PubMed:8286857
Annnotations
CL-cell
Id | Subject | Object | Predicate | Lexical cue | cl_id |
---|---|---|---|---|---|
T1 | 28-40 | Cell | denotes | tumour cells | http://purl.obolibrary.org/obo/CL:0001063 |
T2 | 182-193 | Cell | denotes | tumour cell | http://purl.obolibrary.org/obo/CL:0001063 |
T3 | 214-226 | Cell | denotes | Tumour cells | http://purl.obolibrary.org/obo/CL:0001063 |
T4 | 962-973 | Cell | denotes | tumour cell | http://purl.obolibrary.org/obo/CL:0001063 |
T5 | 1201-1212 | Cell | denotes | tumour cell | http://purl.obolibrary.org/obo/CL:0001063 |
T6 | 1250-1261 | Cell | denotes | tumour cell | http://purl.obolibrary.org/obo/CL:0001063 |
T7 | 1429-1440 | Cell | denotes | tumour cell | http://purl.obolibrary.org/obo/CL:0001063 |
T8 | 1564-1576 | Cell | denotes | tumour cells | http://purl.obolibrary.org/obo/CL:0001063 |
T9 | 1630-1641 | Cell | denotes | tumour cell | http://purl.obolibrary.org/obo/CL:0001063 |
T10 | 1699-1710 | Cell | denotes | tumour cell | http://purl.obolibrary.org/obo/CL:0001063 |
Glycan-Motif
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 616-641 | https://glytoucan.org/Structures/Glycans/G27798EJ | denotes | alpha-galactosyl epitopes |
T2 | 790-815 | https://glytoucan.org/Structures/Glycans/G27798EJ | denotes | alpha-galactosyl epitopes |
GlyCosmos6-Glycan-Motif-Image
Id | Subject | Object | Predicate | Lexical cue | image |
---|---|---|---|---|---|
T1 | 616-641 | Glycan_Motif | denotes | alpha-galactosyl epitopes | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G27798EJ |
T2 | 790-815 | Glycan_Motif | denotes | alpha-galactosyl epitopes | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G27798EJ |
GlyCosmos6-Glycan-Motif-Structure
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 616-641 | https://glytoucan.org/Structures/Glycans/G27798EJ | denotes | alpha-galactosyl epitopes |
T2 | 790-815 | https://glytoucan.org/Structures/Glycans/G27798EJ | denotes | alpha-galactosyl epitopes |
sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
TextSentencer_T1 | 0-41 | Sentence | denotes | Lectin-induced apoptosis of tumour cells. |
TextSentencer_T2 | 42-213 | Sentence | denotes | The mechanisms of cytotoxic activity of Griffonia simplicifolia 1-B4 (GS1B4) and wheat germ agglutinin (WGA) lectins against various murine tumour cell lines were studied. |
TextSentencer_T3 | 214-307 | Sentence | denotes | Tumour cells that lack lectin-binding carbohydrates were resistant to lysis by these lectins. |
TextSentencer_T4 | 308-403 | Sentence | denotes | However, YAC-1 cells that expressed GS1B4 lectin-binding sites showed low sensitivity to lysis. |
TextSentencer_T5 | 404-718 | Sentence | denotes | To further analyse the relative importance of cell surface carbohydrates in lectin cytotoxicity, BL6-8 melanoma cells, which do not express the alpha 1,3 galactosyltransferase (alpha 1,3GT) gene and cell surface alpha-galactosyl epitopes reacting with GS1B4 lectin, were transfected with cDNA encoding alpha 1,3GT. |
TextSentencer_T6 | 719-1086 | Sentence | denotes | After transfection, BL6-8 cells expressed high levels of GS1B4-binding alpha-galactosyl epitopes, but remained resistant to lysis by GS1B4 lectin, suggesting that the presence of lectin-binding epitopes, while essential, is not sufficient for tumour cell lysis and probably some intracellular mechanisms are involved in the regulation of lectin-mediated cytotoxicity. |
