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sentences

Id Subject Object Predicate Lexical cue
T1 0-104 Sentence denotes Protein kinase C-mediated serine phosphorylation directly activates Raf-1 in murine hematopoietic cells.
T2 105-279 Sentence denotes We have previously found that Raf-1, which is activated by hematopoietic growth factors in association with phosphorylation, is required for hematopoietic cell proliferation.
T3 280-468 Sentence denotes Recently, 12-O-tetradecanoylphorbol 13-acetate has been found to mediate Raf-1 phosphorylation, suggesting that protein kinase C (PKC) may be involved in the Raf-1 activation mechanism(s).
T4 469-704 Sentence denotes Since PKC can be activated by hematopoietic growth factors, it was investigated as a potential "Raf-1 kinase-kinase." Results demonstrate that bryostatin 1, a pharmacologic activator of PKC, induces activation of Raf-1 in FDC-P1 cells.
T5 705-845 Sentence denotes PKC inhibitors H7 and staurosporine block both bryostatin 1- and interleukin-3-mediated Raf-1 phosphorylation and FDC-P1 cell proliferation.
T6 846-1018 Sentence denotes Additionally, an antisense c-raf oligodeoxyribonucleotide specifically inhibits bryostatin 1-mediated proliferation, indicating a necessary role for Raf-1 in PKC signaling.
T7 1019-1103 Sentence denotes Purified PKC can phosphorylate Raf-1 serine residues to high stoichiometry in vitro.
T8 1104-1276 Sentence denotes Comparative phosphopeptide maps localize two PKC phosphorylation sites to Raf-1 phosphopeptides isolated from hematopoietic growth factor- or bryostatin 1-stimulated cells.
T9 1277-1361 Sentence denotes The sites of PKC-mediated Raf-1 phosphorylation are deduced to be Ser497 and Ser619.
T10 1362-1478 Sentence denotes Furthermore, PKC-mediated serine phosphorylation is sufficient to activate the enzymatic function of Raf-1 in vitro.
T11 1479-1647 Sentence denotes These findings demonstrate that activated PKC can promote hematopoietic cell growth by regulating the enzymatic activity of Raf-1 through direct serine phosphorylation.
T1 0-104 Sentence denotes Protein kinase C-mediated serine phosphorylation directly activates Raf-1 in murine hematopoietic cells.
T2 105-279 Sentence denotes We have previously found that Raf-1, which is activated by hematopoietic growth factors in association with phosphorylation, is required for hematopoietic cell proliferation.
T3 280-468 Sentence denotes Recently, 12-O-tetradecanoylphorbol 13-acetate has been found to mediate Raf-1 phosphorylation, suggesting that protein kinase C (PKC) may be involved in the Raf-1 activation mechanism(s).
T4 469-704 Sentence denotes Since PKC can be activated by hematopoietic growth factors, it was investigated as a potential "Raf-1 kinase-kinase." Results demonstrate that bryostatin 1, a pharmacologic activator of PKC, induces activation of Raf-1 in FDC-P1 cells.
T5 705-845 Sentence denotes PKC inhibitors H7 and staurosporine block both bryostatin 1- and interleukin-3-mediated Raf-1 phosphorylation and FDC-P1 cell proliferation.
T6 846-1018 Sentence denotes Additionally, an antisense c-raf oligodeoxyribonucleotide specifically inhibits bryostatin 1-mediated proliferation, indicating a necessary role for Raf-1 in PKC signaling.
T7 1019-1103 Sentence denotes Purified PKC can phosphorylate Raf-1 serine residues to high stoichiometry in vitro.
T8 1104-1276 Sentence denotes Comparative phosphopeptide maps localize two PKC phosphorylation sites to Raf-1 phosphopeptides isolated from hematopoietic growth factor- or bryostatin 1-stimulated cells.
T9 1277-1361 Sentence denotes The sites of PKC-mediated Raf-1 phosphorylation are deduced to be Ser497 and Ser619.
T10 1362-1478 Sentence denotes Furthermore, PKC-mediated serine phosphorylation is sufficient to activate the enzymatic function of Raf-1 in vitro.
T11 1479-1647 Sentence denotes These findings demonstrate that activated PKC can promote hematopoietic cell growth by regulating the enzymatic activity of Raf-1 through direct serine phosphorylation.

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 84-103 Body_part denotes hematopoietic cells http://purl.obolibrary.org/obo/CL_0000988
T2 246-264 Body_part denotes hematopoietic cell http://purl.obolibrary.org/obo/CL_0000988
T3 1537-1555 Body_part denotes hematopoietic cell http://purl.obolibrary.org/obo/CL_0000988

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 84-103 Cell denotes hematopoietic cells http://purl.obolibrary.org/obo/CL:0000988
T2 246-264 Cell denotes hematopoietic cell http://purl.obolibrary.org/obo/CL:0000988
T3 1537-1555 Cell denotes hematopoietic cell http://purl.obolibrary.org/obo/CL:0000988