| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-158 |
Sentence |
denotes |
Selective modification of Sendai virus hemagglutinin neuraminidase by pyridoxal 5'-phosphate: evidence for an allosteric modulation of neuraminidase activity. |
| T2 |
159-352 |
Sentence |
denotes |
Incubation of Sendai virus with pyridoxal 5'-phosphate (PLP) causes inhibition of hemolytic activity, a slight reduction of hemagglutinating activity, and an increase in neuraminidase activity. |
| T3 |
353-521 |
Sentence |
denotes |
The effects on hemagglutination and neuraminidase are prevented by the presence in the incubation mixture of sialyl lactose, a substrate of hemagglutinin-neuraminidase. |
| T4 |
522-734 |
Sentence |
denotes |
Incubation with PLP of the water-soluble enzymatic domain of the neuraminidase has no effect on enzymatic activity, while the allosteric inhibition (Dallocchio et al. (1991) Biochem. Int. 25, 663-668) disappears. |
| T5 |
735-832 |
Sentence |
denotes |
Both virus-bound and solubilized neuraminidase are selectively modified by PLP at the lysine-553. |
| T6 |
833-1006 |
Sentence |
denotes |
Our data suggest that PLP inactivates a previously undetected inhibitory site on the viral neuraminidase, and that a physiological effector is present on the viral envelope. |
