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PubMed:8298305 JSONTXT

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GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 11-26 Glycan_Motif denotes O-glycan core 1 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00031MO
T2 73-79 Glycan_Motif denotes core 2 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00033MO
T3 180-191 Glycan_Motif denotes sialic acid https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY
T4 371-377 Glycan_Motif denotes core 2 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00033MO
T5 482-488 Glycan_Motif denotes core 2 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00033MO
T6 514-525 Glycan_Motif denotes sialic acid https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY
T7 799-805 Glycan_Motif denotes core 2 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00033MO
T8 832-838 Glycan_Motif denotes core 2 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00033MO
T9 890-896 Glycan_Motif denotes core 2 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00033MO
T10 961-967 Glycan_Motif denotes core 4 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00037MO
T11 1084-1090 Glycan_Motif denotes core 2 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00033MO
T12 1132-1138 Glycan_Motif denotes core 2 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00033MO
T13 1238-1244 Glycan_Motif denotes Core 2 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00033MO
T14 1333-1354 Glycan_Motif denotes N-acetylgalactosamine https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G27025MB
T15 1377-1386 Glycan_Motif denotes galactose https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G68158BT|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G65889KE
T17 1735-1744 Glycan_Motif denotes galactose https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G68158BT|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G65889KE
T19 1886-1892 Glycan_Motif denotes core 2 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00033MO

