PubMed:8300582
Annnotations
GlyCosmos6-Glycan-Motif-Image
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 37-44 | Glycan_Motif | denotes | heparin | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G54161DR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00021MO |
| T3 | 106-113 | Glycan_Motif | denotes | heparin | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G54161DR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00021MO |
| T5 | 115-122 | Glycan_Motif | denotes | Heparin | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G54161DR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00021MO |
| T7 | 525-532 | Glycan_Motif | denotes | heparin | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G54161DR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00021MO |
| T9 | 830-837 | Glycan_Motif | denotes | heparin | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G54161DR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00021MO |
| T11 | 952-959 | Glycan_Motif | denotes | heparin | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G54161DR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00021MO |
| T13 | 1091-1098 | Glycan_Motif | denotes | heparin | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G54161DR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00021MO |
| T15 | 1448-1455 | Glycan_Motif | denotes | heparin | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G54161DR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00021MO |
| T17 | 1619-1626 | Glycan_Motif | denotes | heparin | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G54161DR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00021MO |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-114 | Sentence | denotes | Characterization of sequences within heparin-binding EGF-like growth factor that mediate interaction with heparin. |
| T2 | 115-384 | Sentence | denotes | Heparin-binding (HB) epidermal growth factor (EGF)-like growth factor (HB-EGF), a member of the EGF protein family, is a potent mitogen for fibroblasts, smooth muscle cells, and keratinocytes that was initially identified as a secreted product of macrophage-like cells. |
| T3 | 385-533 | Sentence | denotes | HB-EGF and EGF appear to act on target cells utilizing the same receptor, but HB-EGF is distinguishable from EGF by its strong affinity for heparin. |
| T4 | 534-746 | Sentence | denotes | To facilitate studies of structure-function relationships in HB-EGF, a bacterial recombinant expression system was established that produced biologically active HB-EGF with the expected disulfide bonding pattern. |
| T5 | 747-1077 | Sentence | denotes | Mutagenesis and protease digestion studies of the recombinant HB-EGF, coupled with heparin-binding analyses of synthetic peptides, indicated that the sequences within HB-EGF mediating its interaction with heparin are located primarily in a stretch of 21 amino acids characterized by a high content of lysine and arginine residues. |
| T6 | 1078-1273 | Sentence | denotes | Most of this heparin-binding domain lies in an amino-terminal region of HB-EGF that has no counterpart in EGF, but a portion of the 21-residue sequence extends into the EGF-like region of HB-EGF. |
| T7 | 1274-1456 | Sentence | denotes | In addition, the mutagenesis and synthetic peptide studies indicated that sequences in HB-EGF lying outside of the 21-residue stretch can also influence the interaction with heparin. |
| T8 | 1457-1750 | Sentence | denotes | Finally, a synthetic peptide derived from the 21-residue stretch was found to compete with HB-EGF for binding to Chinese hamster ovary cells, suggesting that the heparin-binding sequences in HB-EGF may also mediate the interaction of this factor with cell surface heparan sulfate proteoglycan. |
| T1 | 0-114 | Sentence | denotes | Characterization of sequences within heparin-binding EGF-like growth factor that mediate interaction with heparin. |
| T2 | 115-384 | Sentence | denotes | Heparin-binding (HB) epidermal growth factor (EGF)-like growth factor (HB-EGF), a member of the EGF protein family, is a potent mitogen for fibroblasts, smooth muscle cells, and keratinocytes that was initially identified as a secreted product of macrophage-like cells. |
| T3 | 385-533 | Sentence | denotes | HB-EGF and EGF appear to act on target cells utilizing the same receptor, but HB-EGF is distinguishable from EGF by its strong affinity for heparin. |
| T4 | 534-746 | Sentence | denotes | To facilitate studies of structure-function relationships in HB-EGF, a bacterial recombinant expression system was established that produced biologically active HB-EGF with the expected disulfide bonding pattern. |
