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PubMed:8289813 JSONTXT

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DisGeNET

Id Subject Object Predicate Lexical cue
T0 102-106 gene:9733 denotes p100
T1 0-21 disease:C0023493 denotes Human T-cell leukemia
T2 102-106 gene:6490 denotes p100
T3 0-21 disease:C0023493 denotes Human T-cell leukemia
T4 102-106 gene:22974 denotes p100
T5 0-21 disease:C0023493 denotes Human T-cell leukemia
T6 102-106 gene:27044 denotes p100
T7 0-21 disease:C0023493 denotes Human T-cell leukemia
T8 102-106 gene:1523 denotes p100
T9 0-21 disease:C0023493 denotes Human T-cell leukemia
T10 102-106 gene:84164 denotes p100
T11 0-21 disease:C0023493 denotes Human T-cell leukemia
T12 102-106 gene:4791 denotes p100
T13 0-21 disease:C0023493 denotes Human T-cell leukemia
T14 102-106 gene:4940 denotes p100
T15 0-21 disease:C0023493 denotes Human T-cell leukemia
R1 T0 T1 associated_with p100,Human T-cell leukemia
R2 T2 T3 associated_with p100,Human T-cell leukemia
R3 T4 T5 associated_with p100,Human T-cell leukemia
R4 T6 T7 associated_with p100,Human T-cell leukemia
R5 T8 T9 associated_with p100,Human T-cell leukemia
R6 T10 T11 associated_with p100,Human T-cell leukemia
R7 T12 T13 associated_with p100,Human T-cell leukemia
R8 T14 T15 associated_with p100,Human T-cell leukemia

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 35-38 protein denotes Tax
T2 90-119 protein denotes NF-kappa B2 p100 gene product
T3 294-321 cell_line denotes activated human CD4 T cells
T4 351-365 protein denotes 40-kDa protein
T5 373-376 protein denotes Tax
T6 479-493 DNA denotes cellular genes
T7 495-498 protein denotes Tax
T8 526-533 cell_type denotes T cells
T9 588-602 DNA denotes cellular genes
T10 626-636 cell_type denotes lymphocyte
T11 700-721 protein denotes transcription factors
T12 738-741 protein denotes Tax
T13 810-831 protein denotes transcription factors
T14 858-872 protein denotes NF-kappa B/Rel
T15 877-894 protein denotes CREB/ATF families
T16 911-927 protein denotes cellular factors
T17 928-933 protein denotes HEB-1
T18 938-944 protein denotes p67SRF
T19 1080-1104 cell_type denotes primary leukemic T cells
T20 1148-1151 protein denotes Tax
T21 1182-1186 protein denotes p100
T22 1207-1235 DNA denotes Rel-related NF-kappa B2 gene
T23 1245-1262 cell_line denotes transfected cells
T24 1270-1307 cell_line denotes HTLV-I-infected leukemic T-cell lines
T25 1350-1353 protein denotes Tax
T26 1359-1363 protein denotes p100
T27 1391-1394 protein denotes Tax
T28 1432-1489 DNA denotes human immunodeficiency virus type 1 long terminal repeats
T29 1502-1506 protein denotes p100
T30 1578-1589 protein denotes Tax protein
T31 1616-1619 protein denotes Tax
T32 1663-1673 protein denotes NF-kappa B
T33 1709-1713 protein denotes p100

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 0-38 NP denotes Human T-cell leukemia virus type I Tax
C2 153-196 NP denotes Human T-cell leukemia virus type I (HTLV-I)
C3 200-248 NP denotes the etiologic agent of the adult T-cell leukemia
C4 250-321 NP denotes an aggressive and often fatal malignancy of activated human CD4 T cells
C5 323-329 NP denotes HTLV-I
C6 338-376 NP denotes an essential 40-kDa protein termed Tax
C7 377-381 NP denotes that
C8 434-449 NP denotes this retrovirus
C9 495-499 NP denotes Tax-
C10 580-602 NP denotes various cellular genes
C11 603-607 NP denotes that
C12 738-741 NP denotes Tax
C13 1013-1048 NP denotes the profound state of viral latency
C14 1049-1053 NP denotes that
C15 1141-1151 NP denotes HTLV-I Tax
C16 1182-1186 NP denotes p100
C17 1188-1235 NP denotes the product of the Rel-related NF-kappa B2 gene
C18 1350-1353 NP denotes Tax
C19 1359-1363 NP denotes p100
C20 1391-1395 NP denotes Tax-
C21 1417-1427 NP denotes the HTLV-I
C22 1502-1507 NP denotes p100-
C24 1616-1619 NP denotes Tax
C23 1604-1619 NP denotes a mutant of Tax
C25 1620-1624 NP denotes that
C26 1709-1713 NP denotes p100
R1 C3 C2 coref-ident the etiologic agent of the adult T-cell leukemia,Human T-cell leukemia virus type I (HTLV-I)
R2 C4 C3 coref-appos an aggressive and often fatal malignancy of activated human CD4 T cells,the etiologic agent of the adult T-cell leukemia
R3 C5 C2 coref-ident HTLV-I,Human T-cell leukemia virus type I (HTLV-I)
R4 C7 C6 coref-relat that,an essential 40-kDa protein termed Tax
R5 C8 C5 coref-ident this retrovirus,HTLV-I
R6 C9 C6 coref-other Tax-,an essential 40-kDa protein termed Tax
R7 C11 C10 coref-relat that,various cellular genes
R8 C12 C9 coref-ident Tax,Tax-
R9 C14 C13 coref-relat that,the profound state of viral latency
R10 C15 C1 coref-ident HTLV-I Tax,Human T-cell leukemia virus type I Tax
R11 C17 C16 coref-appos the product of the Rel-related NF-kappa B2 gene,p100
R12 C18 C12 coref-ident Tax,Tax
R13 C19 C16 coref-ident p100,p100
R14 C20 C18 coref-ident Tax-,Tax
R15 C21 C2 coref-ident the HTLV-I,Human T-cell leukemia virus type I (HTLV-I)
R16 C22 C19 coref-ident p100-,p100
R17 C24 C18 coref-ident Tax,Tax
R18 C25 C23 coref-relat that,a mutant of Tax
R19 C26 C22 coref-ident p100,p100-

