PubMed:8288588 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/8288588","sourcedb":"PubMed","sourceid":"8288588","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/8288588","text":"Thrombospondin 3 is a developmentally regulated heparin binding protein.\nThe thrombospondins (TSPs) are a growing family of cell surface and extracellular matrix molecules composed of multiple repeating elements. Thrombospondin 3 is a recently described member that possesses the calcium binding Type 3 repeats, has 4 epidermal growth factor receptor-like Type 2 repeats, a complete absence of the complement-like Type 1 repeats, and a distinct N terminus that has no significant homology to the other TSPs. Metabolic labeling and immunoprecipitation analysis of cells transfected with a TSP3 expression vector revealed it to be an oligomeric heparin binding protein present in both the cell layer and medium. Finally, a combination of in situ hybridization and immunocytochemistry demonstrated TSP3 to be expressed in a temporal and spatial manner during murine embryogenesis, especially in the gut, cartilage, lung, and central nervous 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