> top > docs > PubMed:8389757 > annotations

PubMed:8389757 JSONTXT

Annnotations TAB JSON ListView MergeView

sentences

Id Subject Object Predicate Lexical cue
T1 0-156 Sentence denotes Defective translocation of protein kinase C in multidrug-resistant HL-60 cells confers a reversible loss of phorbol ester-induced monocytic differentiation.
T2 157-276 Sentence denotes Previous studies have demonstrated that human HL-60 myeloid leukemia cells differentiate in response to phorbol esters.
T3 277-390 Sentence denotes This event is associated with induction of the c-jun early response gene and appearance of a monocytic phenotype.
T4 391-564 Sentence denotes The present studies have examined the effects of vincristine-selected, multidrug resistance on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced HL-60 cell differentiation.
T5 565-776 Sentence denotes The results demonstrate that multidrug-resistant HL-60 cells, designated HL-60/vinc, fail to respond to TPA with an increase in c-jun transcripts or other phenotypic characteristics of monocytic differentiation.
T6 777-971 Sentence denotes By contrast, treatment of HL-60/vinc cells with okadaic acid, an inhibitor of serine/threonine protein phosphatases, induces c-jun transcription, growth arrest, and expression of the c-fms gene.
T7 972-1102 Sentence denotes Studies were also performed with an HL-60/vinc revertant (HL-60/vinc/R) line that has regained partial sensitivity to vincristine.
T8 1103-1299 Sentence denotes The finding that HL-60/vinc/R cells respond to TPA with induction of a monocytic phenotype, but not c-jun expression, suggests that c-jun induction is not obligatory for monocytic differentiation.
T9 1300-1489 Sentence denotes Other studies further demonstrate that the jun-B and fra-1 genes are induced by TPA in both HL-60/vinc and HL-60/vinc/R cells, whereas c-fos expression is attenuated in the HL-60/vinc line.
T10 1490-1609 Sentence denotes Since TPA activates protein kinase C (PKC), we examined translocation of PKC from the cytosol to the membrane fraction.
T11 1610-1761 Sentence denotes Although HL-60 and HL-60/vinc/R cells demonstrated translocation of PKC activity, this subcellular redistribution was undetectable in HL-60/vinc cells.
T12 1762-1962 Sentence denotes Activity of the mitogen-activated protein kinase family with associated phosphorylation of c-Jun Y-peptide was markedly diminished in TPA-treated HL-60/vinc cells, but not in response to okadaic acid.
T13 1963-2196 Sentence denotes Taken together, these findings suggest that vincristine resistance confers insensitivity to TPA-induced differentiation and can include defects in PKC-mediated signaling events and induction of jun/fos early response gene expression.
T1 0-156 Sentence denotes Defective translocation of protein kinase C in multidrug-resistant HL-60 cells confers a reversible loss of phorbol ester-induced monocytic differentiation.
T2 157-276 Sentence denotes Previous studies have demonstrated that human HL-60 myeloid leukemia cells differentiate in response to phorbol esters.
T3 277-390 Sentence denotes This event is associated with induction of the c-jun early response gene and appearance of a monocytic phenotype.
T4 391-564 Sentence denotes The present studies have examined the effects of vincristine-selected, multidrug resistance on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced HL-60 cell differentiation.
T5 565-776 Sentence denotes The results demonstrate that multidrug-resistant HL-60 cells, designated HL-60/vinc, fail to respond to TPA with an increase in c-jun transcripts or other phenotypic characteristics of monocytic differentiation.
T6 777-971 Sentence denotes By contrast, treatment of HL-60/vinc cells with okadaic acid, an inhibitor of serine/threonine protein phosphatases, induces c-jun transcription, growth arrest, and expression of the c-fms gene.
T7 972-1102 Sentence denotes Studies were also performed with an HL-60/vinc revertant (HL-60/vinc/R) line that has regained partial sensitivity to vincristine.
T8 1103-1299 Sentence denotes The finding that HL-60/vinc/R cells respond to TPA with induction of a monocytic phenotype, but not c-jun expression, suggests that c-jun induction is not obligatory for monocytic differentiation.
T9 1300-1489 Sentence denotes Other studies further demonstrate that the jun-B and fra-1 genes are induced by TPA in both HL-60/vinc and HL-60/vinc/R cells, whereas c-fos expression is attenuated in the HL-60/vinc line.
T10 1490-1609 Sentence denotes Since TPA activates protein kinase C (PKC), we examined translocation of PKC from the cytosol to the membrane fraction.
T11 1610-1761 Sentence denotes Although HL-60 and HL-60/vinc/R cells demonstrated translocation of PKC activity, this subcellular redistribution was undetectable in HL-60/vinc cells.
T12 1762-1962 Sentence denotes Activity of the mitogen-activated protein kinase family with associated phosphorylation of c-Jun Y-peptide was markedly diminished in TPA-treated HL-60/vinc cells, but not in response to okadaic acid.
T13 1963-2196 Sentence denotes Taken together, these findings suggest that vincristine resistance confers insensitivity to TPA-induced differentiation and can include defects in PKC-mediated signaling events and induction of jun/fos early response gene expression.