| T5 | 747-1077 | Sentence | denotes | Mutagenesis and protease digestion studies of the recombinant HB-EGF, coupled with heparin-binding analyses of synthetic peptides, indicated that the sequences within HB-EGF mediating its interaction with heparin are located primarily in a stretch of 21 amino acids characterized by a high content of lysine and arginine residues. |
| T6 | 1078-1273 | Sentence | denotes | Most of this heparin-binding domain lies in an amino-terminal region of HB-EGF that has no counterpart in EGF, but a portion of the 21-residue sequence extends into the EGF-like region of HB-EGF. |
| T7 | 1274-1456 | Sentence | denotes | In addition, the mutagenesis and synthetic peptide studies indicated that sequences in HB-EGF lying outside of the 21-residue stretch can also influence the interaction with heparin. |
| T8 | 1457-1750 | Sentence | denotes | Finally, a synthetic peptide derived from the 21-residue stretch was found to compete with HB-EGF for binding to Chinese hamster ovary cells, suggesting that the heparin-binding sequences in HB-EGF may also mediate the interaction of this factor with cell surface heparan sulfate proteoglycan. |
Glycosmos6-MAT
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 268-281 | http://purl.obolibrary.org/obo/MAT_0000303 | denotes | smooth muscle |
| T2 | 275-281 | http://purl.obolibrary.org/obo/MAT_0000025 | denotes | muscle |
GlyCosmos6-Glycan-Motif-Structure
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 37-44 | https://glytoucan.org/Structures/Glycans/G00021MO | denotes | heparin |
| T2 | 37-44 | https://glytoucan.org/Structures/Glycans/G54161DR | denotes | heparin |
| T3 | 106-113 | https://glytoucan.org/Structures/Glycans/G00021MO | denotes | heparin |
| T4 | 106-113 | https://glytoucan.org/Structures/Glycans/G54161DR | denotes | heparin |
| T5 | 115-122 | https://glytoucan.org/Structures/Glycans/G00021MO | denotes | Heparin |
| T6 | 115-122 | https://glytoucan.org/Structures/Glycans/G54161DR | denotes | Heparin |
| T7 | 525-532 | https://glytoucan.org/Structures/Glycans/G00021MO | denotes | heparin |
| T8 | 525-532 | https://glytoucan.org/Structures/Glycans/G54161DR | denotes | heparin |
| T9 | 830-837 | https://glytoucan.org/Structures/Glycans/G00021MO | denotes | heparin |
| T10 | 830-837 | https://glytoucan.org/Structures/Glycans/G54161DR | denotes | heparin |
| T11 | 952-959 | https://glytoucan.org/Structures/Glycans/G00021MO | denotes | heparin |
| T12 | 952-959 | https://glytoucan.org/Structures/Glycans/G54161DR | denotes | heparin |
| T13 | 1091-1098 | https://glytoucan.org/Structures/Glycans/G00021MO | denotes | heparin |
| T14 | 1091-1098 | https://glytoucan.org/Structures/Glycans/G54161DR | denotes | heparin |
| T15 | 1448-1455 | https://glytoucan.org/Structures/Glycans/G00021MO | denotes | heparin |
| T16 | 1448-1455 | https://glytoucan.org/Structures/Glycans/G54161DR | denotes | heparin |
| T17 | 1619-1626 | https://glytoucan.org/Structures/Glycans/G00021MO | denotes | heparin |
| T18 | 1619-1626 | https://glytoucan.org/Structures/Glycans/G54161DR | denotes | heparin |
Glycosmos6-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 1721-1736 | http://www.glycoepitope.jp/epitopes/EP0086 | denotes | heparan sulfate |
Anatomy-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 268-281 | Body_part | denotes | smooth muscle | http://purl.obolibrary.org/obo/MAT_0000303 |
HP-phenotype
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 417-429 | Phenotype | denotes | target cells | HP:0034280 |
NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 1570-1585 | OrganismTaxon | denotes | Chinese hamster | 10029 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 136-152 | Body_part | denotes | epidermal growth | http://purl.obolibrary.org/obo/UBERON_0000021 |
| T2 | 255-266 | Body_part | denotes | fibroblasts | http://purl.obolibrary.org/obo/CL_0000057 |
| T3 | 268-287 | Body_part | denotes | smooth muscle cells | http://purl.obolibrary.org/obo/CL_0000192 |
| T4 | 293-306 | Body_part | denotes | keratinocytes | http://purl.obolibrary.org/obo/CL_0000312 |
| T5 | 362-372 | Body_part | denotes | macrophage | http://purl.obolibrary.org/obo/CL_0000235 |
| T6 | 1586-1591 | Body_part | denotes | ovary | http://purl.obolibrary.org/obo/UBERON_0000992 |
CL-cell
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 255-266 | Cell | denotes | fibroblasts | http://purl.obolibrary.org/obo/CL:0000057 |
| T2 | 268-287 | Cell | denotes | smooth muscle cells | http://purl.obolibrary.org/obo/CL:0000192 |
| T3 | 293-306 | Cell | denotes | keratinocytes | http://purl.obolibrary.org/obo/CL:0000312 |
| T4 | 362-372 | Cell | denotes | macrophage | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |