> top > docs > PubMed:8383844 > annotations

PubMed:8383844 JSONTXT

Annnotations TAB JSON ListView MergeView

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-186 Sentence denotes Competition between transcription factors HNF1 and HNF3, and alternative cell-specific activation by DBP and C/EBP contribute to the regulation of the liver-specific aldolase B promoter.
TextSentencer_T2 187-338 Sentence denotes The aldolase B proximal promoter is controlled by at least five elements spanning from -190 to -103 bp with respect to the start site of transcription.
TextSentencer_T3 339-575 Sentence denotes From 5' to 3', we found: a negative DE element, an activating C/EBP-DBP binding site, a CCAAT box binding NFY that seems to play a negative role, and an activating element consisting of two overlapping binding sites for HNF-1 and HNF-3.
TextSentencer_T4 576-743 Sentence denotes Contransfection experiments of aldolase B/CAT constructs and of expression vectors for different transcription factors were carried out in human hepatoma Hep G2 cells.
TextSentencer_T5 744-920 Sentence denotes We found that DBP and HNF-1 are strong transactivators of the aldolase B promoter while C/EBP and vHNF-1 are only weak activators and HNF-3 alone does not modify such activity.
TextSentencer_T6 921-1067 Sentence denotes Deletion of the distal negative element results in a similar transactivation by C/EBP and DBP, enhanced for the former and reduced for the latter.
TextSentencer_T7 1068-1172 Sentence denotes In hepatocytes in primary culture, the strong transactivator is C/EBP while DBP is essentially inactive.
TextSentencer_T8 1173-1321 Sentence denotes This tissue-specificity of C/EBP and DBP action could depend on interaction with tissue-specific proteins bound to a neighbouring site, probably DE.
TextSentencer_T9 1322-1403 Sentence denotes Finally, HNF3 behaves as a very strong anti-activator of the aldolase B promoter.
TextSentencer_T10 1404-1503 Sentence denotes It competitively antagonizes transactivation by HNF-1 and non-competitively transactivation by DBP.
TextSentencer_T11 1504-1654 Sentence denotes This negative effect of HNF-3 and tissue-specificity of the transactivation potential of DBP and C/EBP are unique features of the aldolase B promoter.
T1 0-186 Sentence denotes Competition between transcription factors HNF1 and HNF3, and alternative cell-specific activation by DBP and C/EBP contribute to the regulation of the liver-specific aldolase B promoter.
T2 187-338 Sentence denotes The aldolase B proximal promoter is controlled by at least five elements spanning from -190 to -103 bp with respect to the start site of transcription.
T3 339-575 Sentence denotes From 5' to 3', we found: a negative DE element, an activating C/EBP-DBP binding site, a CCAAT box binding NFY that seems to play a negative role, and an activating element consisting of two overlapping binding sites for HNF-1 and HNF-3.
T4 576-743 Sentence denotes Contransfection experiments of aldolase B/CAT constructs and of expression vectors for different transcription factors were carried out in human hepatoma Hep G2 cells.
T5 744-920 Sentence denotes We found that DBP and HNF-1 are strong transactivators of the aldolase B promoter while C/EBP and vHNF-1 are only weak activators and HNF-3 alone does not modify such activity.
T6 921-1067 Sentence denotes Deletion of the distal negative element results in a similar transactivation by C/EBP and DBP, enhanced for the former and reduced for the latter.
T7 1068-1172 Sentence denotes In hepatocytes in primary culture, the strong transactivator is C/EBP while DBP is essentially inactive.
T8 1173-1321 Sentence denotes This tissue-specificity of C/EBP and DBP action could depend on interaction with tissue-specific proteins bound to a neighbouring site, probably DE.
T9 1322-1403 Sentence denotes Finally, HNF3 behaves as a very strong anti-activator of the aldolase B promoter.
T10 1404-1503 Sentence denotes It competitively antagonizes transactivation by HNF-1 and non-competitively transactivation by DBP.
T11 1504-1654 Sentence denotes This negative effect of HNF-3 and tissue-specificity of the transactivation potential of DBP and C/EBP are unique features of the aldolase B promoter.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 618-621 gene:847 denotes CAT
T1 721-729 disease:C0023903 denotes hepatoma
T2 618-621 gene:847 denotes CAT
T3 721-729 disease:C2239176 denotes hepatoma
T4 618-621 gene:1384 denotes CAT
T5 721-729 disease:C0023903 denotes hepatoma
T6 618-621 gene:1384 denotes CAT
T7 721-729 disease:C2239176 denotes hepatoma
T8 618-621 gene:10249 denotes CAT
T9 721-729 disease:C0023903 denotes hepatoma
T10 618-621 gene:10249 denotes CAT
T11 721-729 disease:C2239176 denotes hepatoma
R1 T0 T1 associated_with CAT,hepatoma
R2 T2 T3 associated_with CAT,hepatoma
R3 T4 T5 associated_with CAT,hepatoma
R4 T6 T7 associated_with CAT,hepatoma
R5 T8 T9 associated_with CAT,hepatoma
R6 T10 T11 associated_with CAT,hepatoma

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T810 618-621 gene:847 denotes CAT
T811 721-729 disease:C0023903 denotes hepatoma
R1 T810 T811 associated_with CAT,hepatoma
R2 T810 T811 associated_with CAT,hepatoma

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 151-156 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
PD-UBERON-AE-B_T2 1178-1184 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
PD-UBERON-AE-B_T3 1254-1260 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
PD-UBERON-AE-B_T4 1538-1544 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 1178-1184 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
PD-UBERON-AE-B_T2 1254-1260 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
PD-UBERON-AE-B_T3 1538-1544 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
PD-UBERON-AE-B_T4 151-156 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver