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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 35-62 DNA denotes Jun oncogene family members
T2 66-89 protein denotes glucocorticoid receptor
T3 135-151 protein denotes protein kinase C
T4 153-156 protein denotes PKC
T5 163-186 protein denotes glucocorticoid receptor
T6 188-190 protein denotes GR
T7 246-249 protein denotes PKC
T8 329-331 protein denotes GR
T9 396-416 DNA denotes long terminal repeat
T10 418-421 DNA denotes LTR
T11 553-561 DNA denotes MMTV LTR
T12 573-585 cell_line denotes T cell lines
T13 608-627 cell_line denotes NIH-3T3 fibroblasts
T14 685-706 DNA denotes GR-responsive element
T15 708-711 DNA denotes GRE
T16 745-761 DNA denotes deletion mutants
T17 765-795 DNA denotes synthetic GRE oligonucleotides
T18 804-838 protein denotes chloramphenicol acetyl-transferase
T19 880-901 protein denotes GR DNA-binding domain
T20 911-946 protein denotes amino- or carboxyl-terminal domains
T21 997-1000 protein denotes PKC
T22 1048-1051 protein denotes PKC
T23 1063-1068 protein denotes c-jun
T24 1070-1075 protein denotes jun-B
T25 1081-1086 protein denotes jun-D
T26 1159-1187 DNA denotes AP-1/TPA responsive elements
T27 1197-1239 DNA denotes chloramphenicol acetyl-transferase vectors
T28 1257-1264 cell_type denotes T cells
T29 1341-1353 protein denotes Jun proteins
T30 1372-1374 protein denotes GR
T31 1378-1385 cell_type denotes T cells
T32 1430-1471 DNA denotes c-jun, jun-B, or jun-D expression vectors
T33 1489-1491 protein denotes GR
T34 1528-1536 DNA denotes MMTV LTR
T35 1540-1543 DNA denotes GRE
T36 1557-1562 protein denotes c-jun
T37 1567-1572 protein denotes jun-B
T38 1594-1596 protein denotes GR
T39 1624-1634 cell_line denotes HeLa cells
T40 1652-1657 protein denotes c-fos
T41 1686-1688 protein denotes GR
T42 1776-1779 protein denotes Jun
T43 1796-1798 protein denotes GR
T44 1825-1830 protein denotes c-fos
T45 1842-1846 protein denotes AP-1
T46 1905-1915 cell_line denotes HeLa cells
T47 1928-1935 cell_type denotes T cells
T48 1967-1982 protein denotes exogenous c-fos
T49 2011-2013 protein denotes GR
T50 2043-2046 DNA denotes GRE
T51 2050-2057 cell_type denotes T cells
T52 2075-2078 protein denotes Jun
T53 2108-2110 protein denotes GR
T54 2151-2154 DNA denotes GRE
T55 2299-2304 protein denotes c-fos

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-114 Sentence denotes Cell-specific bifunctional role of Jun oncogene family members on glucocorticoid receptor-dependent transcription.
S2 115-423 Sentence denotes Interaction between protein kinase C (PKC)- and glucocorticoid receptor (GR)-mediated signaling is suggested by the ability of the PKC activating phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) to inhibit GR-dependent transcription of the mouse mammary tumor virus (MMTV) long terminal repeat (LTR).
S3 424-628 Sentence denotes Here we report that this interference is cell specific, as TPA augmented dexamethasone-induced transcriptional activation of the MMTV LTR in several T cell lines but was inhibitory in NIH-3T3 fibroblasts.
S4 629-850 Sentence denotes TPA-GR synergism was determined to have occurred at the GR-responsive element (GRE) level by functional analysis of deletion mutants or synthetic GRE oligonucleotides driving chloramphenicol acetyl-transferase expression.
S5 851-964 Sentence denotes Synergism required an intact GR DNA-binding domain, whereas amino- or carboxyl-terminal domains were dispensable.
S6 965-1052 Sentence denotes The effect was abrogated by the PKC inhibitor staurosporine, suggesting a role for PKC.
S7 1053-1325 Sentence denotes Increased c-jun, jun-B, and jun-D expression above basal levels and increased transcriptional activity of AP-1/TPA responsive elements fused to chloramphenicol acetyl-transferase vectors were observed in T cells treated with TPA alone or in combination with dexamethasone.
