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sentences

Id Subject Object Predicate Lexical cue
T1 0-145 Sentence denotes Primary structure, ligand binding, and localization of the human type 3 inositol 1,4,5-trisphosphate receptor expressed in intestinal epithelium.
T2 146-309 Sentence denotes The second messenger, inositol 1,4,5-trisphosphate (InsP3) transduces many hormonal signals which regulate Ca(2+)-dependent processes in the intestinal epithelium.
T3 310-494 Sentence denotes To study the receptors for InsP3 (InsP3Rs), which function as intracellular Ca2+ channels, cDNA clones encoding InsP3Rs were isolated from a human colon adenocarcinoma cell line, HT29.
T4 495-678 Sentence denotes The majority of clones encoded the type 3 InsP3R, the product of the ITPR3 gene on chromosome 6, for which only a 147-amino-acid fragment was known previously (Ozcelik, T., Sudhof, T.
T5 679-716 Sentence denotes C., and Francke, U. (1991) Cytogenet.
T6 717-728 Sentence denotes Cell Genet.
T7 729-735 Sentence denotes Abstr.
T8 736-756 Sentence denotes 58, 1880; Sudhof, T.
T9 757-771 Sentence denotes C., Newton, C.
T10 772-786 Sentence denotes L., Archer, B.
T11 787-809 Sentence denotes T., III, Ushkaryov, Y.
T12 810-829 Sentence denotes A., and Mignery, G.
T13 830-847 Sentence denotes A. (1991) EMBO J.
T14 848-863 Sentence denotes 10, 3199-3206).
T15 864-957 Sentence denotes The complete sequence of the type 3 InsP3R polypeptide (2,671 amino acids) is described here.
T16 958-1084 Sentence denotes Primary structure analysis indicates a pattern of conserved and variable regions which is characteristic of the InsP3R family.
T17 1085-1245 Sentence denotes A 250-kDa protein (SDS-PAGE) which specifically binds InsP3 is immunoprecipitated by affinity-purified antibodies raised against a COOH-terminal fusion protein.
T18 1246-1414 Sentence denotes Transient expression in COS-7 cells of a polypeptide comprising the NH2-terminal 750 amino acids establishes that the ligand-binding domain is localized to this region.
T19 1415-1594 Sentence denotes Lysates from transfected COS-7 cells bind InsP3 with high affinity (Kd = 151 nM) compared with other inositol phosphates (InsP3 >> Ins 1,3,4,5-P4 > InsP6 > Ins 1,4-P2 >> Ins 1-P).
T20 1595-1773 Sentence denotes Immunocytochemical localization in the intestine reveals expression in crypt and villus epithelial cells, but not in cells of the lamina propria, submucosa, or muscularis layers.
T21 1774-1997 Sentence denotes The subcellular distribution and appearance of staining is consistent with localization on the endoplasmic reticulum, with the highest concentration of staining occurring adjacent to the apical brush border of villus cells.
T1 0-145 Sentence denotes Primary structure, ligand binding, and localization of the human type 3 inositol 1,4,5-trisphosphate receptor expressed in intestinal epithelium.
T2 146-309 Sentence denotes The second messenger, inositol 1,4,5-trisphosphate (InsP3) transduces many hormonal signals which regulate Ca(2+)-dependent processes in the intestinal epithelium.
T3 310-494 Sentence denotes To study the receptors for InsP3 (InsP3Rs), which function as intracellular Ca2+ channels, cDNA clones encoding InsP3Rs were isolated from a human colon adenocarcinoma cell line, HT29.
T4 495-678 Sentence denotes The majority of clones encoded the type 3 InsP3R, the product of the ITPR3 gene on chromosome 6, for which only a 147-amino-acid fragment was known previously (Ozcelik, T., Sudhof, T.
T5 679-716 Sentence denotes C., and Francke, U. (1991) Cytogenet.
T6 717-728 Sentence denotes Cell Genet.
T7 729-735 Sentence denotes Abstr.
T8 736-756 Sentence denotes 58, 1880; Sudhof, T.
T9 757-771 Sentence denotes C., Newton, C.
T10 772-786 Sentence denotes L., Archer, B.
T11 787-809 Sentence denotes T., III, Ushkaryov, Y.
T12 810-829 Sentence denotes A., and Mignery, G.
T13 830-847 Sentence denotes A. (1991) EMBO J.
T14 848-863 Sentence denotes 10, 3199-3206).
T15 864-957 Sentence denotes The complete sequence of the type 3 InsP3R polypeptide (2,671 amino acids) is described here.
T16 958-1084 Sentence denotes Primary structure analysis indicates a pattern of conserved and variable regions which is characteristic of the InsP3R family.
T17 1085-1245 Sentence denotes A 250-kDa protein (SDS-PAGE) which specifically binds InsP3 is immunoprecipitated by affinity-purified antibodies raised against a COOH-terminal fusion protein.
T18 1246-1414 Sentence denotes Transient expression in COS-7 cells of a polypeptide comprising the NH2-terminal 750 amino acids establishes that the ligand-binding domain is localized to this region.
T19 1415-1594 Sentence denotes Lysates from transfected COS-7 cells bind InsP3 with high affinity (Kd = 151 nM) compared with other inositol phosphates (InsP3 >> Ins 1,3,4,5-P4 > InsP6 > Ins 1,4-P2 >> Ins 1-P).
T20 1595-1773 Sentence denotes Immunocytochemical localization in the intestine reveals expression in crypt and villus epithelial cells, but not in cells of the lamina propria, submucosa, or muscularis layers.
T21 1774-1997 Sentence denotes The subcellular distribution and appearance of staining is consistent with localization on the endoplasmic reticulum, with the highest concentration of staining occurring adjacent to the apical brush border of villus cells.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 123-133 http://purl.obolibrary.org/obo/MAT_0000043 denotes intestinal
T2 287-297 http://purl.obolibrary.org/obo/MAT_0000043 denotes intestinal
T3 457-462 http://purl.obolibrary.org/obo/MAT_0000526 denotes colon
T4 1634-1643 http://purl.obolibrary.org/obo/MAT_0000043 denotes intestine
T5 1961-1967 http://purl.obolibrary.org/obo/MAT_0000484 denotes apical