TextSentencer_T7 | 1087-1219 | Sentence | denotes | We found that the GS1B4 and WGA lectins induced apoptosis with DNA fragmentation of sensitive, but not resistant, tumour cell lines. |
TextSentencer_T8 | 1220-1330 | Sentence | denotes | DNA fragmentation, as well as tumour cell lysis, was blocked in the presence of the specific inhibitory sugar. |
TextSentencer_T9 | 1331-1548 | Sentence | denotes | To determine whether binding of the lectin to cell surface carbohydrates is sufficient to trigger tumour cell lysis, lectin-sensitive CL8-1 melanoma cells were incubated with GS1B4 lectin immobilized on agarose beads. |
TextSentencer_T10 | 1549-1814 | Sentence | denotes | Although these tumour cells bind to the immobilized lectin, it failed to trigger tumour cell death, suggesting that only soluble lectin is capable of tumour cell lysis and lectin internalization is probably required for their lysis.(ABSTRACT TRUNCATED AT 250 WORDS) |
T1 | 0-41 | Sentence | denotes | Lectin-induced apoptosis of tumour cells. |
T2 | 42-213 | Sentence | denotes | The mechanisms of cytotoxic activity of Griffonia simplicifolia 1-B4 (GS1B4) and wheat germ agglutinin (WGA) lectins against various murine tumour cell lines were studied. |
T3 | 214-307 | Sentence | denotes | Tumour cells that lack lectin-binding carbohydrates were resistant to lysis by these lectins. |
T4 | 308-403 | Sentence | denotes | However, YAC-1 cells that expressed GS1B4 lectin-binding sites showed low sensitivity to lysis. |
T5 | 404-718 | Sentence | denotes | To further analyse the relative importance of cell surface carbohydrates in lectin cytotoxicity, BL6-8 melanoma cells, which do not express the alpha 1,3 galactosyltransferase (alpha 1,3GT) gene and cell surface alpha-galactosyl epitopes reacting with GS1B4 lectin, were transfected with cDNA encoding alpha 1,3GT. |
T6 | 719-1086 | Sentence | denotes | After transfection, BL6-8 cells expressed high levels of GS1B4-binding alpha-galactosyl epitopes, but remained resistant to lysis by GS1B4 lectin, suggesting that the presence of lectin-binding epitopes, while essential, is not sufficient for tumour cell lysis and probably some intracellular mechanisms are involved in the regulation of lectin-mediated cytotoxicity. |
T7 | 1087-1219 | Sentence | denotes | We found that the GS1B4 and WGA lectins induced apoptosis with DNA fragmentation of sensitive, but not resistant, tumour cell lines. |
T8 | 1220-1330 | Sentence | denotes | DNA fragmentation, as well as tumour cell lysis, was blocked in the presence of the specific inhibitory sugar. |
T9 | 1331-1548 | Sentence | denotes | To determine whether binding of the lectin to cell surface carbohydrates is sufficient to trigger tumour cell lysis, lectin-sensitive CL8-1 melanoma cells were incubated with GS1B4 lectin immobilized on agarose beads. |
T10 | 1549-1814 | Sentence | denotes | Although these tumour cells bind to the immobilized lectin, it failed to trigger tumour cell death, suggesting that only soluble lectin is capable of tumour cell lysis and lectin internalization is probably required for their lysis.(ABSTRACT TRUNCATED AT 250 WORDS) |
T1 | 0-41 | Sentence | denotes | Lectin-induced apoptosis of tumour cells. |
T2 | 42-213 | Sentence | denotes | The mechanisms of cytotoxic activity of Griffonia simplicifolia 1-B4 (GS1B4) and wheat germ agglutinin (WGA) lectins against various murine tumour cell lines were studied. |