S8 1326-1544 Sentence denotes The ability of Jun proteins to cooperate with GR in T cells has been investigated after transfection of c-jun, jun-B, or jun-D expression vectors, which augmented GR-dependent transcription from either MMTV LTR or GRE.
S9 1545-1635 Sentence denotes Conversely, c-jun and jun-B transfection blunted GR-dependent transcription in HeLa cells.
S10 1636-1936 Sentence denotes The presence of c-fos had a negative influence on GR function and correlated with the cell-specific synergistic or antagonistic activity of Jun with respect to GR; high basal expression of c-fos as well as AP-1 DNA binding and transcriptional activity were observed in HeLa cells, but not in T cells.
S11 1937-2058 Sentence denotes Furthermore overexpression of exogenous c-fos has an inhibitory effect on GR-dependent transcription from GRE in T cells.
S12 2059-2258 Sentence denotes We propose that Jun plays a bifunctional role on GR-dependent transcriptional activation of GRE, selecting either synergistic or antagonistic activity depending on the cell-specific microenvironment.
S13 2259-2330 Sentence denotes In this regard, intracellular levels of c-fos appear to be influential.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 66-90 NP denotes glucocorticoid receptor-
C2 135-158 NP denotes protein kinase C (PKC)-
C3 163-192 NP denotes glucocorticoid receptor (GR)-
C4 275-317 NP denotes 12-O-tetradecanoylphorbol-13-acetate (TPA)
C5 359-422 NP denotes the mouse mammary tumor virus (MMTV) long terminal repeat (LTR)
C6 483-486 NP denotes TPA
C7 549-561 NP denotes the MMTV LTR
C8 629-633 NP denotes TPA-
C9 633-635 NP denotes GR
C11 685-688 NP denotes GR-
C10 685-712 NP denotes GR-responsive element (GRE)
C12 1278-1281 NP denotes TPA
C13 1372-1374 NP denotes GR
C14 1378-1385 NP denotes T cells
C15 1430-1471 NP denotes c-jun, jun-B, or jun-D expression vectors
C16 1473-1478 NP denotes which
C17 1489-1492 NP denotes GR-
C18 1528-1536 NP denotes MMTV LTR
C19 1540-1543 NP denotes GRE
C20 1594-1597 NP denotes GR-
C21 1624-1634 NP denotes HeLa cells
C22 1652-1657 NP denotes c-fos
C23 1686-1688 NP denotes GR
C24 1796-1798 NP denotes GR
C25 1825-1830 NP denotes c-fos
C26 1905-1915 NP denotes HeLa cells
C27 1928-1935 NP denotes T cells
C28 2011-2014 NP denotes GR-
C29 2050-2057 NP denotes T cells
C30 2108-2111 NP denotes GR-
C31 2151-2154 NP denotes GRE
C32 2299-2304 NP denotes c-fos
R1 C3 C1 coref-ident glucocorticoid receptor (GR)-,glucocorticoid receptor-
R2 C6 C4 coref-ident TPA,12-O-tetradecanoylphorbol-13-acetate (TPA)
R3 C7 C5 coref-ident the MMTV LTR,the mouse mammary tumor virus (MMTV) long terminal repeat (LTR)
R4 C8 C6 coref-ident TPA-,TPA
R5 C9 C3 coref-ident GR,glucocorticoid receptor (GR)-
R6 C11 C3 coref-ident GR-,glucocorticoid receptor (GR)-
R7 C12 C4 coref-ident TPA,12-O-tetradecanoylphorbol-13-acetate (TPA)
R8 C13 C11 coref-ident GR,GR-
R9 C16 C15 coref-relat which,"c-jun, jun-B, or jun-D expression vectors"
R10 C17 C13 coref-ident GR-,GR
R11 C18 C7 coref-ident MMTV LTR,the MMTV LTR
R12 C19 C10 coref-ident GRE,GR-responsive element (GRE)
R13 C20 C17 coref-ident GR-,GR-
R14 C23 C20 coref-ident GR,GR-
R15 C24 C23 coref-ident GR,GR
R16 C25 C22 coref-ident c-fos,c-fos
R17 C26 C21 coref-ident HeLa cells,HeLa cells
R18 C27 C14 coref-ident T cells,T cells
R19 C28 C24 coref-ident GR-,GR
R20 C29 C27 coref-ident T cells,T cells
R21 C30 C28 coref-ident GR-,GR-