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-55 Sentence denotes Processing O-glycan core 1, Gal beta 1-3GalNAc alpha-R.
TextSentencer_T2 56-92 Sentence denotes Specificities of core 2, UDP-GlcNAc:
TextSentencer_T3 93-192 Sentence denotes Gal beta 1-3 GalNAc-R(GlcNAc to GalNAc) beta 6-N-acetylglucosaminyltransferase and CMP-sialic acid:
TextSentencer_T4 193-240 Sentence denotes Gal beta 1-3GalNAc-R alpha 3-sialyltransferase.
TextSentencer_T5 241-526 Sentence denotes To elucidate control mechanisms of O-glycan biosynthesis in leukemia and to develop biosynthetic inhibitors we have characterized core 2 UDP-GlcNAc:Gal beta 1-3GalNAc-R(GlcNAc to GalNAc) beta 6-N-acetylglucosaminyltransferase (EC 2.4.1.102; core 2 beta 6-GlcNAc-T) and CMP-sialic acid:
TextSentencer_T6 527-733 Sentence denotes Gal beta 1-3GalNAc-R alpha 3-sialyltransferase (EC 2.4.99.4; alpha 3-SA-T), two enzymes that are significantly increased in patients with chronic myelogenous leukemia (CML) and acute myeloid leukemia (AML).
TextSentencer_T7 734-1237 Sentence denotes We observed distinct tissue-specific kinetic differences for the core 2 beta 6-GlcNAc-T activity; core 2 beta 6-GlcNAc-T from mucin secreting tissue (named core 2 beta 6-GlcNAc-T M) is accompanied by activities that synthesize core 4 [GlcNAc beta 1-6(GlcNAc beta 1-3)GalNAc-R] and blood group I [GlcNAc beta 1-6(GlcNAc beta 1-3)Gal beta-R] branches; core 2 beta 6-GlcNAc-T in leukemic cells (named core 2 beta-GlcNAc-T L) is not accompanied by these two activities and has a more restricted specificity.
TextSentencer_T8 1238-1784 Sentence denotes Core 2 beta 6-GlcNAc-T M and L both have an absolute requirement for the 4- and 6-hydroxyls of N-acetylgalactosamine and the 6-hydroxyl of galactose of the Gal beta 1-3GalNAc alpha-benzyl substrate but the recognition of other substituents of the sugar rings varies, depending on the tissue. alpha 3-sialyltransferase from human placenta and from AML cells also showed distinct specificity differences, although the enzymes from both tissues have an absolute requirement for the 3-hydroxyl of the galactose residue of Gal beta 1-3GalNAc alpha-Bn.
TextSentencer_T9 1785-1964 Sentence denotes Gal beta 1-3(6-deoxy)GalNAc alpha-Bn and 3-deoxy-Gal beta 1-3GalNAc alpha-Bn competitively inhibited core 2 beta 6-GlcNAc-T and alpha 3-sialyltransferase activities, respectively.
T1 0-55 Sentence denotes Processing O-glycan core 1, Gal beta 1-3GalNAc alpha-R.
T2 56-92 Sentence denotes Specificities of core 2, UDP-GlcNAc:
T3 93-192 Sentence denotes Gal beta 1-3 GalNAc-R(GlcNAc to GalNAc) beta 6-N-acetylglucosaminyltransferase and CMP-sialic acid:
T4 193-240 Sentence denotes Gal beta 1-3GalNAc-R alpha 3-sialyltransferase.
T5 241-526 Sentence denotes To elucidate control mechanisms of O-glycan biosynthesis in leukemia and to develop biosynthetic inhibitors we have characterized core 2 UDP-GlcNAc:Gal beta 1-3GalNAc-R(GlcNAc to GalNAc) beta 6-N-acetylglucosaminyltransferase (EC 2.4.1.102; core 2 beta 6-GlcNAc-T) and CMP-sialic acid:
T6 527-733 Sentence denotes Gal beta 1-3GalNAc-R alpha 3-sialyltransferase (EC 2.4.99.4; alpha 3-SA-T), two enzymes that are significantly increased in patients with chronic myelogenous leukemia (CML) and acute myeloid leukemia (AML).
T7 734-1237 Sentence denotes We observed distinct tissue-specific kinetic differences for the core 2 beta 6-GlcNAc-T activity; core 2 beta 6-GlcNAc-T from mucin secreting tissue (named core 2 beta 6-GlcNAc-T M) is accompanied by activities that synthesize core 4 [GlcNAc beta 1-6(GlcNAc beta 1-3)GalNAc-R] and blood group I [GlcNAc beta 1-6(GlcNAc beta 1-3)Gal beta-R] branches; core 2 beta 6-GlcNAc-T in leukemic cells (named core 2 beta-GlcNAc-T L) is not accompanied by these two activities and has a more restricted specificity.
T8 1238-1784 Sentence denotes Core 2 beta 6-GlcNAc-T M and L both have an absolute requirement for the 4- and 6-hydroxyls of N-acetylgalactosamine and the 6-hydroxyl of galactose of the Gal beta 1-3GalNAc alpha-benzyl substrate but the recognition of other substituents of the sugar rings varies, depending on the tissue. alpha 3-sialyltransferase from human placenta and from AML cells also showed distinct specificity differences, although the enzymes from both tissues have an absolute requirement for the 3-hydroxyl of the galactose residue of Gal beta 1-3GalNAc alpha-Bn.
T9 1785-1964 Sentence denotes Gal beta 1-3(6-deoxy)GalNAc alpha-Bn and 3-deoxy-Gal beta 1-3GalNAc alpha-Bn competitively inhibited core 2 beta 6-GlcNAc-T and alpha 3-sialyltransferase activities, respectively.

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 11-26 https://glytoucan.org/Structures/Glycans/G00031MO denotes O-glycan core 1
T2 180-191 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid
T3 514-525 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid
T4 1333-1354 https://glytoucan.org/Structures/Glycans/G27025MB denotes N-acetylgalactosamine
T5 1377-1386 https://glytoucan.org/Structures/Glycans/G65889KE denotes galactose
T6 1377-1386 https://glytoucan.org/Structures/Glycans/G68158BT denotes galactose
T7 1735-1744 https://glytoucan.org/Structures/Glycans/G65889KE denotes galactose
T8 1735-1744 https://glytoucan.org/Structures/Glycans/G68158BT denotes galactose

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 1015-1020 http://purl.obolibrary.org/obo/MAT_0000083 denotes blood
T2 1015-1020 http://purl.obolibrary.org/obo/MAT_0000315 denotes blood
T3 1567-1575 http://purl.obolibrary.org/obo/MAT_0000279 denotes placenta