T3 | 214-307 | Sentence | denotes | Tumour cells that lack lectin-binding carbohydrates were resistant to lysis by these lectins. |
T4 | 308-403 | Sentence | denotes | However, YAC-1 cells that expressed GS1B4 lectin-binding sites showed low sensitivity to lysis. |
T5 | 404-718 | Sentence | denotes | To further analyse the relative importance of cell surface carbohydrates in lectin cytotoxicity, BL6-8 melanoma cells, which do not express the alpha 1,3 galactosyltransferase (alpha 1,3GT) gene and cell surface alpha-galactosyl epitopes reacting with GS1B4 lectin, were transfected with cDNA encoding alpha 1,3GT. |
T6 | 719-1086 | Sentence | denotes | After transfection, BL6-8 cells expressed high levels of GS1B4-binding alpha-galactosyl epitopes, but remained resistant to lysis by GS1B4 lectin, suggesting that the presence of lectin-binding epitopes, while essential, is not sufficient for tumour cell lysis and probably some intracellular mechanisms are involved in the regulation of lectin-mediated cytotoxicity. |
T7 | 1087-1219 | Sentence | denotes | We found that the GS1B4 and WGA lectins induced apoptosis with DNA fragmentation of sensitive, but not resistant, tumour cell lines. |
T8 | 1220-1330 | Sentence | denotes | DNA fragmentation, as well as tumour cell lysis, was blocked in the presence of the specific inhibitory sugar. |
T9 | 1331-1548 | Sentence | denotes | To determine whether binding of the lectin to cell surface carbohydrates is sufficient to trigger tumour cell lysis, lectin-sensitive CL8-1 melanoma cells were incubated with GS1B4 lectin immobilized on agarose beads. |
T10 | 1549-1814 | Sentence | denotes | Although these tumour cells bind to the immobilized lectin, it failed to trigger tumour cell death, suggesting that only soluble lectin is capable of tumour cell lysis and lectin internalization is probably required for their lysis.(ABSTRACT TRUNCATED AT 250 WORDS) |
GlycoBiology-FMA
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
_T1 | 35-40 | FMAID:68646 | denotes | cells |
_T2 | 35-40 | FMAID:169002 | denotes | cells |
_T3 | 221-226 | FMAID:169002 | denotes | cells |
_T4 | 221-226 | FMAID:68646 | denotes | cells |
_T5 | 252-265 | FMAID:82737 | denotes | carbohydrates |
_T6 | 252-265 | FMAID:197276 | denotes | carbohydrates |
_T7 | 323-328 | FMAID:68646 | denotes | cells |
_T8 | 323-328 | FMAID:169002 | denotes | cells |
_T9 | 450-462 | FMAID:200942 | denotes | cell surface |
_T10 | 450-462 | FMAID:212684 | denotes | cell surface |
_T11 | 455-462 | FMAID:50594 | denotes | surface |
_T12 | 455-462 | FMAID:146300 | denotes | surface |
_T13 | 463-476 | FMAID:82737 | denotes | carbohydrates |
_T14 | 463-476 | FMAID:197276 | denotes | carbohydrates |
_T15 | 516-521 | FMAID:68646 | denotes | cells |
_T16 | 516-521 | FMAID:169002 | denotes | cells |
_T17 | 594-598 | FMAID:198663 | denotes | gene |
_T18 | 603-615 | FMAID:200942 | denotes | cell surface |
_T19 | 603-615 | FMAID:212684 | denotes | cell surface |
_T20 | 608-615 | FMAID:146300 | denotes | surface |
_T21 | 608-615 | FMAID:50594 | denotes | surface |
_T22 | 745-750 | FMAID:68646 | denotes | cells |
_T23 | 745-750 | FMAID:169002 | denotes | cells |
_T24 | 998-1022 | FMAID:201486 | denotes | intracellular mechanisms |
_T25 | 1324-1329 | FMAID:196724 | denotes | sugar |
_T26 | 1377-1389 | FMAID:200942 | denotes | cell surface |
_T27 | 1377-1389 | FMAID:212684 | denotes | cell surface |
_T28 | 1382-1389 | FMAID:50594 | denotes | surface |