R22 C31 C19 coref-ident GRE,GRE
R23 C32 C25 coref-ident c-fos,c-fos

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 35-62 DNA_family_or_group denotes Jun oncogene family members
T2 66-89 protein_family_or_group denotes glucocorticoid receptor
T3 135-151 protein_molecule denotes protein kinase C
T4 153-156 protein_molecule denotes PKC
T5 163-186 protein_family_or_group denotes glucocorticoid receptor
T6 188-190 protein_family_or_group denotes GR
T7 246-249 protein_molecule denotes PKC
T8 275-311 other_organic_compound denotes 12-O-tetradecanoylphorbol-13-acetate
T9 313-316 other_organic_compound denotes TPA
T10 329-331 protein_family_or_group denotes GR
T11 363-388 virus denotes mouse mammary tumor virus
T12 390-394 virus denotes MMTV
T13 396-416 DNA_domain_or_region denotes long terminal repeat
T14 418-421 DNA_domain_or_region denotes LTR
T15 483-486 other_organic_compound denotes TPA
T16 497-510 other_organic_compound denotes dexamethasone
T17 553-561 DNA_domain_or_region denotes MMTV LTR
T18 573-585 cell_line denotes T cell lines
T19 608-627 cell_line denotes NIH-3T3 fibroblasts
T20 629-645 other_name denotes TPA-GR synergism
T21 685-687 protein_family_or_group denotes GR
T22 708-711 DNA_domain_or_region denotes GRE
T23 745-761 DNA_family_or_group denotes deletion mutants
T24 765-774 DNA_family_or_group denotes synthetic
T25 775-778 DNA_domain_or_region denotes GRE
T26 804-838 protein_molecule denotes chloramphenicol acetyl-transferase
T27 880-901 protein_domain_or_region denotes GR DNA-binding domain
T28 997-1000 protein_molecule denotes PKC
T29 1011-1024 other_organic_compound denotes staurosporine
T30 1048-1051 protein_molecule denotes PKC
T31 1063-1068 protein_molecule denotes c-jun
T32 1070-1075 protein_molecule denotes jun-B
T33 1081-1086 protein_molecule denotes jun-D
T34 1159-1187 DNA_domain_or_region denotes AP-1/TPA responsive elements
T35 1197-1231 protein_molecule denotes chloramphenicol acetyl-transferase
T36 1257-1264 cell_type denotes T cells
T37 1278-1281 other_organic_compound denotes TPA
T38 1311-1324 other_organic_compound denotes dexamethasone
T39 1341-1353 protein_family_or_group denotes Jun proteins
T40 1372-1374 protein_family_or_group denotes GR
T41 1378-1385 cell_type denotes T cells
T42 1489-1491 protein_family_or_group denotes GR
T43 1528-1536 DNA_domain_or_region denotes MMTV LTR
T44 1540-1543 DNA_domain_or_region denotes GRE
T45 1557-1562 protein_molecule denotes c-jun
T46 1567-1572 protein_molecule denotes jun-B
T47 1594-1596 protein_family_or_group denotes GR
T48 1624-1634 cell_line denotes HeLa cells
T49 1652-1657 protein_molecule denotes c-fos
T50 1686-1688 protein_family_or_group denotes GR
T51 1776-1779 protein_family_or_group denotes Jun
T52 1796-1798 protein_family_or_group denotes GR
T53 1825-1830 protein_molecule denotes c-fos
T54 1842-1846 protein_molecule denotes AP-1
T55 1863-1887 other_name denotes transcriptional activity
T56 1905-1915 cell_line denotes HeLa cells
T57 1928-1935 cell_type denotes T cells
T58 1967-1976 protein_molecule denotes exogenous
T59 1977-1982 protein_molecule denotes c-fos
T60 2011-2013 protein_family_or_group denotes GR
T61 2043-2046 DNA_domain_or_region denotes GRE
T62 2050-2057 cell_type denotes T cells
T63 2075-2078 protein_family_or_group denotes Jun
T64 2108-2110 protein_family_or_group denotes GR
T65 2151-2154 DNA_domain_or_region denotes GRE
T66 2299-2304 protein_molecule denotes c-fos