NGLY1-deficiency

Id Subject Object Predicate Lexical cue
PD-NGLY1-deficiency-B_T1 85-91 chem:24139 denotes GlcNAc
PD-NGLY1-deficiency-B_T2 115-121 chem:24139 denotes GlcNAc
PD-NGLY1-deficiency-B_T3 410-416 chem:24139 denotes GlcNAc
PD-NGLY1-deficiency-B_T4 496-502 chem:24139 denotes GlcNAc
PD-NGLY1-deficiency-B_T5 813-819 chem:24139 denotes GlcNAc
PD-NGLY1-deficiency-B_T6 846-852 chem:24139 denotes GlcNAc
PD-NGLY1-deficiency-B_T7 904-910 chem:24139 denotes GlcNAc
PD-NGLY1-deficiency-B_T8 969-975 chem:24139 denotes GlcNAc
PD-NGLY1-deficiency-B_T9 985-991 chem:24139 denotes GlcNAc
PD-NGLY1-deficiency-B_T10 1030-1036 chem:24139 denotes GlcNAc
PD-NGLY1-deficiency-B_T11 1046-1052 chem:24139 denotes GlcNAc
PD-NGLY1-deficiency-B_T12 1098-1104 chem:24139 denotes GlcNAc
PD-NGLY1-deficiency-B_T13 1139-1150 chem:24139 denotes beta-GlcNAc
PD-NGLY1-deficiency-B_T14 1252-1258 chem:24139 denotes GlcNAc
PD-NGLY1-deficiency-B_T15 1900-1906 chem:24139 denotes GlcNAc
T1 85-91 chem:24139 denotes GlcNAc
T2 115-121 chem:24139 denotes GlcNAc
T3 410-416 chem:24139 denotes GlcNAc
T4 496-502 chem:24139 denotes GlcNAc
T5 813-819 chem:24139 denotes GlcNAc
T6 846-852 chem:24139 denotes GlcNAc
T7 904-910 chem:24139 denotes GlcNAc
T8 969-975 chem:24139 denotes GlcNAc
T9 985-991 chem:24139 denotes GlcNAc
T10 1030-1036 chem:24139 denotes GlcNAc
T11 1046-1052 chem:24139 denotes GlcNAc
T12 1098-1104 chem:24139 denotes GlcNAc
T13 1139-1150 chem:24139 denotes beta-GlcNAc
T14 1252-1258 chem:24139 denotes GlcNAc
T15 1900-1906 chem:24139 denotes GlcNAc

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 20-26 Glycan denotes core 1 https://api.glycosmos.org/wurcs2image/latest/png/binary/G00031MO
T2 73-79 Glycan denotes core 2 https://api.glycosmos.org/wurcs2image/latest/png/binary/G00033MO
T3 106-112 Glycan denotes GalNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL
T4 125-131 Glycan denotes GalNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL
T5 371-377 Glycan denotes core 2 https://api.glycosmos.org/wurcs2image/latest/png/binary/G00033MO
T6 420-426 Glycan denotes GalNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL
T7 482-488 Glycan denotes core 2 https://api.glycosmos.org/wurcs2image/latest/png/binary/G00033MO
T8 799-805 Glycan denotes core 2 https://api.glycosmos.org/wurcs2image/latest/png/binary/G00033MO
T9 832-838 Glycan denotes core 2 https://api.glycosmos.org/wurcs2image/latest/png/binary/G00033MO
T10 890-896 Glycan denotes core 2 https://api.glycosmos.org/wurcs2image/latest/png/binary/G00033MO
T11 961-967 Glycan denotes core 4 https://api.glycosmos.org/wurcs2image/latest/png/binary/G00037MO
T12 1001-1007 Glycan denotes GalNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL
T13 1084-1090 Glycan denotes core 2 https://api.glycosmos.org/wurcs2image/latest/png/binary/G00033MO
T14 1132-1138 Glycan denotes core 2 https://api.glycosmos.org/wurcs2image/latest/png/binary/G00033MO
T15 1238-1244 Glycan denotes Core 2 https://api.glycosmos.org/wurcs2image/latest/png/binary/G00033MO
T16 1806-1812 Glycan denotes GalNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL
T17 1886-1892 Glycan denotes core 2 https://api.glycosmos.org/wurcs2image/latest/png/binary/G00033MO