_T29 | 1382-1389 | FMAID:146300 | denotes | surface |
_T30 | 1390-1403 | FMAID:82737 | denotes | carbohydrates |
_T31 | 1390-1403 | FMAID:197276 | denotes | carbohydrates |
_T32 | 1480-1485 | FMAID:68646 | denotes | cells |
_T33 | 1480-1485 | FMAID:169002 | denotes | cells |
_T34 | 1571-1576 | FMAID:68646 | denotes | cells |
_T35 | 1571-1576 | FMAID:169002 | denotes | cells |
_T36 | 1728-1743 | FMAID:214710 | denotes | internalization |
uniprot-mouse
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 317-322 | http://www.uniprot.org/uniprot/Q60935 | denotes | YAC-1 |
T2 | 558-579 | http://www.uniprot.org/uniprot/P23336 | denotes | galactosyltransferase |
T3 | 1801-1803 | http://www.uniprot.org/uniprot/Q8VHK8 | denotes | AT |
GlycoBiology-NCBITAXON
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 35-40 | http://purl.bioontology.org/ontology/STY/T025 | denotes | cells |
T2 | 46-56 | http://purl.bioontology.org/ontology/NCBITAXON/127244 | denotes | mechanisms |
T3 | 82-91 | http://purl.bioontology.org/ontology/NCBITAXON/3849 | denotes | Griffonia |
T4 | 82-105 | http://purl.bioontology.org/ontology/NCBITAXON/3850 | denotes | Griffonia simplicifolia |
T5 | 92-105 | http://purl.bioontology.org/ontology/NCBITAXON/941451 | denotes | simplicifolia |
T6 | 221-226 | http://purl.bioontology.org/ontology/STY/T025 | denotes | cells |
T7 | 323-328 | http://purl.bioontology.org/ontology/STY/T025 | denotes | cells |
T8 | 507-515 | http://purl.bioontology.org/ontology/NCBITAXON/1369386 | denotes | melanoma |
T9 | 507-515 | http://purl.bioontology.org/ontology/NCBITAXON/45308 | denotes | melanoma |
T10 | 516-521 | http://purl.bioontology.org/ontology/STY/T025 | denotes | cells |
T11 | 745-750 | http://purl.bioontology.org/ontology/STY/T025 | denotes | cells |
T12 | 1012-1022 | http://purl.bioontology.org/ontology/NCBITAXON/127244 | denotes | mechanisms |
T13 | 1471-1479 | http://purl.bioontology.org/ontology/NCBITAXON/1369386 | denotes | melanoma |
T14 | 1471-1479 | http://purl.bioontology.org/ontology/NCBITAXON/45308 | denotes | melanoma |
T15 | 1480-1485 | http://purl.bioontology.org/ontology/STY/T025 | denotes | cells |
T16 | 1571-1576 | http://purl.bioontology.org/ontology/STY/T025 | denotes | cells |
GO-BP
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 15-24 | http://purl.obolibrary.org/obo/GO_0006915 | denotes | apoptosis |
T2 | 15-24 | http://purl.obolibrary.org/obo/GO_0097194 | denotes | apoptosis |
T3 | 1135-1144 | http://purl.obolibrary.org/obo/GO_0006915 | denotes | apoptosis |
T4 | 1135-1144 | http://purl.obolibrary.org/obo/GO_0097194 | denotes | apoptosis |
T5 | 284-289 | http://purl.obolibrary.org/obo/GO_0043870 | denotes | lysis |
T6 | 397-402 | http://purl.obolibrary.org/obo/GO_0043870 | denotes | lysis |
T7 | 843-848 | http://purl.obolibrary.org/obo/GO_0043870 | denotes | lysis |
T8 | 974-979 | http://purl.obolibrary.org/obo/GO_0043870 | denotes | lysis |
T9 | 1262-1267 | http://purl.obolibrary.org/obo/GO_0043870 | denotes | lysis |
T10 | 1441-1446 | http://purl.obolibrary.org/obo/GO_0043870 | denotes | lysis |
T11 | 1711-1716 | http://purl.obolibrary.org/obo/GO_0043870 | denotes | lysis |
T12 | 1775-1780 | http://purl.obolibrary.org/obo/GO_0043870 | denotes | lysis |
T13 | 284-289 | http://purl.obolibrary.org/obo/GO_0019835 | denotes | lysis |
T14 | 397-402 | http://purl.obolibrary.org/obo/GO_0019835 | denotes | lysis |
T15 | 843-848 | http://purl.obolibrary.org/obo/GO_0019835 | denotes | lysis |
