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PubMed:8288563 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
T1 0-83 Sentence denotes Identification and characterization of a novel tyrosine kinase from megakaryocytes.
T2 84-156 Sentence denotes Protein-tyrosine kinases play pivotal roles in cell signal transduction.
T3 157-299 Sentence denotes We have isolated a cDNA clone encoding a novel human intracytoplasmic tyrosine kinase, termed matk (megakaryocyte-associated tyrosine kinase).
T4 300-383 Sentence denotes Expression of matk mRNA was predominantly found in cells of megakaryocytic lineage.
T5 384-508 Sentence denotes The matk cDNA clone encodes a polypeptide of 527 amino acids and has closest sequence similarity to the csk tyrosine kinase.
T6 509-771 Sentence denotes Sequence comparisons also indicate that matk contains src homology region 2 and 3 domains but lacks the NH2-terminal myristylation signal, the negative regulatory tyrosine (Tyr-527), and the autophosphorylation site (Tyr-416) corresponding to those found in src.
T7 772-902 Sentence denotes Antibodies raised against the NH2 terminus of matk immunoprecipitated a 60-kDa protein from the CMK human megakaryocyte cell line.
T8 903-1014 Sentence denotes Expression of matk mRNA was up-regulated in megakaryocytic cells induced to differentiate by the phorbol ester.
T9 1015-1193 Sentence denotes Based on its restriction in expression and its modulation during in vitro differentiation, it is likely that matk participates in signal transduction during megakaryocytopoiesis.
T1 0-83 Sentence denotes Identification and characterization of a novel tyrosine kinase from megakaryocytes.
T2 84-156 Sentence denotes Protein-tyrosine kinases play pivotal roles in cell signal transduction.
T3 157-299 Sentence denotes We have isolated a cDNA clone encoding a novel human intracytoplasmic tyrosine kinase, termed matk (megakaryocyte-associated tyrosine kinase).
T4 300-383 Sentence denotes Expression of matk mRNA was predominantly found in cells of megakaryocytic lineage.
T5 384-508 Sentence denotes The matk cDNA clone encodes a polypeptide of 527 amino acids and has closest sequence similarity to the csk tyrosine kinase.
T6 509-771 Sentence denotes Sequence comparisons also indicate that matk contains src homology region 2 and 3 domains but lacks the NH2-terminal myristylation signal, the negative regulatory tyrosine (Tyr-527), and the autophosphorylation site (Tyr-416) corresponding to those found in src.
T7 772-902 Sentence denotes Antibodies raised against the NH2 terminus of matk immunoprecipitated a 60-kDa protein from the CMK human megakaryocyte cell line.
T8 903-1014 Sentence denotes Expression of matk mRNA was up-regulated in megakaryocytic cells induced to differentiate by the phorbol ester.
T9 1015-1193 Sentence denotes Based on its restriction in expression and its modulation during in vitro differentiation, it is likely that matk participates in signal transduction during megakaryocytopoiesis.

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 204-209 OrganismTaxon denotes human 9606
T2 872-877 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 68-82 Body_part denotes megakaryocytes http://purl.obolibrary.org/obo/CL_0000556
T2 257-270 Body_part denotes megakaryocyte http://purl.obolibrary.org/obo/CL_0000556
T3 360-374 Body_part denotes megakaryocytic http://purl.obolibrary.org/obo/CL_0000556
T4 878-891 Body_part denotes megakaryocyte http://purl.obolibrary.org/obo/CL_0000556
T5 947-961 Body_part denotes megakaryocytic http://purl.obolibrary.org/obo/CL_0000556

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 68-82 Cell denotes megakaryocytes http://purl.obolibrary.org/obo/CL:0000556
T2 257-270 Cell denotes megakaryocyte http://purl.obolibrary.org/obo/CL:0000556
T3 360-374 Cell denotes megakaryocytic http://purl.obolibrary.org/obo/CL:0000556
T4 878-891 Cell denotes megakaryocyte http://purl.obolibrary.org/obo/CL:0000556
T5 947-961 Cell denotes megakaryocytic http://purl.obolibrary.org/obo/CL:0000556