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 301-309 Phenotype denotes leukemia HP:0001909
T2 665-693 Phenotype denotes chronic myelogenous leukemia HP:0005506
T3 695-698 Phenotype denotes CML HP:0005506
T4 704-726 Phenotype denotes acute myeloid leukemia HP:0004808
T5 728-731 Phenotype denotes AML HP:0004808
T6 1585-1588 Phenotype denotes AML HP:0004808

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 301-309 Disease denotes leukemia http://purl.obolibrary.org/obo/MONDO_0005059
T2 665-699 Disease denotes chronic myelogenous leukemia (CML) http://purl.obolibrary.org/obo/MONDO_0011996
T3 704-732 Disease denotes acute myeloid leukemia (AML) http://purl.obolibrary.org/obo/MONDO_0004996|http://purl.obolibrary.org/obo/MONDO_0018874
T5 1585-1588 Disease denotes AML http://purl.obolibrary.org/obo/MONDO_0018874

Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 20-26 Glycan denotes core 1 https://api.glycosmos.org/wurcs2image/latest/png/binary/G00031MO
T2 73-79 Glycan denotes core 2 https://api.glycosmos.org/wurcs2image/latest/png/binary/G00033MO
T3 106-112 Glycan denotes GalNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL
T4 125-131 Glycan denotes GalNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL
T5 371-377 Glycan denotes core 2 https://api.glycosmos.org/wurcs2image/latest/png/binary/G00033MO
T6 420-426 Glycan denotes GalNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL
T7 482-488 Glycan denotes core 2 https://api.glycosmos.org/wurcs2image/latest/png/binary/G00033MO
T8 799-805 Glycan denotes core 2 https://api.glycosmos.org/wurcs2image/latest/png/binary/G00033MO
T9 832-838 Glycan denotes core 2 https://api.glycosmos.org/wurcs2image/latest/png/binary/G00033MO
T10 890-896 Glycan denotes core 2 https://api.glycosmos.org/wurcs2image/latest/png/binary/G00033MO
T11 961-967 Glycan denotes core 4 https://api.glycosmos.org/wurcs2image/latest/png/binary/G00037MO
T12 1001-1007 Glycan denotes GalNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL
T13 1084-1090 Glycan denotes core 2 https://api.glycosmos.org/wurcs2image/latest/png/binary/G00033MO
T14 1132-1138 Glycan denotes core 2 https://api.glycosmos.org/wurcs2image/latest/png/binary/G00033MO
T15 1806-1812 Glycan denotes GalNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL
T16 1886-1892 Glycan denotes core 2 https://api.glycosmos.org/wurcs2image/latest/png/binary/G00033MO

GlyCosmos15-HP

Id Subject Object Predicate Lexical cue hp_id
T1 301-309 Phenotype denotes leukemia HP:0001909
T2 665-693 Phenotype denotes chronic myelogenous leukemia HP:0005506
T3 695-698 Phenotype denotes CML HP:0005506
T4 704-726 Phenotype denotes acute myeloid leukemia HP:0004808
T5 728-731 Phenotype denotes AML HP:0004808
T6 1585-1588 Phenotype denotes AML HP:0004808

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 755-761 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T2 876-882 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T3 1015-1020 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T4 1522-1528 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T5 1567-1575 Body_part denotes placenta http://purl.obolibrary.org/obo/UBERON_0001987

GlyCosmos15-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 301-309 Disease denotes leukemia MONDO:0004355|MONDO:0005059
T3 665-699 Disease denotes chronic myelogenous leukemia (CML) MONDO:0011996
T4 695-698 Disease denotes CML MONDO:0011996
T5 704-732 Disease denotes acute myeloid leukemia (AML) MONDO:0004996|MONDO:0018874
T7 728-731 Disease denotes AML MONDO:0015667|MONDO:0018874
T9 1585-1588 Disease denotes AML MONDO:0015667|MONDO:0018874

