
C12 1033-1039 NP denotes MM-LDL
C14 1041-1047 NP denotes Agents
C15 1048-1053 NP denotes which
C16 1063-1067 NP denotes cAMP
C13 1041-1067 NP denotes Agents which elevated cAMP
C17 1096-1106 NP denotes NF kappa B
C18 1130-1155 NP denotes this transcription factor
C19 1217-1268 NP denotes endothelial leukocyte adhesion molecule (ELAM) mRNA
C20 1299-1309 NP denotes NF kappa B
C21 1338-1347 NP denotes ELAM mRNA
C22 1390-1396 NP denotes MM-LDL
C23 1488-1520 NP denotes agents that elevated cAMP levels
R1 C2 C1 coref-pron their,minimally oxidized LDL (MM-LDL) activated endothelial cells
R2 C4 C3 coref-relat which,the signaling pathways
R3 C7 C6 coref-ident the second messenger for the effects of MM-LDL cited above,cAMP
R4 C8 C5 coref-ident MM-LDL,MM-LDL
R5 C10 C9 coref-relat which,Agents
R6 C11 C6 coref-ident cAMP,cAMP
R7 C12 C8 coref-ident MM-LDL,MM-LDL
R8 C15 C13 coref-relat which,Agents which elevated cAMP
R9 C16 C11 coref-ident cAMP,cAMP
R10 C18 C17 coref-ident this transcription factor,NF kappa B
R11 C20 C17 coref-ident NF kappa B,NF kappa B
R12 C21 C19 coref-ident ELAM mRNA,endothelial leukocyte adhesion molecule (ELAM) mRNA
R13 C22 C12 coref-ident MM-LDL,MM-LDL
R14 C23 C14 coref-ident agents that elevated cAMP levels,Agents

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 19-30 other_name denotes low density
T2 31-42 protein_domain_or_region denotes lipoprotein
T3 77-94 cell_type denotes endothelial cells
T4 111-141 nucleotide denotes cyclic adenosine monophosphate
T5 173-197 cell_line denotes minimally oxidized LDL (
T6 197-203 protein_family_or_group denotes MM-LDL
T7 215-232 cell_type denotes endothelial cells
T8 268-277 cell_type denotes monocytes
T9 286-297 cell_type denotes neutrophils
T10 308-316 other_name denotes monocyte
T11 325-343 other_name denotes neutrophil binding
T12 361-391 protein_molecule denotes monocyte chemotactic protein-1
T13 396-430 protein_molecule denotes monocyte colony-stimulating factor
T14 432-437 protein_molecule denotes M-CSF
T15 517-543 other_name denotes monocyte-specific response
T16 574-590 other_name denotes monocyte binding
T17 595-606 other_name denotes mRNA levels
T18 611-616 protein_molecule denotes M-CSF
T19 620-626 protein_family_or_group denotes MM-LDL
T20 675-692 cell_type denotes endothelial cells
T21 732-736 nucleotide denotes cAMP
T22 780-786 protein_family_or_group denotes MM-LDL
T23 814-831 cell_type denotes endothelial cells
T24 837-843 protein_family_or_group denotes MM-LDL
T25 884-888 nucleotide denotes cAMP
T26 920-924 nucleotide denotes cAMP
T27 943-956 other_organic_compound denotes cholera toxin
T28 958-973 other_organic_compound denotes pertussis toxin
T29 975-989 amino_acid_monomer denotes dibutyryl cAMP
T30 995-1008 other_organic_compound denotes isoproterenol
T31 1033-1039 protein_family_or_group denotes MM-LDL
T32 1063-1067 nucleotide denotes cAMP
T33 1096-1106 protein_molecule denotes NF kappa B
T34 1217-1256 protein_molecule denotes endothelial leukocyte adhesion molecule
T35 1258-1262 protein_molecule denotes ELAM
T36 1299-1309 protein_molecule denotes NF kappa B
T37 1311-1315 protein_molecule denotes ELAM
T38 1338-1342 protein_molecule denotes ELAM
T39 1390-1396 protein_family_or_group denotes MM-LDL
T40 1436-1446 cell_type denotes neutrophil
T41 1458-1461 lipid denotes LPS
T42 1509-1513 nucleotide denotes cAMP