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PubMed:8249302 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-128 Sentence denotes DNA-sequence rearrangement required for the adaptation of JC polyomavirus to growth in a human neuroblastoma cell line (IMR-32).
TextSentencer_T2 129-326 Sentence denotes Infection of a human neuroblastoma cell line (IMR-32) with the JC polyomavirus (JCV) strain Mad-1 with subsequent serial passage results in the generation of a virus adapted to growth in IMR-32 (K.
TextSentencer_T3 327-338 Sentence denotes Akatani, M.
TextSentencer_T4 339-347 Sentence denotes Imai, M.
TextSentencer_T5 348-358 Sentence denotes Kimura, K.
TextSentencer_T6 359-376 Sentence denotes Nagashima, and N.
TextSentencer_T7 377-388 Sentence denotes Ikegami, J.
TextSentencer_T8 389-393 Sentence denotes Med.
TextSentencer_T9 394-412 Sentence denotes Virol., in press).
TextSentencer_T10 413-511 Sentence denotes To understand the basis of this adaptation, we molecularly cloned JCV DNAs from the adapted virus.
TextSentencer_T11 512-634 Sentence denotes The cloned JCV DNAs consisted of essentially three species (M1-IMRa, -IMRb, and -IMRc) with rearranged regulatory regions.
TextSentencer_T12 635-816 Sentence denotes Two TATA sequences are present in the regulatory region of the parental virus Mad-1, but one distal from the origin of replication was commonly deleted in M1-IMRa, -IMRb, and -IMRc.
TextSentencer_T13 817-913 Sentence denotes We showed that these regulatory regions were required for the efficient growth of JCV in IMR-32.
TextSentencer_T14 914-1040 Sentence denotes Various JCV strains should be propagated in IMR-32, if their regulatory regions are replaced with those defined in this study.
TextSentencer_T15 1041-1207 Sentence denotes Since it is difficult to propagate JCV in cells other than primary human fetal glial cells, this system may be useful for structural and immunological studies of JCV.
T1 0-128 Sentence denotes DNA-sequence rearrangement required for the adaptation of JC polyomavirus to growth in a human neuroblastoma cell line (IMR-32).
T2 129-326 Sentence denotes Infection of a human neuroblastoma cell line (IMR-32) with the JC polyomavirus (JCV) strain Mad-1 with subsequent serial passage results in the generation of a virus adapted to growth in IMR-32 (K.
T3 327-338 Sentence denotes Akatani, M.
T4 339-347 Sentence denotes Imai, M.
T5 348-358 Sentence denotes Kimura, K.
T6 359-376 Sentence denotes Nagashima, and N.
T7 377-388 Sentence denotes Ikegami, J.
T8 389-393 Sentence denotes Med.
T9 394-412 Sentence denotes Virol., in press).
T10 413-511 Sentence denotes To understand the basis of this adaptation, we molecularly cloned JCV DNAs from the adapted virus.
T11 512-634 Sentence denotes The cloned JCV DNAs consisted of essentially three species (M1-IMRa, -IMRb, and -IMRc) with rearranged regulatory regions.
T12 635-816 Sentence denotes Two TATA sequences are present in the regulatory region of the parental virus Mad-1, but one distal from the origin of replication was commonly deleted in M1-IMRa, -IMRb, and -IMRc.
T13 817-913 Sentence denotes We showed that these regulatory regions were required for the efficient growth of JCV in IMR-32.
T14 914-1040 Sentence denotes Various JCV strains should be propagated in IMR-32, if their regulatory regions are replaced with those defined in this study.
T15 1041-1207 Sentence denotes Since it is difficult to propagate JCV in cells other than primary human fetal glial cells, this system may be useful for structural and immunological studies of JCV.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 221-226 gene:4084 denotes Mad-1
T1 150-163 disease:C0027819 denotes neuroblastoma
T2 221-226 gene:4084 denotes Mad-1
T3 150-163 disease:C0700095 denotes neuroblastoma
T4 221-226 gene:8379 denotes Mad-1
T5 150-163 disease:C0027819 denotes neuroblastoma
T6 221-226 gene:8379 denotes Mad-1
T7 150-163 disease:C0700095 denotes neuroblastoma
R1 T0 T1 associated_with Mad-1,neuroblastoma
R2 T2 T3 associated_with Mad-1,neuroblastoma
R3 T4 T5 associated_with Mad-1,neuroblastoma
R4 T6 T7 associated_with Mad-1,neuroblastoma

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T1081 221-226 gene:8379 denotes Mad-1
T1082 150-163 disease:C0027819 denotes neuroblastoma
R1 T1081 T1082 associated_with Mad-1,neuroblastoma
R2 T1081 T1082 associated_with Mad-1,neuroblastoma
R3 T1081 T1082 associated_with Mad-1,neuroblastoma
R4 T1081 T1082 associated_with Mad-1,neuroblastoma