T16 | 974-979 | http://purl.obolibrary.org/obo/GO_0019835 | denotes | lysis |
T17 | 1262-1267 | http://purl.obolibrary.org/obo/GO_0019835 | denotes | lysis |
T18 | 1441-1446 | http://purl.obolibrary.org/obo/GO_0019835 | denotes | lysis |
T19 | 1711-1716 | http://purl.obolibrary.org/obo/GO_0019835 | denotes | lysis |
T20 | 1775-1780 | http://purl.obolibrary.org/obo/GO_0019835 | denotes | lysis |
T21 | 382-393 | http://purl.obolibrary.org/obo/GO_0046960 | denotes | sensitivity |
T22 | 1171-1180 | http://purl.obolibrary.org/obo/GO_0046960 | denotes | sensitive |
T23 | 1455-1464 | http://purl.obolibrary.org/obo/GO_0046960 | denotes | sensitive |
T24 | 436-454 | http://purl.obolibrary.org/obo/GO_0098657 | denotes | importance of cell |
T25 | 548-579 | http://purl.obolibrary.org/obo/GO_0001962 | denotes | alpha 1,3 galactosyltransferase |
T26 | 1043-1053 | http://purl.obolibrary.org/obo/GO_0065007 | denotes | regulation |
T27 | 1150-1167 | http://purl.obolibrary.org/obo/GO_0006309 | denotes | DNA fragmentation |
T28 | 1220-1237 | http://purl.obolibrary.org/obo/GO_0006309 | denotes | DNA fragmentation |
T29 | 1637-1647 | http://purl.obolibrary.org/obo/GO_0008219 | denotes | cell death |
T30 | 1642-1647 | http://purl.obolibrary.org/obo/GO_0016265 | denotes | death |
GO-MF
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 244-251 | http://purl.obolibrary.org/obo/GO_0070026 | denotes | binding |
T2 | 357-364 | http://purl.obolibrary.org/obo/GO_0070026 | denotes | binding |
T3 | 782-789 | http://purl.obolibrary.org/obo/GO_0070026 | denotes | binding |
T4 | 905-912 | http://purl.obolibrary.org/obo/GO_0070026 | denotes | binding |
T5 | 1352-1359 | http://purl.obolibrary.org/obo/GO_0070026 | denotes | binding |
T6 | 1577-1581 | http://purl.obolibrary.org/obo/GO_0070026 | denotes | bind |
T7 | 244-251 | http://purl.obolibrary.org/obo/GO_0003680 | denotes | binding |
T8 | 357-364 | http://purl.obolibrary.org/obo/GO_0003680 | denotes | binding |
T9 | 782-789 | http://purl.obolibrary.org/obo/GO_0003680 | denotes | binding |
T10 | 905-912 | http://purl.obolibrary.org/obo/GO_0003680 | denotes | binding |
T11 | 1352-1359 | http://purl.obolibrary.org/obo/GO_0003680 | denotes | binding |
T12 | 1577-1581 | http://purl.obolibrary.org/obo/GO_0003680 | denotes | bind |
T13 | 244-251 | http://purl.obolibrary.org/obo/GO_0017091 | denotes | binding |
T14 | 357-364 | http://purl.obolibrary.org/obo/GO_0017091 | denotes | binding |
T15 | 782-789 | http://purl.obolibrary.org/obo/GO_0017091 | denotes | binding |
T16 | 905-912 | http://purl.obolibrary.org/obo/GO_0017091 | denotes | binding |
T17 | 1352-1359 | http://purl.obolibrary.org/obo/GO_0017091 | denotes | binding |
T18 | 1577-1581 | http://purl.obolibrary.org/obo/GO_0017091 | denotes | bind |
T19 | 244-251 | http://purl.obolibrary.org/obo/GO_0005488 | denotes | binding |
T20 | 357-364 | http://purl.obolibrary.org/obo/GO_0005488 | denotes | binding |
T21 | 782-789 | http://purl.obolibrary.org/obo/GO_0005488 | denotes | binding |
T22 | 905-912 | http://purl.obolibrary.org/obo/GO_0005488 | denotes | binding |
T23 | 1352-1359 | http://purl.obolibrary.org/obo/GO_0005488 | denotes | binding |
T24 | 1577-1581 | http://purl.obolibrary.org/obo/GO_0005488 | denotes | bind |
T25 | 244-265 | http://purl.obolibrary.org/obo/GO_0030246 | denotes | binding carbohydrates |
GO-CC