GlyCosmos15-Taxon

Id Subject Object Predicate Lexical cue db_id
T1 651-659 Organism denotes patients 9606
T2 1561-1566 Organism denotes human 9606

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-92 Sentence denotes Processing O-glycan core 1, Gal beta 1-3GalNAc alpha-R. Specificities of core 2, UDP-GlcNAc:
T2 93-192 Sentence denotes Gal beta 1-3 GalNAc-R(GlcNAc to GalNAc) beta 6-N-acetylglucosaminyltransferase and CMP-sialic acid:
T3 193-240 Sentence denotes Gal beta 1-3GalNAc-R alpha 3-sialyltransferase.
T4 241-526 Sentence denotes To elucidate control mechanisms of O-glycan biosynthesis in leukemia and to develop biosynthetic inhibitors we have characterized core 2 UDP-GlcNAc:Gal beta 1-3GalNAc-R(GlcNAc to GalNAc) beta 6-N-acetylglucosaminyltransferase (EC 2.4.1.102; core 2 beta 6-GlcNAc-T) and CMP-sialic acid:
T5 527-733 Sentence denotes Gal beta 1-3GalNAc-R alpha 3-sialyltransferase (EC 2.4.99.4; alpha 3-SA-T), two enzymes that are significantly increased in patients with chronic myelogenous leukemia (CML) and acute myeloid leukemia (AML).
T6 734-1237 Sentence denotes We observed distinct tissue-specific kinetic differences for the core 2 beta 6-GlcNAc-T activity; core 2 beta 6-GlcNAc-T from mucin secreting tissue (named core 2 beta 6-GlcNAc-T M) is accompanied by activities that synthesize core 4 [GlcNAc beta 1-6(GlcNAc beta 1-3)GalNAc-R] and blood group I [GlcNAc beta 1-6(GlcNAc beta 1-3)Gal beta-R] branches; core 2 beta 6-GlcNAc-T in leukemic cells (named core 2 beta-GlcNAc-T L) is not accompanied by these two activities and has a more restricted specificity.
T7 1238-1964 Sentence denotes Core 2 beta 6-GlcNAc-T M and L both have an absolute requirement for the 4- and 6-hydroxyls of N-acetylgalactosamine and the 6-hydroxyl of galactose of the Gal beta 1-3GalNAc alpha-benzyl substrate but the recognition of other substituents of the sugar rings varies, depending on the tissue. alpha 3-sialyltransferase from human placenta and from AML cells also showed distinct specificity differences, although the enzymes from both tissues have an absolute requirement for the 3-hydroxyl of the galactose residue of Gal beta 1-3GalNAc alpha-Bn. Gal beta 1-3(6-deoxy)GalNAc alpha-Bn and 3-deoxy-Gal beta 1-3GalNAc alpha-Bn competitively inhibited core 2 beta 6-GlcNAc-T and alpha 3-sialyltransferase activities, respectively.

GlyCosmos15-FMA

Id Subject Object Predicate Lexical cue db_id
T1 755-761 Body_part denotes tissue FMA:9637
T2 876-882 Body_part denotes tissue FMA:9637
T3 1015-1020 Body_part denotes blood FMA:9670
T4 1522-1528 Body_part denotes tissue FMA:9637
T5 1567-1575 Body_part denotes placenta FMA:0329329|FMA:63934
T7 1672-1679 Body_part denotes tissues FMA:9637

GlyCosmos15-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 1015-1020 Body_part denotes blood http://purl.obolibrary.org/obo/MAT_0000315
T2 1567-1575 Body_part denotes placenta http://purl.obolibrary.org/obo/MAT_0000279

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 1561-1566 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 755-761 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T2 876-882 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T3 1015-1020 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T4 1522-1528 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T5 1567-1575 Body_part denotes placenta http://purl.obolibrary.org/obo/UBERON_0001987

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 1015-1020 Body_part denotes blood http://purl.obolibrary.org/obo/MAT_0000083|http://purl.obolibrary.org/obo/MAT_0000315
T3 1567-1575 Body_part denotes placenta http://purl.obolibrary.org/obo/MAT_0000279