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 27-43 protein denotes protein kinase C
T2 47-78 cell_line denotes multidrug-resistant HL-60 cells
T3 197-231 cell_line denotes human HL-60 myeloid leukemia cells
T4 324-349 DNA denotes c-jun early response gene
T5 594-625 cell_line denotes multidrug-resistant HL-60 cells
T6 693-710 RNA denotes c-jun transcripts
T7 803-819 cell_line denotes HL-60/vinc cells
T8 855-892 protein denotes serine/threonine protein phosphatases
T9 902-907 DNA denotes c-jun
T10 960-970 DNA denotes c-fms gene
T11 1008-1028 cell_line denotes HL-60/vinc revertant
T12 1030-1042 cell_line denotes HL-60/vinc/R
T13 1120-1138 cell_line denotes HL-60/vinc/R cells
T14 1203-1208 DNA denotes c-jun
T15 1235-1240 DNA denotes c-jun
T16 1343-1348 DNA denotes jun-B
T17 1353-1358 DNA denotes fra-1
T18 1359-1364 DNA denotes genes
T19 1392-1402 cell_line denotes HL-60/vinc
T20 1407-1425 cell_line denotes HL-60/vinc/R cells
T21 1435-1440 DNA denotes c-fos
T22 1510-1526 protein denotes protein kinase C
T23 1528-1531 protein denotes PKC
T24 1563-1566 protein denotes PKC
T25 1619-1624 cell_line denotes HL-60
T26 1629-1647 cell_line denotes HL-60/vinc/R cells
T27 1678-1681 protein denotes PKC
T28 1744-1760 cell_line denotes HL-60/vinc cells
T29 1778-1817 protein denotes mitogen-activated protein kinase family
T30 1853-1868 protein denotes c-Jun Y-peptide
T31 1896-1924 cell_line denotes TPA-treated HL-60/vinc cells
T32 2110-2113 protein denotes PKC
T33 2157-2184 DNA denotes jun/fos early response gene