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 35-40 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T2 | 221-226 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T3 | 323-328 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T4 | 516-521 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T5 | 745-750 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T6 | 1480-1485 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T7 | 189-193 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
T8 | 450-454 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
T9 | 603-607 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
T10 | 969-973 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
T11 | 1208-1212 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
T12 | 1257-1261 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
T13 | 1377-1381 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
T14 | 1436-1440 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
T15 | 1637-1641 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
T16 | 1706-1710 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
T17 | 450-462 | http://purl.obolibrary.org/obo/GO_0009986 | denotes | cell surface |
T18 | 603-615 | http://purl.obolibrary.org/obo/GO_0009986 | denotes | cell surface |
T19 | 1377-1389 | http://purl.obolibrary.org/obo/GO_0009986 | denotes | cell surface |
T20 | 998-1011 | http://purl.obolibrary.org/obo/GO_0005622 | denotes | intracellular |
GlycoBiology-Epitope
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
PD-GlycoEpitope-B_T1 | 616-641 | http://www.glycoepitope.jp/epitopes/EP0200 | denotes | alpha-galactosyl epitopes |
PD-GlycoEpitope-B_T2 | 790-815 | http://www.glycoepitope.jp/epitopes/EP0200 | denotes | alpha-galactosyl epitopes |
GlyTouCan-IUPAC
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
GlycanIUPAC_T1 | 1324-1329 | "http://rdf.glycoinfo.org/glycan/G59665TO" | denotes | sugar |
GlycanIUPAC_T2 | 1324-1329 | "http://rdf.glycoinfo.org/glycan/G32915EI" | denotes | sugar |
GlycanIUPAC_T3 | 1324-1329 | "http://rdf.glycoinfo.org/glycan/G60625TS" | denotes | sugar |
HP-phenotype
Id | Subject | Object | Predicate | Lexical cue | hp_id |
---|---|---|---|---|---|
T1 | 28-34 | Phenotype | denotes | tumour | HP:0002664 |
T2 | 182-188 | Phenotype | denotes | tumour | HP:0002664 |
T3 | 214-220 | Phenotype | denotes | Tumour | HP:0002664 |
T4 | 507-515 | Phenotype | denotes | melanoma | HP:0002861 |
T5 | 962-968 | Phenotype | denotes | tumour | HP:0002664 |
T6 | 1201-1207 | Phenotype | denotes | tumour | HP:0002664 |
T7 | 1250-1256 | Phenotype | denotes | tumour | HP:0002664 |
T8 | 1429-1435 | Phenotype | denotes | tumour | HP:0002664 |
T9 | 1471-1479 | Phenotype | denotes | melanoma | HP:0002861 |
T10 | 1564-1570 | Phenotype | denotes | tumour | HP:0002664 |
T11 | 1630-1636 | Phenotype | denotes | tumour | HP:0002664 |
T12 | 1699-1705 | Phenotype | denotes | tumour | HP:0002664 |
mondo_disease
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T1 | 507-515 | Disease | denotes | melanoma | http://purl.obolibrary.org/obo/MONDO_0005105 |
T2 | 1471-1479 | Disease | denotes | melanoma | http://purl.obolibrary.org/obo/MONDO_0005105 |
Lectin-Jamboree
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 0-6 | lectin | denotes | Lectin |
T2 | 151-158 | lectin | denotes | lectins |
T3 | 237-243 | lectin | denotes | lectin |
T4 | 299-306 | lectin | denotes | lectins |
T5 | 350-356 | lectin | denotes | lectin |