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-152 Sentence denotes Human T-cell leukemia virus type I Tax associates with and is negatively regulated by the NF-kappa B2 p100 gene product: implications for viral latency.
S2 153-322 Sentence denotes Human T-cell leukemia virus type I (HTLV-I) is the etiologic agent of the adult T-cell leukemia, an aggressive and often fatal malignancy of activated human CD4 T cells.
S3 323-494 Sentence denotes HTLV-I encodes an essential 40-kDa protein termed Tax that not only transactivates the long terminal repeat of this retrovirus but also induces an array of cellular genes.
S4 495-722 Sentence denotes Tax-mediated transformation of T cells likely involves the deregulated expression of various cellular genes that normally regulate lymphocyte growth produced by altered activity of various endogenous host transcription factors.
S5 723-945 Sentence denotes In particular, Tax is capable of modulating the expression or activity of various host transcription factors, including members of the NF-kappa B/Rel and CREB/ATF families, as well as the cellular factors HEB-1 and p67SRF.
S6 946-1105 Sentence denotes An additional distinguishing characteristic of HTLV-I infection is the profound state of viral latency that is present in circulating primary leukemic T cells.
S7 1106-1308 Sentence denotes In this study, we demonstrate that HTLV-I Tax can physically associate with p100, the product of the Rel-related NF-kappa B2 gene, both in transfected cells and in HTLV-I-infected leukemic T-cell lines.
S8 1309-1590 Sentence denotes Furthermore, the physical interaction of Tax with p100 leads to the inhibition of Tax-induced activation of the HTLV-I and human immunodeficiency virus type 1 long terminal repeats, reflecting p100-mediated cytoplasmic sequestration of the normally nuclearly expressed Tax protein.
S9 1591-1714 Sentence denotes In contrast, a mutant of Tax that selectively fails to activate nuclear NF-kappa B expression does not associate with p100.
S10 1715-1907 Sentence denotes Together, these results suggest that the cytoplasmic interplay of Tax and p100 may play an important role in the initiation and maintenance of HTLV-1 latency observed in adult T-cell leukemia.

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 6-34 virus denotes T-cell leukemia virus type I
T2 35-38 protein_molecule denotes Tax
T3 90-111 DNA_domain_or_region denotes NF-kappa B2 p100 gene
T4 153-187 virus denotes Human T-cell leukemia virus type I
T5 189-195 virus denotes HTLV-I
T6 227-248 other_name denotes adult T-cell leukemia
T7 294-321 cell_line denotes activated human CD4 T cells
T8 323-329 virus denotes HTLV-I
T9 351-365 protein_molecule denotes 40-kDa protein
T10 373-376 protein_molecule denotes Tax
T11 439-449 virus denotes retrovirus
T12 479-493 DNA_family_or_group denotes cellular genes
T13 495-498 protein_molecule denotes Tax
T14 526-533 cell_type denotes T cells
T15 588-602 DNA_family_or_group denotes cellular genes
T16 626-636 cell_type denotes lymphocyte
T17 700-721 protein_family_or_group denotes transcription factors
T18 738-741 protein_molecule denotes Tax
T19 810-831 protein_family_or_group denotes transcription factors
T20 858-872 protein_family_or_group denotes NF-kappa B/Rel
T21 877-894 protein_family_or_group denotes CREB/ATF families
T22 911-927 protein_family_or_group denotes cellular factors
T23 928-933 protein_molecule denotes HEB-1
T24 938-944 protein_molecule denotes p67SRF
T25 993-999 virus denotes HTLV-I
T26 1080-1104 cell_type denotes primary leukemic T cells
T27 1141-1147 virus denotes HTLV-I
T28 1148-1151 protein_molecule denotes Tax
T29 1182-1186 protein_molecule denotes p100
T30 1207-1235 DNA_domain_or_region denotes Rel-related NF-kappa B2 gene
T31 1245-1262 cell_line denotes transfected cells
T32 1270-1276 virus denotes HTLV-I
T33 1350-1353 protein_molecule denotes Tax
T34 1359-1363 protein_molecule denotes p100
T35 1391-1394 protein_molecule denotes Tax
T36 1421-1427 virus denotes HTLV-I
T37 1432-1489 DNA_domain_or_region denotes human immunodeficiency virus type 1 long terminal repeats
T38 1502-1506 protein_molecule denotes p100
T39 1578-1581 protein_molecule denotes Tax
T40 1616-1619 protein_molecule denotes Tax
T41 1663-1673 protein_molecule denotes NF-kappa B
T42 1709-1713 protein_molecule denotes p100