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-156 Sentence denotes Defective translocation of protein kinase C in multidrug-resistant HL-60 cells confers a reversible loss of phorbol ester-induced monocytic differentiation.
S2 157-276 Sentence denotes Previous studies have demonstrated that human HL-60 myeloid leukemia cells differentiate in response to phorbol esters.
S3 277-390 Sentence denotes This event is associated with induction of the c-jun early response gene and appearance of a monocytic phenotype.
S4 391-564 Sentence denotes The present studies have examined the effects of vincristine-selected, multidrug resistance on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced HL-60 cell differentiation.
S5 565-776 Sentence denotes The results demonstrate that multidrug-resistant HL-60 cells, designated HL-60/vinc, fail to respond to TPA with an increase in c-jun transcripts or other phenotypic characteristics of monocytic differentiation.
S6 777-971 Sentence denotes By contrast, treatment of HL-60/vinc cells with okadaic acid, an inhibitor of serine/threonine protein phosphatases, induces c-jun transcription, growth arrest, and expression of the c-fms gene.
S7 972-1102 Sentence denotes Studies were also performed with an HL-60/vinc revertant (HL-60/vinc/R) line that has regained partial sensitivity to vincristine.
S8 1103-1299 Sentence denotes The finding that HL-60/vinc/R cells respond to TPA with induction of a monocytic phenotype, but not c-jun expression, suggests that c-jun induction is not obligatory for monocytic differentiation.
S9 1300-1489 Sentence denotes Other studies further demonstrate that the jun-B and fra-1 genes are induced by TPA in both HL-60/vinc and HL-60/vinc/R cells, whereas c-fos expression is attenuated in the HL-60/vinc line.
S10 1490-1609 Sentence denotes Since TPA activates protein kinase C (PKC), we examined translocation of PKC from the cytosol to the membrane fraction.
S11 1610-1761 Sentence denotes Although HL-60 and HL-60/vinc/R cells demonstrated translocation of PKC activity, this subcellular redistribution was undetectable in HL-60/vinc cells.
S12 1762-1962 Sentence denotes Activity of the mitogen-activated protein kinase family with associated phosphorylation of c-Jun Y-peptide was markedly diminished in TPA-treated HL-60/vinc cells, but not in response to okadaic acid.
S13 1963-2196 Sentence denotes Taken together, these findings suggest that vincristine resistance confers insensitivity to TPA-induced differentiation and can include defects in PKC-mediated signaling events and induction of jun/fos early response gene expression.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 27-43 NP denotes protein kinase C
C2 47-78 NP denotes multidrug-resistant HL-60 cells
C3 486-529 NP denotes 12-O-tetradecanoylphorbol-13-acetate (TPA)-
C4 594-625 NP denotes multidrug-resistant HL-60 cells
C5 638-648 NP denotes HL-60/vinc
C6 669-672 NP denotes TPA
C7 803-819 NP denotes HL-60/vinc cells
C8 825-837 NP denotes okadaic acid
C9 839-892 NP denotes an inhibitor of serine/threonine protein phosphatases
C11 1005-1048 NP denotes an HL-60/vinc revertant (HL-60/vinc/R) line
C12 1049-1053 NP denotes that
C10 1005-1101 NP denotes an HL-60/vinc revertant (HL-60/vinc/R) line that has regained partial sensitivity to vincristine
C13 1120-1138 NP denotes HL-60/vinc/R cells
C14 1150-1153 NP denotes TPA
C15 1380-1383 NP denotes TPA
C16 1392-1402 NP denotes HL-60/vinc
C17 1407-1425 NP denotes HL-60/vinc/R cells
C18 1469-1488 NP denotes the HL-60/vinc line
C19 1496-1499 NP denotes TPA
C20 1510-1532 NP denotes protein kinase C (PKC)
C21 1563-1566 NP denotes PKC
C22 1629-1647 NP denotes HL-60/vinc/R cells
C23 1744-1760 NP denotes HL-60/vinc cells
C24 1896-1900 NP denotes TPA-
C25 2055-2059 NP denotes TPA-
C26 2110-2114 NP denotes PKC-
R1 C4 C2 coref-ident multidrug-resistant HL-60 cells,multidrug-resistant HL-60 cells
R2 C6 C3 coref-ident TPA,12-O-tetradecanoylphorbol-13-acetate (TPA)-
R3 C7 C5 coref-ident HL-60/vinc cells,HL-60/vinc
R4 C9 C8 coref-appos an inhibitor of serine/threonine protein phosphatases,okadaic acid
R5 C12 C10 coref-relat that,an HL-60/vinc revertant (HL-60/vinc/R) line that has regained partial sensitivity to vincristine
R6 C13 C11 coref-other HL-60/vinc/R cells,an HL-60/vinc revertant (HL-60/vinc/R) line
R7 C14 C6 coref-ident TPA,TPA
R8 C15 C14 coref-ident TPA,TPA
R9 C16 C5 coref-ident HL-60/vinc,HL-60/vinc
R10 C17 C13 coref-ident HL-60/vinc/R cells,HL-60/vinc/R cells
R11 C18 C10 coref-ident the HL-60/vinc line,an HL-60/vinc revertant (HL-60/vinc/R) line that has regained partial sensitivity to vincristine
R12 C19 C15 coref-ident TPA,TPA
R13 C20 C1 coref-ident protein kinase C (PKC),protein kinase C
R14 C21 C20 coref-ident PKC,protein kinase C (PKC)
R15 C22 C17 coref-ident HL-60/vinc/R cells,HL-60/vinc/R cells
R16 C23 C18 coref-ident HL-60/vinc cells,the HL-60/vinc line
R17 C24 C15 coref-ident TPA-,TPA
R18 C25 C24 coref-ident TPA-,TPA-
R19 C26 C21 coref-ident PKC-,PKC