T6 | 480-486 | lectin | denotes | lectin |
T7 | 662-668 | lectin | denotes | lectin |
T8 | 858-864 | lectin | denotes | lectin |
T9 | 898-904 | lectin | denotes | lectin |
T10 | 1057-1063 | lectin | denotes | lectin |
T11 | 1119-1126 | lectin | denotes | lectins |
T12 | 1367-1373 | lectin | denotes | lectin |
T13 | 1448-1454 | lectin | denotes | lectin |
T14 | 1512-1518 | lectin | denotes | lectin |
T15 | 1601-1607 | lectin | denotes | lectin |
T16 | 1678-1684 | lectin | denotes | lectin |
T17 | 1721-1727 | lectin | denotes | lectin |
Lectin-Jamboree-small
Id | Subject | Object | Predicate | Lexical cue | glycosmos_id |
---|---|---|---|---|---|
T1 | 146-149 | Lectin | denotes | WGA | GL_003502 |
T2 | 1115-1118 | Lectin | denotes | WGA | GL_003502 |
Lectin-Jamboree-Sentence
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 0-41 | Sentence | denotes | Lectin-induced apoptosis of tumour cells. |
T2 | 42-213 | Sentence | denotes | The mechanisms of cytotoxic activity of Griffonia simplicifolia 1-B4 (GS1B4) and wheat germ agglutinin (WGA) lectins against various murine tumour cell lines were studied. |
T3 | 214-307 | Sentence | denotes | Tumour cells that lack lectin-binding carbohydrates were resistant to lysis by these lectins. |
T4 | 308-403 | Sentence | denotes | However, YAC-1 cells that expressed GS1B4 lectin-binding sites showed low sensitivity to lysis. |
T5 | 404-718 | Sentence | denotes | To further analyse the relative importance of cell surface carbohydrates in lectin cytotoxicity, BL6-8 melanoma cells, which do not express the alpha 1,3 galactosyltransferase (alpha 1,3GT) gene and cell surface alpha-galactosyl epitopes reacting with GS1B4 lectin, were transfected with cDNA encoding alpha 1,3GT. |
T6 | 719-1086 | Sentence | denotes | After transfection, BL6-8 cells expressed high levels of GS1B4-binding alpha-galactosyl epitopes, but remained resistant to lysis by GS1B4 lectin, suggesting that the presence of lectin-binding epitopes, while essential, is not sufficient for tumour cell lysis and probably some intracellular mechanisms are involved in the regulation of lectin-mediated cytotoxicity. |
T7 | 1087-1219 | Sentence | denotes | We found that the GS1B4 and WGA lectins induced apoptosis with DNA fragmentation of sensitive, but not resistant, tumour cell lines. |
T8 | 1220-1330 | Sentence | denotes | DNA fragmentation, as well as tumour cell lysis, was blocked in the presence of the specific inhibitory sugar. |
T9 | 1331-1548 | Sentence | denotes | To determine whether binding of the lectin to cell surface carbohydrates is sufficient to trigger tumour cell lysis, lectin-sensitive CL8-1 melanoma cells were incubated with GS1B4 lectin immobilized on agarose beads. |
T10 | 1549-1814 | Sentence | denotes | Although these tumour cells bind to the immobilized lectin, it failed to trigger tumour cell death, suggesting that only soluble lectin is capable of tumour cell lysis and lectin internalization is probably required for their lysis.(ABSTRACT TRUNCATED AT 250 WORDS) |
NCBITAXON
Id | Subject | Object | Predicate | Lexical cue | db_id |
---|---|---|---|---|---|
T1 | 82-105 | OrganismTaxon | denotes | Griffonia simplicifolia | 3850 |
T2 | 123-128 | OrganismTaxon | denotes | wheat | 4565 |
Anatomy-UBERON
Id | Subject | Object | Predicate | Lexical cue | uberon_id |
---|---|---|---|---|---|
T1 | 998-1011 | Body_part | denotes | intracellular | http://purl.obolibrary.org/obo/GO_0005622 |