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 457-477 Disease denotes colon adenocarcinoma http://purl.obolibrary.org/obo/MONDO_0002271

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 59-64 OrganismTaxon denotes human 9606
T2 451-456 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 123-144 Body_part denotes intestinal epithelium http://purl.obolibrary.org/obo/UBERON_0001277
T2 287-308 Body_part denotes intestinal epithelium http://purl.obolibrary.org/obo/UBERON_0001277
T3 372-385 Body_part denotes intracellular http://purl.obolibrary.org/obo/GO_0005622
T4 457-462 Body_part denotes colon http://purl.obolibrary.org/obo/UBERON_0001155
T5 578-588 Body_part denotes chromosome http://purl.obolibrary.org/obo/GO_0005694
T6 1634-1643 Body_part denotes intestine http://purl.obolibrary.org/obo/UBERON_0000160
T7 1676-1682 Body_part denotes villus http://purl.obolibrary.org/obo/UBERON_0001213
T8 1683-1699 Body_part denotes epithelial cells http://purl.obolibrary.org/obo/CL_0000066
T9 1725-1739 Body_part denotes lamina propria http://purl.obolibrary.org/obo/UBERON_0000030
T10 1741-1750 Body_part denotes submucosa http://purl.obolibrary.org/obo/UBERON_0000009
T11 1755-1765 Body_part denotes muscularis http://purl.obolibrary.org/obo/UBERON_0006660
T12 1881-1890 Body_part denotes reticulum http://purl.obolibrary.org/obo/UBERON_0007361
T13 1968-1980 Body_part denotes brush border http://purl.obolibrary.org/obo/UBERON_0012424
T14 1984-1990 Body_part denotes villus http://purl.obolibrary.org/obo/UBERON_0001213

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 123-133 Body_part denotes intestinal http://purl.obolibrary.org/obo/MAT_0000043
T2 287-297 Body_part denotes intestinal http://purl.obolibrary.org/obo/MAT_0000043
T3 457-462 Body_part denotes colon http://purl.obolibrary.org/obo/MAT_0000526
T4 1634-1643 Body_part denotes intestine http://purl.obolibrary.org/obo/MAT_0000043
T5 1961-1967 Body_part denotes apical http://purl.obolibrary.org/obo/MAT_0000484

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 1683-1699 Cell denotes epithelial cells http://purl.obolibrary.org/obo/CL:0000066