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 27-43 protein_molecule denotes protein kinase C
T2 47-78 cell_line denotes multidrug-resistant HL-60 cells
T3 108-155 other_name denotes phorbol ester-induced monocytic differentiation
T4 197-231 cell_line denotes human HL-60 myeloid leukemia cells
T5 261-275 other_organic_compound denotes phorbol esters
T6 324-349 DNA_domain_or_region denotes c-jun early response gene
T7 370-389 other_name denotes monocytic phenotype
T8 486-522 other_organic_compound denotes 12-O-tetradecanoylphorbol-13-acetate
T9 524-527 other_organic_compound denotes TPA
T10 594-613 cell_line denotes multidrug-resistant
T11 614-625 cell_line denotes HL-60 cells
T12 669-672 other_organic_compound denotes TPA
T13 693-698 DNA_domain_or_region denotes c-jun
T14 750-775 other_name denotes monocytic differentiation
T15 803-819 cell_line denotes HL-60/vinc cells
T16 825-837 other_organic_compound denotes okadaic acid
T17 855-861 amino_acid_monomer denotes serine
T18 861-871 amino_acid_monomer denotes /threonine
T19 902-907 DNA_domain_or_region denotes c-jun
T20 960-970 DNA_domain_or_region denotes c-fms gene
T21 1008-1028 cell_line denotes HL-60/vinc revertant
T22 1030-1042 cell_line denotes HL-60/vinc/R
T23 1090-1101 other_organic_compound denotes vincristine
T24 1120-1138 cell_line denotes HL-60/vinc/R cells
T25 1150-1153 other_organic_compound denotes TPA
T26 1174-1193 other_name denotes monocytic phenotype
T27 1203-1208 DNA_domain_or_region denotes c-jun
T28 1235-1240 DNA_domain_or_region denotes c-jun
T29 1273-1298 other_name denotes monocytic differentiation
T30 1343-1348 DNA_domain_or_region denotes jun-B
T31 1353-1358 DNA_domain_or_region denotes fra-1
T32 1359-1364 DNA_family_or_group denotes genes
T33 1380-1383 other_organic_compound denotes TPA
T34 1392-1402 cell_line denotes HL-60/vinc
T35 1407-1425 cell_line denotes HL-60/vinc/R cells
T36 1435-1440 DNA_domain_or_region denotes c-fos
T37 1496-1499 other_organic_compound denotes TPA
T38 1510-1526 protein_molecule denotes protein kinase C
T39 1528-1531 protein_molecule denotes PKC
T40 1563-1566 protein_molecule denotes PKC
T41 1576-1583 cell_component denotes cytosol
T42 1591-1608 cell_component denotes membrane fraction
T43 1619-1624 cell_line denotes HL-60
T44 1629-1647 cell_line denotes HL-60/vinc/R cells
T45 1678-1681 protein_molecule denotes PKC
T46 1697-1723 other_name denotes subcellular redistribution
T47 1744-1760 cell_line denotes HL-60/vinc cells
T48 1778-1817 protein_family_or_group denotes mitogen-activated protein kinase family
T49 1853-1868 protein_subunit denotes c-Jun Y-peptide
T50 1896-1899 other_organic_compound denotes TPA
T51 1908-1924 cell_line denotes HL-60/vinc cells
T52 1949-1961 other_organic_compound denotes okadaic acid
T53 2007-2018 other_organic_compound denotes vincristine
T54 2055-2058 other_organic_compound denotes TPA
T55 2110-2113 protein_molecule denotes PKC
T56 2157-2184 DNA_domain_or_region denotes jun/fos early response gene

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 209-225 Phenotype denotes myeloid leukemia HP:0012324

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 209-225 Disease denotes myeloid leukemia http://purl.obolibrary.org/obo/MONDO_0004643
T2 1353-1356 Disease denotes fra http://purl.obolibrary.org/obo/MONDO_0011462

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 197-202 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 1576-1583 Body_part denotes cytosol http://purl.obolibrary.org/obo/GO_0005829
T2 1591-1599 Body_part denotes membrane http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 130-139 Cell denotes monocytic http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054
T3 370-379 Cell denotes monocytic http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054
T5 750-759 Cell denotes monocytic http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054
T7 1174-1183 Cell denotes monocytic http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054
T9 1273-1282 Cell denotes monocytic http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054