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PubMed:8307953 JSONTXT

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CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 40-50 Cell denotes fibroblast http://purl.obolibrary.org/obo/CL:0000057
T2 183-193 Cell denotes fibroblast http://purl.obolibrary.org/obo/CL:0000057
T3 379-391 Cell denotes myeloid cell http://purl.obolibrary.org/obo/CL:0000763

GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 0-7 Glycan_Motif denotes Heparin https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G54161DR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00021MO
T3 127-134 Glycan_Motif denotes heparin https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G54161DR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00021MO
T5 674-681 Glycan_Motif denotes heparin https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G54161DR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00021MO
T7 790-797 Glycan_Motif denotes heparin https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G54161DR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00021MO
T9 899-906 Glycan_Motif denotes heparin https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G54161DR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00021MO
T11 1261-1268 Glycan_Motif denotes heparin https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G54161DR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00021MO
T13 1416-1423 Glycan_Motif denotes heparin https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G54161DR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00021MO
T15 1445-1452 Glycan_Motif denotes heparin https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G54161DR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00021MO
T17 1518-1525 Glycan_Motif denotes heparin https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G54161DR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00021MO
T19 1688-1695 Glycan_Motif denotes heparin https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G54161DR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00021MO
T21 1883-1890 Glycan_Motif denotes heparin https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G54161DR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00021MO

sentences

Id Subject Object Predicate Lexical cue
T1 0-114 Sentence denotes Heparin increases the affinity of basic fibroblast growth factor for its receptor but is not required for binding.
T2 115-562 Sentence denotes The role of heparin or heparan sulfates in the interaction of basic fibroblast growth factor (bFGF) with its high affinity receptor were investigated using purified extracellular ligand-binding region of FGF receptor-1 (FGFR-1) and intact receptors expressed in a myeloid cell line (32D) that does not express detectable levels of heparan sulfate proteoglycans or in Chinese hamster ovary (CHO) cell mutants defective in heparan sulfate synthesis.
T3 563-682 Sentence denotes The purified extracellular domain of FGFR-1 formed complexes with 125I-bFGF both in the presence or absence of heparin.
T4 683-847 Sentence denotes Intact FGFR-1 expressed in 32D cells also bound the same amount of 125I-bFGF in the presence or absence of heparin when saturating concentrations of bFGF were used.
T5 848-1042 Sentence denotes Varying the concentration of 125I-bFGF showed that heparin increased the amount of 125I-bFGF bound at low bFGF concentrations and increased the affinity of bFGF for its receptor by about 3-fold.
T6 1043-1184 Sentence denotes To eliminate the possibility of alteration of bFGF properties through the chemical modification reactions, bFGF was labeled biosynthetically.
T7 1185-1269 Sentence denotes The binding of biosynthetically labeled bFGF to FGFR-1 also did not require heparin.
T8 1270-1511 Sentence denotes When FGFR-1 or FGFR-2 were expressed in mutant CHO cells deficient in heparan sulfate synthesis, the cells also bound 125I-bFGF in the absence of heparin, and the addition of heparin increased the affinity of bFGF for its receptors 2-3-fold.
T9 1512-1658 Sentence denotes Thus, heparin or heparan sulfate is not required for the binding of bFGF to its receptors but increases the binding affinity to a moderate degree.
T10 1659-1757 Sentence denotes Finally, the requirement for heparin in signal transduction through the receptor was investigated.
T11 1758-1891 Sentence denotes Expression of c-fos mRNA was induced by bFGF in 32D cells expressing FGFR-1 to the same extent in the presence or absence of heparin.
T1 0-114 Sentence denotes Heparin increases the affinity of basic fibroblast growth factor for its receptor but is not required for binding.
T2 115-562 Sentence denotes The role of heparin or heparan sulfates in the interaction of basic fibroblast growth factor (bFGF) with its high affinity receptor were investigated using purified extracellular ligand-binding region of FGF receptor-1 (FGFR-1) and intact receptors expressed in a myeloid cell line (32D) that does not express detectable levels of heparan sulfate proteoglycans or in Chinese hamster ovary (CHO) cell mutants defective in heparan sulfate synthesis.
T3 563-682 Sentence denotes The purified extracellular domain of FGFR-1 formed complexes with 125I-bFGF both in the presence or absence of heparin.
T4 683-847 Sentence denotes Intact FGFR-1 expressed in 32D cells also bound the same amount of 125I-bFGF in the presence or absence of heparin when saturating concentrations of bFGF were used.
T5 848-1042 Sentence denotes Varying the concentration of 125I-bFGF showed that heparin increased the amount of 125I-bFGF bound at low bFGF concentrations and increased the affinity of bFGF for its receptor by about 3-fold.
T6 1043-1184 Sentence denotes To eliminate the possibility of alteration of bFGF properties through the chemical modification reactions, bFGF was labeled biosynthetically.
T7 1185-1269 Sentence denotes The binding of biosynthetically labeled bFGF to FGFR-1 also did not require heparin.
T8 1270-1511 Sentence denotes When FGFR-1 or FGFR-2 were expressed in mutant CHO cells deficient in heparan sulfate synthesis, the cells also bound 125I-bFGF in the absence of heparin, and the addition of heparin increased the affinity of bFGF for its receptors 2-3-fold.
T9 1512-1658 Sentence denotes Thus, heparin or heparan sulfate is not required for the binding of bFGF to its receptors but increases the binding affinity to a moderate degree.
T10 1659-1757 Sentence denotes Finally, the requirement for heparin in signal transduction through the receptor was investigated.
T11 1758-1891 Sentence denotes Expression of c-fos mRNA was induced by bFGF in 32D cells expressing FGFR-1 to the same extent in the presence or absence of heparin.

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 0-7 https://glytoucan.org/Structures/Glycans/G00021MO denotes Heparin
T2 0-7 https://glytoucan.org/Structures/Glycans/G54161DR denotes Heparin
T3 127-134 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T4 127-134 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T5 674-681 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T6 674-681 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T7 790-797 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T8 790-797 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T9 899-906 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T10 899-906 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T11 1261-1268 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T12 1261-1268 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T13 1416-1423 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T14 1416-1423 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T15 1445-1452 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T16 1445-1452 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T17 1518-1525 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T18 1518-1525 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T19 1688-1695 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T20 1688-1695 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T21 1883-1890 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T22 1883-1890 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin

Glycosmos6-GlycoEpitope

Id Subject Object Predicate Lexical cue
T1 446-461 http://www.glycoepitope.jp/epitopes/EP0086 denotes heparan sulfate
T2 536-551 http://www.glycoepitope.jp/epitopes/EP0086 denotes heparan sulfate
T3 1340-1355 http://www.glycoepitope.jp/epitopes/EP0086 denotes heparan sulfate
T4 1529-1544 http://www.glycoepitope.jp/epitopes/EP0086 denotes heparan sulfate

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 482-497 OrganismTaxon denotes Chinese hamster 10029

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 40-50 Body_part denotes fibroblast http://purl.obolibrary.org/obo/CL_0000057
T2 183-193 Body_part denotes fibroblast http://purl.obolibrary.org/obo/CL_0000057
T3 280-293 Body_part denotes extracellular http://purl.obolibrary.org/obo/GO_0005576
T4 379-391 Body_part denotes myeloid cell http://purl.obolibrary.org/obo/CL_0000763
T5 498-503 Body_part denotes ovary http://purl.obolibrary.org/obo/UBERON_0000992
T6 576-589 Body_part denotes extracellular http://purl.obolibrary.org/obo/GO_0005576