| Id |
Subject |
Object |
Predicate |
Lexical cue |
| TextSentencer_T1 |
0-93 |
Sentence |
denotes |
Hormonal regulation of transforming growth factor beta-2 expression in human prostate cancer. |
| TextSentencer_T2 |
94-274 |
Sentence |
denotes |
We have previously shown that a transforming factor-beta species (TGF beta) is a hormonally regulated negative growth factor in estrogen responsive MCF-7 human breast cancer cells. |
| TextSentencer_T3 |
275-441 |
Sentence |
denotes |
We now demonstrate that androgen withdrawal leads to a significant stimulation of TGF beta-2 mRNA in the androgen-responsive human prostate carcinoma cell line LNCaP. |
| TextSentencer_T4 |
442-549 |
Sentence |
denotes |
These data indicate that TGF beta-2 is a marker of (anti)androgen action in human prostate cancer in vitro. |
| TextSentencer_T5 |
550-878 |
Sentence |
denotes |
Based on these results we addressed the question of whether TGF beta-2 represented a marker of (anti)androgen action in prostate cancer in vivo: expression of TGF beta mRNA was determined by RNAase protection analysis in normal and malignant prostate tissue obtained from 9 prostate carcinoma patients without endocrine therapy. |
| TextSentencer_T6 |
879-1017 |
Sentence |
denotes |
In parallel, the nuclear dihydrotestosterone (DHT) concentration was measured as an indicator of androgen stimulation in the same tissues. |
| TextSentencer_T7 |
1018-1054 |
Sentence |
denotes |
The following results were obtained. |
| TextSentencer_T8 |
1055-1171 |
Sentence |
denotes |
Both normal and cancerous tissues show nuclear accumulation of DHT indicating a functional androgen receptor system. |
| TextSentencer_T9 |
1172-1240 |
Sentence |
denotes |
TGF beta-2 is equally expressed in both normal and cancerous tissue. |
| TextSentencer_T10 |
1241-1348 |
Sentence |
denotes |
Expression of TGF beta-2 and nuclear DHT concentrations are correlated in both benign and malignant tissue. |
| TextSentencer_T11 |
1349-1443 |
Sentence |
denotes |
We conclude that TGF beta-2 is a marker of (anti)hormonal action in androgen-dependent tissue. |
| T1 |
0-93 |
Sentence |
denotes |
Hormonal regulation of transforming growth factor beta-2 expression in human prostate cancer. |
| T2 |
94-274 |
Sentence |
denotes |
We have previously shown that a transforming factor-beta species (TGF beta) is a hormonally regulated negative growth factor in estrogen responsive MCF-7 human breast cancer cells. |
| T3 |
275-441 |
Sentence |
denotes |
We now demonstrate that androgen withdrawal leads to a significant stimulation of TGF beta-2 mRNA in the androgen-responsive human prostate carcinoma cell line LNCaP. |
| T4 |
442-549 |
Sentence |
denotes |
These data indicate that TGF beta-2 is a marker of (anti)androgen action in human prostate cancer in vitro. |
| T5 |
550-878 |
Sentence |
denotes |
Based on these results we addressed the question of whether TGF beta-2 represented a marker of (anti)androgen action in prostate cancer in vivo: expression of TGF beta mRNA was determined by RNAase protection analysis in normal and malignant prostate tissue obtained from 9 prostate carcinoma patients without endocrine therapy. |
| T6 |
879-1017 |
Sentence |
denotes |
In parallel, the nuclear dihydrotestosterone (DHT) concentration was measured as an indicator of androgen stimulation in the same tissues. |
| T7 |
1018-1054 |
Sentence |
denotes |
The following results were obtained. |
| T8 |
1055-1171 |
Sentence |
denotes |
Both normal and cancerous tissues show nuclear accumulation of DHT indicating a functional androgen receptor system. |
| T9 |
1172-1240 |
Sentence |
denotes |
TGF beta-2 is equally expressed in both normal and cancerous tissue. |
| T10 |
1241-1348 |
Sentence |
denotes |
Expression of TGF beta-2 and nuclear DHT concentrations are correlated in both benign and malignant tissue. |
| T11 |
1349-1443 |
Sentence |
denotes |
We conclude that TGF beta-2 is a marker of (anti)hormonal action in androgen-dependent tissue. |
